Adequate method of randomization | 57 | 43.5% |
Adequate method of allocation concealment | 41 | 31.3% |
Similarity at baseline regarding the most important prognostic indicators | 89 | 67.9% |
Appropriate patient blinding to the intervention | 30 | 22.9% |
Appropriate care provider blinding to the intervention | 4 | 3.1% |
Appropriate outcome assessor blinding to the intervention | 66 | 50.4% |
Similar or no cointerventions between-groups | 40 | 30.5% |
Acceptable compliance in all groups | 53 | 40.5% |
Described and acceptable drop-out rates | 99 | 75.6% |
Similarity of timing of the outcome assessment in all groups | 118 | 90.1% |
Inclusion of an intention-to-treat analysis | 57 | 45.5% |
Absence of selective outcome reporting | 78 | 59.5% |
Absence of other potential bias | 7 | 5.3% |
|
Total risk of bias scores (max 13); median (IQR) | 6 | 4–7 |