Adverse Events From Spinal Manipulation
in the Pregnant and Postpartum Periods:
A Critical Review of the Literature

This section is compiled by Frank M. Painter, D.C.
Send all comments or additions to:

FROM:   Chiropractic & Manual Therapies 2012 (Mar 28);   20:   8 ~ FULL TEXT

Kent Jason Stuber, Shari Wynd, and Carol Ann Weis

Division of Graduate Education and Research,
Canadian Memorial Chiropractic College,
6100 Leslie Street,
Toronto, ON M2H 3J1, Canada.

BACKGROUND:   The safety of spinal manipulation during pregnancy and the postpartum periods has been a matter of debate among manual therapists. Spinal manipulative therapy during these periods is a commonly performed intervention as musculoskeletal pain is common in these patients. To date there has not been an evaluation of the literature on this topic exclusively.

METHODS:   A literature search was conducted on PubMed, CINAHL and the Index to Chiropractic Literature along with reference searching for articles published in English and French in the peer-reviewed literature that documented adverse effects of spinal manipulation during either pregnancy or postpartum. Case reports, case series, and any other clinical study designs were deemed acceptable for inclusion, as were systematic reviews. The appropriate Scottish Intercollegiate Guidelines Network (SIGN) tools were used to rate included articles for quality when applicable.

RESULTS:   Five articles identifying adverse events in seven subjects following spinal manipulation were included in this review, along with two systematic reviews. The articles were published between 1978 and 2009. Two articles describing adverse effects from spinal manipulation on two postpartum patients were included, while the remaining three articles on five patients with adverse effects following spinal manipulation were on pregnant patients. Injury severity ranged from minor injury such as increasing pain after treatment that resolved within a few days to more severe injuries including fracture, stroke, and epidural hematoma. SIGN scores of the prospective observational cohort study and systematic reviews indicated acceptable quality.

CONCLUSIONS:   There are only a few reported cases of adverse events following spinal manipulation during pregnancy and the postpartum period identified in the literature. While improved reporting of such events is required in the future, it may be that such injuries are relatively rare.

Keywords:   Chiropractic, Spinal manipulative Therapy, Pregnancy, Postpartum, Adverse effects

From the Full-Text Article:


Musculoskeletal pain is a common occurrence during pregnancy and the postpartum period. For example, low back pain has been reported to occur as frequently as 50% to 85% of pregnant women [1–4] and at two to three years postpartum, eight to 20% of these women still report persistent symptoms [5, 6]. Although low back pain is often accepted as an unavoidable complaint during pregnancy, for some women the pain can be debilitating, interfering with sleep, work and normal activities of daily living [7, 8]. However, the etiology of this pain is unknown [9]. It has been suggested that low back pain experienced during pregnancy is multifactoral in nature and some of the proposed mechanisms include, but are not limited to, the influence of altered circulating relaxin levels producing ligamentous laxity [7, 10], maternal weight gain and/or biomechanical changes due to pregnancy [7].

In the non-pregnant population, low back pain is a significant cause of pain and disability as well, with 80% of the population experiencing an episode during their lifetime [7, 11]. Neck pain [12, 13] and headaches [14] are also a substantial source of pain and disability in the non-pregnant population [12]. One of the effective treatment options used by manual practitioners for those suffering from low back pain [15, 16] cervical spine [16, 17] and some headache pain [18, 19] is spinal manipulative therapy (SMT). SMT is usually characterized as a localized force of high velocity and low amplitude directed at a spinal segment [1]. Severe adverse effects of SMT are rare in the cervical spine [20–22] and lumbar spine [23].

Manual treatment options for pregnancy-induced pain, such as back pain, have been reported to be limited [1]. However, chiropractors report seeing pregnant patients frequently, and surveys of chiropractors reflect an opinion that SMT is safe for pregnant patients [1, 24]. While the safety of SMT for adult and pediatric populations has undergone scrutiny in both public and scientific domains [13, 22, 25], the safety of SMT in sub-groups of the population including pregnant and postpartum patients has received little attention. This lack of evidence is surprising given the obvious importance of the welfare of the expectant and new mother. Given the hormonal and the coagulability status of peripartum and postpartum individuals, it is possible that SMT is a contraindication to the musculoskeletal complaints associated with pregnancy.

It is accepted that females are more susceptible to increases in joint laxity than men [26–28]. Hormonal causes have been postulated as a potential source for this increase in female joint laxity [29–32]. Relaxin, a polypeptide that is produced by the corpus luteum during pregnancy [32], is one of the implicated hormones. In the pregnant female, relaxin is essential in order to secure the passage of the fetus during parturition in several animal species [33]; it has been associated with a decrease in soft tissue tension especially in preparing the female body for delivery including relaxing the pelvic ligaments, inhibiting spontaneous uterine contractions, ripening of the uterine cervix, and stimulating the mammary glands [34]. Although relaxin increases laxity in the symphysis pubis in preparation for birth, its effects are not solely limited to that joint. In addition, women immediately postpartum are thought to also have this hormone-mediated ligament laxity that might reduce the protective stability of the intervertebral articulations [35].

Hypercoaguable disorders that promote thrombosis have been categorized as thrombophilias [36]. During pregnancy and the postpartum state the risk of thrombophilia increases compared to the non-pregnant state [36, 37]. Thromboembolism or pulmonary embolism has been identified as the leading cause of maternal death in the United States [36, 37]. These hypercoaguable disorders during pregnancy can be a result of venous stasis, changes in the vessel wall and changes in the composition of blood; also known as Virchow's triad [36].

In the absence of a prospective study of the safety of SMT during the antepartum and postpartum periods, it would be beneficial to survey the scientific literature for the number and types of injuries sustained by pregnant and postpartum patients following spinal manipulation. While systematic reviews of the literature on the use of SMT for pregnancy and related conditions have been conducted [1, 11], an exploration of the literature specifically for adverse events associated with SMT and pregnancy has not yet been undertaken. Accordingly, the aim of this study is to critically review the literature for reported cases of iatrogenic injuries following spinal manipulative therapy during the pregnancy and postpartum periods.



To collect and synthesize available evidence on adverse events associated with SMT during the pregnancy and postpartum periods.

      Search strategy

A literature search was conducted in three different electronic databases: PubMed (including MEDLINE), CINAHL, and the Index to Chiropractic Literature. The date ranges applied were from the beginning of each respective database to October 2011. The following search terms were employed: adverse effects, adverse reactions, adverse events, harm, pregnancy, postpartum, chiropractic, spinal manipulative therapy, spinal manipulation, and manual therapy. These search terms were categorized and combined using Boolean terms (please see Additional file 1: Appendix 1 for the complete search strategy). Reference searching of relevant articles retrieved from the electronic literature search was also undertaken, as was a search of each of the authors' personal collections.

Specific inclusion criteria for this review were:

      Study designs

All clinical study designs published in peer-reviewed journals. Conference proceedings, cross-sectional and other descriptive designs and narrative reviews were excluded.


Female patients who are either pregnant or postpartum (defined as the period between the delivery of the child and six weeks after the birth) [38].


Spinal Manipulative Therapy (SMT) (defined as a manual therapy technique that uses a high velocity low amplitude thrust applied at a spinal motion segment [39] to any region of the spine.


Not relevant.


Any adverse events associated with SMT.


Articles in either English or French were considered for inclusion.

      Study selection

Two of the authors (KS and SW) independently reviewed the titles and abstracts of the electronic database searches for any that appeared to match the inclusion criteria. The full text versions of any potentially relevant articles were obtained and reviewed by the same two authors using the inclusion criteria described above. Each of the authors compiled a list of articles to include that was compared, and any disagreements were resolved through discussion.

      Data collection and rating process

A data extraction sheet was compiled by one of the authors (KS) and relevant data from each included article was entered into the sheet. The appropriate Scottish Intercollegiate Guidelines Network (SIGN) tools were used to rate included articles for quality, although any case reports included in the review were not rated for quality as there is no applicable SIGN tool for case reports. The overall assessment of a paper using a SIGN tool is given one of three scores: "++" indicates the highest level of methodological quality for that study type, fulfilling all or most of the internal validity criteria for that particular study type, "+" indicates some criteria were fulfilled, and "–" indicates that few or none of the criteria were satisfied. Two of the authors (KS and SW) rated the articles using the applicable SIGN tool. One of the authors (KS) was an author on one of the systematic reviews and thus that article was rated by the other two authors (SW and CAW) to avoid potential bias. Where reviewers disagreed, consensus was achieved by discussion.


Meta-analysis could not be conducted as only case reports and an observational cohort study were identified; data are summarized in text (percentages).


Figure 1 depicts the flow of articles through the review process [40]. One full text article was excluded because it did not use HVLA spinal manipulation [41]. Five articles that identified possible adverse events in seven subjects following spinal manipulation of a pregnant or post-partum subject were identified from the literature search, along with two relevant systematic reviews [1, 11] (the full list of included articles appears in Additional file 2: Appendix 2). The five articles consisted of four case reports [20, 21, 35, 42] and one prospective observational cohort study [43]. The four case reports all detailed adverse events following cervical manipulation, whereas the prospective observational cohort study described three adverse events following lumbar manipulation. The articles were published between 1978 and 2009.

Figure 2 describes the four case reports included, while (Additional file 3: Table S1) provides additional details on those case reports. One case report [42] was identified by reference searching. A systematic review of manipulative therapy during pregnancy [1] was identified from the authors' personal collections.

Figure 1.   PRISMA Information Flow [40]

Figure 2.   Case Report Descriptions.

Murphy et al published an observational cohort study in 2009, which evaluated a diagnosis-based decision rule for pregnancy-related lumbopelvic pain [43]. One hundred and fifteen patients began the study and complete data was obtained on 78 subjects. In terms of adverse effects three subjects (3.8%) reported increased pain after treatment; this was reported as resolving for two of these patients in less than 48 hours and in one week for the third patient. The treatments that each patient received depended on their specific diagnosis and it is unsure what diagnosis these patients were given. However nearly all patients (68/78) received some form of manual therapy. No other complications were reported in this study. The overall SIGN rating assigned to this article was "+", indicating acceptable quality although it was limited by a lack of blinding and possible confounders.

The systematic review by Stuber and Smith in 2008 on spinal manipulation for pregnancy-related lower back pain indicated that no adverse effects were noted in any of the papers that they reviewed, although only one of the articles specifically commented on an absence of adverse events [11]. The systematic review by Khorsan et al published in 2009 identified only the case report by Schmitz et al as having an adverse event resulting from manipulative therapy during pregnancy [1]. Most of the studies included in that review did not report adverse effects at all, although it was noted that three clinical studies indicated that there were no adverse events during their trials. The overall SIGN rating assigned to both of these systematic reviews was "++", indicating good quality.


To our knowledge, this is the first critical review of the literature regarding adverse events from spinal manipulation during pregnancy and postpartum and it provides healthcare professionals with a comprehensive evaluation of the available scientific literature. This review revealed adverse affects during spinal manipulation in three studies during pregnancy and two studies in the postpartum period. Of the studies identified, four case studies demonstrated adverse events following cervical manipulation whereas the observational cohort study demonstrated adverse events following lumbar manipulation. The remaining two papers that were identified were systematic reviews. As such reports of adverse events following spinal manipulation in these populations are scarce in the literature.

Mild and transient adverse events were reported as a result of lumbar spinal manipulation [43] whereas the serious adverse events reported in the literature all occurred following cervical spinal manipulation either during pregnancy [20, 21] or postpartum [35, 42]. Murphy and colleagues found that 3.4% of their pregnant population incurred an injury following manual therapy which resulted in a transient increase in pain after a single session. They found this to be much lower than other studies that have focused on manual therapy in which the rate of injury was approximately one third of the study group [43]. As such they suggested that SMT of the lumbar spine is safe for this population, however a larger sample size would be needed to detect rare complications [43]. This review did not identify any injuries or adverse events that could be associated specifically with either being pregnant or in the postpartum period (such as premature delivery or an abnormally difficult delivery, etc), that is to say that the adverse events identified may have occurred in a non-pregnant patient.

In the non-pregnant population severe complications after cervical spinal manipulation are rare [13, 22]. However rare, reported complications include vertebral artery dissection, cord or root injury, epidural hematoma, cervical disc rupture and vertebral fracture [21]. Pregnant and postpartum populations are not immune to this possibility and given the hormonal and coagulability status of pregnant and postpartum patients it is possible that SMT is contraindicated in pregnant and postpartum patients with musculoskeletal complaints. However, this may depend on the spinal regions and complaints being treated as different consideration may need to be given to manipulation of the cervical spine versus the thoracic or lumbopelvic regions.

Most contraindications to spinal manipulation are evident during a careful history and physical exam [21]. Clinicians who use SMT as part of the plan of management for pregnant patients should consider prothrombotic and joint laxity risk factors when deciding whether to undertake such a therapy in order to minimize the risks of potentially dangerous neurological complications [35]. Patients at higher risk for complications, such as those in a post-thrombotic state and possibly those with lax joints, should be treated with additional care and consideration. There is an increased importance to counsel this patient with respect to the risks of SMT [20, 35] and these patients should be made aware of the signs and symptoms of possible neurovascular complications [20, 35]. However, based on the literature reviewed, it cannot be ascertained as to what role those factors may have actually played in the etiology of the adverse events documented, if any.

Although this study has resulted in very few papers to review, it had strengths including the thorough search of the literature to help reduce bias in the review. The authors searched multiple relevant electronic databases over all possible years represented in those databases, employed a number of broad search terms, performed reference and hand-searching, examined personal libraries, and used multiple authors to determine articles for inclusion in the review and to evaluate and rate the literature.

The major limitation of this critical review was the number of studies available and the hierarchy of evidence that the studies available yielded. The papers identified for this review were case studies and a prospective observational cohort study, both of which are lower levels of evidence. Given the levels and paucity of evidence identified, the possible level of risk to pregnant and postpartum patients undergoing spinal manipulative therapy cannot be measured or stated definitively, nor can it be determined if any such risk level is higher or lower than in the non-pregnant or postpartum populations. However, this does allow for hypothesis generation and should help drive future directions for research. There is a need to design and execute larger and higher quality observational and randomized controlled studies investigating the potential benefits of the use of spinal manipulation as a treatment during pregnancy or postpartum particularly for those with low back pain. Such studies should ensure that any possible adverse events are tracked throughout. One possible option for an observational study design may be a case-crossover study as adverse events from spinal manipulative therapy may be rare in these populations [44, 45]. The previous systematic reviews on spinal manipulation as a treatment during pregnancy have highlighted the lower levels of evidence available thus far on the topic [1, 11]. Another limitation of this review was including only articles published in English and French.


There are only a handful of reported cases of adverse events following spinal manipulation during pregnancy and the postpartum period in the literature with the severity ranging from mild increases in pain that resolved quickly to significant life-threatening injuries. While improved reporting of such events is required in the future, it may be that such injuries are relatively rare. Clearly future research into efficacy of this treatment for these populations and the rates of occurrence of adverse events is necessary to determine whether or not this is true.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

KJS conceived the study, participated in its design and coordination, conducted the literature search, screened the literature search results, analyzed and interpreted the data, and drafted the manuscript. SW conceived the study, participated in its design, screened the literature search results, and analyzed and interpreted the data. CAW analyzed and interpreted the data and drafted the manuscript. All authors read and approved the final manuscript.

Supplementary Material

Additional file 1:   Search strategy.

Additional file 2:   List of included articles.

Additional file 3:   Case report details.


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