BMJ Open 2024 (Nov 19); 14 (11): e083509

Table 3. Proportion of total effect mediated by individual mediators and combined.

Model outcome	Mediator(s)	Estimate	SE	95% CI	P value
Physical function	Pain interference	0.57	0.27	0.31 to 1.20	0.002
	Pain intensity	0.84	1.22	0.50 to 2.29	0.004
	Combined	0.77	3.68	0.43 to 2.00	0.006
Fatigue	Pain interference	0.36	0.20	0.18 to 0.91	<0.001
	Pain intensity	0.57	0.63	0.35 to 1.72	0.006
	Combined	0.62	1.09	0.30 to 1.65	0.002
Sleep disturbance	Pain interference	0.34	22.64	0.14 to 0.76	0.004
	Pain intensity	0.73	0.60	0.32 to 1.76	0.008
	Combined	0.49	3.42	0.31 to 1.49	0.008
Social roles	Pain interference	0.45	0.31	0.25 to 1.13	<0.001
	Pain intensity	0.94	0.72	0.53 to 2.22	<0.001
	Combined	0.81	0.71	0.50 to 1.97	0.004