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Daily Archives: January 29, 2010

How To Do An Effective Online Search

By |January 29, 2010|Education|

When you want to find something online, it can be overwhelming to get thousands of responses. A typical example is a search for the term “chiropractic” on Google. You will get 14,200,000 responses, in no particular order. Who’s got the time to weed through that?

That’s why something called Boolian Logic can help you get the information you want faster. The idea is to string together several search words into a “search string”. Below is a list of the 4 Boolian “operators”, with a simple explanation of how you can use them to do a much more specific search. (more…)

Cell Size and Scale

By |January 29, 2010|Education|

Cell Size

Use the slider at the Genetic Science Learning Center to view a stunning example of scale.

Some cells are visible to the unaided eye

The smallest objects that the unaided human eye can see are about 0.1 mm long. That means that under the right conditions, you might be able to see an ameoba proteus, a human egg, and a paramecium without using magnification. A magnifying glass can help you to see them more clearly, but they will still look tiny.

Smaller cells are easily visible under a light microscope. It’s even possible to make out structures within the cell, such as the nucleus, mitochondria and chloroplasts. Light microscopes use a system of lenses to magnify an image. The power of a light microscope is limited by the wavelength of visible light, which is about 500 nm. The most powerful light microscopes can resolve bacteria but not viruses.

‘Ghostly’ Drug May Help Fight RA

By |January 29, 2010|Research|

Study Shows Molecule Can Infiltrate Immune Cells to Treat Rheumatoid Arthritis
Source WebMD

Jan. 28, 2010 – A ghostly “suicide” drug wafts into immune cells in joints, making the cells self-destruct and reducing rheumatoid arthritis in mice.

The drug, technically a BH3 mimetic dubbed TAT-BH3, is a man-made molecule. One part of the molecule lets it drift through cell walls. The other part mimics a chemical signal missing in the macrophage immune cells that build up inside joints afflicted by rheumatoid arthritis (RA).

Because they are missing this signal, macrophages in RA joints don’t die off as they are supposed to do. They live on, destroying bone and inflaming the joint, says Harris Perlman, PhD, associate professor of medicine at Chicago’s Northwestern University Feinberg School of Medicine.

“In RA, there is this persistent inflammation that never shuts down. Part of the reason is these macrophages are missing a protein they need to die off,” Perlman tells WebMD. “So this drug says OK, let’s replace this protein. Let’s bring back the death pathway.”

Perhaps because normal cells aren’t clinging to life like the zombie macrophages involved in RA, the drug doesn’t kill normal macrophages. The drug was not toxic to mice.