| PMC full text: | Published online 2014 Nov 18. doi: 10.3390/nu6115184
|
Table 3
n-3 PUFA and breast cancer risk: Xenograft rodent models.
| Animal Model | n-3 PUFA Source | Feeding Period | Main Findings | Mechanism | Reference |
|---|---|---|---|---|---|
| Athymic nu/nu mice MDA-MB 231 | 3% w/w fish oil concentrate (10.2 g/kg EPA, 7.2 g/kg DHA, 3.0 g/kg ALA) | 7-week (fed after tumor established) | ↓ tumor growth rate ↑ effectiveness of doxorubucin | ↑ EPA incorporation into tumor ↑ lipid peroxidation in tumor | [30] |
| Athymic nu/nu mice (NCr-nu/nu) MDA-MB 435 | 40 or 80 g/kg EPA, DHA | 13-week (fed before transplantation) | ↓ tumor growth, size ↓ tumor weight | ↑ EPA, DHA in tumor phospholipids ↓ LA, AA in tumor phospholipids ↓ AA-derived eicosanoids | [20] |
| Inbred F44 rats R3230AC | 5% marine oil supplementation (18% EPA, 12% DHA) | 4-week (fed before transplantation) | ↓ tumor weight, volume | ↑ EPA, DHA, AA incorporation into tumor ↓ Prostaglandins 2 series | [112] |
| BALB/cAnN mice Mouse BC cell | 10% or 20% w/w menhaden fish oil | 7-week (fed before transplantation) | ↑ tumor latency ↓ tumor growth rate | NA | [114] |
| Athymic nude mice MCF-7 | 19% w/w menhaden oil (1.9 g/kg ALA, 19.4 g/kg EPA, 24.3 g/kg DHA) | 6 or 8-week (fed after tumor established) | ↓ tumor volume | ↑ lipid peroxidation in tumor | [113] |
↓: decrease;
NA: not available.