Table 1
Global all-age DALYs and age-standardised DALY rates in 1990, 2006, and 2016 with mean percentage changes between 1990 and 2016, 2006 and 2016, and 1990 and 2016 for all causes
| All-age DALYs (thousands) | Age-standardised DALY rate (per 100 000) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1990 | 2006 | 2016 | Percentage change, 1990–2016 | Percentage change, 2006–16 | 1990 | 2006 | 2016 | Percentage change, 1990–2016 | Percentage change, 2006–16 | ||||
| All causes | 2 448 430·5 (2 305 218·2 to 2 608 339·5) | 2 490 698·9 (2 308 527·1 to 2 689 861·1) | 2 391 258·0 (2 184 254·1 to 2 631 699·0) | –2·3 (−5·9 to 0·9) | –4·0 (−6·0 to −2·1)* | 48 407·8 (45 385·4 to 51 762·0) | 40 485·1 (37 556·0 to 43 679·3) | 33 641·0 (30 808·7 to 36 924·3) | –30·5 (−32·6 to −28·6)* | –16·9 (−18·6 to −15·3)* | |||
| Communicable, maternal, neonatal, and nutritional diseases | 1 114 176·6 (1 073 948·8 to 1 156 050·2) | 918 804·8 (885 242·1 to 959 452·3) | 667 823·7 (632 212·4 to 708 405·1) | –40·1 (−42·7 to −37·4)* | –27·3 (−29·8 to −24·9)* | 18 071·6 (17 386·0 to 18 790·5) | 13 801·1 (13 286·8 to 14 406·5) | 9396·8 (8894·5 to 9956·2) | –48·0 (−50·1 to −45·8)* | –31·9 (−34·2 to −29·7)* | |||
| HIV/AIDS and tuberculosis | 84 184·5 (79 728·6 to 89 558·0) | 159 063·9 (152 851·5 to 165 139·0) | 101 133·3 (97 487·1 to 105 092·9) | 20·1 (13·0 to 26·7)* | –36·4 (−37·9 to −34·7)* | 1788·1 (1690·1 to 1918·3) | 2439·5 (2345·8 to 2531·5) | 1355·2 (1306·2 to 1407·5) | –24·2 (−29·7 to −20·1)* | –44·5 (−45·7 to −43·0)* | |||
| Tuberculosis | 68 029·7 (64 153·4 to 73 066·3) | 56 881·5 (54 312·6 to 59 442·6) | 43 557·9 (41 529·0 to 45 716·5) | –36·0 (−41·3 to −32·4)* | –23·4 (−26·1 to −20·6)* | 1480·1 (1390·4 to 1613·6) | 916·5 (874·7 to 956·7) | 593·1 (565·5 to 621·7) | –59·9 (−63·7 to −57·7)* | –35·3 (−37·6 to −32·9)* | |||
| Drug-susceptible tuberculosis | 67 560·5 (63 730·5 to 72 611·6) | 51 760·2 (49 194·0 to 54 289·2) | 39 869·8 (38 054·8 to 41 916·2) | –41·0 (−45·6 to −37·5)* | –23·0 (−25·7 to −20·0)* | 1469·5 (1380·7 to 1603·6) | 834·1 (791·6 to 873·6) | 543·0 (517·8 to 571·1) | –63·0 (−66·4 to −60·8)* | –34·9 (−37·2 to −32·5)* | |||
| Multidrug-resistant tuberculosis without extensive drug resistance | 469·2 (378·3 to 578·8) | 4886·9 (4122·2 to 5829·2) | 3319·4 (2787·6 to 3910·3) | 607·5 (511·8 to 717·0)* | –32·1 (−38·5 to −24·8)* | 10·6 (8·5 to 13·1) | 78·7 (66·3 to 93·9) | 45·1 (37·9 to 53·2) | 327·6 (267·7 to 394·1)* | –42·7 (−48·1 to −36·5)* | |||
| Extensively drug-resistant tuberculosis | ·· | 234·5 (194·6 to 279·1) | 368·8 (301·1 to 444·5) | ·· | 57·3 (36·1 to 82·1)* | ·· | 3·8 (3·1 to 4·5) | 5·0 (4·1 to 6·0) | ·· | 32·5 (14·8 to 53·2)* | |||
| Latent tuberculosis infection | ·· | ·· | ·· | ·· | ·· | ·· | ·· | ·· | ·· | ·· | |||
| HIV/AIDS | 16 154·8 (14 497·1 to 18 106·5) | 102 182·3 (96 751·1 to 107 544·2) | 57 575·4 (54 618·5 to 60 967·9) | 256·4 (220·1 to 293·5)* | –43·6 (−45·4 to −41·6)* | 308·1 (276·2 to 345·6) | 1522·9 (1443·6 to 1601·3) | 762·1 (723·6 to 806·2) | 147·4 (121·5 to 173·2)* | –50·0 (−51·5 to −48·2)* | |||
| Drug-susceptible HIV/AIDS-Tuberculosis | 4668·5 (3624·4 to 5760·2) | 24 070·5 (16 708·0 to 31 379·1) | 11 724·0 (8154·4 to 15 522·4) | 151·1 (116·8 to 191·3)* | –51·3 (−54·0 to −48·6)* | 88·2 (68·0 to 109·1) | 359·7 (249·9 to 468·7) | 155·5 (108·2 to 205·9) | 76·2 (52·6 to 103·8)* | –56·8 (−59·2 to −54·4)* | |||
| Multidrug-resistant HIV/AIDS-Tuberculosis without extensive drug resistance | 25·9 (16·0 to 40·6) | 2051·8 (1282·8 to 3070·2) | 979·2 (597·7 to 1481·6) | 3673·4 (2732·2 to 4952·8)* | –52·3 (−61·7 to −41·2)* | 0·5 (0·3 to 0·8) | 30·7 (19·2 to 45·8) | 13·0 (7·9 to 19·7) | 2486·4 (1853·0 to 3358·6)* | –57·6 (−66·1 to −47·8)* | |||
| Extensively drug-resistant HIV/AIDS-Tuberculosis | ·· | 39·9 (24·8 to 61·1) | 57·3 (34·5 to 89·4) | ·· | 43·5 (25·5 to 65·4)* | ·· | 0·6 (0·4 to 0·9) | 0·8 (0·5 to 1·2) | ·· | 26·8 (10·8 to 46·4)* | |||
| HIV/AIDS resulting in other diseases | 11 460·3 (9938·9 to 13 435·6) | 76 020·0 (67 021·8 to 86 026·2) | 44 814·9 (39 932·9 to 50 112·4) | 291·1 (245·9 to 337·5)* | –41·0 (−43·6 to −38·2)* | 219·3 (189·8 to 257·4) | 1131·9 (999·9 to 1280·9) | 592·9 (528·6 to 663·0) | 170·3 (138·2 to 203·1)* | –47·6 (−49·9 to −45·1)* | |||
| Diarrhoea, lower respiratory, and other common infectious diseases | 557 388·0 (522 551·7 to 600 325·4) | 337 062·8 (317 957·5 to 359 176·2) | 229 961·4 (213 682·3 to 247 975·2) | –58·7 (−61·9 to −55·2)* | –31·8 (−35·3 to −27·8)* | 8951·2 (8378·0 to 9601·7) | 5152·7 (4858·8 to 5514·9) | 3275·6 (3051·7 to 3531·8) | –63·4 (−66·0 to −60·7)* | –36·4 (−39·7 to −33·0)* | |||
| Diarrhoeal diseases | 175 168·6 (150 592·6 to 201 351·3) | 113 944·8 (99 183·9 to 135 659·8) | 74 414·6 (63 402·0 to 93 414·9) | –57·5 (−62·8 to −50·1)* | –34·7 (−41·0 to −28·1)* | 2914·2 (2482·9 to 3469·2) | 1768·5 (1526·0 to 2136·7) | 1063·1 (907·5 to 1332·3) | –63·5 (−67·6 to −58·3)* | –39·9 (−45·2 to −34·3)* | |||
| Intestinal infectious diseases | 15 662·6 (8797·4 to 25 360·4) | 12 822·7 (7207·6 to 20 879·4) | 10 601·7 (6041·1 to 17 309·3) | –32·3 (−43·5 to −21·8)* | –17·3 (−25·1 to −10·8)* | 249·7 (140·6 to 404·8) | 184·6 (103·8 to 300·4) | 144·3 (82·3 to 235·2) | –42·2 (−51·5 to −33·7)* | –21·9 (−29·4 to −15·6)* | |||
| Typhoid fever | 13 362·8 (7235·9 to 22 248·3) | 10 793·8 (5876·4 to 17 717·0) | 8843·0 (4901·5 to 14 436·1) | –33·8 (−44·0 to −23·6)* | –18·1 (−25·7 to −12·1)* | 212·5 (115·0 to 353·9) | 155·3 (84·8 to 254·0) | 120·4 (66·6 to 196·8) | –43·3 (−51·9 to −35·1)* | –22·4 (−29·7 to −16·6)* | |||
| Paratyphoid fever | 1867·3 (850·2 to 3711·1) | 1773·6 (826·8 to 3439·6) | 1607·0 (759·0 to 3109·8) | –13·9 (−27·1 to −1·5)* | –9·4 (−17·9 to −1·8)* | 30·6 (13·9 to 60·4) | 25·6 (11·9 to 49·6) | 21·7 (10·2 to 42·0) | –29·0 (−39·4 to −19·2)* | –15·1 (−22·9 to −8·0)* | |||
| Other intestinal infectious diseases | 432·5 (107·2 to 1290·8) | 255·4 (58·5 to 753·4) | 151·7 (42·1 to 412·1) | –64·9 (−90·6 to 42·1) | –40·6 (−84·7 to 126·3) | 6·7 (1·7 to 19·5) | 3·8 (0·9 to 11·2) | 2·2 (0·6 to 5·9) | –67·5 (−91·3 to 31·5) | –42·9 (−85·2 to 114·5) | |||
| Lower respiratory infections | 202 365·5 (182 794·4 to 220 607·6) | 131 015·4 (121 489·8 to 139 228·6) | 91 844·6 (84 674·4 to 98 252·6) | –54·6 (−58·7 to −49·4)* | –29·9 (−34·4 to −25·3)* | 3237·1 (2942·1 to 3515·4) | 2022·6 (1879·0 to 2147·6) | 1326·7 (1221·8 to 1419·7) | –59·0 (−62·5 to −54·6)* | –34·4 (−38·6 to −30·2)* | |||
| Upper respiratory infections | 4868·6 (3012·8 to 7444·9) | 5551·2 (3380·7 to 8488·2) | 5991·2 (3621·1 to 9193·8) | 23·1 (19·0 to 26·3)* | 7·9 (6·2 to 9·4)* | 88·2 (54·9 to 134·0) | 83·0 (50·8 to 126·9) | 81·0 (49·0 to 124·0) | –8·3 (−10·5 to −6·9)* | –2·5 (−3·8 to −1·5)* | |||
| Otitis media | 3111·7 (2057·2 to 4485·0) | 3171·4 (2005·0 to 4675·3) | 3187·5 (1993·2 to 4716·5) | 2·4 (−3·8 to 7·0) | 0·5 (−2·1 to 3·0) | 53·4 (35·3 to 76·9) | 46·7 (29·6 to 68·9) | 43·3 (27·1 to 64·2) | –18·9 (−23·7 to −15·1)* | –7·3 (−9·8 to −4·9)* | |||
| Meningitis | 30 239·3 (23 939·3 to 34 552·6) | 24 957·4 (21 655·0 to 28 764·2) | 21 865·9 (18 204·6 to 28 280·5) | –27·7 (−41·7 to 3·1) | –12·4 (−23·9 to 7·8) | 481·8 (385·6 to 549·0) | 369·9 (321·3 to 426·1) | 306·1 (254·0 to 398·0) | –36·5 (−48·5 to −9·7)* | –17·2 (−28·1 to 2·1) | |||
| Pneumococcal meningitis | 2187·5 (1808·2 to 2576·0) | 1940·0 (1649·9 to 2287·4) | 1902·8 (1569·5 to 2382·2) | –13·0 (−26·3 to 10·0) | –1·9 (−11·5 to 12·0) | 37·2 (31·0 to 43·4) | 29·1 (24·8 to 34·2) | 26·2 (21·6 to 32·7) | –29·6 (−39·6 to −11·3)* | –9·9 (−18·7 to 3·2) | |||
| Haemophilus influenzae type B meningitis | 3330·3 (2606·2 to 3982·2) | 2725·7 (2276·3 to 3165·4) | 2426·0 (1967·2 to 3212·2) | –27·1 (−41·5 to 3·7) | –11·0 (−23·9 to 9·3) | 52·4 (41·5 to 62·0) | 40·3 (33·7 to 46·8) | 34·1 (27·6 to 45·1) | –34·8 (−47·4 to −7·4)* | –15·3 (−27·6 to 3·9) | |||
| Meningococcal meningitis | 14 191·0 (11 094·1 to 16 492·1) | 11 548·6 (9913·5 to 13 418·2) | 8327·1 (6806·4 to 10 911·9) | –41·3 (−53·1 to −16·3)* | –27·9 (−37·7 to −12·2)* | 224·2 (177·0 to 259·3) | 170·8 (146·7 to 199·1) | 116·6 (95·2 to 152·9) | –48·0 (−58·4 to −26·0)* | –31·7 (−41·1 to −16·8)* | |||
| Other meningitis | 10 530·5 (8030·6 to 12 434·2) | 8743·1 (7350·6 to 10 148·8) | 9210·0 (7559·7 to 12 250·5) | –12·5 (−30·3 to 28·9) | 5·3 (−9·4 to 33·0) | 168·1 (129·1 to 197·5) | 129·7 (109·2 to 150·4) | 129·2 (105·5 to 173·3) | –23·1 (−38·2 to 12·4) | –0·4 (−14·4 to 26·1) | |||
| Encephalitis | 7918·4 (5206·9 to 10 751·2) | 7380·9 (6422·5 to 9033·9) | 6704·1 (5469·3 to 8574·2) | –15·3 (−44·0 to 40·6) | –9·2 (−24·4 to 10·8) | 135·5 (91·8 to 180·2) | 111·5 (97·1 to 136·5) | 92·7 (75·7 to 118·4) | –31·6 (−53·6 to 10·0) | –16·9 (−30·8 to 1·2) | |||
| Diphtheria | 842·7 (611·3 to 1167·2) | 263·8 (183·1 to 374·7) | 86·9 (62·5 to 123·4) | –89·7 (−93·2 to −84·0)* | –67·0 (−78·6 to −47·7)* | 12·9 (9·4 to 17·9) | 3·9 (2·7 to 5·6) | 1·2 (0·9 to 1·8) | –90·5 (−93·7 to −85·3)* | –68·6 (−79·8 to −49·7)* | |||
| Whooping cough | 14 651·2 (6598·0 to 28 290·2) | 9778·0 (4727·9 to 17 764·8) | 6249·9 (3360·7 to 10 754·7) | –57·3 (−77·1 to −19·2)* | –36·1 (−63·1 to 17·1) | 219·5 (98·9 to 424·0) | 144·6 (69·9 to 262·6) | 89·4 (48·1 to 153·9) | –59·3 (−78·1 to −22·8)* | –38·1 (−64·3 to 13·3) | |||
| Tetanus | 24 893·6 (14 235·3 to 33 445·8) | 6340·9 (3695·4 to 7940·5) | 2366·6 (1446·0 to 3062·9) | –90·5 (−92·7 to −87·7)* | –62·7 (−68·8 to −55·4)* | 385·3 (222·8 to 516·6) | 93·3 (54·4 to 116·8) | 33·6 (20·3 to 43·4) | –91·3 (−93·2 to −88·9)* | –64·0 (−70·0 to −57·1)* | |||
| Measles | 76 350·8 (31 267·6 to 147 358·9) | 20 794·3 (8237·6 to 43 871·3) | 5724·8 (2148·6 to 12 257·6) | –92·5 (−94·4 to −90·5)* | –72·5 (−76·9 to −67·7)* | 1150·7 (471·2 to 2220·4) | 307·9 (122·0 to 649·2) | 81·3 (30·5 to 174·2) | –92·9 (−94·7 to −91·0)* | –73·6 (−77·8 to −69·0)* | |||
| Varicella and herpes zoster | 1314·9 (1138·7 to 1509·6) | 1042·2 (909·6 to 1205·0) | 923·5 (779·5 to 1098·7) | –29·8 (−40·3 to −18·8)* | –11·4 (−20·6 to −2·8)* | 22·8 (19·8 to 25·9) | 16·2 (14·1 to 18·9) | 13·0 (11·0 to 15·4) | –42·8 (−50·3 to −35·4)* | –19·7 (−27·6 to −12·2)* | |||
| Neglected tropical diseases and malaria | 87 294·8 (71 756·4 to 103 455·7) | 99 229·2 (85 820·3 to 113 978·1) | 74 995·1 (63 114·8 to 86 650·7) | –14·1 (−31·0 to 6·2) | –24·4 (−37·6 to −8·6)* | 1423·8 (1183·4 to 1676·5) | 1478·5 (1280·4 to 1696·3) | 1050·5 (882·7 to 1217·9) | –26·2 (−40·4 to −9·3)* | –28·9 (−41·5 to −14·0)* | |||
| Malaria | 60 389·3 (46 548·2 to 74 912·5) | 77 253·7 (64 810·3 to 91 256·8) | 56 201·2 (45 785·6 to 67 880·8) | –6·9 (−30·5 to 26·5) | –27·2 (−43·3 to −6·7)* | 931·0 (722·1 to 1150·5) | 1147·0 (963·0 to 1354·6) | 794·7 (646·5 to 962·2) | –14·6 (−36·1 to 15·2) | –30·7 (−46·2 to −11·1)* | |||
| Chagas disease | 309·8 (286·3 to 334·8) | 226·1 (204·9 to 251·3) | 219·0 (194·6 to 250·7) | –29·3 (−34·4 to −23·7)* | –3·1 (−8·2 to 2·7) | 7·7 (7·1 to 8·3) | 4·0 (3·7 to 4·5) | 3·1 (2·8 to 3·6) | –59·3 (−62·2 to −56·0)* | –22·6 (−26·7 to −17·8)* | |||
| Leishmaniasis | 2531·5 (1470·2 to 4203·0) | 1897·2 (1151·9 to 3064·4) | 981·0 (658·3 to 1480·6) | –61·2 (−67·2 to −52·0)* | –48·3 (−54·0 to −39·6)* | 45·7 (27·0 to 75·4) | 28·4 (17·2 to 45·7) | 13·4 (9·0 to 20·3) | –70·6 (−74·9 to −64·1)* | –52·6 (−57·7 to −44·9)* | |||
| Visceral leishmaniasis | 2406·1 (1350·5 to 4080·8) | 1684·8 (943·7 to 2878·0) | 707·9 (400·1 to 1206·2) | –70·6 (−74·4 to −66·4)* | –58·0 (−61·9 to −53·9)* | 43·1 (24·4 to 72·6) | 25·1 (14·1 to 42·9) | 9·8 (5·5 to 16·6) | –77·4 (−79·9 to −74·6)* | –61·1 (−64·7 to −57·2)* | |||
| Cutaneous and mucocutaneous leishmaniasis | 125·3 (67·7 to 217·2) | 212·4 (131·6 to 329·4) | 273·1 (177·2 to 398·9) | 117·9 (67·5 to 215·8)* | 28·6 (16·8 to 42·9)* | 2·6 (1·4 to 4·4) | 3·3 (2·0 to 5·0) | 3·7 (2·4 to 5·4) | 43·5 (11·8 to 103·5)* | 12·5 (1·7 to 26·1)* | |||
| African trypanosomiasis | 1046·8 (559·1 to 1711·5) | 539·0 (288·0 to 876·8) | 128·4 (64·7 to 215·0) | –87·7 (−91·3 to −82·2)* | –76·2 (−83·2 to −65·9)* | 19·2 (10·3 to 31·6) | 7·8 (4·2 to 12·8) | 1·7 (0·9 to 2·9) | –91·1 (−93·6 to −87·2)* | –78·2 (−84·6 to −68·8)* | |||
| Schistosomiasis | 2096·8 (1340·2 to 3410·1) | 2464·8 (1447·7 to 4194·7) | 1863·6 (1122·0 to 3175·2) | –11·1 (−17·5 to −6·7)* | –24·4 (−26·2 to −21·9)* | 42·8 (27·5 to 69·2) | 37·5 (22·2 to 63·5) | 24·9 (15·0 to 42·3) | –41·9 (−46·3 to −38·9)* | –33·7 (−35·4 to −31·6)* | |||
| Cysticercosis | 489·0 (363·4 to 621·4) | 500·8 (359·2 to 657·1) | 468·1 (322·8 to 625·8) | –4·3 (−13·5 to 3·9) | –6·5 (−12·4 to −0·9)* | 10·5 (7·8 to 13·4) | 8·0 (5·7 to 10·5) | 6·3 (4·4 to 8·4) | –40·0 (−45·2 to −35·0)* | –21·0 (−26·0 to −16·5)* | |||
| Cystic echinococcosis | 326·8 (237·4 to 449·1) | 226·2 (161·3 to 313·8) | 136·5 (95·3 to 193·7) | –58·2 (−68·4 to −44·3)* | –39·6 (−53·9 to −16·3)* | 6·3 (4·5 to 8·7) | 3·5 (2·5 to 4·8) | 1·8 (1·3 to 2·6) | –70·6 (−77·7 to −61·1)* | –46·6 (−59·1 to −26·5)* | |||
| Lymphatic filariasis | 1595·7 (733·4 to 2983·5) | 1897·7 (873·9 to 3542·8) | 1189·0 (587·7 to 2114·9) | –25·5 (−41·4 to −9·3)* | –37·4 (−52·4 to −26·0)* | 32·5 (14·9 to 60·7) | 28·9 (13·3 to 54·0) | 15·8 (7·8 to 28·1) | –51·5 (−61·8 to −41·2)* | –45·3 (−58·4 to −35·5)* | |||
| Onchocerciasis | 1420·4 (777·0 to 2254·9) | 1266·4 (705·0 to 2003·3) | 962·5 (452·3 to 1672·1) | –32·2 (−47·6 to −16·8)* | –24·0 (−41·6 to −6·5)* | 28·4 (16·0 to 45·4) | 19·1 (11·0 to 30·1) | 12·9 (6·1 to 22·4) | –54·6 (−65·7 to −43·4)* | –32·6 (−48·5 to −17·5)* | |||
| Trachoma | 231·1 (156·9 to 324·3) | 246·5 (166·2 to 348·4) | 245·2 (162·4 to 353·6) | 6·1 (−2·6 to 14·6) | –0·5 (−6·5 to 5·2) | 6·7 (4·5 to 9·4) | 4·9 (3·3 to 6·9) | 3·7 (2·5 to 5·3) | –44·3 (−49·0 to −39·6)* | –23·8 (−28·5 to −19·3)* | |||
| Dengue | 822·8 (308·1 to 1364·0) | 1798·2 (789·6 to 2494·8) | 2956·9 (1359·2 to 4146·9) | 259·4 (104·2 to 683·3)* | 64·4 (36·2 to 115·9)* | 13·9 (5·2 to 23·2) | 26·7 (11·7 to 37·1) | 40·2 (18·6 to 56·3) | 189·0 (65·5 to 523·4)* | 50·5 (24·7 to 97·7)* | |||
| Yellow fever | 784·5 (170·6 to 2314·6) | 424·5 (89·8 to 1247·2) | 374·0 (80·8 to 1075·1) | –52·3 (−61·3 to −41·2)* | –11·9 (−26·9 to 7·4) | 13·2 (2·9 to 39·0) | 6·1 (1·3 to 18·0) | 5·0 (1·1 to 14·5) | –61·8 (−68·5 to −52·9)* | –17·1 (−31·3 to 1·3) | |||
| Rabies | 2979·4 (1867·4 to 4076·4) | 1451·6 (867·1 to 1868·0) | 744·2 (383·8 to 1106·3) | –75·0 (−82·7 to −61·4)* | –48·7 (−58·9 to −34·1)* | 51·3 (32·6 to 71·3) | 21·5 (12·9 to 27·5) | 10·1 (5·2 to 15·1) | –80·3 (−86·5 to −69·9)* | –52·9 (−62·4 to −39·5)* | |||
| Intestinal nematode infections | 7460·9 (4726·6 to 11 584·0) | 4083·3 (2617·1 to 6154·1) | 3331·2 (2076·2 to 5158·6) | –55·4 (−57·9 to −52·6)* | –18·4 (−22·9 to −14·3)* | 132·8 (83·2 to 206·9) | 60·8 (39·0 to 91·6) | 45·0 (28·2 to 69·6) | –66·1 (−68·0 to −64·0)* | –25·9 (−30·0 to −22·2)* | |||
| Ascariasis | 4634·7 (2996·9 to 7119·9) | 1902·0 (1325·4 to 2758·9) | 1308·8 (883·2 to 1942·4) | –71·8 (−74·6 to −68·4)* | –31·2 (−37·6 to −24·8)* | 80·3 (51·4 to 124·0) | 28·3 (19·8 to 41·1) | 17·9 (12·1 to 26·4) | –77·8 (−79·9 to −74·9)* | –37·0 (−42·8 to −31·0)* | |||
| Trichuriasis | 671·4 (364·9 to 1142·9) | 421·5 (233·0 to 717·2) | 337·0 (186·2 to 573·6) | –49·8 (−55·2 to −44·3)* | –20·0 (−27·9 to −11·6)* | 12·5 (6·8 to 21·2) | 6·3 (3·5 to 10·7) | 4·5 (2·5 to 7·7) | –63·7 (−67·8 to −59·7)* | –27·8 (−34·9 to −20·2)* | |||
| Hookworm disease | 2154·8 (1278·7 to 3371·1) | 1759·8 (1058·9 to 2739·1) | 1685·4 (1001·5 to 2648·9) | –21·8 (−26·7 to −16·6)* | –4·2 (−9·5 to 1·3) | 40·0 (23·7 to 62·8) | 26·2 (15·7 to 40·7) | 22·6 (13·5 to 35·5) | –43·4 (−47·2 to −39·6)* | –13·5 (−18·2 to −8·5)* | |||
| Food-borne trematodiases | 1425·0 (591·7 to 2937·7) | 1659·6 (832·5 to 3083·5) | 1771·2 (923·9 to 3158·4) | 24·3 (−3·9 to 71·7) | 6·7 (1·3 to 15·7)* | 27·9 (12·0 to 56·7) | 25·4 (12·9 to 46·8) | 23·7 (12·2 to 42·0) | –15·3 (−34·0 to 13·1) | –7·0 (−11·4 to 0·5) | |||
| Leprosy | 23·0 (15·5 to 32·3) | 31·3 (21·3 to 44·0) | 31·6 (21·4 to 44·0) | 37·5 (34·0 to 40·9)* | 1·1 (−1·3 to 3·6) | 0·6 (0·4 to 0·8) | 0·5 (0·4 to 0·8) | 0·4 (0·3 to 0·6) | –20·7 (−22·7 to −18·8)* | –18·1 (−20·0 to −16·2)* | |||
| Ebola virus disease | ·· | ·· | 0·3 (0·2 to 1·1) | ·· | ·· | ·· | ·· | ·· | ·· | ·· | |||
| Zika virus disease | ·· | ·· | 5·1 (3·4–8·0) | ·· | ·· | ·· | ·· | 0·1 (0·0–0·1) | ·· | ·· | |||
| Guinea worm disease | 50·7 (35·3 to 69·2) | 0·2 (0·1 to 0·3) | ·· | –100·0 (−100·0 to −100·0)* | –99·5 (−99·7 to −99·4)* | 1·1 (0·7 to 1·4) | ·· | ·· | –100·0 (−100·0 to −100·0)* | –99·6 (−99·7 to −99·5)* | |||
| Other neglected tropical diseases | 3311·2 (2409·7 to 4421·6) | 3262·2 (2470·4 to 4130·1) | 3386·0 (2569·6 to 4260·7) | 2·3 (−22·0 to 31·6) | 3·8 (−14·9 to 23·9) | 52·2 (38·2 to 69·0) | 48·3 (36·6 to 61·2) | 47·4 (35·9 to 59·7) | –9·1 (−29·8 to 15·8) | –1·9 (−19·5 to 17·3) | |||
| Maternal disorders | 21 597·1 (20 063·6 to 22 834·1) | 18 093·0 (16 785·8 to 19 171·8) | 13 763·0 (12 668·6 to 15 064·0) | –36·3 (−41·3 to −31·0)* | –23·9 (−29·3 to −17·4)* | 388·6 (361·4 to 411·5) | 257·2 (238·8 to 272·5) | 179·0 (164·7 to 195·8) | –53·9 (−57·6 to −50·2)* | –30·4 (−35·4 to −24·4)* | |||
| Maternal haemorrhage | 6945·7 (5770·8 to 8257·7) | 5416·4 (4627·6 to 6301·7) | 4078·3 (3311·7 to 5035·2) | –41·3 (−47·4 to −34·9)* | –24·7 (−32·5 to −16·0)* | 124·4 (103·1 to 148·1) | 77·0 (65·8 to 89·7) | 53·0 (43·1 to 65·4) | –57·4 (−61·7 to −53·0)* | –31·2 (−38·2 to −23·3)* | |||
| Maternal sepsis and other maternal infections | 2102·5 (1614·0 to 2721·4) | 1562·3 (1223·7 to 1984·3) | 1139·4 (833·1 to 1525·2) | –45·8 (−51·9 to −39·7)* | –27·1 (−35·7 to −18·1)* | 37·6 (29·0 to 48·2) | 22·1 (17·3 to 28·0) | 14·8 (10·9 to 19·8) | –60·6 (−64·8 to −56·1)* | –33·0 (−40·9 to −24·8)* | |||
| Maternal hypertensive disorders | 2469·0 (1945·4 to 3125·5) | 2478·1 (1983·1 to 3052·0) | 1996·8 (1569·9 to 2483·1) | –19·1 (−26·0 to −11·2)* | –19·4 (−27·3 to −11·1)* | 44·0 (34·8 to 55·2) | 35·1 (28·2 to 43·2) | 26·0 (20·5 to 32·3) | –40·9 (−45·8 to −35·4)* | –25·8 (−33·1 to −17·9)* | |||
| Maternal obstructed labour and uterine rupture | 1440·8 (1086·2 to 1865·8) | 1240·4 (944·6 to 1582·8) | 969·0 (716·6 to 1270·1) | –32·8 (−37·4 to −27·7)* | –21·9 (−27·4 to −15·9)* | 27·0 (20·4 to 35·0) | 17·9 (13·6 to 22·9) | 12·6 (9·3 to 16·5) | –53·3 (−56·5 to −50·0)* | –29·5 (−34·5 to −24·1)* | |||
| Maternal abortion, miscarriage, and ectopic pregnancy | 1743·4 (1338·9 to 2235·5) | 1469·0 (1150·0 to 1845·5) | 1145·1 (855·9 to 1541·6) | –34·3 (−40·9 to −26·8)* | –22·1 (−30·6 to −12·6)* | 31·9 (24·6 to 40·6) | 20·9 (16·4 to 26·3) | 14·9 (11·1 to 19·9) | –53·3 (−57·8 to −48·0)* | –28·8 (−36·6 to −20·4)* | |||
| Indirect maternal deaths | 2611·6 (1943·4 to 3385·8) | 2577·2 (1949·1 to 3277·1) | 1987·9 (1463·8 to 2619·8) | –23·9 (−30·7 to −16·4)* | –22·9 (−30·1 to −14·8)* | 47·0 (35·2 to 60·4) | 36·7 (27·7 to 46·6) | 25·8 (19·1 to 34·0) | –45·0 (−49·7 to −39·9)* | –29·6 (−36·2 to −22·1)* | |||
| Late maternal deaths | 374·2 (244·4 to 552·4) | 298·2 (178·6 to 480·8) | 228·5 (134·6 to 370·9) | –39·0 (−50·1 to −28·8)* | –23·4 (−29·9 to −16·2)* | 6·7 (4·4 to 9·8) | 4·2 (2·5 to 6·8) | 3·0 (1·8 to 4·8) | –55·8 (−63·7 to −49·2)* | –29·9 (−35·5 to −23·5)* | |||
| Maternal deaths aggravated by HIV/AIDS | 36·9 (21·5 to 52·5) | 128·5 (81·8 to 169·0) | 105·4 (66·7 to 142·9) | 185·9 (142·7 to 243·7)* | –17·9 (−27·8 to −6·0)* | 0·7 (0·4 to 0·9) | 1·9 (1·2 to 2·4) | 1·4 (0·9 to 1·9) | 104·5 (73·6 to 146·1)* | –26·1 (−35·0 to −15·3)* | |||
| Other maternal disorders | 3872·9 (3015·3 to 4777·9) | 2923·1 (2365·7 to 3539·5) | 2112·5 (1628·9 to 2673·2) | –45·5 (−50·6 to −39·9)* | –27·7 (−34·7 to −19·7)* | 69·3 (54·4 to 84·9) | 41·5 (33·6 to 50·0) | 27·5 (21·2 to 34·8) | –60·4 (−64·0 to −56·5)* | –33·7 (−40·1 to −26·4)* | |||
| Neonatal disorders | 261 357·2 (248 875·2 to 282 758·2) | 211 984·8 (203 477·1 to 221 317·2) | 163 569·7 (154 643·2 to 172 756·7) | –37·4 (−42·7 to −32·7)* | –22·8 (−26·8 to −18·9)* | 3818·4 (3635·3 to 4130·2) | 3073·5 (2949·7 to 3208·5) | 2364·2 (2237·5 to 2493·4) | –38·1 (−43·2 to −33·5)* | –23·1 (−27·0 to −19·2)* | |||
| Neonatal preterm birth complications | 112 767·2 (105 488·9 to 124 122·5) | 81 159·7 (76 378·0 to 89 409·0) | 62 031·6 (57 062·9 to 67 530·0) | –45·0 (−50·3 to −39·5)* | –23·6 (−29·9 to −17·4)* | 1652·8 (1546·2 to 1819·4) | 1176·6 (1107·3 to 1296·0) | 892·7 (822·1 to 970·7) | –46·0 (−51·2 to −40·7)* | –24·1 (−30·4 to −18·1)* | |||
| Neonatal encephalopathy due to birth asphyxia, and trauma | 68 251·9 (61 749·3 to 76 860·5) | 60 334·8 (55 822·8 to 65 138·9) | 47 031·7 (41 794·2 to 51 919·1) | –31·1 (−41·3 to −20·8)* | –22·1 (−29·3 to −14·6)* | 993·0 (897·9 to 1117·7) | 874·2 (808·8 to 943·9) | 682·2 (606·6 to 751·3) | –31·3 (−41·4 to −21·4)* | –22·0 (−29·1 to −14·6)* | |||
| Neonatal sepsis and other neonatal infections | 24 573·0 (18 972·5 to 31 156·6) | 25 874·0 (21 266·6 to 32 360·3) | 23 675·8 (20 056·0 to 30 684·5) | –3·6 (−22·7 to 20·9) | –8·5 (−19·1 to 4·0) | 360·8 (278·4 to 460·0) | 375·7 (308·9 to 469·6) | 341·7 (291·0 to 444·5) | –5·3 (−23·7 to 18·6) | –9·0 (−19·5 to 3·2) | |||
| Haemolytic disease and other neonatal jaundice | 12 277·3 (10 225·3 to 15 113·1) | 7996·0 (7149·5 to 9006·9) | 4912·8 (4310·5 to 5605·8) | –60·0 (−69·1 to −50·4)* | –38·6 (−46·2 to −30·3)* | 179·9 (149·9 to 221·4) | 116·1 (103·8 to 130·8) | 70·7 (62·0 to 80·7) | –60·7 (−69·6 to −51·4)* | –39·1 (−46·6 to −30·8)* | |||
| Other neonatal disorders | 43 487·8 (37 402·4 to 50 951·9) | 36 620·3 (33 314·2 to 40 250·5) | 25 917·7 (23 440·4 to 28 405·4) | –40·4 (−50·6 to −28·5)* | –29·2 (−36·1 to −21·0)* | 631·9 (543·4 to 740·9) | 530·9 (483·0 to 583·6) | 376·8 (340·8 to 413·1) | –40·4 (−50·6 to −28·4)* | –29·0 (−35·9 to −20·7)* | |||
| Nutritional deficiencies | 69 823·3 (57 049·4 to 85 126·9) | 64 648·9 (51 489·2 to 80 980·6) | 60 936·1 (46 656·8 to 79 062·8) | –12·7 (−23·8 to −1·2)* | –5·7 (−12·3 to 0·1) | 1167·8 (949·2 to 1434·1) | 971·1 (775·1 to 1213·5) | 844·3 (649·4 to 1090·3) | –27·7 (−35·9 to −19·1)* | –13·1 (−18·9 to −7·7)* | |||
| Protein-energy malnutrition | 35 843·1 (29 589·9 to 41 569·5) | 26 417·6 (23 896·5 to 29 406·0) | 20 718·9 (18 009·6 to 24 194·8) | –42·2 (−51·8 to −26·7)* | –21·6 (−32·3 to −8·8)* | 561·0 (467·3 to 647·0) | 398·8 (361·7 to 443·4) | 296·7 (258·1 to 346·4) | –47·1 (−55·8 to −33·4)* | –25·6 (−35·7 to −13·6)* | |||
| Iodine deficiency | 4355·1 (2983·7 to 6048·6) | 3453·9 (2363·8 to 4790·9) | 3240·6 (2213·3 to 4488·7) | –25·6 (−28·2 to −22·9)* | –6·2 (−8·7 to −3·5)* | 84·5 (58·0 to 117·3) | 52·4 (35·9 to 72·6) | 43·5 (29·8 to 60·3) | –48·5 (−50·2 to −46·7)* | –16·9 (−19·2 to −14·5)* | |||
| Vitamin A deficiency | 188·5 (116·6 to 294·4) | 225·3 (139·7 to 348·3) | 252·4 (158·8 to 388·3) | 33·9 (27·4 to 41·0)* | 12·0 (8·7 to 15·5)* | 3·2 (2·0 to 4·9) | 3·4 (2·1 to 5·2) | 3·4 (2·2 to 5·3) | 7·0 (2·2 to 11·4)* | 2·6 (−0·3 to 5·6) | |||
| Iron-deficiency anaemia | 27 097·5 (18 018·7 to 38 749·1) | 32 422·9 (21 535·8 to 46 668·3) | 34 841·8 (23 085·2 to 49 693·9) | 28·6 (26·5 to 30·4)* | 7·5 (6·2 to 8·9)* | 475·7 (317·4 to 679·7) | 482·7 (320·9 to 693·0) | 474·1 (314·1 to 676·0) | –0·3 (−1·5 to 0·7) | –1·8 (−3·0 to −0·5)* | |||
| Other nutritional deficiencies | 2339·1 (1908·0 to 2766·9) | 2129·2 (1791·2 to 2366·5) | 1882·4 (1592·2 to 2158·7) | –19·5 (−32·9 to 5·7) | –11·6 (−20·4 to 0·7) | 43·3 (36·7 to 50·2) | 33·8 (28·4 to 37·4) | 26·4 (22·4 to 30·3) | –38·9 (−48·1 to −24·3)* | –21·7 (−29·1 to −11·6)* | |||
| Other communicable, maternal, neonatal, and nutritional diseases | 32 531·7 (25 112·3 to 42 021·4) | 28 722·2 (22 674·6 to 36 833·4) | 23 465·1 (18 762·9 to 29 098·8) | –27·9 (−36·2 to −18·6)* | –18·3 (−25·2 to −10·6)* | 533·7 (424·3 to 675·0) | 428·7 (340·1 to 547·4) | 328·0 (261·3 to 409·8) | –38·5 (−44·8 to −31·3)* | –23·5 (−29·8 to −16·4)* | |||
| Sexually transmitted diseases excluding HIV | 16 447·6 (9960·1 to 25 590·4) | 15 145·5 (9416·5 to 22 818·4) | 12 016·0 (7764·9 to 17 118·7) | –26·9 (−37·6 to −13·9)* | –20·7 (−30·2 to −9·4)* | 254·0 (157·8 to 389·9) | 222·6 (138·7 to 335·0) | 169·4 (108·1 to 242·8) | –33·3 (−42·1 to −22·6)* | –23·9 (−32·8 to −13·4)* | |||
| Syphilis | 14 613·8 (8275·0 to 23 755·0) | 12 825·3 (7321·4 to 20 493·5) | 9415·8 (5467·7 to 14 602·8) | –35·6 (−45·5 to −23·1)* | –26·6 (−35·8 to −14·9)* | 217·9 (124·4 to 352·0) | 188·3 (107·7 to 300·6) | 135·5 (78·6 to 210·2) | –37·8 (−47·4 to −25·8)* | –28·1 (−37·1 to −16·8)* | |||
| Chlamydial infection | 425·2 (287·5 to 639·0) | 519·6 (341·4 to 782·1) | 562·4 (370·3 to 851·1) | 32·3 (25·6 to 39·6)* | 8·2 (5·9 to 10·4)* | 8·0 (5·4 to 11·8) | 7·5 (5·0 to 11·3) | 7·3 (4·8 to 11·0) | –8·6 (−14·2 to −3·4)* | –3·3 (−5·6 to −1·4)* | |||
| Gonococcal infection | 465·0 (334·8 to 630·0) | 582·3 (412·5 to 824·5) | 675·2 (467·7 to 974·9) | 45·2 (26·9 to 64·5)* | 16·0 (10·3 to 21·8)* | 9·2 (6·8 to 12·4) | 8·6 (6·1 to 12·1) | 8·8 (6·1 to 12·7) | –4·3 (−17·1 to 9·2) | 2·7 (−2·7 to 7·8) | |||
| Trichomoniasis | 125·7 (48·3 to 265·4) | 170·9 (65·2 to 362·0) | 198·2 (75·9 to 420·8) | 57·7 (55·1 to 60·5)* | 15·9 (14·8 to 17·1)* | 2·5 (0·9 to 5·2) | 2·5 (1·0 to 5·4) | 2·6 (1·0 to 5·5) | 4·7 (3·6 to 5·8)* | 1·8 (0·9 to 2·7)* | |||
| Genital herpes | 132·8 (43·0 to 302·2) | 187·9 (61·0 to 428·1) | 221·4 (71·2 to 507·1) | 66·8 (61·5 to 70·0)* | 17·8 (15·5 to 19·7)* | 2·9 (0·9 to 6·6) | 3·0 (1·0 to 6·8) | 3·0 (1·0 to 6·8) | 2·9 (1·3 to 4·8)* | –0·2 (−1·6 to 1·5) | |||
| Other sexually transmitted diseases | 685·1 (474·3 to 964·9) | 859·5 (589·4 to 1221·9) | 943·0 (643·7 to 1349·4) | 37·6 (30·6 to 44·7)* | 9·7 (7·4 to 12·2)* | 13·5 (9·4 to 18·9) | 12·6 (8·7 to 17·9) | 12·3 (8·4 to 17·6) | –8·7 (−13·7 to −4·0)* | –2·6 (−4·8 to −0·4)* | |||
| Hepatitis | 9017·2 (8255·1 to 9723·9) | 7718·6 (7259·2 to 8169·0) | 5777·8 (5492·2 to 6078·9) | –35·9 (−41·5 to −30·1)* | –25·1 (−29·2 to −21·0)* | 163·7 (151·1 to 175·3) | 117·8 (111·0 to 124·6) | 78·6 (74·8 to 82·7) | –52·0 (−55·9 to −48·3)* | –33·3 (−36·8 to −29·6)* | |||
| Acute hepatitis A | 1271·9 (1017·1 to 1540·7) | 849·3 (677·0 to 1036·3) | 450·7 (364·0 to 544·8) | –64·6 (−72·1 to −55·0)* | –46·9 (−58·9 to −32·0)* | 19·5 (15·7 to 23·5) | 12·6 (10·1 to 15·3) | 6·4 (5·2 to 7·8) | –67·1 (−74·0 to −58·4)* | –49·0 (−60·6 to −34·6)* | |||
| Hepatitis B | 4656·5 (4209·1 to 5096·9) | 4373·2 (4013·0 to 4741·4) | 3823·8 (3543·7 to 4119·0) | –17·9 (−24·6 to −10·7)* | –12·6 (−17·9 to −7·0)* | 94·2 (86·2 to 102·2) | 68·7 (63·5 to 74·3) | 51·6 (47·9 to 55·6) | –45·2 (−49·2 to −40·9)* | –24·9 (−29·2 to −20·4)* | |||
| Hepatitis C | 88·4 (72·0 to 107·8) | 90·9 (73·8 to 112·2) | 83·7 (66·3 to 104·2) | –5·3 (−17·1 to 7·5) | –7·9 (−17·6 to 3·0) | 1·8 (1·5 to 2·3) | 1·5 (1·2 to 1·9) | 1·1 (0·9 to 1·4) | –37·1 (−44·2 to −29·1)* | –22·3 (−30·4 to −13·0)* | |||
| Acute hepatitis E | 3000·4 (2479·7 to 3449·1) | 2405·2 (2090·1 to 2702·9) | 1419·6 (1230·3 to 1610·1) | –52·7 (−60·4 to −44·5)* | –41·0 (−47·5 to −33·9)* | 48·1 (40·0 to 55·0) | 35·1 (30·5 to 39·4) | 19·4 (16·9 to 22·0) | –59·6 (−65·9 to −52·9)* | –44·6 (−50·6 to −38·0)* | |||
| Other infectious diseases | 7066·9 (4328·0 to 9252·2) | 5858·1 (4069·7 to 7316·8) | 5671·3 (3883·9 to 7280·7) | –19·8 (−39·1 to 6·8) | –3·2 (−20·2 to 20·7) | 116·1 (74·8 to 148·6) | 88·2 (61·7 to 109·9) | 80·0 (54·2 to 103·5) | –31·1 (−46·9 to −10·6)* | –9·4 (−25·1 to 13·1) | |||
| Non-communicable diseases | 1 074 539·5 (957 634·8 to 1 197 008·3) | 1 312 102·0 (1 163 063·8 to 1 472 494·4) | 1 468 000·0 (1 296 535·4 to 1 658 537·7) | 36·6 (32·9 to 39·9)* | 11·9 (10·3 to 13·2)* | 25 460·8 (22 961·5 to 28 096·0) | 22 707·2 (20 288·0 to 25 308·0) | 20 786·9 (18 438·7 to 23 410·0) | –18·4 (−20·6 to −16·4)* | –8·5 (−9·9 to −7·3)* | |||
| Neoplasms | 151 550·6 (148 429·7 to 155 144·0) | 189 094·4 (185 939·0 to 192 035·5) | 213 221·0 (208 458·6 to 217 584·4) | 40·7 (36·8 to 44·9)* | 12·8 (10·8 to 15·0)* | 3812·1 (3739·6 to 3895·3) | 3377·2 (3321·1 to 3427·3) | 3024·9 (2956·4 to 3086·9) | –20·6 (−22·7 to −18·4)* | –10·4 (−12·0 to −8·7)* | |||
| Lip and oral cavity cancer | 2583·8 (2488·9 to 2719·1) | 3668·0 (3546·8 to 3781·2) | 4634·7 (4429·7 to 4823·4) | 79·4 (64·8 to 88·9)* | 26·4 (20·8 to 31·5)* | 65·9 (63·5 to 69·2) | 64·6 (62·5 to 66·6) | 64·4 (61·6 to 67·0) | –2·2 (−10·0 to 2·9) | –0·2 (−4·5 to 3·8) | |||
| Nasopharynx cancer | 1590·5 (1506·1 to 1686·4) | 1785·6 (1722·8 to 1842·5) | 1906·0 (1809·3 to 2011·6) | 19·8 (13·1 to 28·0)* | 6·7 (0·2 to 13·1)* | 37·7 (35·7 to 40·0) | 30·1 (29·1 to 31·0) | 26·0 (24·7 to 27·4) | –31·1 (−34·9 to −26·4)* | –13·5 (−18·7 to −8·5)* | |||
| Other pharynx cancer | 1794·9 (1683·0 to 1987·4) | 2530·4 (2412·5 to 2620·7) | 3209·6 (2949·9 to 3393·4) | 78·8 (51·1 to 97·1)* | 26·8 (15·8 to 34·9)* | 45·5 (42·7 to 50·3) | 44·5 (42·4 to 46·1) | 44·4 (40·8 to 46·9) | –2·3 (−17·3 to 7·5) | –0·2 (−8·7 to 6·2) | |||
| Oesophageal cancer | 7809·6 (7554·6 to 8065·4) | 9206·9 (9018·2 to 9394·6) | 9276·1 (9019·5 to 9564·2) | 18·8 (13·7 to 24·4)* | 0·8 (−2·2 to 4·3) | 207·4 (200·7 to 214·2) | 170·0 (166·6 to 173·5) | 132·7 (129·1 to 136·8) | –36·0 (−38·8 to −33·1)* | –22·0 (−24·2 to −19·3)* | |||
| Stomach cancer | 19 027·0 (18463·7 to 19 584·4) | 19 048·8 (18 712·9 to 19 405·6) | 18 345·5 (17 888·0 to 18 860·9) | –3·6 (−6·8 to 0·4) | –3·7 (−6·2 to −1·2)* | 499·4 (485·0 to 513·6) | 348·1 (342·0 to 354·6) | 262·9 (256·2 to 270·1) | –47·4 (−49·1 to −45·3)* | –24·5 (−26·5 to −22·6)* | |||
| Colon and rectum cancer | 11 021·7 (10 741·7 to 11 482·7) | 14 637·5 (14 356·4 to 14 918·1) | 17 197·2 (16 480·2 to 17 851·9) | 56·0 (44·5 to 63·5)* | 17·5 (11·6 to 22·3)* | 297·6290·6 to 309·1) | 272·4 (267·2 to 277·4) | 249·0 (238·6 to 258·4) | –16·4 (−22·3 to −12·5)* | –8·6 (−13·0 to −4·8)* | |||
| Liver cancer | 13 311·9 (12 450·1 to 14 010·2) | 18 332·3 (17 719·9 to 18 813·2) | 21 143·8 (20 268·1 to 21 985·9) | 58·8 (49·2 to 70·4)* | 15·3 (11·5 to 19·9)* | 331·7 (311·0 to 348·5) | 321·7 (310·9 to 329·8) | 295·2 (283·0 to 306·7) | –11·0 (−16·4 to −4·6)* | –8·2 (−11·3 to −4·7)* | |||
| Due to hepatitis B | 6537·7 (5718·9 to 7253·4) | 8838·7 (7823·1 to 9718·0) | 9802·3 (8568·3 to 10 960·1) | 49·9 (39·7 to 63·4)* | 10·9 (6·3 to 16·3)* | 158·5 (138·5 to 176·2) | 151·2 (133·7 to 167·0) | 134·7 (118·2 to 150·6) | –15·0 (−20·6 to −7·6)* | –10·9 (−14·4 to −6·6)* | |||
| Due to hepatitis C | 1850·2 (1639·8 to 2057·7) | 2735·7 (2447·6 to 3011·7) | 3310·5 (2930·7 to 3673·3) | 78·9 (69·0 to 86·6)* | 21·0 (16·9 to 24·9)* | 49·6 (44·1 to 55·3) | 51·2 (45·9 to 56·4) | 47·9 (42·5 to 53·0) | –3·6 (−8·7 to 0·3) | –6·5 (−9·8 to −3·7)* | |||
| Due to alcohol use | 1686·3 (1384·8 to 2013·9) | 2282·2 (1912·1 to 2710·9) | 2925·7 (2463·2 to 3400·9) | 73·5 (55·4 to 102·0)* | 28·2 (20·4 to 38·5)* | 45·0 (36·9 to 53·3) | 42·1 (35·2 to 49·9) | 41·8 (35·4 to 48·5) | –7·0 (−16·5 to 7·8) | –0·6 (−6·7 to 7·2) | |||
| Due to other causes | 3237·7 (2880·7 to 3688·9) | 4475·8 (4004·8 to 5058·9) | 5105·3 (4527·7 to 5757·7) | 57·7 (46·9 to 68·8)* | 14·1 (8·5 to 19·1)* | 78·6 (70·0 to 89·7) | 77·2 (69·0 to 87·0) | 70·8 (62·9 to 79·7) | –9·9 (−15·9 to −3·8)* | –8·3 (−12·4 to −4·6)* | |||
| Gallbladder and biliary tract cancer | 2311·8 (2201·3 to 2555·0) | 2885·3 (2655·7 to 3078·8) | 3311·1 (3002·9 to 3530·9) | 43·2 (26·0 to 53·5)* | 14·8 (9·7 to 19·8)* | 63·2 (60·3 to 69·5) | 53·9 (49·7 to 57·4) | 47·8 (43·5 to 50·9) | –24·3 (−33·2 to −19·0)* | –11·2 (−15·0 to −7·5)* | |||
| Pancreatic cancer | 4505·6 (4423·5 to 4576·2) | 6492·4 (6404·8 to 6602·1) | 8230·7 (8008·2 to 8445·8) | 82·7 (78·3 to 87·1)* | 26·8 (22·7 to 30·4)* | 122·8 (120·5 to 124·6) | 122·1 (120·5 to 124·1) | 119·5 (116·2 to 122·6) | –2·6 (−5·0 to −0·3)* | –2·1 (−5·2 to 0·7) | |||
| Larynx cancer | 2290·5 (2207·2 to 2369·6) | 2505·6 (2431·0 to 2569·8) | 2749·8 (2661·2 to 2845·7) | 20·1 (14·9 to 25·6)* | 9·8 (6·0 to 13·6)* | 59·6 (57·5 to 61·6) | 45·3 (44·0 to 46·5) | 38·7 (37·4 to 40·0) | –35·1 (−37·9 to −32·1)* | –14·6 (−17·5 to −11·7)* | |||
| Tracheal, bronchus, and lung cancer | 24 411·4 (23 862·3 to 25 086·9) | 32 059·3 (31 518·1 to 32 631·0) | 36 441·0 (35 401·2 to 37 462·8) | 49·3 (43·0 to 54·5)* | 13·7 (10·1 to 16·9)* | 650·6 (636·2 to 667·8) | 596·0 (586·5 to 606·2) | 526·1 (511·2 to 540·8) | –19·1 (−22·5 to −16·4)* | –11·7 (−14·4 to −9·2)* | |||
| Malignant skin melanoma | 947·1 (853·4 to 1081·6) | 1296·7 (1166·4 to 1434·0) | 1550·5 (1378·4 to 1714·1) | 63·7 (46·0 to 74·9)* | 19·6 (13·6 to 25·4)* | 23·6 (21·3 to 27·2) | 22·8 (20·5 to 25·1) | 21·8 (19·4 to 24·0) | –7·4 (−17·8 to −1·3)* | –4·3 (−9·0 to 0·3) | |||
| Non-melanoma skin cancer | 635·7 (611·9 to 658·6) | 864·4 (841·4 to 887·8) | 1022·6 (981·1 to 1068·7) | 60·9 (54·6 to 70·1)* | 18·3 (14·0 to 23·6)* | 17·0 (16·4 to 17·7) | 16·1 (15·7 to 16·6) | 14·9 (14·3 to 15·6) | –12·3 (−15·6 to −7·5)* | –7·6 (−10·8 to −3·5)* | |||
| Non-melanoma skin cancer (squamous-cell carcinoma) | 635·2 (611·4 to 658·1) | 863·5 (839·9 to 886·8) | 1021·5 (980·2 to 1067·6) | 60·8 (54·6 to 70·1)* | 18·3 (14·0 to 23·6)* | 17·0 (16·4 to 17·7) | 16·1 (15·7 to 16·6) | 14·9 (14·3 to 15·6) | –12·3 (−15·6 to −7·5)* | –7·6 (−10·8 to −3·5)* | |||
| Non-melanoma skin cancer (basal-cell carcinoma) | 0·5 (0·2 to 1·0) | 0·9 (0·4 to 1·8) | 1·1 (0·4 to 2·2) | 122·9 (109·6 to 138·3) | 23·8 (16·1 to 31·7) | ·· | ·· | ·· | 15·8 (10·3 to 21·7) | -5·6 (-11·5 to 0·4) | |||
| Breast cancer | 9804·9 (9186·6 to 10 790·8) | 13 209·0 (12 668·7 to 13 875·4) | 15 107·8 (14 264·6 to 16 175·8) | 54·1 (34·8 to 70·0)* | 14·4 (6·3 to 22·2)* | 248·6 (233·7 to 272·3) | 229·4 (220·2 to 240·7) | 208·5 (196·9 to 223·1) | –16·2 (−26·2 to −8·2)* | –9·1 (−15·4 to −3·2)* | |||
| Cervical cancer | 6047·7 (5226·5 to 7655·0) | 7040·2 (5878·2 to 7516·1) | 7390·0 (6019·9 to 7868·6) | 22·2 (2·0 to 41·2)* | 5·0 (−1·3 to 13·2) | 149·0 (129·1 to 188·6) | 119·3 (99·8 to 127·4) | 100·6 (82·0 to 107·1) | –32·5 (−43·5 to −22·0)* | –15·7 (−20·8 to −9·2)* | |||
| Uterine cancer | 1573·9 (1480·6 to 1651·3) | 1955·1 (1868·8 to 2035·2) | 2122·8 (2010·4 to 2229·7) | 34·9 (26·3 to 47·1)* | 8·6 (2·7 to 16·4)* | 41·3 (39·0 to 43·3) | 35·6 (34·0 to 37·0) | 30·1 (28·5 to 31·7) | –27·1 (−31·6 to −20·6)* | –15·3 (−19·9 to −9·3)* | |||
| Ovarian cancer | 2661·5 (2531·2 to 2741·5) | 3523·0 (3393·4 to 3660·7) | 4258·1 (4035·8 to 4459·3) | 60·0 (51·8 to 68·2)* | 20·9 (13·9 to 27·0)* | 68·3 (65·3 to 70·2) | 62·5 (60·2 to 64·8) | 59·3 (56·2 to 62·1) | –13·2 (−17·5 to −8·8)* | –5·0 (−10·4 to −0·2)* | |||
| Prostate cancer | 3226·7 (2808·5 to 3505·0) | 4765·1 (4006·7 to 5107·8) | 6073·7 (4992·7 to 6582·3) | 88·2 (67·8 to 100·9)* | 27·5 (20·3 to 33·4)* | 97·5 (85·4 to 105·9) | 97·2 (82·2 to 104·2) | 93·9 (77·2 to 101·8) | –3·7 (−13·6 to 2·7) | –3·4 (−8·7 to 1·3) | |||
| Testicular cancer | 400·0 (380·0 to 423·9) | 393·1 (378·2 to 412·0) | 391·8 (372·4 to 412·0) | –2·0 (−8·2 to 3·7) | –0·3 (−4·4 to 4·0) | 7·9 (7·5 to 8·3) | 5·9 (5·7 to 6·2) | 5·2 (4·9 to 5·4) | –34·3 (−38·5 to −30·5)* | –12·3 (−15·8 to −8·6)* | |||
| Kidney cancer | 1753·1 (1707·2 to 1806·3) | 2476·1 (2418·4 to 2528·9) | 3023·6 (2911·4 to 3135·9) | 72·5 (64·5 to 80·9)* | 22·1 (17·6 to 26·5)* | 44·2 (43·2 to 45·4) | 45·0 (44·0 to 46·0) | 43·4 (41·8 to 45·0) | –1·9 (−6·1 to 2·2) | –3·7 (−7·2 to −0·2)* | |||
| Bladder cancer | 2235·8 (2157·3 to 2326·8) | 2796·3 (2735·8 to 2859·6) | 3315·2 (3193·2 to 3425·5) | 48·3 (38·9 to 53·9)* | 18·6 (13·9 to 22·4)* | 63·3 (61·2 to 65·7) | 54·3 (53·1 to 55·6) | 49·5 (47·7 to 51·1) | –21·8 (−26·6 to −19·0)* | –9·0 (−12·4 to −6·1)* | |||
| Brain and nervous system cancer | 5620·2 (4833·4 to 5997·6) | 6729·7 (6094·9 to 7049·7) | 7660·0 (6922·8 to 8280·4) | 36·3 (25·9 to 54·7)* | 13·8 (9·4 to 20·8)* | 116·8 (101·5 to 123·9) | 109·1 (98·5 to 114·1) | 105·0 (94·9 to 113·3) | –10·0 (−16·4 to 2·6) | –3·7 (−7·3 to 2·3) | |||
| Thyroid cancer | 768·4 (713·7 to 817·8) | 960·7 (918·0 to 1004·4) | 1122·8 (1071·3 to 1183·5) | 46·1 (35·1 to 60·9)* | 16·9 (11·0 to 23·8)* | 19·1 (17·9 to 20·3) | 16·9 (16·2 to 17·6) | 15·8 (15·0 to 16·6) | –17·6 (−23·5 to −9·7)* | –6·8 (−11·4 to −1·3)* | |||
| Mesothelioma | 398·9 (361·5 to 440·9) | 535·4 (509·7 to 569·4) | 660·9 (619·4 to 700·6) | 65·7 (43·6 to 81·4)* | 23·4 (17·8 to 28·2)* | 10·5 (9·5 to 11·7) | 9·8 (9·3 to 10·3) | 9·5 (8·9 to 10·1) | –9·3 (−21·7 to −0·8)* | –2·8 (−7·1 to 0·9) | |||
| Hodgkin's lymphoma | 1589·4 (1176·0 to 1775·3) | 1269·1 (1048·1 to 1466·8) | 1126·8 (943·7 to 1337·1) | –29·1 (−35·9 to −15·9)* | –11·2 (−14·5 to −8·0)* | 31·8 (23·8 to 35·5) | 19·7 (16·4 to 22·9) | 15·2 (12·8 to 18·1) | –52·1 (−56·7 to −43·2)* | –22·7 (−25·4 to −20·1)* | |||
| Non-Hodgkin lymphoma | 4095·3 (3844·4 to 4377·0) | 5528·6 (5174·2 to 5736·3) | 6783·0 (6172·5 to 7083·3) | 65·6 (49·2 to 74·7)* | 22·7 (16·0 to 27·2)* | 92·8 (88·3 to 98·0) | 93·6 (88·1 to 96·9) | 94·9 (86·6 to 99·1) | 2·3 (−7·4 to 7·3) | 1·4 (−4·1 to 5·0) | |||
| Multiple myeloma | 1141·8 (1032·1 to 1308·8) | 1664·3 (1489·5 to 1831·8) | 2114·0 (1901·5 to 2339·1) | 85·2 (72·6 to 98·4)* | 27·0 (22·6 to 32·6)* | 30·7 (27·9 to 35·5) | 31·0 (27·6 to 34·0) | 30·5 (27·4 to 33·9) | –0·7 (−8·6 to 5·8) | –1·5 (−4·9 to 2·7) | |||
| Leukaemia | 10 455·3 (9415·6 to 12 242·4) | 10 401·6 (9581·8 to 11 171·9) | 10 204·0 (9319·4 to 10 809·1) | –2·4 (−14·2 to 7·2) | –1·9 (−6·2 to 2·3) | 204·7 (186·8 to 234·4) | 166·3 (153·6 to 178·1) | 141·6 (129·3 to 149·9) | –30·9 (−38·4 to −25·0)* | –14·9 (−18·4 to −11·3)* | |||
| Acute lymphoid leukaemia | 2158·2 (1900·3 to 3001·6) | 2339·9 (2178·5 to 2794·3) | 2426·6 (2216·0 to 2688·8) | 12·4 (−15·5 to 28·2) | 3·7 (−7·8 to 9·9) | 37·8 (33·5 to 51·5) | 35·0 (32·7 to 41·7) | 33·1 (30·2 to 36·6) | –12·5 (−33·3 to −1·5)* | –5·7 (−15·9 to −0·2)* | |||
| Chronic lymphoid leukaemia | 468·8 (434·3 to 553·7) | 617·1 (580·4 to 709·0) | 703·1 (654·0 to 805·0) | 50·0 (38·9 to 61·4)* | 13·9 (9·2 to 19·1)* | 12·6 (11·7 to 14·6) | 11·6 (10·9 to 13·3) | 10·3 (9·7 to 11·8) | –17·6 (−22·8 to −12·2)* | –11·1 (−14·6 to −7·2)* | |||
| Acute myeloid leukaemia | 1707·6 (1577·2 to 2023·1) | 2327·1 (2152·7 to 2540·6) | 2651·6 (2444·2 to 2838·1) | 55·3 (34·6 to 68·5)* | 13·9 (8·7 to 18·2)* | 35·4 (33·1 to 41·0) | 38·0 (35·2 to 41·2) | 36·9 (34·1 to 39·4) | 4·3 (−8·5 to 12·2) | –2·9 (−7·0 to 0·6) | |||
| Chronic myeloid leukaemia | 706·2 (639·5 to 775·2) | 654·3 (596·6 to 723·6) | 609·6 (550·3 to 676·0) | –13·7 (−21·0 to −6·6)* | –6·8 (−11·1 to −2·2)* | 16·6 (15·2 to 18·1) | 11·0 (10·1 to 12·1) | 8·4 (7·6 to 9·3) | –49·5 (−53·5 to −45·7)* | –23·5 (−26·9 to −20·1)* | |||
| Other leukaemia | 5414·4 (4487·0 to 6178·9) | 4463·2 (3848·9 to 4762·2) | 3813·1 (3326·8 to 4039·8) | –29·6 (−38·9 to −18·9)* | –14·6 (−19·6 to −9·0)* | 102·3 (86·4 to 114·9) | 70·6 (60·9 to 75·1) | 52·9 (46·2 to 56·0) | –48·4 (−54·7 to −41·5)* | –25·1 (−29·4 to −20·4)* | |||
| Other neoplasms | 7536·4 (7307·3 to 7843·6) | 10 533·8 (9864·9 to 10 811·8) | 12 847·7 (11 679·5 to 13 268·0) | 70·5 (52·9 to 78·0)* | 22·0 (17·2 to 25·3)* | 163·6 (158·9 to 170·2) | 174·2 (163·3 to 178·5) | 178·5 (162·3 to 184·3) | 9·2 (−2·3 to 13·4) | 2·5 (−1·5 to 5·2) | |||
| Cardiovascular diseases | 266 709·6 (258 611·1 to 274 986·6) | 321 851·2 (312 966·3 to 330 487·6) | 353 120·9 (341 794·5 to 364 965·3) | 32·4 (28·8 to 36·2)* | 9·7 (7·4 to 12·2)* | 7267·3 (7049·6 to 7496·0) | 6046·0 (5878·1 to 6208·3) | 5178·4 (5010·6 to 5352·2) | –28·7 (−30·7 to −26·8)* | –14·3 (−16·1 to −12·4)* | |||
| Rheumatic heart disease | 13 277·2 (11 854·4 to 14 558·1) | 11 235·5 (10 229·5 to 12 162·0) | 9803·1 (9154·5 to 10 556·6) | –26·2 (−32·8 to −18·5)* | –12·8 (−18·3 to −6·9)* | 296·4 (263·4 to 324·9) | 185·4 (169·1 to 199·9) | 135·9 (127·1 to 145·8) | –54·2 (−58·2 to −49·1)* | –26·7 (−31·3 to −21·7)* | |||
| Ischaemic heart disease | 118 996·9 (115 809·8 to 122 723·6) | 153 547·6 (149 867·7 to 156 971·0) | 174 611·1 (169 736·1 to 179 827·6) | 46·7 (42·5 to 51·5)* | 13·7 (10·7 to 16·7)* | 3344·1 (3255·9 to 3448·7) | 2908·3 (2840·4 to 2971·7) | 2562·8 (2491·4 to 2640·8) | –23·4 (−25·6 to −21·0)* | –11·9 (−14·2 to −9·6)* | |||
| Cerebrovascular disease | 95 306·8 (91 616·6 to 100 606·2) | 111 916·0 (108 069·6 to 115 501·2) | 116 445·1 (111 385·4 to 121 406·9) | 22·2 (16·7 to 27·0)* | 4·0 (1·6 to 6·5)* | 2600·1 (2496·3 to 2744·0) | 2116·6 (2041·9 to 2186·6) | 1711·2 (1635·3 to 1784·4) | –34·2 (−37·2 to −31·5)* | –19·1 (−21·0 to −17·2)* | |||
| Ischaemic stroke | 37 687·2 (35 505·5 to 39 624·6) | 46 909·9 (44 168·6 to 49 455·6) | 51 897·4 (47 896·6 to 55 567·7) | 37·7 (32·2 to 43·4)* | 10·6 (7·1 to 14·0)* | 1112·1 (1049·6 to 1169·6) | 934·8 (880·6 to 985·5) | 787·5 (728·4 to 843·2) | –29·2 (−32·0 to −26·2)* | –15·8 (−18·4 to −13·1)* | |||
| Haemorrhagic stroke | 57 619·6 (55 206·4 to 61 574·1) | 65 006·1 (63 154·6 to 66 941·1) | 64 547·7 (62 622·3 to 66 497·6) | 12·0 (6·3 to 17·0)* | –0·7 (−2·8 to 1·5) | 1488·0 (1427·4 to 1594·8) | 1181·8 (1148·5 to 1216·2) | 923·6 (896·2 to 951·9) | –37·9 (−41·3 to −35·2)* | –21·8 (−23·5 to −20·1)* | |||
| Hypertensive heart disease | 12 136·6 (9824·4 to 13 763·9) | 13 571·4 (11 603·8 to 15 049·4) | 16 335·1 (13 456·6 to 17 843·7) | 34·6 (24·7 to 52·5)* | 20·4 (10·2 to 32·9)* | 338·6 (274·9 to 382·5) | 259·6 (221·8 to 287·4) | 242·5 (199·7 to 265·0) | –28·4 (−33·4 to −19·1)* | –6·6 (−14·6 to 2·8) | |||
| Cardiomyopathy and myocarditis | 6713·9 (5820·8 to 7248·0) | 8576·8 (7305·3 to 9168·4) | 8718·2 (7574·9 to 9628·0) | 29·9 (16·7 to 44·8)* | 1·6 (−7·1 to 12·9) | 159·0 (133·6 to 171·9) | 145·7 (123·9 to 155·8) | 122·7 (106·4 to 135·1) | –22·9 (−30·0 to −13·5)* | –15·8 (−22·8 to −6·8)* | |||
| Myocarditis | 1253·7 (1032·8 to 1618·8) | 1422·2 (1132·2 to 1574·2) | 1367·5 (1118·2 to 1513·1) | 9·1 (−20·2 to 28·8) | –3·9 (−12·7 to 5·6) | 24·8 (20·8 to 30·4) | 23·0 (18·1 to 25·4) | 19·1 (15·6 to 21·1) | –22·8 (−41·0 to −11·7)* | –16·8 (−24·3 to −8·0)* | |||
| Alcoholic cardiomyopathy | 1815·2 (1512·9 to 2177·5) | 2878·5 (2414·3 to 3221·2) | 2591·2 (2055·7 to 3240·6) | 42·8 (11·8 to 80·0)* | –10·0 (−27·6 to 14·3) | 44·5 (37·1 to 53·3) | 47·8 (40·1 to 53·2) | 35·2 (28·0 to 43·9) | –21·0 (−37·8 to −0·8)* | –26·3 (−40·4 to −7·6)* | |||
| Other cardiomyopathy | 3644·9 (2878·4 to 4234·4) | 4276·1 (3615·3 to 4655·1) | 4759·4 (4089·9 to 5094·4) | 30·6 (14·5 to 52·0)* | 11·3 (4·3 to 19·4)* | 89·7 (68·9 to 103·1) | 75·0 (63·1 to 81·5) | 68·3 (58·5 to 73·2) | –23·8 (−32·3 to −9·1)* | –8·8 (−14·3 to −2·7)* | |||
| Atrial fibrillation and flutter | 3044·8 (2345·7 to 3888·0) | 4460·7 (3484·6 to 5666·6) | 5951·3 (4649·6 to 7516·9) | 95·5 (91·1 to 100·0)* | 33·4 (31·8 to 35·1)* | 97·8 (76·0 to 123·5) | 93·7 (73·6 to 118·1) | 93·4 (73·2 to 118·1) | –4·5 (−6·5 to −2·4)* | –0·2 (−1·3 to 0·8) | |||
| Aortic aneurysm | 1942·5 (1855·5 to 2068·9) | 2510·2 (2437·9 to 2611·8) | 2881·8 (2800·8 to 2975·5) | 48·4 (39·9 to 58·1)* | 14·8 (10·7 to 20·1)* | 54·4 (52·1 to 57·6) | 47·8 (46·5 to 49·6) | 42·6 (41·4 to 44·0) | –21·7 (−25·8 to −17·0)* | –10·9 (−13·9 to −7·1)* | |||
| Peripheral artery disease | 678·4 (486·1 to 948·0) | 970·9 (719·7 to 1325·7) | 1235·1 (922·2 to 1683·9) | 82·1 (68·0 to 103·9)* | 27·2 (20·9 to 35·7)* | 21·4 (15·4 to 29·7) | 20·3 (15·1 to 27·9) | 19·3 (14·4 to 26·3) | –9·4 (−17·0 to 0·5) | –4·9 (−9·6 to 1·3) | |||
| Endocarditis | 1536·3 (1320·2 to 1751·3) | 1998·3 (1748·2 to 2320·0) | 2368·7 (2104·5 to 2797·1) | 54·2 (39·0 to 69·5)* | 18·5 (12·0 to 23·8)* | 34·6 (29·7 to 39·2) | 34·0 (29·6 to 39·2) | 33·6 (29·8 to 39·7) | –3·0 (−11·4 to 5·3) | –1·3 (−6·7 to 2·9) | |||
| Other cardiovascular and circulatory diseases | 13 076·2 (10 976·0 to 14 815·8) | 13 063·8 (11 561·4 to 15 422·4) | 14 771·4 (13 010·9 to 17 397·0) | 13·0 (3·2 to 31·9)* | 13·1 (9·8 to 17·3)* | 320·9 (269·6 to 364·9) | 234·7 (208·1 to 276·1) | 214·5 (189·4 to 251·8) | –33·2 (−38·7 to −22·3)* | –8·6 (−11·2 to −5·3)* | |||
| Chronic respiratory diseases | 86 833·7 (79 815·5 to 92 631·5) | 86 665·1 (81 193·2 to 92 630·9) | 92 528·7 (86 142·3 to 99 725·6) | 6·6 (2·0 to 15·4)* | 6·8 (4·5 to 9·7)* | 2256·8 (2079·1 to 2386·5) | 1601·5 (1507·8 to 1698·0) | 1351·7 (1261·3 to 1452·3) | –40·1 (−43·1 to −34·6)* | –15·6 (−17·6 to −13·2)* | |||
| Chronic obstructive pulmonary disease | 59 810·7 (53 271·2 to 64 128·3) | 59 572·5 (56 816·4 to 62 571·2) | 63 434·3 (60 586·3 to 66 676·3) | 6·1 (0·6 to 18·4)* | 6·5 (3·8 to 10·1)* | 1666·8 (1486·0 to 1780·7) | 1151·0 (1098·0 to 1205·8) | 945·3 (904·1 to 994·8) | –43·3 (−46·2 to −36·8)* | –17·9 (−19·9 to −15·1)* | |||
| Pneumoconiosis | 568·0 (494·8 to 787·9) | 560·3 (506·1 to 635·2) | 577·1 (517·2 to 647·3) | 1·6 (−25·7 to 16·9) | 3·0 (−4·5 to 8·4) | 15·0 (13·2 to 20·5) | 10·4 (9·4 to 11·8) | 8·4 (7·6 to 9·4) | –44·0 (−58·3 to −36·2)* | –19·1 (−24·6 to −15·0)* | |||
| Silicosis | 303·5 (251·4 to 461·0) | 273·2 (247·2 to 310·8) | 270·6 (243·6 to 301·5) | –10·8 (−43·4 to 6·3) | –0·9 (−14·2 to 5·7) | 8·0 (6·7 to 11·9) | 5·0 (4·5 to 5·7) | 3·9 (3·5 to 4·4) | –50·9 (−68·2 to −42·0)* | –22·1 (−32·2 to −17·1)* | |||
| Asbestosis | 50·9 (40·8 to 70·6) | 73·0 (57·2 to 86·9) | 83·9 (67·9 to 97·5) | 64·8 (29·6 to 83·7)* | 14·8 (9·2 to 21·8)* | 1·3 (1·1 to 1·9) | 1·4 (1·1 to 1·6) | 1·2 (1·0 to 1·4) | –5·8 (−26·4 to 4·6) | –9·2 (−13·7 to −3·3)* | |||
| Coal workers’ pneumoconiosis | 103·4 (70·5 to 127·8) | 87·5 (65·5 to 104·6) | 89·1 (70·2 to 108·9) | –13·9 (−30·6 to 15·1) | 1·8 (−6·8 to 12·7) | 2·9 (1·9 to 3·5) | 1·7 (1·2 to 2·0) | 1·3 (1·0 to 1·6) | –54·3 (−63·3 to −38·6)* | –21·6 (−28·2 to −13·5)* | |||
| Other pneumoconiosis | 110·2 (80·0 to 173·3) | 126·6 (104·4 to 161·8) | 133·5 (112·1 to 165·9) | 21·2 (−8·3 to 52·8) | 5·5 (−2·2 to 13·2) | 2·9 (2·1 to 4·5) | 2·3 (1·9 to 3·0) | 1·9 (1·6 to 2·4) | –32·1 (−47·9 to −15·2)* | –16·7 (−22·7 to −10·6)* | |||
| Asthma | 23 840·9 (19 339·2 to 28 695·4) | 22 827·4 (18 531·6 to 27 887·8) | 23 720·5 (18 911·2 to 29 790·8) | –0·5 (−11·3 to 9·8) | 3·9 (−0·8 to 8·2) | 514·7 (419·4 to 621·4) | 375·2 (305·9 to 454·5) | 329·2 (263·1 to 413·2) | –36·0 (−44·1 to −28·2)* | –12·2 (−16·9 to −7·7)* | |||
| Interstitial lung disease and pulmonary sarcoidosis | 1285·5 (924·8 to 1966·3) | 2052·5 (1506·0 to 2609·2) | 2721·6 (2075·3 to 3177·4) | 111·7 (55·3 to 165·5)* | 32·6 (18·7 to 43·0)* | 33·8 (24·7 to 50·2) | 38·7 (28·4 to 48·6) | 40·2 (30·5 to 46·9) | 19·0 (−11·4 to 49·3) | 3·9 (−6·4 to 11·7) | |||
| Other chronic respiratory diseases | 1328·6 (906·1 to 1714·7) | 1652·5 (1286·3 to 1932·2) | 2075·2 (1697·7 to 2315·1) | 56·2 (27·5 to 93·2)* | 25·6 (17·5 to 34·0)* | 26·6 (18·3 to 33·4) | 26·2 (20·3 to 30·5) | 28·5 (23·3 to 31·8) | 7·4 (−10·0 to 30·2) | 9·0 (2·1 to 16·4)* | |||
| Cirrhosis and other chronic liver diseases | 28 184·1 (26 769·7 to 29 706·9) | 36 122·1 (34 848·4 to 39 549·1) | 38 856·7 (36 890·5 to 42 795·8) | 37·9 (28·7 to 49·4)* | 7·6 (2·5 to 13·7)* | 659·0 (627·6 to 693·9) | 603·3 (582·6 to 657·4) | 531·1 (504·3 to 584·5) | –19·4 (−24·6 to −12·8)* | –12·0 (−16·1 to −7·2)* | |||
| Due to hepatitis B | 7875·2 (7193·4 to 8627·5) | 10 373·1 (9525·8 to 11 593·2) | 11 240·7 (10 162·6 to 13 138·6) | 42·7 (31·8 to 58·9)* | 8·4 (2·5 to 15·3)* | 189·9 (173·4 to 208·5) | 173·9 (160·1 to 195·5) | 153·3 (138·5 to 178·9) | –19·3 (−25·4 to −10·3)* | –11·8 (−16·5 to −6·1)* | |||
| Due to hepatitis C | 6333·5 (5732·9 to 7049·7) | 8709·0 (7906·3 to 9751·8) | 9769·1 (8819·4 to 10 985·0) | 54·2 (44·4 to 66·7)* | 12·2 (6·8 to 18·5)* | 155·1 (139·9 to 172·8) | 147·4 (133·6 to 164·2) | 133·5 (120·7 to 150·0) | –13·9 (−19·3 to −7·3)* | –9·4 (−13·8 to −4·4)* | |||
| Due to alcohol use | 6466·4 (5920·0 to 7057·2) | 8878·9 (8112·9 to 9688·5) | 9754·0 (8873·6 to 10 861·8) | 50·8 (42·0 to 61·5)* | 9·9 (4·8 to 15·9)* | 161·5 (148·2 to 175·7) | 151·3 (138·5 to 165·1) | 133·5 (121·6 to 148·2) | –17·3 (−22·0 to −11·6)* | –11·8 (−15·7 to −6·9)* | |||
| Due to other causes | 7509·0 (6800·3 to 8254·4) | 8161·1 (7451·7 to 9036·0) | 8092·8 (7310·3 to 9160·6) | 7·8 (−1·9 to 20·4) | –0·8 (−5·9 to 5·0) | 152·5 (138·5 to 167·9) | 130·7 (119·2 to 144·8) | 110·8 (100·2 to 125·3) | –27·4 (−32·9 to −19·2)* | –15·3 (−19·4 to −10·9)* | |||
| Digestive diseases | 32 345·7 (28 585·3 to 34 769·7) | 33 020·0 (30 716·0 to 35 440·1) | 34 368·9 (31 754·4 to 37 405·9) | 6·3 (−0·5 to 17·9) | 4·1 (0·4 to 7·7)* | 720·8 (640·2 to 770·7) | 561·3 (523·0 to 601·8) | 484·9 (448·4 to 526·8) | –32·7 (−36·3 to −26·0)* | –13·6 (−16·4 to −10·8)* | |||
| Peptic ulcer disease | 10 011·0 (8963·1 to 10 836·7) | 7708·0 (7085·6 to 8454·8) | 7106·0 (6459·4 to 8011·1) | –29·0 (−35·4 to −20·6)* | –7·8 (−11·8 to −3·8)* | 237·1 (212·3 to 257·4) | 134·0 (123·2 to 146·5) | 100·2 (91·2 to 112·5) | –57·8 (−61·6 to −52·7)* | –25·2 (−28·4 to −22·0)* | |||
| Gastritis and duodenitis | 1952·5 (1571·5 to 2395·4) | 2235·1 (1806·0 to 2810·5) | 2689·8 (2104·0 to 3454·3) | 37·8 (24·2 to 50·6)* | 20·4 (13·5 to 26·7)* | 45·9 (37·1 to 56·0) | 38·4 (31·2 to 48·1) | 37·7 (29·6 to 48·3) | –17·8 (−25·0 to −10·7)* | –1·7 (−7·2 to 3·2) | |||
| Appendicitis | 2200·3 (1726·6 to 2565·2) | 2412·3 (2109·1 to 2744·1) | 2150·0 (1928·1 to 2484·8) | –2·3 (−16·9 to 19·1) | –10·9 (−18·1 to −3·0)* | 41·3 (32·8 to 47·4) | 37·2 (32·3 to 42·2) | 29·3 (26·3 to 33·9) | –29·0 (−38·5 to −15·1)* | –21·1 (−27·5 to −14·2)* | |||
| Paralytic ileus and intestinal obstruction | 6853·7 (5275·8 to 7778·5) | 7379·6 (6085·8 to 7981·1) | 7626·5 (6380·0 to 8328·6) | 11·3 (−1·7 to 32·7) | 3·4 (−2·8 to 10·6) | 131·2 (101·5 to 146·5) | 120·6 (99·3 to 130·0) | 108·0 (90·5 to 117·7) | –17·7 (−25·7 to −3·7)* | –10·5 (−15·4 to −5·0)* | |||
| Inguinal, femoral, and abdominal hernia | 2405·0 (1863·4 to 3003·9) | 2854·3 (2251·5 to 3551·6) | 3106·1 (2401·1 to 3932·1) | 29·1 (19·9 to 39·6)* | 8·8 (5·5 to 11·4)* | 54·2 (42·2 to 67·3) | 48·2 (38·2 to 59·9) | 43·5 (33·7 to 55·0) | –19·7 (−26·4 to −12·2)* | –9·7 (−12·8 to −7·6)* | |||
| Inflammatory bowel disease | 1217·7 (916·1 to 1735·5) | 1606·7 (1305·0 to 2000·0) | 1844·4 (1541·5 to 2195·5) | 51·5 (14·2 to 81·3)* | 14·8 (2·7 to 22·6)* | 27·4 (21·5 to 36·3) | 27·4 (22·3 to 33·5) | 25·8 (21·6 to 30·7) | –6·0 (−23·3 to 7·3) | –5·9 (−14·8 to 0·3) | |||
| Vascular intestinal disorders | 1012·2 (904·2 to 1107·2) | 1457·8 (1317·3 to 1656·0) | 1702·6 (1568·9 to 1943·4) | 68·2 (55·2 to 86·2)* | 16·8 (10·4 to 23·5)* | 28·1 (25·5 to 30·5) | 28·1 (25·7 to 31·8) | 25·5 (23·4 to 29·0) | –9·3 (−15·3 to 0·2) | –9·4 (−14·1 to −4·6)* | |||
| Gallbladder and biliary diseases | 1665·1 (1368·2 to 1821·1) | 1851·7 (1729·6 to 2093·8) | 2098·0 (1953·3 to 2401·6) | 26·0 (14·4 to 56·3)* | 13·3 (9·8 to 17·6)* | 42·8 (35·5 to 47·3) | 33·9 (31·8 to 38·2) | 30·5 (28·4 to 35·0) | –28·8 (−36·1 to −12·3)* | –10·0 (−12·8 to −6·6)* | |||
| Pancreatitis | 2035·5 (1723·4 to 2341·3) | 3046·0 (2707·5 to 3380·8) | 3347·0 (2910·4 to 3722·1) | 64·4 (44·7 to 82·4)* | 9·9 (2·9 to 16·8)* | 47·5 (40·4 to 54·7) | 50·5 (44·9 to 56·2) | 45·8 (39·8 to 50·9) | –3·6 (−15·1 to 6·6) | –9·4 (−15·1 to −3·9)* | |||
| Other digestive diseases | 2992·8 (2482·9 to 3546·7) | 2468·6 (2189·1 to 2834·9) | 2698·5 (2428·7 to 3008·7) | –9·8 (−24·4 to 4·2) | 9·3 (1·9 to 17·8)* | 65·2 (56·4 to 75·0) | 43·0 (38·7 to 48·8) | 38·6 (34·8 to 43·0) | –40·8 (−49·1 to −33·3)* | –10·2 (−15·5 to −4·2)* | |||
| Neurological disorders | 64 973·1 (50 343·0 to 80 732·5) | 87 251·9 (67 830·9 to 107 955·1) | 103 580·0 (81 171·2 to 128 122·4) | 59·4 (55·2 to 64·6)* | 18·7 (17·0 to 20·7)* | 1500·6 (1192·1 to 1832·8) | 1491·2 (1182·9 to 1824·0) | 1478·4 (1171·9 to 1813·0) | –1·5 (−3·3 to 0·4) | –0·9 (−2·1 to 0·3) | |||
| Alzheimer's disease and other dementias | 13 024·5 (11 052·7 to 15 479·9) | 20 912·2 (17 919·7 to 24 689·5) | 28 764·1 (24 510·8 to 33 952·4) | 120·8 (115·3 to 126·5)* | 37·5 (35·3 to 39·7)* | 460·9 (394·5 to 544·4) | 469·6 (403·2 to 552·4) | 470·6 (401·2 to 556·3) | 2·1 (0·1 to 3·8)* | 0·2 (−1·1 to 1·5) | |||
| Parkinson's disease | 1304·3 (1024·7 to 1606·9) | 2385·3 (1901·1 to 2910·3) | 3234·5 (2563·6 to 4012·8) | 148·0 (139·8 to 155·8)* | 35·6 (32·9 to 38·2)* | 42·0 (33·2 to 51·9) | 49·9 (39·7 to 61·0) | 51·3 (40·6 to 63·4) | 22·1 (18·2 to 25·9)* | 2·7 (1·0 to 4·5)* | |||
| Epilepsy | 12 420·8 (10 285·4 to 14 852·0) | 13 435·2 (11 142·0 to 16 031·4) | 13 492·2 (11 014·7 to 16 503·1) | 8·6 (−2·9 to 23·7) | 0·4 (−7·0 to 8·6) | 226·5 (187·9 to 269·3) | 201·6 (166·8 to 240·4) | 182·6 (148·9 to 223·5) | –19·4 (−27·6 to −9·0)* | –9·4 (−16·1 to −2·2)* | |||
| Multiple sclerosis | 694·0 (586·0 to 807·1) | 974·2 (827·1 to 1123·9) | 1151·5 (968·6 to 1345·8) | 65·9 (45·2 to 74·8)* | 18·2 (12·8 to 21·9)* | 16·3 (13·8 to 18·9) | 16·2 (13·8 to 18·6) | 15·6 (13·2 to 18·3) | –4·2 (−16·4 to 0·8) | –3·2 (−7·3 to −0·2)* | |||
| Motor neuron disease | 582·3 (527·8 to 651·4) | 774·9 (745·5 to 817·5) | 926·1 (881·6 to 961·8) | 59·0 (44·5 to 71·6)* | 19·5 (14·7 to 22·4)* | 13·4 (12·5 to 14·6) | 13·7 (13·2 to 14·3) | 13·2 (12·5 to 13·7) | –1·5 (−9·3 to 2·9) | –3·6 (−7·3 to −1·3)* | |||
| Migraine | 29 843·4 (19 092·9 to 41 793·9) | 39 485·3 (25 341·5 to 55 187·3) | 45 121·9 (29 045·8 to 62 826·9) | 51·2 (49·7 to 52·8)* | 14·3 (13·7 to 14·9)* | 599·9 (385·7 to 839·1) | 597·8 (384·6 to 833·2) | 598·6 (385·9 to 833·3) | –0·2 (−0·8 to 0·4) | 0·1 (−0·2 to 0·5) | |||
| Tension-type headache | 4700·9 (2968·1 to 6989·3) | 6236·2 (3972·6 to 9204·2) | 7195·1 (4614·6 to 10 499·9) | 53·1 (47·5 to 58·4)* | 15·4 (13·7 to 17·0)* | 96·2 (61·1 to 142·5) | 95·5 (61·2 to 139·9) | 95·9 (61·5 to 140·0) | –0·2 (−2·5 to 1·9) | 0·4 (−0·5 to 1·4) | |||
| Other neurological disorders | 2402·9 (2004·0 to 2829·7) | 3048·7 (2593·3 to 3555·3) | 3694·5 (3114·1 to 4353·4) | 53·8 (38·5 to 67·8)* | 21·2 (14·0 to 28·5)* | 45·538·7 to 52·8) | 46·9 (40·2 to 54·4) | 50·6 (42·7 to 59·5) | 11·2 (2·1 to 20·0)* | 7·9 (1·9 to 14·2)* | |||
| Mental and substance use disorders | 110 918·3 (83 056·1 to 141 228·0) | 145 067·1 (108 650·3 to 183 887·6) | 162 509·3 (121 886·4 to 206 517·4) | 46·5 (44·9 to 48·7)* | 12·0 (11·2 to 12·9)* | 2240·8 (1681·3 to 2844·2) | 2226·6 (1669·0 to 2821·8) | 2172·7 (1629·4 to 2761·5) | –3·0 (−4·1 to −1·8)* | –2·4 (−3·2 to −1·7)* | |||
| Schizophrenia | 8447·6 (6181·9 to 10 521·3) | 11 492·6 (8420·0 to 14 326·7) | 13 414·3 (9858·7 to 16 714·0) | 58·8 (55·8 to 62·0)* | 16·7 (15·5 to 18·0)* | 179·6 (132·2 to 222·3) | 178·9 (132·0 to 222·3) | 177·2 (130·5 to 220·3) | –1·3 (−2·2 to −0·5)* | –0·9 (−1·7 to −0·2)* | |||
| Alcohol use disorders | 11 264·3 (9057·6 to 14 013·8) | 15 561·7 (12 607·6 to 19 100·6) | 16 244·7 (13 003·1 to 19 955·3) | 44·2 (37·4 to 51·0)* | 4·4 (0·4 to 8·6)* | 237·3 (192·3 to 292·7) | 240·9 (196·4 to 293·9) | 214·4 (172·0 to 262·9) | –9·6 (−14·3 to −5·5)* | –11·0 (−14·6 to −7·5)* | |||
| Drug use disorders | 14 247·5 (11 250·4 to 17 370·8) | 18 009·0 (14 444·2 to 21 739·6) | 20 394·2 (16 204·4 to 24 670·3) | 43·1 (36·5 to 58·5)* | 13·2 (9·8 to 16·9)* | 278·6 (221·2 to 337·7) | 270·5 (217·3 to 325·1) | 268·4 (213·5 to 324·0) | –3·6 (−8·1 to 6·7) | –0·8 (−3·8 to 2·4) | |||
| Opioid use disorders | 10 261·8 (8052·7 to 12 572·0) | 12 817·5 (10 018·1 to 15 694·7) | 14 788·8 (11 380·5 to 18 259·7) | 44·1 (37·5 to 56·0)* | 15·4 (11·2 to 19·5)* | 202·0 (159·3 to 247·4) | 193·1 (151·2 to 236·4) | 194·3 (149·8 to 239·6) | –3·8 (−8·3 to 3·8) | 0·7 (−3·0 to 4·2) | |||
| Cocaine use disorders | 790·1 (568·0 to 1051·1) | 1060·8 (780·4 to 1375·9) | 1154·2 (847·2 to 1512·1) | 46·1 (38·4 to 65·1)* | 8·8 (5·1 to 12·2)* | 15·7 (11·3 to 20·8) | 16·1 (11·8 to 20·8) | 15·3 (11·2 to 20·0) | –2·6 (−7·8 to 9·6) | –4·9 (−8·3 to −1·7)* | |||
| Amphetamine use disorders | 660·3 (430·6 to 985·6) | 834·2 (567·1 to 1190·4) | 881·7 (599·5 to 1243·1) | 33·5 (23·0 to 54·2)* | 5·7 (1·8 to 10·2)* | 11·8 (7·8 to 17·3) | 12·0 (8·2 to 17·0) | 11·5 (7·8 to 16·2) | –1·9 (−8·8 to 13·2) | –3·7 (−7·5 to 0·3) | |||
| Cannabis use disorders | 514·5 (321·8 to 757·2) | 623·9 (389·2 to 905·4) | 646·9 (400·9 to 945·5) | 25·7 (21·7 to 29·8)* | 3·7 (1·2 to 6·0)* | 9·1 (5·7 to 13·3) | 8·8 (5·5 to 12·9) | 8·5 (5·2 to 12·4) | –6·9 (−8·9 to −5·0)* | –4·2 (−5·9 to −2·4)* | |||
| Other drug use disorders | 2020·8 (1550·8 to 2453·2) | 2672·5 (2235·2 to 3177·1) | 2922·5 (2425·1 to 3504·3) | 44·6 (31·6 to 89·2)* | 9·3 (3·8 to 14·5)* | 40·0 (30·8 to 48·3) | 40·5 (34·0 to 47·8) | 38·8 (32·3 to 46·4) | –3·0 (−12·0 to 26·0) | –4·3 (−9·3 to 0·2) | |||
| Depressive disorders | 29 503·5 (20 318·2 to 40 109·0) | 39 052·4 (26 930·5 to 52 535·2) | 44 208·4 (30 573·2 to 59 878·5) | 49·8 (46·9 to 53·1)* | 13·2 (12·2 to 14·4)* | 630·6 (438·2 to 852·5) | 620·1 (430·6 to 831·7) | 597·9 (414·5 to 806·2) | –5·2 (−6·2 to −4·1)* | –3·6 (−4·3 to −2·9)* | |||
| Major depressive disorder | 23 423·5 (16 150·4 to 31 868·1) | 30 670·3 (21 102·1 to 41 462·3) | 34 104·6 (23 469·5 to 46 039·4) | 45·6 (42·4 to 49·2)* | 11·2 (10·1 to 12·3)* | 495·7 (341·2 to 671·8) | 484·6 (334·7 to 655·2) | 461·1 (317·9 to 622·5) | –7·0 (−8·1 to −5·8)* | –4·9 (−5·6 to −4·1)* | |||
| Dysthymia | 6080·0 (4134·8 to 8839·6) | 8382·0 (5676·3 to 12 123·1) | 10 103·8 (6860·6 to 14 611·5) | 66·2 (62·6 to 69·8)* | 20·5 (18·3 to 23·1)* | 134·9 (91·8 to 195·5) | 135·5 (91·6 to 196·3) | 136·8 (93·0 to 197·6) | 1·4 (0·5 to 2·3)* | 1·0 (−0·5 to 2·7) | |||
| Bipolar disorder | 5873·0 (3645·7 to 8618·8) | 7795·1 (4869·3 to 11 432·4) | 8954·0 (5588·3 to 13 186·4) | 52·5 (50·0 to 55·0)* | 14·9 (13·8 to 16·0)* | 118·2 (73·8 to 173·0) | 118·3 (74·1 to 173·1) | 119·3 (74·7 to 175·1) | 0·9 (0·1 to 1·8)* | 0·8 (0·2 to 1·4)* | |||
| Anxiety disorders | 17 893·2 (12 472·9 to 24 294·6) | 23 364·5 (16 285·6 to 31 632·0) | 26 417·4 (18 440·4 to 35 634·4) | 47·6 (45·4 to 49·8)* | 13·1 (11·9 to 14·3)* | 357·0 (249·8 to 482·4) | 356·6 (248·7 to 481·7) | 354·2 (247·1 to 477·8) | –0·8 (−1·8 to 0·2) | –0·7 (−1·7 to 0·2) | |||
| Eating disorders | 1400·4 (920·5 to 2016·6) | 1861·9 (1222·9 to 2684·6) | 2180·1 (1420·8 to 3122·9) | 55·7 (52·2 to 59·3)* | 17·1 (15·2 to 18·8)* | 24·6 (16·2 to 35·3) | 26·2 (17·2 to 37·7) | 28·6 (18·6 to 40·8) | 16·1 (14·3 to 17·7)* | 8·9 (7·6 to 10·1)* | |||
| Anorexia nervosa | 418·9 (263·0 to 626·4) | 523·9 (329·8 to 776·8) | 584·7 (367·2 to 859·0) | 39·6 (36·1 to 43·4)* | 11·6 (9·2 to 14·0)* | 7·1 (4·5 to 10·6) | 7·3 (4·6 to 10·8) | 7·7 (4·8 to 11·3) | 8·1 (5·6 to 10·5)* | 5·4 (3·2 to 7·4)* | |||
| Bulimia nervosa | 981·5 (602·8 to 1471·9) | 1338·0 (818·2 to 1997·1) | 1595·4 (974·5 to 2394·5) | 62·5 (58·5 to 66·9)* | 19·2 (16·9 to 21·1)* | 17·5 (10·6 to 26·3) | 18·9 (11·5 to 28·4) | 20·9 (12·7 to 31·2) | 19·4 (17·5 to 21·2)* | 10·2 (8·7 to 11·7)* | |||
| Autistic spectrum disorders | 6525·8 (4418·6 to 9180·8) | 8104·7 (5491·2 to 11 393·0) | 9025·7 (6119·0 to 12 681·1) | 38·3 (37·3 to 39·4)* | 11·4 (10·8 to 12·0)* | 120·6 (81·9 to 169·6) | 121·1 (82·1 to 170·2) | 121·4 (82·3 to 170·6) | 0·6 (0·0 to 1·2)* | 0·3 (−0·2 to 0·8) | |||
| Autism | 3371·4 (2170·7 to 4891·2) | 4178·3 (2693·8 to 6041·1) | 4649·0 (2976·6 to 6699·0) | 37·9 (36·3 to 39·6)* | 11·3 (10·3 to 12·3)* | 62·8 (40·4 to 90·9) | 62·6 (40·3 to 90·4) | 62·5 (40·0 to 90·2) | –0·4 (−1·3 to 0·5) | –0·1 (−0·9 to 0·8) | |||
| Asperger syndrome and other autistic spectrum disorders | 3154·3 (2078·1 to 4617·6) | 3926·4 (2574·5 to 5735·4) | 4376·7 (2864·1 to 6392·9) | 38·8 (37·5 to 40·1)* | 11·5 (10·9 to 12·1)* | 57·8 (38·0 to 84·2) | 58·5 (38·3 to 85·2) | 58·9 (38·5 to 85·9) | 1·8 (1·2 to 2·3)* | 0·6 (0·1 to 1·1)* | |||
| Attention-deficit hyperactivity disorder | 599·7 (359·0 to 952·7) | 711·9 (426·0 to 1134·5) | 755·2 (452·2 to 1196·6) | 25·9 (23·5 to 28·3)* | 6·1 (5·0 to 7·1)* | 10·2 (6·1 to 16·1) | 10·1 (6·0 to 16·1) | 10·1 (6·0 to 15·9) | –1·3 (−3·0 to 0·5) | –0·5 (−1·4 to 0·4) | |||
| Conduct disorder | 5072·5 (3154·4 to 7682·5) | 5820·5 (3615·8 to 8803·8) | 5947·3 (3701·9 to 8998·5) | 17·2 (15·6 to 18·7)* | 2·2 (0·9 to 3·4)* | 79·5 (49·4 to 120·5) | 79·4 (49·4 to 120·6) | 81·2 (50·5 to 122·9) | 2·1 (0·7 to 3·4)* | 2·3 (1·1 to 3·4)* | |||
| Idiopathic developmental intellectual disability | 3629·4 (1741·7 to 6242·4) | 4500·4 (2160·1 to 7650·1) | 4610·9 (2201·5 to 7932·1) | 27·1 (21·7 to 30·9) | 2·5 (−0·9 to 4·6) | 66·2 (31·8 to 113·6) | 66·1 (31·8 to 112·4) | 61·6 (29·4 to 105·9) | –7·0 (−11·0 to–4·1) | –6·9 (−10·0 to–4·9) | |||
| Other mental and substance use disorders | 6461·6 (4417·8 to 9255·4) | 8792·3 (5989·8 to 12 580·6) | 10 357·1 (7059·0 to 14 807·2) | 60·3 (59·0 to 61·9)* | 17·8 (17·2 to 18·5)* | 138·5 (94·5 to 197·7) | 138·4 (94·3 to 197·8) | 138·5 (94·4 to 197·7) | 0·0 (−0·5 to 0·5) | 0·1 (−0·4 to 0·5) | |||
| Diabetes, urogenital, blood, and endocrine diseases | 81 744·6 (71 204·2 to 94 535·9) | 112 751·7 (98 101·9 to 131 367·5) | 133 747·8 (115 976·8 to 155 676·1) | 63·6 (59·4 to 68·0)* | 18·6 (17·4 to 20·0)* | 1882·2 (1642·5 to 2163·3) | 1942·7 (1699·4 to 2247·3) | 1887·6 (1641·9 to 2192·9) | 0·3 (−1·8 to 2·3) | –2·8 (−3·9 to −1·7)* | |||
| Diabetes mellitus | 27 475·9 (23 282·7 to 32 608·1) | 45 989·7 (38 695·1 to 54 713·4) | 57 233·7 (47 967·9 to 68 279·3) | 108·3 (104·2 to 112·1)* | 24·4 (22·7 to 26·2)* | 708·6 (604·0 to 837·1) | 827·9 (700·5 to 977·9) | 814·2 (686·6 to 965·4) | 14·9 (12·6 to 16·9)* | –1·6 (−3·0 to −0·2)* | |||
| Acute glomerulonephritis | 560·5 (521·8 to 610·3) | 337·8 (325·7 to 355·6) | 325·6 (310·5 to 343·1) | –41·9 (−46·6 to −37·0)* | –3·6 (−8·4 to 1·5) | 11·6 (10·8 to 12·5) | 5·5 (5·3 to 5·8) | 4·5 (4·3 to 4·8) | –60·9 (−63·9 to −57·6)* | –17·4 (−21·5 to −13·2)* | |||
| Chronic kidney disease | 21 597·2 (20 094·0 to 23 354·9) | 29 187·2 (27 250·7 to 31 463·0) | 35 032·4 (32 622·1 to 37 954·3) | 62·2 (56·5 to 68·0)* | 20·0 (17·4 to 22·7)* | 521·4 (484·6 to 565·3) | 515·4 (480·9 to 555·7) | 500·1 (465·5 to 541·4) | –4·1 (−7·5 to −1·2)* | –3·0 (−5·0 to −1·0)* | |||
| Due to diabetes mellitus | 7860·2 (7048·8 to 8711·8) | 11 731·4 (10 615·3 to 12 891·9) | 14 660·6 (13 206·6 to 16 203·7) | 86·5 (77·5 to 92·6)* | 25·0 (21·9 to 27·6)* | 202·9 (182·1 to 225·3) | 212·1 (191·8 to 233·4) | 209·2 (188·8 to 230·8) | 3·1 (−1·4 to 6·1) | –1·4 (−3·5 to 0·5) | |||
| Due to hypertension | 3481·1 (3030·8 to 3987·5) | 5169·1 (4520·8 to 5845·6) | 6606·7 (5760·2 to 7493·9) | 89·8 (80·4 to 96·3)* | 27·8 (24·7 to 30·6)* | 97·3 (84·5 to 110·8) | 99·2 (87·0 to 112·3) | 98·2 (85·5 to 111·1) | 0·9 (−3·9 to 4·0) | –1·0 (−3·3 to 0·9) | |||
| Due to glomerulonephritis | 4609·2 (4053·1 to 5203·8) | 5467·8 (4843·2 to 6157·1) | 5932·9 (5226·4 to 6746·0) | 28·7 (22·3 to 36·4)* | 8·5 (5·5 to 11·8)* | 96·8 (85·7 to 109·7) | 89·0 (79·1 to 100·4) | 82·2 (72·8 to 93·3) | –15·1 (−18·2 to −11·3)* | –7·7 (−9·8 to −5·4)* | |||
| Due to other causes | 5646·7 (5024·1 to 6347·1) | 6819·0 (6061·0 to 7661·1) | 7832·1 (6915·6 to 8848·7) | 38·7 (31·1 to 47·3)* | 14·9 (11·6 to 18·4)* | 124·5 (110·6 to 141·4) | 115·1 (102·5 to 129·8) | 110·6 (97·5 to 125·5) | –11·2 (−14·7 to −7·3)* | –4·0 (−6·2 to −1·4)* | |||
| Urinary diseases and male infertility | 6451·7 (5595·1 to 7476·6) | 8383·8 (7248·0 to 9800·2) | 9965·5 (8532·5 to 11 725·6) | 54·5 (43·5 to 61·3)* | 18·9 (14·9 to 21·6)* | 152·8 (131·3 to 179·4) | 148·8 (128·2 to 175·0) | 143·5 (122·7 to 169·2) | –6·1 (−11·5 to −2·8)* | –3·6 (−6·5 to −1·5)* | |||
| Interstitial nephritis and urinary tract infections | 2443·8 (2111·8 to 2752·8) | 3457·4 (3137·6 to 3688·9) | 4269·2 (4005·5 to 4529·9) | 74·7 (54·0 to 95·1)* | 23·5 (15·5 to 30·3)* | 55·6 (48·9 to 61·3) | 60·7 (55·4 to 64·5) | 61·9 (58·2 to 65·6) | 11·3 (−0·3 to 22·0) | 1·9 (−4·2 to 7·3) | |||
| Urolithiasis | 496·9 (352·4 to 588·4) | 566·9 (491·0 to 658·3) | 622·5 (523·5 to 778·9) | 25·3 (7·1 to 86·6)* | 9·8 (2·6 to 25·5)* | 11·9 (8·6 to 14·1) | 9·7 (8·4 to 11·2) | 8·8 (7·4 to 11·0) | –26·5 (−36·9 to 8·6) | –9·8 (−15·6 to 3·0) | |||
| Benign prostatic hyperplasia | 1818·5 (1164·2 to 2622·2) | 2625·2 (1692·9 to 3763·4) | 3383·9 (2178·0 to 4835·1) | 86·1 (82·2 to 90·8)* | 28·9 (27·6 to 30·3)* | 50·4 (32·4 to 72·4) | 49·9 (32·2 to 72·1) | 49·2 (31·8 to 71·0) | –2·3 (−4·2 to −0·1)* | –1·3 (−2·2 to −0·3)* | |||
| Male infertility | 104·7 (42·2 to 207·7) | 138·3 (55·3 to 275·1) | 165·1 (66·1 to 327·1) | 57·7 (52·9 to 62·6)* | 19·3 (15·7 to 22·6)* | 2·0 (0·8 to 3·9) | 2·0 (0·8 to 4·0) | 2·1 (0·9 to 4·3) | 9·5 (6·8 to 12·1)* | 7·9 (4·9 to 10·6)* | |||
| Other urinary diseases | 1587·8 (1231·6 to 1910·8) | 1596·0 (1346·0 to 1852·1) | 1524·9 (1353·8 to 1722·1) | –4·0 (−17·5 to 18·2) | –4·5 (−12·0 to 7·6) | 32·9 (25·7 to 39·6) | 26·5 (22·4 to 30·7) | 21·4 (19·1 to 24·2) | –34·7 (−44·6 to −20·4)* | –19·0 (−25·5 to −9·1)* | |||
| Gynaecological diseases | 7068·6 (4854·9 to 10 047·8) | 9365·7 (6439·4 to 13 315·0) | 10 460·2 (7184·1 to 14 928·1) | 48·0 (45·8 to 50·2)* | 11·7 (10·4 to 13·1)* | 145·2 (99·4 to 206·1) | 140·4 (96·1 to 200·0) | 136·8 (94·0 to 195·1) | –5·8 (−7·2 to −4·3)* | –2·5 (−3·5 to −1·4)* | |||
| Uterine fibroids | 882·6 (552·9 to 1378·7) | 1237·0 (765·6 to 1961·3) | 1462·5 (897·4 to 2340·2) | 65·7 (59·0 to 71·2)* | 18·2 (16·3 to 19·8)* | 20·1 (12·6 to 31·5) | 19·3 (12·0 to 30·7) | 19·2 (11·8 to 30·7) | –4·6 (−8·6 to −1·5)* | –0·6 (−2·2 to 0·7) | |||
| Polycystic ovarian syndrome | 98·7 (53·5 to 166·2) | 108·9 (57·8 to 188·7) | 112·4 (59·4 to 198·0) | 14·0 (−4·7 to 29·3) | 3·3 (−4·0 to 8·3) | 1·9 (1·1 to 3·3) | 1·6 (0·8 to 2·7) | 1·5 (0·8 to 2·6) | –24·7 (−39·1 to −12·8)* | –7·3 (−14·5 to −2·3)* | |||
| Female infertility | 103·8 (37·9 to 234·0) | 129·8 (47·2 to 288·4) | 179·8 (66·2 to 399·0) | 73·2 (58·8 to 91·0)* | 38·5 (29·4 to 49·5)* | 1·9 (0·7 to 4·3) | 1·9 (0·7 to 4·2) | 2·3 (0·9 to 5·2) | 23·2 (13·8 to 35·5)* | 25·3 (17·7 to 34·8)* | |||
| Endometriosis | 233·8 (156·3 to 325·3) | 310·3 (209·4 to 429·1) | 334·9 (226·3 to 461·8) | 43·2 (36·4 to 50·6)* | 7·9 (5·3 to 10·9)* | 4·4 (3·0 to 6·2) | 4·5 (3·0 to 6·2) | 4·3 (2·9 to 6·0) | –2·3 (−5·9 to 1·4) | –3·8 (−6·1 to −1·4)* | |||
| Genital prolapse | 586·6 (297·3 to 1051·1) | 694·7 (348·9 to 1246·0) | 792·6 (394·6 to 1424·8) | 35·1 (31·0 to 38·0)* | 14·1 (12·5 to 15·4)* | 14·9 (7·5 to 26·6) | 12·3 (6·2 to 22·0) | 11·1 (5·5 to 19·8) | –25·8 (−27·9 to −24·3)* | –10·0 (−11·2 to −9·0)* | |||
| Premenstrual syndrome | 2632·6 (1628·3 to 4036·0) | 3470·7 (2146·2 to 5295·9) | 3791·1 (2344·6 to 5812·9) | 44·0 (42·4 to 45·5)* | 9·2 (7·7 to 10·6)* | 50·7 (31·3 to 77·2) | 50·3 (31·1 to 76·7) | 49·3 (30·5 to 75·6) | –2·7 (−3·7 to −1·9)* | –2·0 (−3·3 to −0·8)* | |||
| Other gynaecological diseases | 2530·6 (1722·7 to 3505·2) | 3414·2 (2325·2 to 4737·6) | 3786·8 (2576·9 to 5232·9) | 49·6 (44·5 to 55·1)* | 10·9 (8·6 to 13·8)* | 51·2 (34·8 to 71·6) | 50·5 (34·4 to 70·1) | 49·2 (33·5 to 67·9) | –4·1 (−6·9 to −0·6)* | –2·7 (−4·7 to −0·1)* | |||
| Haemoglobinopathies and haemolytic anaemias | 12 160·7 (9789·5 to 14 856·4) | 12 033·2 (9847·5 to 14 691·3) | 12 321·6 (9916·9 to 15 372·2) | 1·3 (−8·3 to 15·8) | 2·4 (−2·6 to 8·3) | 213·4 (174·0 to 258·9) | 181·7 (148·9 to 221·9) | 169·7 (136·9 to 211·4) | –20·5 (−27·2 to −10·5)* | –6·6 (−10·9 to −1·3)* | |||
| Thalassaemias | 1432·0 (961·6 to 1835·3) | 771·2 (639·7 to 918·5) | 516·0 (443·5 to 633·5) | –64·0 (−70·0 to −40·5)* | –33·1 (−39·9 to −18·8)* | 21·7 (14·6 to 27·8) | 11·2 (9·3 to 13·4) | 7·2 (6·2 to 8·9) | –66·6 (−72·1 to −45·0)* | –35·5 (−42·1 to −21·6)* | |||
| Thalassaemias trait | 2703·8 (1770·0 to 3974·9) | 2957·1 (1959·0 to 4290·6) | 3280·4 (2156·8 to 4823·8) | 21·3 (17·3 to 25·1)* | 10·9 (8·0 to 13·9)* | 49·7 (32·6 to 73·1) | 44·9 (29·7 to 65·2) | 44·6 (29·3 to 65·5) | –10·2 (−12·1 to −8·4)* | –0·6 (−3·1 to 2·0) | |||
| Sickle cell disorders | 4349·9 (3163·6 to 5209·6) | 4224·4 (3414·2 to 4951·4) | 4117·9 (3587·8 to 4842·0) | –5·3 (−20·7 to 19·9) | –2·5 (−11·6 to 10·5) | 68·7 (50·4 to 81·8) | 60·8 (49·0 to 71·5) | 56·6 (49·1 to 66·5) | –17·7 (−30·6 to 3·8) | –6·9 (−15·9 to 6·1) | |||
| Sickle cell trait | 1119·1 (726·0 to 1651·0) | 1331·4 (871·9 to 1959·4) | 1555·0 (1014·1 to 2282·9) | 39·0 (36·2 to 41·7)* | 16·8 (14·8 to 18·8)* | 19·5 (12·8 to 28·8) | 19·7 (12·9 to 28·9) | 21·1 (13·8 to 31·0) | 8·1 (6·2 to 9·7)* | 7·2 (5·4 to 9·1)* | |||
| G6PD deficiency | 577·8 (488·8 to 691·1) | 702·7 (606·1 to 834·8) | 737·8 (637·7 to 875·0) | 27·7 (18·3 to 42·4)* | 5·0 (1·2 to 10·1)* | 10·9 (9·2 to 13·1) | 10·7 (9·3 to 12·7) | 9·9 (8·6 to 11·8) | –8·8 (−14·7 to 1·2) | –7·3 (−10·7 to −2·8)* | |||
| G6PD trait | 0·4 (0·3 to 0·6) | 0·5 (0·3 to 0·7) | 0·6 (0·4 to 0·8) | 37·0 (30·4 to 43·2)* | 17·6 (14·9 to 20·7)* | ·· | ·· | ·· | –3·0 (−6·5 to 0·1) | 4·9 (2·6 to 7·5)* | |||
| Other haemoglobinopathies and haemolytic anaemias | 1977·7 (1591·8 to 2467·5) | 2046·0 (1610·7 to 2612·6) | 2113·9 (1640·0 to 2730·4) | 6·9 (0·9 to 13·2)* | 3·3 (0·6 to 5·8)* | 42·9 (35·4 to 52·5) | 34·4 (27·5 to 43·3) | 30·2 (23·6 to 38·9) | –29·4 (−34·6 to −23·9)* | –12·1 (−15·2 to −9·4)* | |||
| Endocrine, metabolic, blood, and immune disorders | 6430·0 (5399·9 to 7454·1) | 7454·3 (6326·0 to 8750·0) | 8408·8 (7025·4 to 9979·2) | 30·8 (20·9 to 40·9)* | 12·8 (9·0 to 16·5)* | 129·3 (108·6 to 151·1) | 123·0 (104·1 to 144·5) | 118·7 (99·1 to 140·9) | –8·2 (−13·4 to −3·2)* | –3·5 (−6·4 to −0·8)* | |||
| Musculoskeletal disorders | 86 655·4 (63 137·9 to 112 703·8) | 117 031·2 (85 442·0 to 152 359·0) | 140 030·6 (102 331·5 to 181 687·7) | 61·6 (59·1 to 63·9)* | 19·6 (18·5 to 20·8)* | 2014·2 (1474·2 to 2609·4) | 1944·7 (1422·3 to 2518·0) | 1918·7 (1404·4 to 2493·3) | –4·7 (−5·7 to −3·9)* | –1·3 (−2·0 to −0·6)* | |||
| Rheumatoid arthritis | 3329·7 (2458·2 to 4257·7) | 4443·0 (3238·4 to 5693·1) | 5563·4 (3985·9 to 7171·2) | 67·1 (60·8 to 72·7)* | 25·2 (22·4 to 27·6)* | 82·8 (61·6 to 104·8) | 77·7 (56·9 to 99·3) | 78·0 (55·8 to 100·1) | –5·7 (−9·4 to −2·9)* | 0·4 (−1·8 to 2·2) | |||
| Osteoarthritis | 7947·9 (5593·8 to 10 856·2) | 12 385·2 (8735·1 to 16 806·2) | 16 282·9 (11 486·0 to 22 047·2) | 104·9 (102·9 to 107·2)* | 31·5 (30·8 to 32·2)* | 213·4 (150·2 to 291·8) | 226·6 (159·7 to 308·0) | 232·1 (163·7 to 313·9) | 8·8 (7·6 to 10·2)* | 2·4 (1·9 to 3·0)* | |||
| Low back and neck pain | 55 941·4 (39 562·5 to 73 187·3) | 72 599·3 (51 532·0 to 94 807·4) | 86 584·5 (61 335·4 to 113 628·5) | 54·8 (51·8 to 57·4)* | 19·3 (17·7 to 20·7)* | 1294·3 (914·6 to 1702·0) | 1198·9 (855·0 to 1573·7) | 1182·7 (837·4 to 1550·6) | –8·6 (−9·6 to −7·7)* | –1·4 (−2·4 to −0·5)* | |||
| Low back pain | 39 129·9 (27 512·7 to 51 797·6) | 48 853·4 (34 564·0 to 64 073·6) | 57 648·2 (40 820·5 to 75 877·0) | 47·3 (44·4 to 50·1)* | 18·0 (16·0 to 20·1)* | 897·3 (637·6 to 1178·5) | 805·3 (574·2 to 1053·7) | 788·9 (558·7 to 1034·6) | –12·1 (−12·9 to −11·3)* | –2·0 (−3·6 to −0·9)* | |||
| Neck pain | 16 811·5 (11 404·8 to 23 792·2) | 23 745·9 (16 214·4 to 33 438·2) | 28 936·3 (19 578·5 to 40 543·1) | 72·1 (68·5 to 76·2)* | 21·9 (19·9 to 24·0)* | 397·0 (268·6 to 556·8) | 393·6 (269·1 to 549·8) | 393·8 (267·8 to 550·2) | –0·8 (−2·2 to 0·7) | 0·1 (−1·3 to 1·4) | |||
| Gout | 596·8 (413·3 to 810·6) | 848·9 (589·9 to 1155·4) | 1071·2 (742·4 to 1455·0) | 79·5 (76·2 to 82·9)* | 26·2 (24·3 to 27·9)* | 15·4 (10·6 to 21·1) | 15·2 (10·4 to 20·6) | 15·2 (10·4 to 20·6) | –1·8 (−3·3 to −0·2)* | –0·1 (−1·3 to 1·1) | |||
| Other musculoskeletal disorders | 18 839·6 (13 162·2 to 26 102·7) | 26 754·8 (18 664·4 to 36 839·1) | 30 528·6 (21 196·7 to 42 458·6) | 62·0 (57·4 to 67·0)* | 14·1 (11·4 to 16·8)* | 408·3 (285·4 to 564·2) | 426·3 (298·3 to 586·2) | 410·6 (285·6 to 568·6) | 0·6 (−1·3 to 2·1) | –3·7 (−5·7 to −1·8)* | |||
| Other non-communicable diseases | 164 624·2 (127 834·6 to 209 136·6) | 183 247·3 (141 607·2 to 236 700·6) | 196 036·1 (148 295·9 to 258 150·6) | 19·1 (6·3 to 31·0)* | 7·0 (2·4 to 10·8)* | 3107·0 (2367·7 to 4005·6) | 2912·8 (2241·2 to 3781·4) | 2758·6 (2096·2 to 3616·8) | –11·2 (−17·7 to −5·3)* | –5·3 (−8·4 to −2·6)* | |||
| Congenital birth defects | 68 393·0 (53 592·7 to 84 283·8) | 58 286·5 (48 759·3 to 66 905·7) | 50 429·8 (44 114·0 to 56 200·2) | –26·3 (−38·1 to −8·0)* | –13·5 (−20·8 to −5·2)* | 1042·0 (821·5 to 1280·7) | 853·9 (714·0 to 980·0) | 716·0 (626·4 to 798·7) | –31·3 (−42·1 to −15·1)* | –16·1 (−23·1 to −8·3)* | |||
| Neural tube defects | 10 315·0 (7239·9 to 14 462·5) | 6150·2 (4476·4 to 8763·9) | 5130·9 (3867·1 to 7016·1) | –50·3 (−58·8 to −39·9)* | –16·6 (−27·1 to −5·4)* | 156·9 (111·4 to 218·6) | 90·3 (65·8 to 128·5) | 72·6 (54·5 to 99·5) | –53·8 (−61·3 to −44·5)* | –19·6 (−29·7 to −9·2)* | |||
| Congenital heart anomalies | 27 581·3 (21 339·9 to 34 673·0) | 22 936·6 (19 833·8 to 26 150·9) | 18 563·8 (16 539·0 to 21 464·8) | –32·7 (−44·5 to −7·0)* | –19·1 (−26·5 to −6·9)* | 413·5 (320·8 to 519·5) | 334·6 (289·1 to 381·8) | 264·7 (235·7 to 305·9) | –36·0 (−47·0 to −11·7)* | –20·9 (−28·1 to −9·0)* | |||
| Orofacial clefts | 480·8 (242·6 to 688·3) | 320·2 (200·3 to 468·4) | 238·7 (148·0 to 369·6) | –50·4 (−67·5 to −18·4)* | –25·5 (−41·3 to −8·5)* | 7·2 (3·7 to 10·2) | 4·7 (2·9 to 6·8) | 3·4 (2·1 to 5·3) | –52·4 (−68·8 to −22·9)* | –27·0 (−42·6 to −10·0)* | |||
| Down's syndrome | 1325·4 (767·0 to 3069·7) | 1240·1 (945·4 to 2039·8) | 1166·0 (1005·7 to 1482·8) | –12·0 (−54·8 to 41·0) | –6·0 (−30·4 to 12·8) | 20·7 (12·4 to 46·5) | 18·3 (14·0 to 30·1) | 16·3 (14·0 to 20·7) | –21·4 (−58·2 to 22·5) | –11·2 (−33·7 to 6·2) | |||
| Turner syndrome | 37·8 (18·1 to 60·9) | 44·2 (21·1 to 71·5) | 47·3 (22·1 to 76·5) | 25·2 (20·6 to 30·2)* | 6·9 (3·2 to 10·4)* | 0·7 (0·3 to 1·1) | 0·6 (0·3 to 1·0) | 0·6 (0·3 to 1·0) | –3·4 (−6·7 to −0·1)* | –1·0 (−4·3 to 2·1) | |||
| Klinefelter syndrome | 13·0 (6·3 to 24·4) | 15·7 (7·6 to 29·6) | 17·1 (8·2 to 32·3) | 32·1 (28·5 to 35·8)* | 9·0 (6·2 to 11·7)* | 0·2 (0·1 to 0·4) | 0·2 (0·1 to 0·4) | 0·2 (0·1 to 0·4) | –0·3 (−2·6 to 2·3) | –0·1 (−2·5 to 2·5) | |||
| Other chromosomal abnormalities | 1668·6 (1053·4 to 3061·2) | 1851·6 (1371·3 to 2805·1) | 1952·2 (1542·5 to 2587·9) | 17·0 (−18·1 to 54·2) | 5·4 (−10·1 to 18·4) | 24·9 (15·8 to 45·4) | 26·8 (19·9 to 40·8) | 27·9 (22·0 to 37·1) | 12·2 (−20·7 to 47·3) | 4·0 (−11·4 to 16·7) | |||
| Congenital musculoskeletal and limb anomalies | 2120·7 (1465·8 to 3497·7) | 2234·9 (1621·0 to 3167·4) | 2258·4 (1661·2 to 2988·8) | 6·5 (−21·7 to 26·8) | 1·1 (−12·2 to 9·4) | 36·6 (25·7 to 57·3) | 33·6 (24·4 to 47·1) | 31·2 (23·0 to 41·5) | –14·6 (−32·7 to −2·5)* | –7·0 (−17·7 to −0·0)* | |||
| Urogenital congenital anomalies | 1277·1 (845·2 to 1639·7) | 1202·0 (877·2 to 1462·4) | 1085·9 (858·1 to 1305·3) | –15·0 (−35·6 to 10·8) | –9·7 (−19·8 to 3·1) | 19·4 (12·9 to 24·9) | 17·6 (12·8 to 21·4) | 15·4 (12·2 to 18·6) | –20·4 (−39·5 to 2·8) | –12·1 (−21·9 to 0·3) | |||
| Digestive congenital anomalies | 4666·6 (3171·1 to 8658·0) | 3973·4 (3024·5 to 6520·3) | 3343·0 (2674·6 to 4964·7) | –28·4 (−49·5 to −3·2)* | –15·9 (−27·9 to −1·6)* | 69·9 (47·8 to 128·5) | 58·2 (44·3 to 95·3) | 48·0 (38·3 to 71·5) | –31·3 (−51·3 to −8·1)* | –17·5 (−29·3 to −3·8)* | |||
| Other congenital birth defects | 18 906·7 (10 942·1 to 30 995·8) | 18 317·5 (12 204·8 to 26 209·6) | 16 626·6 (12 154·3 to 21 604·2) | –12·1 (−33·0 to 18·4) | –9·2 (−20·5 to 3·7) | 291·9 (171·4 to 473·1) | 268·9 (179·1 to 384·4) | 235·6 (172·4 to 307·3) | –19·3 (−37·5 to 5·5) | –12·4 (−22·8 to −0·2)* | |||
| Skin and subcutaneous diseases | 41 366·2 (28 152·7 to 59 346·6) | 51 550·5 (35 306·4 to 73 530·7) | 57 394·0 (39 334·2 to 81 653·4) | 38·8 (37·0 to 41·0)* | 11·3 (10·6 to 12·4)* | 756·7 (518·9 to 1081·9) | 770·3 (529·3 to 1097·1) | 781·3 (535·8 to 1110·4) | 3·2 (2·5 to 4·4)* | 1·4 (0·8 to 2·2)* | |||
| Dermatitis | 8427·2 (5021·7 to 13 797·8) | 10 043·3 (6010·8 to 16 327·0) | 11 210·2 (6714·5 to 18 218·1) | 33·0 (31·2 to 35·0)* | 11·6 (10·8 to 12·4)* | 151·8 (91·0 to 246·4) | 151·3 (90·6 to 245·3) | 153·0 (91·6 to 248·4) | 0·7 (−0·3 to 1·8) | 1·1 (0·2 to 1·8)* | |||
| Psoriasis | 3321·0 (2384·1 to 4347·4) | 4638·9 (3323·7 to 6084·4) | 5643·4 (4039·7 to 7377·2) | 69·9 (68·4 to 71·5)* | 21·7 (20·8 to 22·6)* | 69·7 (50·0 to 91·2) | 73·5 (52·6 to 96·1) | 76·6 (54·9 to 100·0) | 9·8 (9·1 to 10·6)* | 4·2 (3·5 to 5·0)* | |||
| Cellulitis | 254·1 (179·0 to 320·6) | 451·3 (288·9 to 558·2) | 607·6 (398·4 to 739·6) | 139·1 (103·8 to 168·2)* | 34·6 (25·1 to 48·9)* | 5·5 (3·9 to 6·9) | 7·6 (4·8 to 9·4) | 8·6 (5·6 to 10·4) | 56·3 (32·3 to 74·2)* | 13·1 (5·5 to 24·8)* | |||
| Pyoderma | 1094·9 (615·2 to 1411·5) | 1577·2 (930·0 to 1948·5) | 1944·8 (1249·8 to 2603·1) | 77·6 (42·6 to 123·0)* | 23·3 (7·9 to 40·5)* | 22·1 (12·9 to 27·9) | 26·0 (15·4 to 32·2) | 27·7 (17·8 to 37·0) | 25·1 (3·6 to 51·2)* | 6·5 (−6·4 to 20·8) | |||
| Scabies | 3332·5 (1844·4 to 5364·2) | 3670·6 (2034·7 to 5849·4) | 3787·8 (2103·6 to 6029·0) | 13·7 (10·8 to 16·7)* | 3·2 (1·8 to 4·6)* | 58·6 (32·4 to 93·0) | 53·9 (29·8 to 85·6) | 51·0 (28·3 to 81·0) | –13·0 (−13·9 to −12·2)* | –5·4 (−6·2 to −4·8)* | |||
| Fungal skin diseases | 2267·4 (900·2 to 4720·9) | 2973·4 (1184·9 to 6172·3) | 3508·8 (1403·0 to 7271·0) | 54·8 (51·8 to 57·7)* | 18·0 (17·0 to 19·1)* | 46·1 (18·3 to 95·7) | 47·7 (18·9 to 98·8) | 48·9 (19·5 to 101·4) | 6·0 (5·3 to 6·8)* | 2·5 (2·2 to 2·9)* | |||
| Viral skin diseases | 4543·4 (2823·8 to 6780·1) | 5425·8 (3369·5 to 8082·0) | 5915·2 (3674·3 to 8828·1) | 30·2 (29·2 to 31·2)* | 9·0 (8·6 to 9·5)* | 80·2 (49·9 to 119·5) | 80·0 (49·8 to 119·1) | 79·9 (49·6 to 119·3) | –0·4 (−0·8 to 0·0) | –0·1 (−0·5 to 0·2) | |||
| Acne vulgaris | 12 086·8 (8150·7 to 17 552·7) | 15 067·6 (10 169·9 to 21 752·0) | 15 836·0 (10 643·5 to 22 842·6) | 31·0 (29·7 to 32·4)* | 5·1 (4·3 to 5·8)* | 202·3 (136·5 to 292·9) | 207·8 (140·1 to 300·1) | 212·1 (143·0 to 306·4) | 4·9 (4·2 to 5·6)* | 2·1 (1·5 to 2·6)* | |||
| Alopecia areata | 350·9 (224·8 to 530·5) | 447·0 (286·2 to 675·8) | 504·2 (322·7 to 760·0) | 43·7 (42·1 to 45·3)* | 12·8 (11·8 to 13·9)* | 6·9 (4·4 to 10·4) | 6·8 (4·3 to 10·2) | 6·7 (4·3 to 10·1) | –3·5 (−4·4 to −2·6)* | –1·3 (−2·2 to −0·5)* | |||
| Pruritus | 452·1 (211·1 to 825·5) | 599·8 (278·6 to 1087·3) | 709·1 (329·7 to 1298·7) | 56·8 (52·5 to 61·0)* | 18·2 (16·7 to 19·8)* | 9·4 (4·4 to 17·2) | 9·6 (4·5 to 17·5) | 9·7 (4·5 to 17·8) | 2·9 (2·4 to 3·5)* | 1·3 (0·8 to 1·8)* | |||
| Urticaria | 3155·2 (2020·3 to 4556·7) | 3684·4 (2348·7 to 5265·8) | 4029·9 (2575·9 to 5745·3) | 27·7 (24·9 to 31·0)* | 9·4 (8·3 to 10·5)* | 55·1 (35·3 to 78·7) | 55·0 (35·1 to 78·7) | 54·9 (35·1 to 78·6) | –0·5 (−1·1 to 0·1) | –0·3 (−0·8 to 0·3) | |||
| Decubitus ulcer | 377·1 (291·5 to 475·3) | 553·3 (411·4 to 680·3) | 670·4 (513·0 to 836·1) | 77·8 (65·5 to 86·8)* | 21·2 (17·1 to 27·4)* | 10·7 (8·2 to 13·6) | 10·8 (8·0 to 13·3) | 10·2 (7·8 to 12·6) | –5·1 (−11·6 to 0·4) | –5·7 (−9·0 to −0·4)* | |||
| Other skin and subcutaneous diseases | 1703·5 (851·6 to 3091·8) | 2417·9 (1203·9 to 4377·1) | 3026·6 (1513·0 to 5474·6) | 77·7 (76·2 to 79·3)* | 25·2 (24·5 to 25·9)* | 38·1 (19·1 to 69·0) | 40·4 (20·2 to 72·9) | 42·2 (21·1 to 76·3) | 10·8 (10·1 to 11·7)* | 4·5 (4·1 to 5·1)* | |||
| Sense organ diseases | 39 443·2 (27 342·1 to 54 552·7) | 54 826·6 (38 158·5 to 76 040·8) | 66 701·9 (46 534·4 to 92 391·9) | 69·1 (67·3 to 71·0)* | 21·7 (20·7 to 22·5)* | 977·4 (686·1 to 1356·7) | 977·9 (685·8 to 1355·9) | 959·3 (670·2 to 1331·0) | –1·9 (−2·5 to −1·2)* | –1·9 (−2·6 to −1·3)* | |||
| Glaucoma | 211·5 (142·7 to 292·9) | 339·7 (230·3 to 471·3) | 461·1 (311·4 to 642·1) | 118·0 (114·5 to 121·8)* | 35·7 (33·7 to 38·0)* | 6·3 (4·3 to 8·7) | 6·9 (4·7 to 9·5) | 7·0 (4·8 to 9·8) | 12·1 (10·4 to 14·0)* | 2·1 (0·8 to 3·6)* | |||
| Cataract | 2698·3 (1924·0 to 3682·2) | 4418·1 (3157·8 to 5992·5) | 5789·0 (4134·6 to 7915·3) | 114·5 (111·4 to 117·9)* | 31·0 (29·4 to 32·6)* | 80·1 (57·2 to 108·9) | 88·3 (63·4 to 119·6) | 88·3 (63·3 to 120·5) | 10·3 (9·0 to 11·7)* | 0·0 (−1·1 to 1·1) | |||
| Macular degeneration | 174·5 (118·9 to 238·7) | 297·1 (202·1 to 406·9) | 408·6 (277·9 to 555·6) | 134·1 (129·3 to 139·0)* | 37·5 (34·7 to 40·4)* | 5·3 (3·6 to 7·3) | 6·1 (4·2 to 8·4) | 6·3 (4·3 to 8·6) | 17·8 (15·3 to 20·4)* | 2·7 (0·7 to 4·7)* | |||
| Refraction and accommodation disorders | 10 172·5 (6357·4 to 15 852·4) | 13 035·5 (8163·5 to 20 302·0) | 14 972·5 (9340·6 to 23 361·5) | 47·2 (45·2 to 49·0)* | 14·9 (13·7 to 15·9)* | 230·6 (144·4 to 359·2) | 220·0 (137·9 to 342·1) | 209·1 (130·4 to 326·0) | –9·3 (−10·0 to −8·7)* | –5·0 (−5·8 to −4·3)* | |||
| Age-related and other hearing loss | 21 193·7 (14 943·8 to 29 581·7) | 29 673·0 (20 837·2 to 41 494·7) | 36 287·5 (25 341·8 to 50 893·6) | 71·2 (67·0 to 75·3)* | 22·3 (20·4 to 24·0)* | 534·7 (379·0 to 745·0) | 533·4 (375·3 to 743·4) | 524·3 (368·0 to 734·0) | –1·9 (−3·5 to −0·7)* | –1·7 (−2·9 to −0·6)* | |||
| Other vision loss | 1205·2 (853·2 to 1628·8) | 1776·9 (1256·9 to 2396·0) | 2241·2 (1578·3 to 3016·4) | 86·0 (80·7 to 91·0)* | 26·1 (23·9 to 28·1)* | 30·1 (21·3 to 40·6) | 31·8 (22·4 to 42·9) | 32·0 (22·5 to 43·1) | 6·3 (4·6 to 8·0)* | 0·7 (−0·8 to 2·0) | |||
| Other sense organ diseases | 3787·5 (2395·1 to 5704·0) | 5286·3 (3336·8 to 7935·4) | 6542·0 (4132·0 to 9828·4) | 72·7 (71·6 to 73·9)* | 23·8 (23·1 to 24·4)* | 90·3 (57·2 to 136·3) | 91·4 (57·9 to 137·9) | 92·3 (58·4 to 139·0) | 2·1 (1·7 to 2·5)* | 0·9 (0·6 to 1·3)* | |||
| Oral disorders | 11 294·7 (6848·2 to 17 556·0) | 15 552·8 (9435·9 to 24 158·8) | 19 006·2 (11 586·8 to 29 629·5) | 68·3 (65·8 to 70·6)* | 22·2 (21·2 to 23·3)* | 270·1 (165·4 to 420·1) | 266·3 (162·9 to 413·0) | 265·7 (162·8 to 413·4) | –1·6 (−2·3 to −0·9)* | –0·2 (−0·7 to 0·2) | |||
| Caries of deciduous teeth | 120·6 (53·2 to 233·0) | 119·1 (52·5 to 231·1) | 127·2 (55·9 to 249·1) | 5·5 (2·8 to 7·3)* | 6·8 (4·5 to 8·5)* | 1·8 (0·8 to 3·5) | 1·8 (0·8 to 3·4) | 1·8 (0·8 to 3·4) | –3·7 (−5·9 to −2·1)* | 0·2 (−1·9 to 1·8) | |||
| Caries of permanent teeth | 1295·7 (581·5 to 2521·8) | 1571·3 (699·0 to 3047·3) | 1707·6 (760·1 to 3324·9) | 31·8 (29·7 to 33·9)* | 8·7 (8·0 to 9·4)* | 25·7 (11·4 to 50·0) | 24·0 (10·7 to 46·5) | 23·0 (10·2 to 44·6) | –10·6 (−11·9 to −9·3)* | –4·2 (−4·8 to −3·6)* | |||
| Periodontal diseases | 2676·0 (1065·8 to 5539·9) | 3893·0 (1550·5 to 8078·4) | 4898·0 (1946·8 to 10 208·7) | 83·0 (80·9 to 84·8)* | 25·8 (24·7 to 26·8)* | 64·2 (25·6 to 134·6) | 65·1 (25·9 to 136·6) | 66·6 (26·6 to 139·4) | 3·8 (3·0 to 4·4)* | 2·3 (1·8 to 2·9)* | |||
| Edentulism and severe tooth loss | 4603·5 (3028·6 to 6528·4) | 6553·4 (4335·5 to 9234·5) | 8338·4 (5467·4 to 11 760·4) | 81·1 (79·7 to 82·5)* | 27·2 (26·0 to 28·4)* | 125·7 (82·1 to 177·4) | 122·8 (80·3 to 172·5) | 121·7 (79·6 to 171·1) | –3·2 (−3·6 to −2·8)* | –0·9 (−1·6 to −0·3)* | |||
| Other oral disorders | 2598·9 (1602·8 to 3894·8) | 3416·0 (2109·2 to 5128·9) | 3935·0 (2427·2 to 5907·9) | 51·4 (50·0 to 52·8) | 15·2 (14·6 to 15·8) | 52·7 (32·6 to 79·0) | 52·7 (32·5 to 79·2) | 52·7 (32·5 to 79·2) | –0·0 (−0·4 to 0·3) | 0·0 (−0·3 to 0·3) | |||
| Sudden infant death syndrome | 4127·1 (3107·6 to 6179·4) | 3031·0 (2487·9 to 3993·4) | 2504·2 (2015·2 to 3003·1) | –39·3 (−57·8 to −20·1)* | –17·4 (−33·2 to −1·1)* | 60·8 (45·8 to 91·0) | 44·4 (36·4 to 58·4) | 36·4 (29·3 to 43·6) | –40·1 (−58·4 to −21·2)* | –18·0 (−33·7 to −1·9)* | |||
| Injuries | 259 714·5 (242 647·1 to 276 817·9) | 259 792·1 (242 234·6 to 280 976·8) | 255 434·3 (236 089·5 to 280 689·1) | –1·6 (−6·2 to 3·8) | –1·7 (−4·7 to 1·4) | 4875·4 (4544·8 to 5239·0) | 3976·8 (3692·0 to 4319·2) | 3457·3 (3192·1 to 3803·2) | –29·1 (−32·0 to −25·9)* | –13·1 (−15·6 to −10·6)* | |||
| Transport injuries | 70 430·3 (67 012·4 to 74 545·4) | 80 802·1 (76 835·3 to 85 315·6) | 78 051·8 (73 391·8 to 83 700·8) | 10·8 (6·4 to 15·9)* | –3·4 (−5·8 to −0·9)* | 1320·1 (1253·5 to 1399·1) | 1218·5 (1155·7 to 1292·0) | 1044·0 (980·2 to 1120·6) | –20·9 (−23·9 to −17·8)* | –14·3 (−16·4 to −12·3)* | |||
| Road injuries | 64 788·4 (61 744·3 to 68 397·9) | 74 299·1 (71 021·9 to 78 088·0) | 71 395·0 (67 520·8 to 76 128·0) | 10·2 (5·5 to 15·2)* | –3·9 (−6·3 to −1·6)* | 1210·6 (1151·7 to 1279·9) | 1119·1 (1066·5 to 1179·6) | 954·5 (901·8 to 1019·0) | –21·1 (−24·1 to −18·0)* | –14·7 (−16·8 to −12·8)* | |||
| Pedestrian road injuries | 24 717·6 (22 795·5 to 28 090·8) | 26 131·7 (24 588·0 to 28 158·5) | 24 001·5 (22 518·2 to 25 750·8) | –2·9 (−15·1 to 4·8) | –8·2 (−13·1 to −5·0)* | 459·3 (424·8 to 520·6) | 398·7 (375·0 to 429·0) | 323·3 (303·6 to 346·5) | –29·6 (−38·3 to −24·6)* | –18·9 (−23·2 to −16·2)* | |||
| Cyclist road injuries | 3390·5 (2919·1 to 3889·2) | 4747·7 (4149·8 to 5488·4) | 4968·2 (4229·6 to 5946·9) | 46·5 (30·4 to 67·8)* | 4·6 (−0·2 to 10·0) | 68·7 (58·8 to 79·8) | 74·3 (64·8 to 86·2) | 67·2 (57·1 to 80·7) | –2·2 (−12·4 to 11·4) | –9·5 (−13·4 to −4·7)* | |||
| Motorcyclist road injuries | 11 467·4 (10 510·3 to 12 944·1) | 15 105·0 (13 758·6 to 16 396·3) | 14 937·5 (13 499·8 to 16 289·9) | 30·3 (18·2 to 40·1)* | –1·1 (−5·4 to 2·6) | 211·8 (194·4 to 239·6) | 222·6 (202·8 to 242·2) | 197·3 (178·6 to 215·4) | –6·8 (−15·5 to 0·2) | –11·3 (−15·1 to −8·2)* | |||
| Motor vehicle road injuries | 24 319·9 (20 644·9 to 27 442·2) | 27 217·7 (24 983·6 to 30 653·8) | 26 211·8 (24 325·0 to 29 404·9) | 7·8 (0·7 to 25·4)* | –3·7 (−7·2 to 2·4) | 452·8 (386·1 to 509·4) | 406·3 (372·9 to 455·6) | 349·4 (324·1 to 391·5) | –22·9 (−27·6 to −11·0)* | –14·0 (−17·0 to −8·9)* | |||
| Other road injuries | 893·0 (714·6 to 1103·6) | 1097·0 (919·3 to 1343·6) | 1275·9 (1026·6 to 1626·3) | 42·9 (23·2 to 73·5)* | 16·3 (9·2 to 23·7)* | 17·9 (14·3 to 22·2) | 17·2 (14·3 to 21·1) | 17·3 (13·9 to 22·1) | –3·3 (−15·0 to 15·3) | 0·8 (−4·9 to 6·7) | |||
| Other transport injuries | 5641·9 (4761·1 to 6609·6) | 6503·0 (5751·7 to 7477·8) | 6656·8 (5797·7 to 7707·3) | 18·0 (5·2 to 38·4)* | 2·4 (−3·0 to 8·9) | 109·5 (92·6 to 128·2) | 99·4 (87·3 to 114·9) | 89·5 (77·8 to 103·9) | –18·3 (−26·4 to −5·1)* | –10·0 (−14·5 to −4·4)* | |||
| Unintentional injuries | 121 695·5 (109 006·9 to 134 119·5) | 111 226·3 (98 814·1 to 125 226·5) | 107 423·5 (94 550·6 to 124 015·0) | –11·7 (−18·4 to −4·3)* | –3·4 (−7·1 to 0·1) | 2282·2 (2056·3 to 2530·5) | 1750·0 (1549·2 to 1975·9) | 1486·2 (1306·5 to 1716·5) | –34·9 (−39·0 to −30·6)* | –15·1 (−18·0 to −12·2)* | |||
| Falls | 26 607·6 (22 592·9 to 31 276·8) | 31 258·7 (26 220·2 to 37 276·0) | 35 773·8 (29 777·6 to 43 175·7) | 34·5 (22·3 to 44·8)* | 14·4 (9·0 to 18·1)* | 589·1 (498·2 to 700·1) | 530·8 (444·1 to 630·7) | 506·5 (422·1 to 610·0) | –14·0 (−20·6 to −9·2)* | –4·6 (−8·8 to −1·8)* | |||
| Drowning | 34 779·0 (29 934·2 to 37 903·4) | 22 886·7 (20 014·2 to 24 143·1) | 16 809·0 (15 206·1 to 18 047·4) | –51·7 (−55·6 to −43·2)* | –26·6 (−30·1 to −20·1)* | 567·0 (491·4 to 614·9) | 337·6 (295·4 to 356·2) | 229·2 (207·1 to 246·3) | –59·6 (−62·8 to −53·0)* | –32·1 (−35·4 to −26·1)* | |||
| Fire, heat, and hot substances | 10 059·5 (7875·0 to 11 492·7) | 8822·8 (7294·7 to 10 004·2) | 8150·8 (6763·6 to 9476·2) | –19·0 (−28·2 to −5·5)* | –7·6 (−13·1 to −0·1)* | 186·1 (150·6 to 212·3) | 135·9 (113·3 to 154·4) | 111·4 (92·4 to 129·4) | –40·2 (−46·0 to −31·7)* | –18·1 (−22·7 to −11·8)* | |||
| Poisonings | 5471·1 (3951·1 to 6579·7) | 3747·9 (2956·8 to 4213·0) | 3149·4 (2379·7 to 3574·1) | –42·4 (−53·8 to −21·9)* | –16·0 (−25·9 to −2·9)* | 95·1 (69·4 to 112·2) | 56·3 (44·5 to 63·3) | 43·0 (32·5 to 48·9) | –54·8 (−63·8 to −39·4)* | –23·6 (−32·8 to −11·8)* | |||
| Exposure to mechanical forces | 12 931·3 (11 440·5 to 14 960·9) | 12 360·8 (10 580·5 to 14 181·8) | 11 921·2 (9836·7 to 14 174·8) | –7·8 (−25·2 to 2·4) | –3·6 (−8·0 to 1·0) | 239·6 (211·3 to 277·2) | 189·7 (162·2 to 219·0) | 162·2 (133·8 to 193·1) | –32·3 (−44·1 to −26·6)* | –14·4 (−18·0 to −11·0)* | |||
| Unintentional firearm injuries | 1681·2 (1345·7 to 1839·8) | 1415·5 (1182·3 to 1575·2) | 1351·5 (1104·3 to 1513·3) | –19·6 (−26·2 to −12·4)* | –4·5 (−10·9 to 0·7) | 30·9 (24·8 to 34·1) | 21·1 (17·6 to 23·5) | 18·1 (14·8 to 20·3) | –41·5 (−46·1 to −36·4)* | –14·3 (−19·9 to −9·9)* | |||
| Unintentional suffocation | 3239·4 (2677·8 to 4135·3) | 2101·3 (1713·6 to 2425·9) | 1757·1 (1410·8 to 2041·2) | –45·8 (−59·1 to −34·4)* | –16·4 (−23·6 to −8·8)* | 50·6 (42·1 to 63·9) | 31·2 (25·4 to 36·0) | 24·7 (19·8 to 28·7) | –51·2 (−63·0 to −41·5)* | –20·8 (−27·6 to −13·7)* | |||
| Other exposure to mechanical forces | 8010·6 (6937·0 to 9470·1) | 8844·1 (7355·1 to 10 402·4) | 8812·6 (7062·9 to 10 749·0) | 10·0 (−10·2 to 20·3) | –0·4 (−5·0 to 4·2) | 158·1 (135·5 to 187·8) | 137·4 (113·9 to 162·8) | 119·5 (96·0 to 145·9) | –24·4 (−37·5 to −19·1)* | –13·1 (−16·6 to −9·6)* | |||
| Adverse effects of medical treatment | 5352·0 (3741·7 to 6317·4) | 5077·1 (4014·2 to 5746·0) | 4991·7 (4229·9 to 5575·1) | –6·7 (−17·7 to 15·4) | –1·7 (−8·0 to 7·5) | 99·5 (73·7 to 114·5) | 80·2 (64·1 to 90·4) | 69·7 (59·2 to 77·9) | –30·0 (−36·6 to −18·4)* | –13·2 (−18·2 to −6·2)* | |||
| Animal contact | 6346·7 (4715·4 to 7403·2) | 6241·9 (4797·7 to 7155·5) | 5936·0 (4650·5 to 6820·3) | –6·5 (−17·4 to 13·4) | –4·9 (−10·6 to 3·5) | 118·2 (89·0 to 138·0) | 95·1 (73·2 to 109·3) | 80·7 (63·2 to 92·7) | –31·7 (−38·8 to −18·1)* | –15·1 (−20·1 to −7·7)* | |||
| Venomous animal contact | 5129·9 (3648·8 to 6063·6) | 5170·5 (3898·3 to 5979·9) | 4865·9 (3689·6 to 5640·6) | –5·2 (−16·8 to 17·5) | –5·9 (−12·1 to 3·0) | 94·9 (68·3 to 111·9) | 78·4 (59·1 to 90·7) | 66·0 (50·0 to 76·6) | –30·4 (−37·9 to −14·7)* | –15·7 (−21·1 to −7·9)* | |||
| Non-venomous animal contact | 1216·9 (949·1 to 1693·5) | 1071·3 (835·4 to 1440·4) | 1070·1 (837·8 to 1396·1) | –12·1 (−25·2 to −0·4)* | –0·1 (−7·7 to 7·1) | 23·3 (18·2 to 31·6) | 16·7 (13·0 to 22·4) | 14·7 (11·5 to 19·1) | –37·1 (−44·5 to −30·2)* | –12·3 (−18·3 to −6·4)* | |||
| Foreign body | 7078·1 (5242·3 to 9108·8) | 6599·7 (5467·6 to 7941·9) | 6742·8 (5709·7 to 7921·3) | –4·7 (−20·0 to 18·0) | 2·2 (−6·6 to 11·3) | 127·2 (98·0 to 159·1) | 102·2 (84·9 to 122·5) | 94·0 (79·8 to 110·3) | –26·1 (−35·1 to −12·1)* | –8·0 (−15·0 to −0·3)* | |||
| Pulmonary aspiration and foreign body in airway | 5386·2 (4058·7 to 7061·1) | 5309·7 (4303·9 to 6377·5) | 5327·3 (4587·3 to 6136·5) | –1·1 (−17·2 to 20·3) | 0·3 (−8·8 to 11·6) | 96·0 (74·8 to 121·0) | 82·1 (66·9 to 98·0) | 74·6 (64·3 to 86·0) | –22·3 (−31·9 to −8·3)* | –9·1 (−16·7 to 0·6) | |||
| Foreign body in eyes | 124·2 (63·7 to 213·3) | 146·6 (78·2 to 243·6) | 185·8 (100·2 to 310·1) | 49·6 (41·7 to 57·3)* | 26·8 (24·1 to 30·1)* | 2·6 (1·4 to 4·3) | 2·4 (1·3 to 3·9) | 2·5 (1·4 to 4·2) | –2·5 (−4·3 to −0·8)* | 8·2 (6·3 to 10·3)* | |||
| Foreign body in other body part | 1567·7 (948·1 to 2028·4) | 1143·5 (869·3 to 1474·9) | 1229·7 (929·1 to 1602·4) | –21·6 (−36·7 to 11·6) | 7·5 (0·6 to 13·4)* | 28·6 (18·2 to 36·8) | 17·7 (13·4 to 22·9) | 16·8 (12·7 to 21·9) | –41·3 (−50·8 to −21·5)* | –5·2 (−10·6 to −0·8)* | |||
| Environmental heat and cold exposure | 4613·3 (3492·7 to 5757·7) | 4712·3 (3611·7 to 5881·4) | 4676·7 (3520·0 to 5993·7) | 1·4 (−9·2 to 11·5) | –0·8 (−7·9 to 6·3) | 96·6 (74·1 to 121·0) | 75·7 (58·1 to 94·5) | 64·1 (48·3 to 82·0) | –33·6 (−40·8 to −27·6)* | –15·3 (−21·8 to −9·7)* | |||
| Other unintentional injuries | 8456·9 (7319·9 to 10 038·8) | 9518·6 (8199·6 to 11 247·0) | 9272·1 (7666·7 to 11 405·2) | 9·6 (−6·2 to 20·4) | –2·6 (−7·2 to 1·8) | 163·8 (140·6 to 195·7) | 146·4 (124·8 to 174·5) | 125·5 (103·7 to 154·8) | –23·4 (−33·6 to −17·0)* | –14·3 (−18·0 to −10·8)* | |||
| Self-harm and interpersonal violence | 57 011·9 (52 622·2 to 60 351·8) | 61 630·8 (56 736·9 to 64 509·4) | 58 717·9 (53 866·4 to 62 809·6) | 3·0 (−3·5 to 11·0) | –4·7 (−8·4 to −0·1)* | 1091·2 (1007·5 to 1153·3) | 919·1 (845·6 to 962·8) | 776·8 (712·6 to 830·8) | –28·8 (−33·2 to −23·4)* | –15·5 (−18·7 to −11·4)* | |||
| Self-harm | 36 069·6 (33 180·8 to 38 321·5) | 37 517·7 (34 901·0 to 39 462·7) | 35 149·6 (32 845·1 to 37 938·3) | –2·5 (−8·5 to 6·3) | –6·3 (−10·4 to −0·9)* | 705·3 (650·2 to 753·4) | 565·6 (526·2 to 594·0) | 465·7 (434·7 to 502·5) | –34·0 (−37·9 to −28·2)* | –17·7 (−21·2 to −12·9)* | |||
| Self-harm by firearm | 2951·5 (2377·2 to 3829·1) | 2875·2 (2348·6 to 3710·6) | 2853·2 (2386·0 to 3589·2) | –3·3 (−13·1 to 13·8) | –0·8 (−7·5 to 9·7) | 57·9 (47·4 to 75·0) | 43·2 (35·6 to 55·7) | 37·8 (31·6 to 47·6) | –34·8 (−41·0 to −24·0)* | –12·6 (−18·4 to −3·9)* | |||
| Self-harm by other specified means | 33 118·1 (30 211·8 to 35 109·1) | 34 642·5 (32 074·6 to 36 526·4) | 32 296·4 (30 216·7 to 34 924·8) | –2·5 (−8·5 to 6·3) | –6·8 (−11·0 to −1·3)* | 647·4 (590·9 to 686·4) | 522·4 (481·9 to 549·9) | 427·9 (399·9 to 462·6) | –33·9 (−37·9 to −28·1)* | –18·1 (−21·8 to −13·3)* | |||
| Interpersonal violence | 20 942·3 (17 360·5 to 23 608·2) | 24 113·2 (19 792·0 to 26 579·9) | 23 568·3 (19 646·6 to 26 479·2) | 12·5 (3·6 to 22·4)* | –2·3 (−6·9 to 3·5) | 385·9 (318·6 to 436·9) | 353·5 (290·4 to 391·3) | 311·1 (259·7 to 349·8) | –19·4 (−25·8 to −12·5)* | –12·0 (−16·1 to −7·0)* | |||
| Physical violence by firearm | 6529·3 (4689·4 to 7918·7) | 8381·5 (5616·3 to 9307·9) | 8720·1 (5844·7 to 9853·4) | 33·5 (15·0 to 48·5)* | 4·0 (−0·7 to 9·0) | 119·1 (84·7 to 144·7) | 120·5 (80·8 to 133·8) | 114·3 (76·6 to 129·1) | –4·1 (−17·5 to 6·7) | –5·2 (−9·6 to −0·6)* | |||
| Physical violence by sharp object | 5070·8 (3833·9 to 6262·5) | 5886·3 (4626·0 to 7279·7) | 5288·2 (4290·5 to 6922·3) | 4·3 (−8·9 to 25·1) | –10·2 (−16·5 to −0·5)* | 94·5 (71·8 to 117·5) | 86·4 (67·6 to 106·7) | 69·5 (56·4 to 90·9) | –26·5 (−36·0 to −12·1)* | –19·6 (−25·1 to −10·7)* | |||
| Sexual violence | 1162·6 (774·9 to 1647·4) | 1319·4 (884·1 to 1879·0) | 1365·8 (917·1 to 1946·0) | 17·5 (14·4 to 20·6)* | 3·5 (2·2 to 4·8)* | 21·2 (14·2 to 30·0) | 19·1 (12·9 to 27·3) | 18·1 (12·2 to 25·8) | –14·5 (−15·6 to −13·3)* | –5·5 (−6·2 to −4·9)* | |||
| Physical violence by other means | 8179·6 (6388·8 to 9519·2) | 8526·0 (7045·4 to 10 132·6) | 8194·1 (7011·8 to 10 058·4) | 0·2 (−15·5 to 20·3) | –3·9 (−12·3 to 4·9) | 151·1 (120·0 to 176·2) | 127·5 (105·6 to 151·6) | 109·3 (93·5 to 133·9) | –27·7 (−38·2 to −14·0)* | –14·3 (−21·6 to −6·5)* | |||
| Forces of nature, conflict and terrorism, and executions and police conflict | 10 576·7 (8362·5 to 12 866·6) | 6132·8 (4005·8 to 8352·3) | 11 241·1 (8003·1 to 14 753·8) | 6·3 (−25·0 to 46·5) | 83·3 (24·2 to 183·3)* | 181·9 (143·2 to 221·0) | 89·3 (58·2 to 121·9) | 150·3 (107·0 to 197·3) | –17·4 (−41·4 to 14·1) | 68·3 (14·3 to 159·6)* | |||
| Exposure to forces of nature | 3090·2 (1185·9 to 4943·3) | 946·7 (636·1 to 1276·6) | 617·1 (369·5 to 992·6) | –80·0 (−90·2 to −49·1)* | –34·8 (−50·5 to −15·8)* | 53·5 (20·8 to 85·5) | 14·0 (9·4 to 19·0) | 8·3 (5·0 to 13·4) | –84·5 (−92·3 to −60·9)* | –40·9 (−54·9 to −24·4)* | |||
| Conflict and terrorism | 6889·0 (5852·1 to 7909·2) | 4824·1 (2855·5 to 6799·0) | 10 326·0 (7176·9 to 13 627·5) | 49·9 (5·2 to 100·3)* | 114·0 (36·2 to 271·3)* | 117·4 (99·2 to 135·3) | 69·9 (41·6 to 98·8) | 138·1 (95·9 to 182·2) | 17·6 (−17·4 to 57·1) | 97·4 (25·7 to 240·9)* | |||
| Executions and police conflict | 733·5 (292·1 to 958·6) | 418·5 (263·0 to 654·0) | 355·7 (221·1 to 576·5) | –51·5 (−65·3 to −12·8)* | –15·0 (−22·4 to −7·5)* | 13·4 (5·4 to 17·6) | 6·2 (3·9 to 9·9) | 4·7 (2·9 to 7·7) | –64·8 (−74·6 to −37·4)* | –24·2 (−30·2 to −17·8)* | |||