Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

doi:10.1073/pnas.1301816110

Table 2.

MNI coordinates of regions showing reduced loss of GM with B-vitamin treatment

Cortical region	Side	MNI (mm)			Local maximum t
Cortical region	Side	x	y	z	Local maximum t
Medial temporal areas
Hippocampus	L	−40	−30	−14	4.23
Hippocampus	R	40	−20	−14	4.03
Parahippocampal gyrus	L	−22	−32	−14	3.80
Parahippocampal gyrus	R	20	−40	−12	3.66
Entorhinal cortex	L	−26	−12	−44	3.47
Entorhinal cortex	R	20	−22	−28	3.20

Other visuospatial areas
Retrosplenial precuneus/ventral posterior cingulate	L	−6	−40	2	3.39
Retrosplenial precuneus/ventral posterior cingulate	R	12	−46	−2	3.16
Lingual gyrus	L	−22	−56	−6	2.70
Lingual gyrus	R	18	−52	−2	3.61
Fusiform gyrus (temporal) (only high tHcy subjects)	L	−40	−8	−44	4.53
Fusiform gyrus (temporal)	R	42	−12	−32	4.28
Fusiform gyrus (temporo-occipital)	R	34	−44	−18	3.33
Fusiform gyrus (occipital)	L	−24	−82	−8	3.66
Lateral occipital cortex	L	−42	−76	2	3.37
Lateral occipital cortex (only high tHcy subjects)	R	40	−74	−4	4.33
Inferior parietal lobule (supramarginal gyrus)	R	52	−42	36	3.21
Inferior parietal lobule (angular gyrus)	R	64	−48	16	2.87

Other temporal areas
Middle temporal gyrus	R	60	−18	−6	3.09
Inferior temporal gyrus	L	−50	−60	−14	4.16
Inferior temporal gyrus	L	−48	−46	−28	4.44
Inferior temporal gyrus	R	50	−20	−28	3.93

Cerebellum
Cerebellum (crus I)	R	42	−48	−32	3.94
Cerebellum (crus II)	R	40	−52	−44	3.92
Cerebellum (IX)	L	−16	−50	−46	3.82
Cerebellum (VIIIb)	L	−20	−42	−48	4.05

Anterior areas (only high tHcy subjects)
Straight gyrus	—	4	44	−26	3.58
Piriform cortex	L	−28	14	−14	4.52
Piriform cortex	R	34	10	−14	2.94
Striatum	L	−18	14	−2	2.86
Striatum	R	6	4	−2	2.96
Pars triangularis	L	−48	28	14	3.07
Middle frontal gyrus (BA46)	R	40	46	8	4.33
Superior frontal gyrus (BA9)	R	24	36	32	3.41
Dorsal anterior cingulate (BA32)	—	4	46	8	2.38
Ventral anterior cingulate (BA24)	R	12	12	48	3.39
Ventral anterior cingulate (BA24)	L	−14	24	32	2.64

Common local peaks (unless specified otherwise) of the significant clusters (P < 0.05 FWE-corrected) showing reduced GM atrophy in the B-vitamin group in contrast with the placebo group for all MCI 156 subjects (Fig. 2) and for subjects with high tHcy level (Fig. 3). Local maximum t values correspond to Fig. 3. BA, Brodmann area.