Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence

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Published online 2009 Jun 26. doi: 10.1186/1750-1326-4-27

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Table 1

Comparison of the apoptotic caspases.

Caspase	Group	Cleavage Preference¹	Prodomain	Comments
Caspase-2	Initiator	DAVAD	CARD
Caspase-3	Executioner	DEVD	Short
Caspase-6	Executioner	VEVD	Short	Implicated in neurite retraction [4]
Caspase-7	Executioner	DEVD	Short
Caspase-8	Initiator	IETD	DED	Extrinsic pathway
Caspase-9	Initiator	LEHD	CARD	Intrinsic pathway
Caspase-10	Initiator	(similar to caspase-8)	DED	Extrinsic pathway

1. Note that preferences do not exclude cleavage at other sites with Asp in the P1 position, and that the P1' position is also important (see text).