Figure 4

Interdependent molecular-, cell-, and tissue-level dynamics in wound repair and regeneration

The shown schematics illustrate reversible, EMT-like, structural/metabolic/signaling transitions that enable wound repair, regeneration, and adaptability of multicellular architectures. The success or failure of tissue repair, adaptation, and plasticity depends on the reversible dynamics that take place at the molecular-, cell-, and tissue levels of organization in an interdependent manner.