Figure 8

The Alzheimer's disease susceptibility network

Products of the AD susceptibility genes and products of the genes that are differentially methylated in AD patients form a “tightly-knit” protein interaction cluster, being interconnected via at most one shared interacting partner. The resulting AD susceptibility network is discussed in the text.

Brief descriptions of the proteins circled red are given in Table 2

Underlined proteins are discussed in the text.

Adapted from [129] by permission from Macmillan Publishers Ltd: Nature Neuroscience; De Jager, PL et al., Nat Neurosci 17(9):1156-63; ©2014.