Editorial: Osteoarthritis as an Autoinflammatory Disease Caused by
Chondrocyte-mediated Inflammatory Responses
Arthritis & Rheumatism 2012 (Mar); 64 (3): 613–616 ~ FULL TEXT
Osteoarthritis (OA) is considered to be primarily a disease of the hyaline articular cartilage, which secondarily affects subchondral bone and synovial membrane. The exact nature and mechanisms of OA, particularly during the early phases of the disease, are unknown. OA per se might in part relate to the poor inherent repair capacity of the articular cartilage, which during the lifetime of modern (long-lived) human beings, is gradually subjected to progressive and accumulative wear and tear. However, the idea of OA as a simple wear-and-tear disease has been widely rejected because various biologic processes, such as inflammation and enzymatic cartilage degradation, are apparently involved in its pathogenesis. Recent findings provide possible new explanatory pathogenic models that intimately link the two phenomena — biomechanical wear and tear of the cartilage (osteoarthrosis) and inflammation (osteoarthritis) — to each other.