Table 1

Cohort Selection Flow Chart for Patients With Low Back Pain

CriteriaNumber of IndividualsNumber of Individuals Lost
Individuals with low-back pain as primary or secondary diagnosis between July 1, 2013, and June 30, 2017, in a visit with primary care physicians, urgent care, or emergency department (index date)253,388Not applicable

Individuals with no opioid prescription in 6 mo before the index date (baseline)86,903166,485

Individuals with no low-back pain diagnosis in baseline (incident diagnosis)77,4769,427

Individuals with continuous enrollment in baseline70,7626,714

Individuals with continuous enrollment in the 12 mo post–index date (follow-up period)68,2422,520

Individuals ≥18 y of age on index date58,5909,652

Individuals ≤63 y of age on index date50,4548,136

Individuals with both medical and pharmacy benefits and non-Medicare insurance in the study period47,8642,590

Individuals without cancer in the baseline46,7591,105

Individuals without osteomyelitis, cauda equina, lumbar/pelvic fracture, and quadriplegia/paraplegia in the baseline46,599160

Individuals without cancer in the follow-up period44,8901,709

Individuals without osteomyelitis, cauda equina, lumbar/pelvic fracture, and quadriplegia/paraplegia in the follow-up period44,105785

Individuals without buprenorphine-naloxone as the first opioid prescription after the index date44,08421

Individuals without missing/unknown sex40,9293,155