Fig. 3.

B-vitamin treatment is only effective in participants with higher tHcy levels (P < 0.05 FWE-corrected). (A) Brain regions in green demonstrate where B-vitamin treatment significantly reduces GM loss in participants with high tHcy levels (>11.06 μmol/L) at baseline (x = 26 and −8, y = −34 and −52, z = 0 and −16). (B) Percentage of GM loss for each of the 77 participants with high tHcy level: placebo group (n = 35) showed an average loss of 5.2% (±3.4) of GM volume over 2 y, whereas B-vitamin group (n =42) showed an average loss of 0.6% (±2.1).