Fig. 2.

B-vitamin treatment significantly reduces regional loss of GM (P < 0.05 FWE-corrected). (A) Brain regions in blue demonstrate where B-vitamin treatment significantly reduces GM loss over the 2-y period (x = 26 and −8, y = −34 and −52, z = 0 and −16). All blue areas correspond to regions of significant loss in placebo and known to be vulnerable in AD (Fig. 1). (B) Percentage of GM loss for the 156 participants over the 2-y period, averaged across those brain regions that showed significant effect of B vitamins: placebo group (red triangles) had an average loss of 3.7% (±3.7), whereas the B-vitamin group (green circles) showed a loss of 0.5% (±2.9).