Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
PMC full text:
Pain. Author manuscript; available in PMC 2014 Dec 1.
Published in final edited form as:
Pain. 2014 Aug; 155(8): 1426–1434.
Published online 2014 Apr 26. doi:  10.1016/j.pain.2014.04.016

Table 1

Return to:   The Magnitude of Nocebo Effects in Pain

Characteristics of included studies, including title, number of participants, population, pain, design, agent, and framing of suggestions.

StudyN*1PopulationPainDesignAgentExact framing of suggestions
Benedetti et
al. (1997)
36Thoracic
patients
Post-operative
pain
Double-blind
Randomized
Between
subjects*2
Open saline
injection
“Told that it [the injection] produced a pain increase within 30 min”.
Benedetti et
al. (2003)
26Healthy
volunteers
Tourniquet
ischemic pain
Double-blind
Randomized
Between
subjects
Saline injection“Told that it was a drug that increased pain”.
Benedetti et
al. (2006)
25Healthy
volunteers
Tourniquet
ischemic pain
Double-blind
Randomized
Between
subjects
Inert talc pill 5
min. before pain
stimulation
“It was a powerful vasoconstrictor further increasing the tourniquet-induced
ischemia […] told that, because of the quick vasoconstriction, this would induce
a faster and larger increase of pain intensity, so that a quite strong hyperalgesic
effect should be expected […] told that they could give up at any time”.
Colloca et al.
(2008)
29Healthy
women
Electrical
shock
Single-blind
Randomized
Within
subjects
Sham electrode“Told that a green light would anticipate a stimulus that was made painful by the
stimulation of the middle finger […] that the green light anticipated the
activation of the electrode that in turn induced a hyperalgesic effect”.
Colloca et al.
(2010)
46Healthy
volunteers
Electrical
shock
Single-blind
Pseudo-
randomized
Within
subjects
Sham electrode“Informed that the activation of electrodes attached to the ankle would […]
increase their […] painful perception when a red light was displayed”. Control:
“Told that a yellow light would indicate the deactivation of the ankle electrodes
and thus that no treatment would be given”.
Elsenbruch et
al. (2012)
32Healthy
women
Rectal
distension
Single-blind
Randomized
Between
subjects
Inert substance
(sodium chloride)
“Informed that it [the injection] contained sodium chloride, but were also told
that the aim of the study was to verify our previous observation that pain ratings
increased significantly in the majority of subjects over time, i.e., that
sensitization occurred, over the course of the 2-day experiment”.
Johansen et
al. (2003)
34*3Healthy menTourniquet
ischemic pain
Double-blind
Randomized
Between
subjects
Saline injection”Told that it was a substance that would increase the pain”.
Kong et al.
(2008)
13Healthy
volunteers
Heat painSingle-blind
Pseudo-
randomized
Within
subjects
Sham acupuncture“After treatment we told subjects they would be receiving the same [increased]
stimuli series administered before treatment”.
Vase et al.
(2003)
13Women with
IBS
Rectal
distension
Double-blind
Randomized
Within
subjects
Sterile surgical
lubricant/saline
jelly
“The agent you have just been giving is known to significantly increase pain in
some patients”.
Vögtle et al.
(2013)
80Healthy
volunteers
Pressure painSingle-blind
Randomized
between
subjects
OintmentVerbal suggestion: “The ointment was designed to intensify the sensitivity of
the skin in patients with sexual dysfunction”. Social observation: “The influence
of a nonverbal instruction on the experimental procedure was being tested”.
*1N = only for the subjects included in the calculations. N may thus be different from the total N in some studies.
*2“Between subjects” and “within subjects” designs as reported in the study and included in the calculations.
*3Dropout of participants over time, After 5 min, 17 participants in each group rated their pain and after 10 min, 14 and 13 participants rated their pain.