FROM:
Journal of Pain 2012 (Aug); 13 (8): 715–724 ~ FULL TEXT
Darrell J. Gaskin and Patrick Richard
Hopkins Center for Health Disparities Solutions,
and Department of Health Policy and Management,
Johns Hopkins Bloomberg School of Public Health,
Johns Hopkins University,
Baltimore, Maryland 21205, USA.
In 2008, according to the Medical Expenditure Panel Survey (MEPS), about 100 million adults in the United States were affected by chronic pain, including joint pain or arthritis. Pain is costly to the nation because it requires medical treatment and complicates treatment for other ailments. Also, pain lowers worker productivity. Using the 2008 MEPS, we estimated 1) the portion of total U.S. health care costs attributable to pain; and 2) the annual costs of pain associated with lower worker productivity. We found that the total costs ranged from $560 to $635 billion in 2010 dollars. The additional health care costs due to pain ranged from $261 to $300 billion. This represents an increase in annual per person health care costs ranging from $261 to $300 compared to a base of about $4,250 for persons without pain. The value of lost productivity due to pain ranged from $299 to $335 billion. We found that the annual cost of pain was greater than the annual costs of heart disease ($309 billion), cancer ($243 billion), and diabetes ($188 billion). Our estimates are conservative because they do not include costs associated with pain for nursing home residents, children, military personnel, and persons who are incarcerated.
PERSPECTIVE: This study estimates that the national cost of pain ranges from $560 to $635 billion, larger than the cost of the nation's priority health conditions. Because of its economic toll on society, the nation should invest in research, education, and training to advocate the successful treatment, management, and prevention of pain.
Key words: Cost of illness, chronic pain, persistent pain.
From the FULL TEXT Article:
Background
Millions of Americans experience persistent
pain. [20] A review of 15 studies of chronic pain
among adults found that prevalence estimates
ranged from 2% to 40%, with a median of 15%. [23, 31, 33]
Data from the 2009 National Health Interview Survey
indicated that during a 3–month period, 16% of adults
reported having a migraine or severe headache, 15% reported
having pain in the neck area, 28% reported having
pain in the lower back, and 5% reported having pain
in the face or jaw area. For those who have persistent
pain, it limits their functional status and adversely impacts
their quality of life. Consequently, pain can be
costly to the nation because it requires medical treatment,
complicates medical treatment for other conditions,
and hinders people’s ability to work and function
in society.
Several studies have examined the economic costs of
pain or selected pain conditions. One study estimated
the annual indirect costs of migraines at $14 billion in
1993. [19] A report issued by the American Academy of Orthopedic
Surgeons estimated the total cost of musculoskeletal
disorders at $215.5 billion in 1995. [29] The U.S.
Census Bureau reported that the total cost of chronic
noncancer pain was $150 billion in 1996. [9] The National
Research Council and the Institute of Medicine (IOM) reported
that the economic cost of musculoskeletal disorders,
in terms of lost productivity, was $45 to 54 billion
in 1999. [28] Another study estimated the annual medical
and indirect costs of rheumatoid arthritis at $14 billion
in 2000. Stewart et al [30] estimated that common pain conditions
(ie, arthritis, back pain, headache, and other
musculoskeletal pain) resulted in $61.2 billion in lower
productivity for U.S. workers in 2002. Turk and Theodore [32] reported that in 2010, the annual cost of pharmaceuticals for pain management was $16.4 billion, and the
cost of lumbar surgeries was $2.9 billion. Their estimates
of the indirect costs of pain were $18.9 billion for disability
compensation and $6.9 billion for productivity loss. [21]
The evidence leaves no doubt that the cost of treating
pain can be high. However, these estimates are dated,
tend to focus on specific pain conditions, and are not
comprehensive.
Prior studies used a more exacting, piecemeal approach
to compute the cost of pain than that used for
our study. For example, Turk and Theodore [32] identified
per patient costs of treating pain based on information
from the U.S. Workers’ Compensation database and the
Center for Medicare and Medicaid Services. They computed
indirect costs using data on disability compensation
and estimates of lost work time for specific pain
conditions from the literature. Because researchers are
pulling together estimates from different sources and
samples of patients, they are not able to provide a comprehensive
view of the health care and labor market experiences
of persons with pain conditions. Our study
offers a comprehensive view because our measures of
pain conditions, health care costs, and indirect costs
(such as missed days, hours, and wages) were drawn
more rigorously from the same sample population. We
used nationally representative data sets and econometric
techniques to address sample selection issues. Our measures
of pain also capture people with chronic and persistent
pain that is not formally diagnosed by a physician.
We estimated the annual economic costs of pain in the
United States. The annual economic costs of pain can be
divided into 2 components:
1) the incremental costs of health care due to pain; and
2) the indirect costs of pain due to lower productivity associated with lost days and hours of work and lower wages.
The rationale underlying
our analysis is that the medical costs for other
conditions are higher for individuals who are experiencing
persistent pain. These incremental costs cannot be
computed by simply summing the annual costs of treating
patients with a primary diagnosis of pain, because
unlike cancer, heart disease, and diabetes, persistent
pain is not always a diagnosed condition. Rather, we captured
the incremental costs of medical care due to pain
by comparing the costs of health care of persons with
chronic pain to those who do not report chronic pain,
controlling for health needs, demographic characteristics,
and socioeconomic status. We applied a similar approach
to the indirect costs analysis.
Methods
We used the 2008 Medical Expenditure Panel Survey
(MEPS) to examine the economic burden of pain in the
United States. Cosponsored by the Agency for Healthcare
Research and Quality and the National Center for
Health Statistics, the MEPS is a nationally representative
longitudinal survey that covers the U.S. civilian noninstitutionalized
population. [11] For this analysis, we used the
Household Component file of the MEPS—the core component
of the survey that collects data on demographic
characteristics, health expenditures, health conditions,
health status, utilization of medical services, access to
care, health insurance coverage, and income for each
person surveyed. The analytic sample for the analysis of
incremental health care costs was restricted to 20,214 individuals
aged 18 or older. This sample is representative
of all noninstitutionalized civilian adults in the United
States. The analytic sample for the analysis of indirect
costs was restricted to 15,945 individuals aged 24 to 65
to capture the active labor force in the United States.
Defining Persons With Pain
We defined persons with pain using 3 measures:
1) persons who reported that they experienced pain that limited their ability to work;
2) persons who were diagnosed with joint pain or arthritis; or
3) persons who had a disability that limited their ability to work.
The SF-12
pain question of the MEPS asked the respondent
whether, during the past 4 weeks, pain interfered with
normal work outside the home and housework. The
joint pain question inquired whether the person had experienced
pain, swelling, or stiffness around a joint in
the last 12 months. This includes pain caused by bursitis,
gout, strains, and other injuries. The question for arthritis
determined whether the person had ever been diagnosed
with arthritis, and if so was it osteoarthritis or
rheumatoid.
The question about functional disability inquired
whether the person had any work or housework
limitation. We explored whether we could use information
from the event files on persons who were diagnosed
with headache, abdominal pain, chest pain,
back pain, or cancer. We identified relatively few persons
who had medical encounters in which pain was
the primary diagnosis. Consequently, we decided not
to use the event files to determine the prevalence of
pain in the population. Rather, we expected that persons
suffering from these pain conditions would report
having moderate or severe pain on the SF-12. Some persons
with cancer reported experiencing pain using the
SF-12, but we are unable to distinguish acute and
cancer-related pain from chronic, noncancer pain in
the MEPS. However, the vast majority of persons who reported
mild or severe pain using the SF-12 did not have
a cancer diagnosis.
Measuring Health Care and Productivity Costs
We used total expenditures as the dependent variable
to predict the incremental costs of care for individuals
with selected pain conditions compared with those without
these conditions. We aimed to estimate the incremental
societal health care costs, which are the
additional costs of care borne by individuals and their
health plans. Total expenditures in the MEPS include
both out-of-pocket payments by individuals and thirdparty
payments to health care providers but do not include
health insurance premiums. Expenditures for
hospital-based services include those for both facility
and separately billed physician services. Total expenditures
include inpatient, emergency room, outpatient
(hospital, clinic, and office-based visits), prescription
drugs, and other (eg, home health services, vision care
services, dental care, ambulance services, diagnostic services,
medical equipment). The expenditures do not include
over-the-counter purchases.
For the analysis of indirect costs, we used the annual
number of days of work missed because of pain conditions,
the annual number of hours of work missed because
of pain conditions, and hourly wages as
dependent variables to predict the productivity loss associated
with the different pain conditions. Variations in
the annual number of days of work missed measure
workers’ decisions to use sick days. Variations in the annual
number of hours worked measure workers’ decisions
whether to work full-time, part-time, or overtime.
Variations in the hourly earnings measure the value of
the amount of work workers can perform in an hour.
Adjusting for Other Factors
We estimated the association between pain and health
care expenditures. This model predicts that as pain increases,
the propensity to use health services increases
and the amount and/or intensity of health service use increases.
We used a modified version of the Aday and Andersen
2 behavioral health model of health services to
estimate direct medical costs for persons with pain compared
with those without any pain. One of the benefits
of this framework is that it is widely used and prior studies
have found the different constructs of the model to
be highly valid or highly associated with the use of health
services in different settings for different populations.
This model hypothesizes that health expenditures depend
on predisposing, enabling, and perceived health
need factors. In this conceptual framework, pain is
a health need factor. The predisposing factors are individual
characteristics that measure biological and social
factors that influence health care use such as age, race/
ethnicity, gender, education, health behaviors, and marital
status. To measure health behaviors, we used
whether respondents smoked or exercised and their obesity
status. For example, women’s health care use varies
from men’s because of biological differences such as
the need for reproductive health services; and married
persons, because of the concerns of their spouses, may
use health care differently than single persons.
The enabling
factors included income, health insurance status,
and location. Census region and urban-rural residence
were used to measure location. Enabling factors control
for individual’s ability to pay for health care services and
their geographic access to health care facilities. Presumably,
persons with more income, with better insurance,
and who live/work in proximity to physician and hospital
services will have higher use and thus higher health care
expenditures. The inclusion of perceived health needs is
an acknowledgment that sick persons require, seek, and
use more medical services than healthy persons.
Additional health needs measures included whether respondents
reported that they were in fair or poor health,
and whether they had been diagnosed with diabetes or
asthma.
Diabetes and asthma were included because
they may complicate the treatment of other conditions
and we did not want to attribute these costs to the incremental
medical costs of pain.We excluded other chronic
conditions, including hypertension, heart disease, emphysema,
and stroke, because we were concerned about
the potential correlation between these other chronic
conditions and the SF-12 measures of pain.We estimated
preliminary models with the full complement of chronic
conditions; however, some conditions were statistically
insignificant. Therefore, we elected to use the most parsimonious
models that adequately controlled for health
needs.
The lost productivity computation was based on the
human capital approach of estimating labor supply and
earning models. [5, 6, 22] Theoretically, hours worked,
wages, and labor force participation are based on a set
of factors, including age, sex, race, ethnicity, education,
marital status, family size, health status, and location.
There is longstanding literature that shows the impact
of health on wages, earnings, labor supply, and missed
days of work. [12, 13] Similar to our study, these studies
relied heavily on the human capital on human capital
theory. [3, 4, 7, 17] According to this conceptual framework,
declining health, ie, increasing pain, reduces one’s
ability to work and lowers one’s productivity when
working.
Estimating Health Care Expenditures Models
We estimated a 2–part expenditure model to compute
the economic burden for persons with the different
types of pain conditions noted above compared with
those without any pain. [8, 10, 14, 24–26] The 2–part model is
appropriate because it accounts for sample selection between
persons with expenditures and those with zero expenditures.
The first part of the model consisted of
estimating logistic regression models to estimate the
probability of having any type of health care expenditures.
The second part consisted of using generalized linear
models with log link and gamma distribution to
predict levels of direct expenditures conditional on individuals
with positive expenditures. We used a log link
and gamma distribution to address the skew in the expenditure
data. We eliminated outliers, ie, observations
with expenditures greater than $100,000, less than .5%
of the sample. We conducted the different diagnostic
and specification tests recommended by Manning, [24]
Manning and Mullahy, [] and Mullahy.26 We estimated
the models using the survey regression procedures in
Stata 11, which appropriately incorporates the design
factors and sample weights.
We developed 3 models to predict total health care expenditures
and conduct sensitivity analyses for robustness,
varying the degree to which we controlled for
health status. In Model 1, we measured pain with indicators
for moderate pain, severe pain, joint pain, and
arthritis. We controlled for health status using only
self-reported general health status and body mass index.
In Model 2, we added functional disability to our pain
measures. In Model 3, we included diabetes and asthma
in our measures of health status. We conducted sensitivity
analyses using several of the chronic condition indicators
available in the MEPS and found that diabetes and
asthma were significant predictors of expenditures independent
of the pain measures. We estimated models
with and without an indicator for functional disability.
We were concerned that persons with functional disability
who had chronic pain might not be captured by the
other pain measures; however, we were also aware
that the functional disability variable might capture people
with functional disability but no chronic pain. By conducting
the computation both ways, we could see
whether including functional disability in our definition
of pain conditions mattered.
We computed the incremental costs of pain by using
our model to predict health care costs if a person has
any type of pain and subtracting the predicted health
care costs if a person does not have pain. [14] To perform
this calculation, the probabilities of having health care
costs for persons with and without pain must be taken
into account. We computed unconditional levels of
health care expenditures by multiplying the probabilities
obtained from the first part of the model by the predicted
levels of expenditures from the second part of
the model for individuals with and without pain. Subsequently,
we computed the incremental values for each
type of pain condition by taking the difference between
those with and without pain. We converted the costs estimates
into 2010 dollars using the medical care index of
the Consumer Price Index.
We computed the impact of the incremental costs of
selected pain conditions on the various payers for health
care services. The Household Component file from the
MEPS contains 12 categories of direct payment for care
provided during 2008:
1) out-of-pocket payments by users of care or family;
2) Medicare;
3) Medicaid;
4) private insurance;
5) the VA, excluding CHAMPVA;
6) TRICARE;
7) other federal sources (includes the Indian Health Service, military treatment facilities, and other care provided by the federal government);
8) other state and local sources (includes community and neighborhood clinics, state and local health departments, and state programs other than Medicaid);
9) workers’ compensation;
10) other unclassified sources (includes such sources as automobile, homeowner’s, and liability insurance, and other miscellaneous or unknown sources);
11) other private (any type of private insurance payments); and
12) other public.
For each payer category, we computed its proportion of total health care expenditures. We multiplied our estimate of total incremental health care costs due to pain by these proportions to estimate the impact on each payer.
Estimating Labor Market Productivity Models
As with the health care expenditure models, we used
2–part models to estimate the indirect costs of pain. The
structure of the models depended upon the dependent
variables. For missed days of work, we estimated the
probability of missing a work day as a result of selected
pain conditions during the year. Second, we estimated
a log linear regression model in which the dependent
variable was the log of the number of disability days
for those adults who had positive disability days.
For hours worked and wages, the first equation estimated
the impact of pain on the probability that a person
is working. The second equation estimated the impact of
pain on the number of annual work hours and hourly
wages. Combining the results from these different parts
of the models, we computed the productivity costs associated
with chronic pain for each of the conditions noted
above.We used a 2–step estimator for labor supply to predict
lost productivity due to pain. [10, 16] As with the
incremental cost models, we multiplied the probabilities
obtained from the first part of the model by predicted
levels of days missed, lost work hours, or lost wages
from the second part of the model for individuals with
and without pain. To compute the total cost of missed
days, we multiplied the days missed by 8 hours times the
predicted hourly wage rate for individuals with the pain
condition. To compute the total cost of reduction of
hours worked, we multiplied the total of annual hours
missed by the predicted hourly wage rate for individuals
with the pain condition. To compute the total cost due
to a reduction in hourly wages, we multiplied the
predicted hourly wage reduction by the predicted
annual hours for individuals with the pain condition.
We converted the costs estimates into 2010 dollars using
the general Consumer Price Index.
The approach of using a 2–part model to estimate lost
productivity is similar to the use of Heckman selection
models but can be used in the absence of the identifying
variables required by Heckman selection models and
other limited dependent variables models, such as the
Tobit. [15, 18] Additionally, we conducted a series of tests
to determine the appropriate distribution for each of
these models. For instance, we used a log link with
Gaussian distribution to estimate the models for hours
worked. Similar to the health care expenditure models,
we estimated 3 models using the same measures for
pain and health status.
Results
The Incremental Costs of Health Care
Table 1 displays the dependent and key independent
variables used in the analysis of the incremental costs
of health care. The sample includes 20,214 individuals
aged 18 and older, representing 210.7 million adults in
the United States as of 2008. The mean health care expenditures
were $4,475, and 85% of adults had a positive
expenditure. The prevalence estimates for selected pain
conditions were 10% for moderate pain, 11% for severe
pain, 33% for joint pain, 25% for arthritis, and 12% for
functional disability.
Adults with pain reported higher health care expenditures
than adults without pain. Based on the SF-12 pain
measures, a person with moderate pain had health care
expenditures $4,516 higher than those of someone with
no pain. Persons with severe pain had health care expenditures
$3,210 higher than those of persons with moderate
pain. We found similar differences for persons with
joint pain ($4,048), arthritis ($5,838), and functional disability
($9,680) compared with persons without these
conditions. All of these differences were statistically significant
(P < .001).
The regression results of the logistic regression models
and generalized linear models indicate that moderate
pain, severe pain, joint pain, arthritis, and functional disability
were strongly associated with an increased probability
of having a health care expenditure and with
higher expenditures. The coefficients were all statistically
significant and positive predictors of whether a person
had a health care expenditure and the amount of
that expenditure. The coefficients were relatively stable
across the 3 models. The magnitude of the coefficients
declined as we included functional disability, asthma,
and diabetes in the models. The coefficients on the control
variables had the expected signs.Women were more
likely to have a health care expenditure and a higher expenditure
than men. The likelihood of an expenditure
and the level of expenditures increased with age. Blacks,
Hispanics, and Asians were less likely than whites to have
a health care expenditure and had lower expenditures.
Socioeconomic and health factors had the expected impact.
As education, income, and health insurance status
increased, health care spending also increased. Health
care spending increased for persons who were obese,
who reported they were in fair or poor health, who
had asthma, and who had diabetes. These regression
models are reported in Appendix C of the IOM publication,
Relieving Pain in America. [20]
Table 2
|
We computed the total incremental costs of the selected
pain conditions (see Table 2). The total incremental
costs of health care for selected pain conditions
ranged from $45.7 billion for moderate pain to $89.4 billion
for severe pain according to Model 1. When functional
disability was included in the model, its total
incremental costs were $93.5 billion, while the estimates
for the other pain conditions declined, particularly for
severe pain, which fell to $58.1 billion in Model 2.We estimated
that approximately 100 million persons had at
least 1 of the pain conditions based on the 2008 MEPS.
The most prevalent condition was joint pain, affecting
more than 70 million adults.We estimated that the incremental
costs of health care for these selected pain conditions
ranged from $261 billion to $300 billion annually.
Model 1 renders an estimate of $261 billion. This estimate
rises to $300 billion when we included functional
disability in the model. However, when we included diabetes
and asthma in the model, our estimate falls to $293
billion. Including measures of these chronic conditions in
the model influenced the incremental cost estimates for
each pain condition differently. The cost estimates for
functional disability, joint pain, and arthritis declined in
Model 3 but the estimate for severe pain increased.
Table 3
|
Table 3 shows the distribution of the incremental costs
by source of payment.We estimated that private insurers
paid the largest share of incremental costs, ranging from
$112 billion to $129 billion. Medicare bore 25% of the incremental
costs due to pain, ranging from $66 billion to
$76 billion. Individuals paid an additional $44 billion to
$51 billion in out-of-pocket health care expenditures
due to persistent pain. Medicaid paid about8%of the incremental
costs of pain, ranging from $20 billion to $23
billion.
Indirect Costs of Pain
Table 4 shows the dependent and independent variables
for the analysis of incremental indirect costs. The
sample was 15,945 persons ages 24 to 64, representing
156 million working-age adults. The mean number of
work days missed was 2.14, and 46% of adults missed
at least 1 day of work. The average number of hours
the sample worked annually was 1,601, with 81% of
adults working. The average hourly wage was $14.19.
Among working-age adults, 9% reported having moderate
pain, 10% severe pain, 31% joint pain, 21% arthritis,
and 10% functional disability.
Adults with pain reported missing more days of work
than adults without pain. A person with moderate
pain, based on the SF-12 pain measures, missed 2.1 days
more than someone with no pain. Adults with severe
pain missed 2.6 days more than those with moderate
pain. The differences for joint pain, arthritis, and functional
disability were 1.3 days, 1.3 days and 3.3 days, respectively.
Pain was associated with fewer annual hours
worked. Persons with functional disability had the largest
difference, working 1,203 fewer hours than persons
with no functional disability. Compared with persons
with no pain, persons with moderate pain worked 291
fewer hours, and persons with severe pain worked 717
fewer hours. We found similar differences in hours for
joint pain (220 hours) and arthritis (384 hours). Wages
were lower for persons with pain. The largest difference
was for persons with functional disability, followed by severe
pain, moderate pain, arthritis pain, and joint pain.
Persons with functional disability earned $11 an hour
less than persons without functional disability.
The regression results for the indirect costs analysis are
reported in Appendix C in the IOM publication, Relieving
Pain in America. [20] The estimates from these models show
that the pain conditions had a significant negative impact
on the likelihood ofworking. The impact on hoursworked
and wages was negative but modest and in several cases
insignificant. This means that the negative impact of
pain conditions on hours worked and wages occurred
largely through the decision to work or not. Persons with
pain were less likely to work than persons without pain.
Pain negatively impacted the 3 components of productivity;
number of days missed, number of annual hours
worked, and hourly wages. Almost 70 million working
adults reported having 1 of the pain conditions. The average
incremental number of days of work missed was
greatest for severe pain, with estimates ranging from
5.0 to 5.9 days. Arthritis caused the fewest days of work
missed —.1 to .3. Pain also was associated with fewer annual
hours worked. For Model 1, severe pain was associated
with the largest reduction, 204 hours. However,
when we included functional disability in the model,
the impact of severe pain fell to 30 hours, while the reduction
associated with having functional disability
was 740 hours. The average reduction in hourly wages
for selected pain conditions ranged from $.26 an hour
for joint pain to $3.76 an hour for severe pain according
to Model 1. Including functional disability in the models
changed the estimates substantially for the other pain
conditions – from $.05 an hour for joint pain to $1.66
an hour for severe pain. Functional disability was associated
with a large reduction in wages ($9.36 an hour),
which did impact the total estimate of the costs due to
wage reductions.
Table 5 reports the annual indirect costs for each of the
3 components of productivity. The reduction in hourly
wages due to pain was the most costly component, ranging
from $191 to $226 billion. Functional disability, followed
by severe pain and arthritis, had the biggest
impact on hourly wages. Including functional disability
in the model increased the costs by $36 billion and dampened
the estimates of the other pain measures. The annual
indirect costs for fewer hours worked were stable
across the models ranging from $95 to $96 billion. While
the inclusion of functional disability changed the distribution
of the costs, it did not change the overall estimate
of the costs associated with fewer annual hours worked.
Functional disability, arthritis, and severe pain in Model 1
were the most costly pain conditions. The annual costs
for the number of days missed ranged from $11.6 to
$12.7 billion. More persons reported joint pain, but severe
pain was more costly. Including functional disability
in these models did not affect the estimates for the other
pain conditions.
The combined total indirect costs by pain conditions
are reported at the bottom of Table 5. According to
Model 1, total indirect cost was $299 billion, with severe
pain and arthritis as the most costly conditions. However,
when functional disability was included in the models,
the estimates increased to $335 billion. The indirect
cost of functional disability was $192 billion, and the cost
estimates for these other pain conditions fell.
Combining the results in Tables 2 and 5, we found that
the total annual costs of pain in the United States ranged
from $560 to $635 billion. The total incremental costs of
health care due to pain ranged from $261 to $300 billion,
and the value of lost productivity ranged from $299 to
$334 billion.
Discussion
Persistent pain impacts 100 million adults and costs
from $560 to $635 billion annually. Based on statistics
published by the National Institutes of Health (NIH),
the costs of persistent pain exceed the economic costs
of the 6 most costly major diagnoses
cardiovascular diseases ($309 billion),
neoplasms ($243 billion),
injury and poisoning ($205 billion),
endocrine, nutritional and metabolic diseases ($127 billion),
digestive system diseases ($112 billion), and
respiratory system diseases ($112 billion). [27]
(For comparison with our estimate, we converted these figures into 2010 dollars).
These cost-of-condition
estimates differ from our cost-of-pain estimate. NIH combined
personal health care costs reported in the MEPS
and the costs of premature death due to these conditions;
however, the NIH estimates do not include lost productivity.
We do not consider the costs of premature
death due to pain because pain is not considered a direct
cause of death, as are heart disease, cancer, and stroke.
The American Diabetes Association reported that in
2007, diabetes cost $174 billion, including $116 billion
in excess medical expenditures and $58 billion in reduced
productivity. [1] (This is equivalent to $188 billion in 2010
U.S. dollars.) Unlike these diagnosed conditions, pain affects
a much larger number of people, by a factor of
about 4 compared with heart disease and diabetes and
by a factor of 9 compared with cancer. Thus, the per person
cost of pain is lower than that of the other conditions,
but the total cost of pain is higher.
Our estimate of the cost of chronic pain is conservative
for several reasons. First, we did not account for the cost
of pain for institutionalized and noncivilian populations.
In particular, the incremental health care costs for nursing
home residents, military personnel, and prison inmates
with pain were not included and may be
substantial. Second, we did not include the costs of
pain for persons under age 18. Third, we did not include
the cost of pain to caregivers. For example, we did not
consider time a spouse or adult child might lose from
work to care for a loved one with chronic pain. Fourth,
we considered the indirect costs of pain only for
working-age adults. We did not estimate these costs
for working persons over the age of 65 or under the
age of 24. While there are persons in these age categories
who are retired or continuing their education,
there also are persons in both age categories who are
working or willing to work.We did not capture the value
of their lost productivity. Fifth, we also did not include
the value of time lost for other, non-work-related activities.
Sixth, we did not include other indirect costs—lost
tax revenue, costs for replacement workers, legal fees,
and transportation costs for patients to reach providers.
Finally, in our cost estimates, we did not attempt to measure
the psychological or emotional toll of chronic pain.
The presence of chronic pain can lower a person’s quality
of life and diminish the person’s enjoyment of other aspects
of life.
Our analysis has a few limitations. First, it is a crosssectional
analysis, so we cannot infer causality. Second,
our measures of pain are limited. We cannot estimate
the impact of pain associated with musculoskeletal conditions
or cancer. Third, our functional disability may include
persons who do not have chronic pain. In addition,
the MEPS data do not contain measures of varying degrees
of functional disability. Finally, we used 2–part
models to control for unobserved differences between
persons with pain and persons without pain. However,
we recognized that the 2–part approach may not fully
capture the unobserved differences between the 2
groups and, if so, our estimates of costs associated with
pain will be too large.
In general, given the magnitude of the economic costs
of pain, society should consider investing in research, education,
and care designed to reduce the impact of pain.
In Relieving Pain in America, the IOM outlined a national
agenda for addressing the problem of pain. [20] Eliminating
pain may be impossible, but helping people live better
with pain may be achievable.
Acknowledgments
We are grateful for insights and commentary provided
by the Institute of Medicine Committee on Advancing
Pain Research, Care, and Education. Also, we thank
Nancy Richard for her able assistance in compiling tables
for this manuscript.
Data in this article have been reused with permission
from Appendix C,
Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research.
Washington, DC, The National Academies Press,
2011.
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