PMC full text: | Published online 2011 Nov 24. doi: 10.1155/2012/953139
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Table 3
Duration and cause of pain | Outcomes | GRADE* | Findings |
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Acupuncture versus no treatment | |||
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Acute/subacute, chronic, and mixed, (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Unknown specific | Pain intensity score (SF-MPQ) |
Low
Design: RCT ROB: Medium Consistency: NA (only 1 trial) Directness: yes | In one trial [75], acupuncture was significantly better than no treatment in reducing pain intensity short-term after the end of treatment (mean change: −15.2 ± 13.3 versus −5.3 ± 8.7, P = 0.043). |
| |||
Unknown nonspecific | NA |
Insufficient
No trial | NA |
| |||
Acupuncture versus placebo | |||
| |||
Acute/subacute specific, nonspecific | NA |
Insufficient
No trial | NA |
| |||
Chronic specific | Pain intensity score (VAS) |
Moderate
Design: RCT ROB: Medium Consistency: yes Directness: yes Precision: yes | In three trials, acupuncture [77, 209] or dry needling [78] was similar to sham acupuncture [77] or laser acupuncture [78, 209] immediately or at short term after the treatment. In one of these trials [78], posttreatment mean VAS values in dry needling and sham laser acupuncture groups were 29.2 (±21.9) and 28.0 (±19.4), respectively. The meta-analysis of two trials indicated no significant difference between acupuncture and placebo immediately after the end of treatment (pooled mean difference: 0.27, 95% CI: −0.60, 1.13) [79]. See Figure 6. |
NDI score |
Low
Design: RCT ROB: Medium Consistency: NA (only 1 trial) Directness: yes | In one trial [77], the mean disability score was not significantly different between acupuncture and sham-acupuncture groups immediately posttreatment (5.5 ± 4.5 versus 6.2 ± 3.1, P = 0.52). | |
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Chronic nonspecific | Pain intensity score (VAS) |
Low
Design: RCT ROB: Medium Consistency: no Directness: yes Precision: yes | The meta-analysis of three trials showed no significant difference between acupuncture and sham-acupuncture immediately posttreatment (pooled mean difference: −0.24, 95% CI: −1.20, 0.73) [80–82] (See Figure 6). Trials comparing acupuncture to other types of placebos (e.g., TENS, drug) [83, 85–87, 210] could not be pooled due to heterogeneity across outcomes, followup periods, or missing data. |
NDI score |
Moderate
Design: RCT ROB: Low Consistency: NA (only 1 trial) Directness: yes | In one trial [83, 210], intermediate posttreatment mean disability was significantly reduced in acupuncture compared to placebo group (8.89 ± 6.57 versus 10.72 ± 9.11, P < 0.05). | |
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Mixed specific | Pain intensity score (VAS) |
Low
Design: RCT ROB: High Consistency: NA (only 1 trial) Directness: yes | In one trial [88], there was no significant difference between acupuncture and placebo (laser pen) at intermediate-term posttreatment followup (2.59 ± 2.18 versus 2.89 ± 2.63, P > 0.05). |
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Mixed nonspecific | NA |
Insufficient
No trial | NA |
| |||
Unknown specific | No pain or disability outcome reported | NA | One trial [27] reporting % subjects without symptoms. |
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Unknown nonspecific | NA |
Insufficient
No trial | NA |
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Acupuncture versus pain medication | |||
| |||
Acute/subacute, mixed (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Chronic specific | Pain intensity score (VAS, SF-MPQ) |
Low
Design: RCT ROB: High Consistency: no Directness: yes | Of the three trials [89–91] comparing acupuncture to medications, in two [89, 90] there was no significant difference between acupuncture and injection of lidocaine [89, 90], lidocaine plus corticoid [90], or botulinum toxin [90] at short-term posttreatment followup. In one of the trials [89], two-week posttreatment mean VAS values were 3.82 ± 2.47 for acupuncture and 3.46 ± 2.47 for lidocaine (P > 0.05). In another trial [91], acupuncture was better than NSAIDs immediately after treatment (mean VAS score: 1.87 ± 1.90 versus 4.76 ± 2.05, P < 0.05). |
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Chronic nonspecific | Pain intensity score (VAS) |
Low
Design: RCT ROB: High Consistency: yes Directness: yes | None of three trials comparing acupuncture to medication (e.g., NSAIDs, analgesics) demonstrated significant between-group differences [69, 70, 87]. In one of the trials [69], acupuncture had a better mean score versus pain medication group at immediate (mean VAS score: 4.0 ± 4.4 versus 6.0 ± 4.4) or at intermediate-term followup (mean VAS score: 2.5 versus 4.7) [69, 72]. |
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Unknown specific | Pain intensity score (VAS, SF-MPQ) |
Low
Design: RCT ROB: High Consistency: yes Directness: yes | In two trials [28, 92], acupuncture was significantly more effective than injection of lidocaine in the short-term. In one trial [28], the mean pain scores were 5.71 ± 2.49 versus 6.91 ± 3.22 (P < 0.05). |
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Unknown nonspecific | NA |
Insufficient
No trial | NA |
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Acupuncture versus physiotherapy | |||
| |||
Acute/subacute, chronic, mixed, or unknown (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Acupuncture versus mobilization | |||
| |||
Acute/subacute, mixed, or unknown (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Chronic specific | NA |
Insufficient
No trial | NA |
| |||
Chronic nonspecific | Pain intensity score (VAS) |
Low
Design: RCT ROB: Medium Consistency: NA (only 1 trial) Directness: yes | In one trial [93], there was no significant difference between acupuncture and standard localized mobilization techniques at short- or intermediate-term posttreatment followup (no numerical data on mean scores were reported). |
Disability (NPQ score) |
Low
Design: RCT ROB: Medium Consistency: NA (only 1 trial) Directness: yes | In one trial [93], there was no significant difference between acupuncture and standard localized mobilization techniques at short- or intermediate-term posttreatment followup (no numerical data on mean scores were reported). | |
| |||
Acupuncture versus usual care | |||
| |||
Acute/subacute, mixed, or unknown (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Chronic specific | NA |
Insufficient
No trial | NA |
| |||
Chronic nonspecific | Disability (NPQ score) |
Low
Design: RCT ROB: Medium Consistency: NA (only 1 trial) Directness: yes | In one trial [94], acupuncture was added to general practice care and showed no difference in disability (NPQ) compared to general practice care alone immediately posttreatment (22.73 ± 18.64 versus 25.72 ± 16.29, P > 0.05). |
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Acupuncture versus manipulation | |||
| |||
Acute/subacute, mixed, or unknown (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Chronic specific | Pain intensity score (VAS) |
Low
Design: RCT ROB: High Consistency: NA (only 1 trial) Directness: yes | In one trial [24], there was no significant difference between acupuncture and spinal manipulation at short-term followup (mean VAS: 4.46 ± 3.11 versus 4.43 ± 2.51). |
| |||
Chronic nonspecific | Pain intensity score (mean % VAS) |
Low
Design: RCT ROB: High Consistency: no Directness: yes | In one trial [69], acupuncture was better than manipulation in reducing pain intensity at short-term followup (50.0% versus 42.0%). In another trial [70], immediate posttreatment reduction in pain intensity was significantly greater in manipulation (VAS: 33.0%) versus acupuncture (VAS score % reduction not reported). |
Pain intensity score (VAS) |
Low
Design: RCT ROB: High Consistency: NA (only 1 trial) Directness: yes | In one trial [69, 72], median pain intensity scores in the acupuncture and manipulation groups did not differ at intermediate-term followup (VAS median scores: 2.5 versus 2.8, P = NR). | |
Disability score (NDI) |
Low
Design: RCT ROB: High Consistency: yes Directness: yes | Two trials demonstrated significant superiority of manipulation over acupuncture in improving neck disability. In the first trial [70], median NDI score reduction in neck disability immediately posttreatment was significantly greater in manipulation (−10.0, 95% CI: −14.0, −4.0) than acupuncture group (−6.0, 95% CI: −16.0, 2.0). In the second trial [69], the posttreatment NDI values were significantly more improved in manipulation (median: 22; range: 2–44) than acupuncture group (median: 30; range: 16–47); P value not reported. | |
| |||
Acupuncture versus massage | |||
| |||
Acute/subacute, mixed, or unknown (specific, nonspecific) | NA |
Insufficient
No trial | NA |
| |||
Chronic specific | Pain intensity score (VAS) |
Low
Design: RCT ROB: High Consistency: NA (only 1 trial) Directness: yes | In one trial [209], acupuncture was significantly better (VAS score scale: 0–100) compared to massage in a short-term posttreatment followup (mean VAS score change from baseline: 24.22 versus 7.89, P = 0.005). |
| |||
Chronic nonspecific | NA |
Insufficient
No trial | NA |
*Precision in formal grading was applied only to pooled results.
VAS: visual analog scale; RMDQ: Roland-Morris disability scale; NHP: Nottingham health profile; MPQ: McGill pain questionnaire; PDI: pain disability index; SF: short form; NPQ: neck pain questionnaire; SF-PQ: short form pain questionnaire; PRI: pain rating index; PPI: present pain intensity; NA: not applicable; NDI: neck disability index.