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Parameter	1 week (SD)	2 weeks (SD)	4 weeks (SD)	8 weeks (SD)	12 weeks (SD	16 weeks (SD)
Osteophytes/animal	2.5 (0.7)	3.3 (0.6)	3.7 (0.6)	4.0 (N/A)	4.0 (0.0)	4.0 (0.0)
Severity osteophytes	0.8 (0.4)	1.3 (0.4)	1.6 (0.3)	1.5 (N/A)	1.9 (0.9)	2.8 (0.1)
ASD/animal	5.0 (0.0)	6.3 (1.5)	6.7 (1.5)	8.0 (N/A)	7.3 (1.2)	8.0 (0.0)
Severity ASD	0.9 (0.4)	1.3 (0.5)	1.5 (0.7)	2.1 (N/A)	2.3 (0.6)	2.3 (0.6)

ASD, articular surface degeneration.