Table 2
Primary outcomes main analysis and by risk subgroup at 6-month follow-up
| Pre-intervention period | Post-intervention period | Difference | 95% CI | |||||
|---|---|---|---|---|---|---|---|---|
| N | Change | 95% CI | N | Change | 95% CI | |||
| Function (RMDQ) | ||||||||
| Main analysis | ||||||||
| Control clinics | 297 | − 3.33 | (− 4.18, − 2.49) | 546 | − 3.89 | (− 4.64, − 3.14) | − 0.55 | (− 1.26, 0.15) |
| Intervention clinics | 245 | − 3.98 | (− 4.86, − 3.09) | 428 | − 4.03 | (− 4.81, − 3.25) | − 0.05 | (− 0.83, 0.73) |
| Difference | − 0.64 | (− 1.86, 0.58) | − 0.14 | (− 1.22, 0.94) | 0.50 | (− 0.55, 1.55) | ||
| P value | 0.349 | |||||||
| Subgroup, low risk | ||||||||
| Control clinics | 122 | − 5.18 | (− 5.98, − 4.39) | 234 | − 5.75 | (− 6.37, − 5.12) | − 0.56 | (− 1.42, 0.29) |
| Intervention clinics | 109 | − 5.60 | (− 6.41, − 4.78) | 170 | − 5.60 | (− 6.29, − 4.91) | − 0.01 | (− 0.94, 0.93) |
| Difference | − 0.41 | (− 1.48, 0.65) | 0.14 | (− 0.70, 0.98) | 0.56 | (− 0.71, 1.82) | ||
| P value | 0.389 | |||||||
| Subgroup, moderate risk | ||||||||
| Control clinics | 108 | − 3.54 | (− 5.11, − 1.97) | 203 | − 3.90 | (− 5.30, − 2.50) | − 0.36 | (− 1.61, 0.89) |
| Intervention clinics | 88 | − 3.34 | (− 4.98, − 1.70) | 165 | − 3.77 | (− 5.21, − 2.32) | − 0.43 | (− 1.82, 0.96) |
| Difference | 0.20 | (− 2.06, 2.46) | 0.13 | (− 1.86, 2.13) | − 0.06 | (− 1.94, 1.81) | ||
| P value | 0.946 | |||||||
| Subgroup, high risk | ||||||||
| Control clinics | 67 | − 1.42 | (− 3.33, 0.49) | 109 | − 2.49 | (− 4.15, − 0.82) | − 1.07 | (− 2.92, 0.79) |
| Intervention clinics | 48 | − 3.78 | (− 5.82, − 1.74) | 93 | − 3.09 | (− 4.77, − 1.41) | 0.69 | (− 1.46, 2.84) |
| Difference | − 2.36 | (− 4.77, 0.05) | − 0.60 | (− 2.48, 1.27) | 1.76 | (− 1.10, 4.62) | ||
| P value | 0.229 | |||||||
| Pain intensity | ||||||||
| Main analysis | ||||||||
| Control clinics | 297 | − 1.64 | (− 1.94, − 1.34) | 534 | − 1.96 | (− 2.20, − 1.72) | − 0.32 | (− 0.66, 0.01) |
| Intervention clinics | 245 | − 1.81 | (− 2.13, − 1.48) | 415 | − 2.00 | (− 2.26, − 1.74) | − 0.19 | (− 0.56, 0.18) |
| Difference | − 0.17 | (− 0.61, 0.27) | − 0.039 | (− 0.39, 0.31) | 0.13 | (− 0.37, 0.63) | ||
| P value | 0.61 | |||||||
| Subgroup, low risk | ||||||||
| Control clinics | 122 | − 2.13 | (− 2.54, − 1.72) | 228 | − 2.25 | (− 2.56, − 1.94) | − 0.12 | (− 0.59, 0.35) |
| Intervention clinics | 109 | − 2.27 | (− 2.69, − 1.85) | 168 | − 2.42 | (− 2.78, − 2.07) | − 0.15 | (− 0.66, 0.36) |
| Difference | − 0.14 | (− 0.69, 0.41) | − 0.173 | (− 0.59, 0.25) | − 0.03 | (− 0.72, 0.66) | ||
| P value | 0.926 | |||||||
| Subgroup, moderate risk | ||||||||
| Control clinics | 108 | − 1.59 | (− 2.23, − 0.95) | 200 | − 1.93 | (− 2.48, − 1.38) | − 0.34 | (− 0.91, 0.23) |
| Intervention clinics | 88 | − 1.47 | (− 2.14, − 0.79) | 157 | − 1.79 | (− 2.37, − 1.21) | − 0.33 | (− 0.97, 0.32) |
| Difference | 0.13 | (− 0.80, 1.05) | 0.14 | (− 0.65, 0.93) | 0.02 | (− 0.85, 0.88) | ||
| P value | 0.973 | |||||||
| Subgroup, high risk | ||||||||
| Control clinics | 67 | − 0.74 | (− 1.55, 0.07) | 106 | − 1.54 | (− 2.24, − 0.84) | − 0.8 | (− 1.62, 0.03) |
| Intervention clinics | 48 | − 1.6 | (− 2.47, − 0.73) | 90 | − 1.54 | (− 2.25, − 0.82) | 0.06 | (− 0.89, 1.01) |
| Difference | − 0.86 | (− 1.88, 0.17) | 0.002 | (− 0.79, 0.79) | 0.86 | (− 0.41, 2.12) | ||
| P value | 0.183 | |||||||