Science 1997 (Jan 10); 275 (5297): 218–220
Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH,
Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM
Department of Medicinal Chemistry and Pharmacognosy,
College of Pharmacy,
University of Illinois at Chicago,
Chicago, IL 60612, USA
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.