Table 1
Cohort Selection Flow Chart for Patients With Low Back Pain
Criteria Number of Individuals Number of Individuals Lost Individuals with low-back pain as primary or secondary diagnosis between July 1, 2013, and June 30, 2017, in a visit with primary care physicians, urgent care, or emergency department (index date) 253,388 Not applicable Individuals with no opioid prescription in 6 mo before the index date (baseline) 86,903 166,485 Individuals with no low-back pain diagnosis in baseline (incident diagnosis) 77,476 9,427 Individuals with continuous enrollment in baseline 70,762 6,714 Individuals with continuous enrollment in the 12 mo post–index date (follow-up period) 68,242 2,520 Individuals ≥18 y of age on index date 58,590 9,652 Individuals ≤63 y of age on index date 50,454 8,136 Individuals with both medical and pharmacy benefits and non-Medicare insurance in the study period 47,864 2,590 Individuals without cancer in the baseline 46,759 1,105 Individuals without osteomyelitis, cauda equina, lumbar/pelvic fracture, and quadriplegia/paraplegia in the baseline 46,599 160 Individuals without cancer in the follow-up period 44,890 1,709 Individuals without osteomyelitis, cauda equina, lumbar/pelvic fracture, and quadriplegia/paraplegia in the follow-up period 44,105 785 Individuals without buprenorphine-naloxone as the first opioid prescription after the index date 44,084 21 Individuals without missing/unknown sex 40,929 3,155