Reversal of cognitive decline: A novel therapeutic program

doi:10.18632/aging.100690

Table 2

Summary of patients treated with the therapeutic system described

Patient	History, evaluation	Diagnosis	Status
67F 3/3	2yr memory ⇓; FH+	aMCI	Normal x 2.5 yrs; working
69M 4/3	12yr memory ⇓; FDG-PET+, NPsych+	Early AD	“Clearly improved;” working
70M 4/3	4yr memory ⇓; NPsych+, failed MemTrax	AD	Improved; MemTrax passed
75M 3/3	1yr memory ⇓	SCI	Improved; working
75F C677T	1yr memory ⇓	aMCI/early AD	Improved
55F 3/3	4yr memory ⇓	aMCI/early AD	Normal; working
72M 3/3	7yr memory ⇓	aMCI	Improved; working
55M 4/3	2yr memory ⇓	SCI	Normal; working
63F 4/3	FH dementia, mild memory ⇓	SCI	Normal, negative amyloid PET; working
60F 4/3	4yr rapid decline; MoCA 6, amyloid PET+	Late AD	Decline

F, female; M, male; 3/3, ApoE 3/3; 4/3, ApoE 4/3; C677T, the C677T mutation in methylene tetrahydrofolate reductase (MTHFR); FH, family history; aMCI, amnestic mild cognitive impairment; SCI, subjective cognitive impairment; FDG-PET+, fluorodeoxyglucose positron emission tomography interpreted as typical of Alzheimer's disease; amyloid PET+, amyloid PET scan read as abnormal, indicative of amyloid accumulation; NPsych+, quantitative neuropsychology tests showing abnormalities typical of AD; MoCA, Montreal Cognitive Assessment; MemTrax, an iPhone application that quantitates memory.