Widely Used Anti-Inflammatory Drug Risky Even in Small Doses
SOURCE: MedPage Today
“Naproxen use increases the risk for complicated gastroduodenal ulcers in a dose-dependent fashion”
American College of Gastroenterology (ACG) 2009
Even at low doses, naproxen (Aleve, Anaprox, Naprosyn, Naprelan) may increase the risk of upper gastrointestinal complications, researchers said here.
Patients taking a 500-mg/day dose had a 2.5-fold increased risk of hospitalization from complicated gastric or duodenal ulcer, while those on the 750-mg/day dose had almost a threefold increased risk, Gurkirpal Singh, MD, of Stanford University, and colleagues reported at the American College of Gastroenterology meeting. 
The 1,000-mg/day dose carried more than a threefold increased risk of hospitalization. “We found that naproxen use is not safe even at lower doses,” Singh said. “We need to be careful about prescribing it, even in lower doses.” The lowest doses are available over the counter. (more…)