FROM: Today's Chiropractic 2005 (May)
By Joan Fallon, D.C., DICCP
Recently autism has been in the news on a daily basis. With a large increase
in the numbers of cases—one in 166 live births, as the most recent statistic—health
authorities have undertaken significant studies related to the etiologies of
autism. Characterized by multiple deficits in the areas of communication, development
and behavior; autistic children are found in every community in this country
and abroad. Recent findings point to a significant increase in autism, which
cannot be accounted for by means such as misclassification. The state of California
recently reported a 273 percent increase in the number of cases between 1987
and 1998. Estimates now hover around the four through 20 per 100,000 children.
Recent findings from the MIND Institute at the University of California at Davis
states that, ‘‘The unprecedented increase in autism in California
is real and cannot be explained away by artificial factors, such as misclassification
and criteria changes, according to the results of a large statewide epidemiological
Many causes of autism have been postulated, ranging from environmental and toxicological
causes to genetics. The most current thinking including that of many members
of the U.S. Congress and others is that vaccination, and specifically the mercury-based
preservative in the vaccines, is causing brain damage in children resulting
in autism. Conflicting findings have prevailed in the literature with respect
to the potential of vaccines as a causative factor in autism. Certain findings,
such as those of Andrew Wakefield, have pointed to a live measles virus in the
GI tracts of children with autism. Some studies have confirmed his findings,
others have disputed it. Further, there are many anecdotal reports of regressive
autism following administration of one or more vaccinations. Other parents report
developmental problems from birth pointing to autism.
Last year the author proposed, in a widely published paper, a mechanism by which
the use of amoxicillin/clavulanate may be a possible contributing factor in
the causation of autism. Administered liberally since 1989, Augmentin as it
is known in the U.S. began being cited in the literature for Otitis Media in
1989. During the manufacture of Augmentin, a large buildup of urea is common.
The nitrogen poses a potential explosive component and the potential for nitrogen/urea
poisoning of the GI system exists in children treated with Augmentin.
Most likely, autism has multiple etiologies with environmental and genetics
causes all playing a role in the etiology. Whether vaccine or medication induced,
other toxins or allergens as a factor, the etiology of autism continues to be
In 1989, Horvath from the University of Maryland proposed that a child with
autism who received an endoscopy had significant changes occur with respect
to his autism. Determined that the factor involved was the administration of
secretin which was used to detect stomach tumors during the endoscopic procedure,
secretin was proposed as a potential treatment for autism. Having mixed findings
with respect to the potential efficacy of secretin, the debate still rages in
many quarters of the autistic community. During that time certain mechanisms
were discussed as to why the secretin could potentially be efficacious. It was
determined by the author that potentially certain toxins such as vaccines and
or antibiotics such as Augmentin could injure the lining of the small intestine.
Augmentin of course has long been known to cause GI irritation, and Wakefield’s
findings of measles in the small intestines could potentially set the child
up for GI dysfunction.
Injury to the lining of the small intestines could injure the secretory cells
in the lining. The secretory cells of the small intestine among other things
respond to the pH change in the small intestine. A bolus of food from the stomach
enters the small intestine at a pH of 1 or close to 1. This acidic bolus triggers
the secretory cells of the small intestine to send out the hormone secretin.
The secretin, which is a neuropeptide, reaches the pancreas which responds by
sending out zymogens which are the precursors to the digestive enzymes as well
as bicarbonate ions. The zymogens are sent out by the pancreas to prevent autolysis
of the pancreas itself that could happen in the presence of activated enzymes.
The bicarbonate ions change the pH of proximal small intestines to approximately
a 6.4 pH. The zymogens are then converted into active enzymes. Trypsinogen changes
to trypsin which then in turn converts the chymotrypsinogen to chymotrypsin
and so on. These changes can only take place in the presence of the secretin
Mechanism of Action
If the small intestine or pancreas itself is injured through the use of medications
such as Augmentin, or from vaccination or other insult, it is likely that the
secretin mechanism is unavailable or disrupted. For example, if the secretin
mechanism is altered due to injury to the lining of the small intestines by
the urea/nitrogen residue from Augmentin, then the entire pH change cannot take
place. If the pH change does not occur then the conversion of the inactive to
the active forms of the digestive enzymes does not occur.
The face of the lack of conversion of the enzymes, incomplete or absent digestion
of certain foodstuffs can and will occur. So for example, if a lipase or protease
such as chymotrypsin is not converted from chymotrypsinogen to chymotryspin,
or the pancreas does not manufacture sufficient amounts of the enzymes, incomplete
protein digestion will occur. In the case of an incomplete or absent digestion
of a fat or a protein, the molecule of undigested protein for example, remains
in the small intestines and can act as an allergen. This allergen can act as
a toxin to the body and produce buildup of certain substances, which are further
toxic to the body.
In the case of fats, undigested fats can become rancid and cause a toxic buildup
in the body. The rancid fats can create an allergic irritation or act as a poison.
This is the idea which has been referred to as “leaky gut syndrome.”
By definition, “leaky gut syndrome” is a change in the permeability
of the intestinal lining to large macromolecules such as those of undigested
fats and proteins which generally comes from an inflammation or other change
or damage to the mucosa of the small intestine. Further, if there is damage
to the small intestinal lining, then the IgA (immunoglobulin A) present in that
lining can be injured and absent, allowing pathogens to enter which otherwise
would not be there.
The presence therefore of allergens, and pathogens can upset the balance to
further allow other things such as yeast overgrowth to occur.
So, What Does the Brain Have To Do With It?
If we examine the fact that the GI system in autistics is affected by these
conditions, and there is a lack of digestion, the brain can be significantly
affected. In the first few years of life, and especially under the age of 2
years, the brain is in demand for growth. The largest growth in the brain takes
place during these first few years, and if not given the building blocks necessary
for that growth, the brain will be at a severe disadvantage.
If protein digestion is not taking place, then the proper number and amounts
of amino acids will not be present to make other proteins. The body therefore
must prioritize the use of the available amino acids, and it is possible or
at least theoretical that the body will sacrifice the use of the available amino
acids to allow the most function not necessarily the highest function. The same
is true of the digestion of fat. If the proper fat digestion is not taking place,
then there is going to be a dearth of formation of myelin and other fat necessary
structures in the body.
The allergens, which can result from the lack of fat and the lack of protein
digestion can therefore lead to autism.
Gastrointestinal Markers of Autism
The examination of autistic children is difficult under the best of circumstances.
Due to their significant sensory issues, obtaining blood and urine samples are
difficult, especially in the child as young as 2.
Examination of the stool therefore is a far more easy method of obtaining a
When examining the potential for GI markers for autism it is important to look
for those markers which keep within the physiology of the above hypotheses.
If there is a potential for a lack of protein digestion, measuring the levels
of chymotrypsin could potentially be a marker for this problem. If the secretory
cells are damaged there could potentially be a lack of secretin in the blood
stream as a result of the pH 1 in the small intestines. Without the pH change
from 1 to 6.4 in the small intestines, the chymotrypsinogen never is converted
to chymotryspin and the level of chymotryspin therefore should be extremely
low should the hypothesis be a good one. Measuring fecal chymotrypsin has long
been done in those children with cystic fibrosis (CF) for they too have pancreatic
involvement and a lack of enzymes to digest food. Indeed all CF patients take
digestive (pancreatic) enzymes when they eat.
Further if there is a condition in the small intestines whereby the lack of
digestion allows for an imbalance and the presence of other pathogens, examining
for those pathogens could be another helpful examination in determining autism.
The presence of these pathogens, as measured by their antigenic presence could
also be used as an early marker for regressive autism.
Examination of the diets of these children will reveal an interesting aversion
to protein. These children generally have diets laden with carbohydrates and
very little protein. This is most likely the body’s adaptation to an inability
to digest protein.
Fecal chymotrypsin was measured in 10 children. Fifty children with Autism and
50 age matched controls who are not autistic, or exhibit autistic behaviors.
The autistic children were confirmed through the use of a CARS test (Childhood
Autism Rating Scale). Fecal chymotrypsin is measured with normal being greater
than 8.4. The results are as follows in FIGURE 1:
The means of the two samples are significantly different, and meet the criteria
for statistically significant findings. The use of fecal chymotrypsin is therefore
an important tool to examine the potential need for protein digestion in the
children with autism. Where N=100 for the total subjects, the mean for the autistics
is 3.1, and for the non-autistics 24.6.
Pancreatic (Digestive Enzymes)
Thirty-one autistic and 31 non autistic children had their chymotrypsin levels
measured. In FIGURE 2.
13 of the autistic children who had abnormal fecal hymotrypsin were administered
pancreatic (digestive) enzymes including a protease, lipase and an amylase for
30 days. The results demonstrate a significant change in the level of fecal
chymotrypsin in FIGURE 3.
Elevation of the fecal chymotrypsin levels was seen throughout the study, across
There are many issues, which can be examined with respect to the etiology of
autism. While the etiology is probably multi-factorial, there has never been
a biological marker for autism. Whether from a spat of chronic ear infections
for which the allopath prescribed numerous antibiotics or from a vaccine, which
produces regressive autism, the GI system of the child is likely damaged based
upon the common GI marker findings.
It is important to look at the entire child, and an important part of their
workup should be a GI marker test, which is commercially available. If damage
has been done by outside intervention such as antibiotics or vaccination, it
is possible that the child will require replacement with pancreatic (digestive)
This study is not intended to examine the full range of scientific data surrounding
these findings but rather to give the practitioner an introduction to potential
biological findings in the child with autism.
Dr. Joan Fallon is a member of the ICA Pediatrics Council Board of Directors
and is the Immediate Past Council Chair. She has been recognized for her autism
research and was awarded a patent for her enzyme therapy treatment by the U.S.
Patent and Trademark Office. Dr. Fallon is a full-time practitioner in New York.
© Copyright 2005 Today's Chiropractic
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