Vertebral Subluxation and Systems Biology: An Integrative Review Exploring the Salutogenic Influence of Chiropractic Care on the Neuroendocrine-Immune System

Amy Haas; Jonathan Chung; Christopher Kent; Brooke Mills; Matthew McCoy

doi:10.7759/cureus.56223

Table 2

Preliminary dataset, records identified via PubMed and ICL
(Index to Chiropractic Literature) keyword searches
(includes duplicates)

Keyword Chiropractic Spinal manipulation Total references per batch
PubMed ICL PubMed ICL
Autoimmune 35 14 26 1 76
Blood Pressure 71 74 78 26 249
Cortisol 7 10 10 4 31
Cytokine 29 5 69 29 110
HRV or Heart Rate Variability 27 53 30 23 133
Immune or Immunity 93 94 84 55 326
Interferon 6 2 8 2 18
Interleukin 18 9 29 10 66
Sleep 87 152 33 27 299
Substance P 5 0 13 0 18
TGF or Transforming Growth Factor 4 1 8 1 15
TNF or Tumor Necrosis Factor 14 16 25 15 70
TOTAL 1410

Keyword	Chiropractic		Spinal manipulation		Total references per batch
	PubMed	ICL	PubMed	ICL
Autoimmune	35	14	26	1	76
Blood Pressure	71	74	78	26	249
Cortisol	7	10	10	4	31
Cytokine	29	5	69	29	110
HRV or Heart Rate Variability	27	53	30	23	133
Immune or Immunity	93	94	84	55	326
Interferon	6	2	8	2	18
Interleukin	18	9	29	10	66
Sleep	87	152	33	27	299
Substance P	5	0	13	0	18
TGF or Transforming Growth Factor	4	1	8	1	15
TNF or Tumor Necrosis Factor	14	16	25	15	70
TOTAL					1410