Table 3.

Characterization of patients who experienced symptoms and perceived them as adverse responses by symptom (n, %)

Symptoms experienced and perceived as AEs (n)	Body region being treated					Chronicity		Experience with manual therapy			Progress in treatment		Sex	Age
Symptoms experienced and perceived as AEs (n)	Arm and Leg	Neck	Mid back	Low back	Pelvis	<3 months	>3 months	First time treatment	Treating same problem	Treating different problem	Improving	Not improving	Female:Male	18-30	31-60	>60
Headache (29)	0	16 (55.1%)	5 (17.2%)	8 (27.5%)	0	4 (13.8%)	25 (86.2%)	5 (17.2%)	17 (58.6%)	7 (24.1%)	28 (96.5%)	1 (3.4%)	8:21	5 (17.2%)	21 (72.4%)	3 (10.3%)
Bruising (20)	6 (30%)	8 (40%)	3 (15%)	3 (15%)	0	3 (15%)	17 (85%)	4 (20%)	10 (50%)	6 (30%)	17 (85%)	3 (15%)	5:15	2 (10%)	16 (80%)	2 (10%)
Increased pain (64)	22 (34.3%)	21 (32.8%)	7 (10.9%)	11 (17.2%)	2 (3%)	12 (18.7%)	51 (79.7%)	11 (17.2%)	26 (40.6%)	26 (40.6%)	26 (40.6%)	7 (10.9%)	20:43	9 (14%)	42 (65.6%)	12 (18.75%)
Increased stiffness (40)	11 (27.5%)	15 (37.5%)	5 (12.5%)	7 (17.5%)	1 (2.5%)	10 (25%)	29 (72.5%)	7 (17.5%)	14 (35%)	18 (45%)	35 (87.5%)	4 (10%)	16:23	6 (15%)	26 (65%)	7 (17.5%)
Increase in existing symptoms (50)	13 (26%)	16 (32%)	7 (14%)	10 (20%)	3 (6%)	12 (24%)	36 (72%)	11 (22%)	19 (38%)	19 (38%)	44 (88%)	5 (10%)	13:36	9 (18%)	32 (64%)	8 (16%)
Onset of new symptoms (21)	1 (4.7%)	9 (42.8%)	2 (9.5%)	6 (28.5%)	3 (14.3%)	6 (28.5%)	15 (71.4%)	3 (14.3%)	12 (57.1%)	6 (28.5%)	18 (85.7%)	3 (14.3%)	6:15	3 (14.3%)	15 (71.4%)	3 (14.3%)
Spreading of symptoms (28)	2 (7.1%)	12 (42.8%)	5 (17.8%)	8 (28.5%)	1 (3.5%)	7 (25%)	21 (75%)	6 (21.4%)	12 (42.8%)	10 (35.7%)	24 (85.7%)	4 (14.3%)	12:16	5 (17.8%)	18 (64.3%)	5 (17.8%)
Dizziness (18)	0	12 (66.6%)	1 (5.5%)	4 (22.2%)	1 (5.5%)	3 (16.6%)	15 (83.3%)	4 (22.2%)	7 (38.8%)	7 (38.8%)	17 (94.4%)	1 (5.5%)	7:11	2 (11.1%)	14 (77.7%)	2 (11.1%)
Increased soreness (55)	18 (32.7%)	22 (40%)	6 (10.9%)	6 (10.9%)	2 (3.6%)	12 (21.8%)	42 (76.3)	9 (16.3%)	18 (32.7%)	27 (49%)	46 (83.6%)	8 (14.5%)	26:28	9 (16.3%)	36 (65.4%)	9 (16.3%)
Breathing difficulties (6)	1 (16.6%)	2 (33.3%)	1 (16.6%)	1 (16.6%)	1 (16.6%)	4 (66.6%)	2 (33.3%)	1 (16.6%)	2 (33.3%)	3 (50%)	5 (83.3%)	1 (16.6%)	3:3	1 (16.6%)	4 (66.6%)	1 (16.6%)
Confusion or disorientation (5)	0	4 (80%)	0	1 (20%)	0	1 (20%)	4 (80%)	2 (40%)	1 (20%)	2 (40%)	5 (100%)	0	3:2	0	4 (80%)	1 (20%)
Loss of movement (4)	2 (50%)	2 (50%)	0	0	0	1 (25%)	3 (75%)	1 (25%)	1 (25%)	2 (50%)	4 (100%)	0	2:2	0	2 (50%)	2 (50%)
Nausea (7)	0	2 (28.5%)	2 (28.5%)	3 (42.8%)	0	2 (28.5%)	5 (71.4%)	1 (14.3%)	4 (57.1%)	2 (28.5%)	6 (85.7%)	1 (14.3%)	3:4	1 (14.3%)	5 (71.4%)	1 (14.3%)
Decreased balance (7)	0	4 (57.1%)	0	3 (42.8%)	0	1 (14.3%)	6 (85.7%)	1 (14.3%)	3 (42.8%)	3 (42.8%)	6 (85.7%)	1 (14.3%)	3:4	0	4 (57.1%)	3 (42.8%)
Increased swelling (10)	4 (40%)	3 (30%)	2 (20%)	0	1 (10%)	3 (30%)	7 (70%)	2 (20%)	3 (30%)	5 (50%)	10 (100%)	0	5:5	2 (20%)	4 (40%)	4 (40%)
Weakness (12)	1 (8.3%)	5 (41.6%)	1 (8.3%)	4 (33.3%)	1 (8.3%)	3 (25%)	9 (75%)	2 (16.6%)	2 (16.6%)	8 (66.6%)	10 (83.3%)	2 (16.6%)	7:5	1 (8.3%)	8 (66.6%)	3 (25%)
Fatigue (22)	6 (27.7%)	8 (36.6%)	3 (13.6%)	2 (9.1%)	3 (13.6%)	5 (22.7%)	17 (77.2%)	5 (22.7%)	6 (27.7%)	11 (50%)	19 (86.3%)	3 (13.6%)	8:14	1 (4.5%)	16 (72.7%)	5 (22.7%)
Anxiety (8)	2 (25%)	4 (50%)	0	2 (25%)	0	3 (37.5%)	5 (62.5%)	2 (25%)	2 (25%)	4 (50%)	6 (75%)	2 (25%)	4:4	0	6 (75%)	2 (25%)
Depression (10)	1 (10%)	6 (60%)	0	3 (30%)	0	2 (20%)	8 (80%)	2 (20%)	3 (30%)	4 (40%)	8 (80%)	2 (20%)	5:5	0	7 (70%)	3 (30%)
Altered Sensation (22)	3 (13.6%)	10 (45.4%)	0	7 (31.8%)	2 (9.1%)	3 (13.6%)	19 (86.3%)	6 (27.7%)	10 (45.4%)	6 (27.7%)	18 (81.8%)	4 (18.2%)	8:14	2 (9.1%)	17 (77.2%)	3 (13.6%)