Chen S, Chen M, Wu X, Lin S, Tao C, Cao H, et al.
Global, Regional and National Burden of Low Back Pain
1990-2019: A Systematic Analysis of the Global
Burden of Disease Study 2019
J Orthop Translat 2021 (Sep 10); 32: 49–58
GBD 2019 Diseases and Injuries Collaborators.
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019:
a systematic analysis for the Global Burden of Disease Study 2019.
Lancet. 2020; 396: 1204-1222
Dieleman JL, Cao J, Chapin A, et al.
US Health Care Spending by Payer and Health Condition, 1996-2016
JAMA 2020 (Mar 3); 323 (9): 863–884
Clinical practice guidelines for the management of
non-specific low back pain in primary care: an updated overview.
Eur Spine J. 2018; 27: 2791-2803
Guideline summary review: an evidence-based clinical guideline
for the diagnosis and treatment of low back pain.
Spine J. 2020; 20: 998-1024
Qaseem A, Wilt TJ, McLean RM, Forciea MA;
Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain:
A Clinical Practice Guideline From the American College of Physicians
Annals of Internal Medicine 2017 (Apr 4); 166 (7): 514–530
National Institute for Health and Care Excellence (NICE):
Low Back Pain and Sciatica in Over 16s: Assessment and Management (PDF)
NICE Guideline, No. 59 2016 (Nov): 1–1067
Cardiovascular risk of nonsteroidal anti-inflammatory drugs:
an under-recognized public health issue.
Cureus. 2017; 9: e1144
Global patterns of opioid use and dependence:
harms to populations, interventions, and future action.
The Lancet. 2019; 394: 1560-1579
Fischhoff B, Brewer NT, Downs JS.
Communicating risks and bnefits: an evidence-based user's guide. 2018. Available at:
Benefits and risks of drug treatments: how to combine the best evidence
on benefits with the best data about adverse effects.
JAMA. 2008; 300: 2417-2419
van Tulder M
Implementation barriers for general practice guidelines on
low back pain. a qualitative study.
Spine. 2001; 26: E348-E353
Nonpharmacologic and pharmacologic management of acute pain from non-low back,
musculoskeletal injuries in adults: a clinical guideline from the
American College of Physicians and American Academy of Family Physicians.
Ann Intern Med. 2020; 173: 739-748
van Tulder MW
Non-steroidal anti-inflammatory drugs for chronic low back pain.
Cochrane Database Syst. Rev. 2016; 2CD012087
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.
BMJ. 2021; 372: n71
Methods for benefit and harm assessment in systematic reviews.
methods research report. (Prepared by the Johns Hopkins University
Evidence-based Practice Center under contract No. 290-2007-10061-I).
AHRQ Publication No. 12(13)-EHC150-EF.
Agency for Healthcare Research and Quality, Rockville, MD2012
Conway J, Federico F, Stewart K, Campbell MJ.
Respectful management of serious clinical adverse events (Second Edition).
IHI Innovation Series white paper. 2011. Cambridge, Massachusetts
Food and Drug Administration (FDA)
What is a Serious Adverse Event? 2018. Available at:
Editorial Board of the Cochrane Back, Neck Group
updated method guidelines for systematic reviews in the
Cochrane Back and Neck Group.
Spine. 2015; 40: 1660-1673
Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. (editors).
Cochrane Handbook for Systematic Reviews of Interventions version 6.2 2021.
Cochrane, 2021. Available at:
Evidence-based resources simplified.
Can Fam Physician. 2008; 54: 241-243
Evidence-based practice in therapeutic health care.
in: Liamputtong P. Research Methods in Health:
Foundations for Evidence-Based Practice. 2nd ed.
Oxford University Press, South Melbourne 2013
Statistical power analysis for the behavioral sciences.
Academic Press, New York 1977: 1-27
Von Korff M
Interpreting change scores for pain and functional status in low back pain:
towards international consensus regarding minimal important change.
Spine (Phila Pa 1976). 2008; 33: 90-94
European Medicine Agency.
European Commission: Enterprise and Industry Direcorate-General.
A guideline on summary of product characteristics (Summary of Product Characteristics). Available at:
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations.
BMJ. 2008; 336: 924-926
Les lombalgiques chroniques et manipulations vertébrales.
Étude prospective à propos de 64 cas.
Ann Readapt Med Phys. 2007; 50: 570-576
Efficacy and safety of thread embedding acupuncture combined with
acupuncture for chronic low back pain: a randomized,
controlled, assessor-blinded, multicenter clinical trial.
Medicine (Baltimore). 2020; 99: e22526
Pragmatic randomized trial evaluating the clinical and
economic effectiveness of acupuncture for chronic low back pain.
American J Epidemiol. 2006; 164: 487-496
Acupuncture in patients with chronic low back pain: a randomized controlled trial.
Arch Intern Med. 2006; 166: 450-457
Acupuncture for chronic low back pain: a multicenter, randomized,
patient-assessor blind, sham-controlled clinical trial.
Spine. 2013; 38: 549-557
German acupuncture trials (GERAC) for chronic low back pain:
randomized, multicenter, blinded, parallel-group
trial with 3 groups.
Arch Intern Med. 2007; 167: 1892-1898
Efficacy and safety of thread embedding acupuncture for
chronic low back pain: a randomized controlled pilot trial.
Trials. 2018; 19: 680
Acupuncture treatment of chronic low-back pain -
A randomized, blinded, placebo-controlled trial with 9-month follow-up.
Pain. 2002; 96: 189-196
Standardized versus individualized acupuncture for
chronic low back pain: a randomized controlled trial.
eCAM. 2013; 2013: 1
Osteopathic manual treatment and ultrasound therapy for
chronic low back pain: a randomized controlled trial.
Ann Fam Med. 2013; 11: 122-129
Treatment of chronic low back pain with etoricoxib, a new cyclo-oxygenase-2
selective inhibitor: improvement in pain and disability -
a randomized, placebo-controlled, 3-month trial.
J Pain. 2003; 4: 307-315
Van Hove I
Efficacy and safety of tapentadol extended release for the management
of chronic low back pain: results of a prospective, randomized,
double-blind, placebo- and active-controlled Phase III study.
Expert Opin Pharmacother. 2010; 11: 1787-1804
Analgesic tolerance without demonstrable opioid-induced hyperalgesia:
a double-blinded, randomized, placebo-controlled trial of
sustained-release morphine for treatment of chronic
non-radicular low-back pain.
Pain. 2012; 153: 1583-1592
Controlled-release oxycodone and naloxone in the treatment of
chronic low back pain: a placebo-controlled, randomized study.
Pain Res Manag. 2013; 18: 75-82
Buprenorphine transdermal system in adults with chronic low back pain:
a randomized, double-blind, placebo-controlled crossover
study, followed by an open-label extension phase.
Clin Ther. 2010; 32: 844-860
Efficacy and safety of flupirtine modified release for the management
of moderate to severe chronic low back pain: results of SUPREME,
a prospective randomized, double-blind, placebo- and
active-controlled parallel-group phase IV study.
Curr Med Res Opin. 2012; 28: 1617-1634
Oxytrex minimizes physical dependence while providing effective
analgesia: a randomized controlled trial in low back pain.
J Pain. 2006; 7: 937-946
Analgesic efficacy and safety of tramadol/acetaminophen combination
tablets (Ultracet) in treatment of chronic low back pain:
a multicenter, outpatient, randomized, double blind,
placebo controlled trial.
J Rheumatol. 2004; 31: 2454-2463
Tramadol/acetaminophen combination tablets for the treatment of
chronic lower back pain: A multicenter, randomized,
double-blind, placebo-controlled outpatient study.
Clin Ther. 2003; 25: 1123-1141
Randomized clinical trial of lumbar instrumental fusion and cognitive
intervention and exercises of patients with chronic low back pain
and disc degeneration.
Ann Rheum Dis. 2003; 62: 88-89
A prospective randomized analysis of spinal fusion and clinical outcome
parameters of titanium versus carbon composite rods for single-level
transforaminal lumbar interbody fusion: a 12 months follow up.
Eur Spine J. 2014; 23: 2477-2478
The long-term outcome of lumbar fusion in the Swedish lumbar spine study.
Spine J. 2016; 16: 579-587
Surgery with disc prosthesis versus rehabilitation in patients with
low back pain and degenerative disc: two year follow-up of randomised study.
BMJ. 2011; 342: d2786
A prospective randomised controlled trial to assess the efficacy of
dynamic stabilisation of the lumbar spine with the Wallis ligament.
Eur Spine J. 2014; 23: 2156-2160
A prospective, randomized, blinded, single-site study to evaluate
the clinical and radiographic differences between frozen and freeze-dried
allograft when used as part of a circumferential anterior
lumbar interbody fusion procedure.
Spine. 2009; 34: 1251-1256
Van de Kelft E
Van Goethem J.
Trabecular metal spacers as standalone or with pedicle screw augmentation,
in posterior lumbar interbody fusion: a prospective,
randomized controlled trial.
Eur Spine J. 2015; 24: 2597-2606
A randomized controlled trial with 5 years of follow-up comparing
minimally invasive and open transforaminal lumbar interbody
fusion in disc herniation at single level.
Exp Ther Med. 2019; 17: 3614-3620
A comparison of intraarticular lumbar facet joint steroid injections
and lumbar facet joint radiofrequency denervation in the treatment
of low back pain: a randomized, controlled, double-blind trial.
Anesth Analg. 2013; 117: 228-235
Evaluation of lumbar facet joint nerve blocks in the management of
chronic low back pain: preliminary report of a randomized,
double-blind controlled trial: clinical trial NCT00355914.
Pain Physician. 2007; 10: 425-440
Effect of facet joint injection versus systemic steroids
in low back pain: a randomized controlled trial.
Spine. 2013; 38: 1995-2002
Evidence of efficacy of acupuncture in the management of low back pain:
a systematic review and meta-analysis of randomised placebo- or sham-controlled trials.
Acupunct Med. 2020; 38: 15-24
Rubinstein SM, De Zoete A, Van Middelkoop M, Assendelft WJJ.
Benefits and Harms of Spinal Manipulative Therapy for the Treatment of
Chronic Low Back Pain: Systematic Review and Meta-analysis
of Randomised Controlled Trials
British Medical Journal 2019 (Mar 13); 364: 1689
Benefits and safety of gabapentinoids in chronic low back pain:
a systematic review and meta-analysis of randomized controlled trials.
PLoS Med. 2017; 14e1002369
Abdel Shaheed C
Efficacy, tolerability, and dose-dependent effects of opioid analgesics
for low back pain: a systematic review and meta-analysis.
JAMA Intern Med. 2016; 176: 958-968
SUcceSS, SUrgery for Spinal Stenosis:
protocol of a randomised, placebo-controlled trial.
BMJ Open. 2019; 9e024944
Abdel Shaheed C
The efficacy and safety of paracetamol for pain relief:
an overview of systematic reviews.
Med J Aust. 2021; 214: 324-331
Gabapentinoid use in the United States 2002 through 2015.
JAMA Intern Med. 2018; 178: 292-294
Trends in gabapentinoid prescribing, co-prescribing of opioids
and benzodiazepines, and associated deaths in Scotland.
Brit J Anaesth. 2020; 125: 159-167
Trends in first gabapentin and pregabalin prescriptions
in primary care in the United Kingdom, 1993-2017.
JAMA. 2018; 320: 2149-2150
Worsening trends in analgesics recommended for spinal pain in primary care.
Eur Spine J. 2018; 27: 1136-1145
Rising pregabalin use and misuse in Australia:
trends in utilization and intentional poisonings.
Addiction. 2019; 114: 1026-1034
Non-medical use of prescription gabapentinoids (gabapentin
and pregabalin) in five European countries.
Front Psychiatry. 2021; 12676224
Prevalence of and factors associated with gabapentinoid use
and misuse among Texas Medicaid recipients.
Clin Drug Invest. 2021; 41: 245-253
UK government to reclassify pregabalin and gabapentin after rise in deaths.
BMJ. 2017; 358: j4441
Gabapentin use, abuse, and the US opioid epidemic: the case for reclassification
as a controlled substance and the need for pharmacovigilance.
Risk Manag Healthc Policy. 2018; 11: 109-116
Barriers, facilitators and resources to opioid deprescribing in
primary care: experiences of general practitioners in Australia.
PAIN. 2022; 163: e518-ee26
Designing clinical research.
Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia 2013
Chou R, Qaseem A, Snow V, Casey D, Cross JT Jr., Shekelle P, Owens DK:
Diagnosis and Treatment of Low Back Pain: A Joint Clinical Practice Guideline
from the American College of Physicians and the American Pain Society
Annals of Internal Medicine 2007 (Oct 2); 147 (7): 478–491