Figure 3

Changes in 4 Secondary Outcomes During the 4-Year Study Period, Compared With Baseline

Data are least squares means at each time point. Values have been adjusted for baseline scores as a fixed effect and the study site as a random effect. For between-group comparisons of scores on the the Mini-Mental State Examination (MMSE) (A), lower scores indicate worse functioning. For comparisons of the Alzheimer Disease Assessment Scale–Cognitive portion (ADAS-cog) (B), Neuropsychiatric Inventory (C), and the Caregiver Activity Survey (D), higher scores indicate worse functioning. Error bars indicate 95% CIs.