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Do Participants with Low Back Pain who Respond to Spinal Manipulative Therapy Differ Biomechanically From Nonresponders, Untreated Controls or Asymptomatic Controls?

Do Participants with Low Back Pain who Respond to Spinal Manipulative Therapy Differ Biomechanically From Nonresponders, Untreated Controls or Asymptomatic Controls?

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SOURCE:   Spine (Phila Pa 1976). 2015 (Sep 1); 40 (17): 1329–1337

Arnold Y. L. Wong, PT, MPhil, PhD,
Eric C. Parent, PT, PhD,
Sukhvinder S. Dhillon, MB, ChB, CCST,
Narasimha Prasad, PhD,
and Gregory N. Kawchuk, DC, PhD

Department of Physical Therapy,
University of Alberta,
Alberta, Canada

STUDY DESIGN:   Nonrandomized controlled study.

OBJECTIVE:   To determine whether patients with low back pain (LBP) who respond to spinal manipulative therapy (SMT) differ biomechanically from nonresponders, untreated controls or asymptomatic controls.

SUMMARY OF BACKGROUND DATA:   Some but not all patients with LBP report improvement in function after SMT. When compared with nonresponders, studies suggest that SMT responders demonstrate significant changes in spinal stiffness, muscle contraction, and disc diffusion. Unfortunately, the significance of these observations remains uncertain given methodological differences between studies including a lack of controls.

METHODS:   Participants with LBP and asymptomatic controls attended 3 sessions for 7 days. On sessions 1 and 2, participants with LBP received SMT (+LBP/+SMT, n = 32) whereas asymptomatic controls did not (-LBP/-SMT, n = 57). In these sessions, spinal stiffness and multifidus thickness ratios were obtained before and after SMT and on day 7. Apparent diffusion coefficients from lumbar discs were obtained from +LBP/+SMT participants before and after SMT on session 1 and from an LBP control group that did not receive SMT (+LBP/-SMT, n = 16). +LBP/+SMT participants were dichotomized as responders/nonresponders on the basis of self-reported disability on day 7. A repeated measures analysis of covariance was used to compare apparent diffusion coefficients among responders, nonresponders, and +LBP/-SMT subjects, as well as spinal stiffness or multifidus thickness ratio among responders, nonresponders, and -LBP/-SMT subjects.

RESULTS:   After the first SMT, SMT responders displayed statistically significant decreases in spinal stiffness and increases in multifidus thickness ratio sustained for more than 7 days; these findings were not observed in other groups. Similarly, only SMT responders displayed significant post-SMT improvement in apparent diffusion coefficients.

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CONCLUSION:   Those reporting post-SMT improvement in disability demonstrated simultaneous changes between self-reported and objective measures of spinal function. This coherence did not exist for asymptomatic controls or no-treatment controls. These data imply that SMT impacts biomechanical characteristics within SMT responders not present in all patients with LBP. This work provides a foundation to investigate the heterogeneous nature of LBP, mechanisms underlying differential therapeutic response, and the biomechanical and imaging characteristics defining responders at baseline

From the FULL TEXT Article:


Spinal manipulative therapy (SMT) is a common intervention for low back pain (LBP). Historically, the results of clinical trials designed to evaluate SMT have been mixed [1–5] with some (but not all) participants reporting a benefit. In recent years, growing evidence suggests that these mixed results are due partially to a differential treatment response in patients. [1, 2, 6]

Although some have suggested that a differential response of participants with LBP to SMT could be caused by psychosocial factors (e.g. , expectation), [7, 8] others have developed and validated a clinical prediction rule (CPR) to identify likely responders to SMT on the basis of clinical characteristics. [1, 6]

This work was based on the observation that patients with LBP who self-reported clinically significant improvement in the modified Oswestry Disability Index (mODI) displayed at least 4 of 5 specific clinical characteristics (see Supplemental Digital Content Appendix I).

After this work, Fritz and coworkers [9] demonstrated that CPR status might be related to LBP disability through its relation to lumbar multifidus (LM) contraction thickness. They also found that post-SMT improvement of the mODI score for more than 1 week was associated with

(1)   immediate decrease in the spinal stiffness at L3 and

(2)   immediate increase in the LM contraction thickness at L4–L5 during contralateral arm lifting. [9, 10]

Intervertebral disc (IVD) properties have also demonstrated a similar association with those who respond positively to SMT. Beattie and coworkers [11] found that patients with LBP who experienced clinically significant post-SMT reduction in pain showed statistically significant increases in water diffusion within the L1–L2, L2–L3, and L5–S1 discs, whereas patients without reduction in post-SMT LBP did not.

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