Table 60, Fibromyalgia: effects of psychological therapies compared with pharmacological treatmentsa - Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update

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Intervention	Function Short-Term Effect Size SOE	Function Intermediate-Term Effect Size SOE	Function Long-Term Effect Size SOE	Pain Short-Term Effect Size SOE	Pain Intermediate-Term Effect Size SOE	Pain Long-Term Effect Size SOE
Exercise: Versus Paroxetine	no evidence	no evidence	no evidence	no evidence	insufficient evidence	no evidence
CBT Plus Amitriptyline: Versus Amitriptyline	insufficient evidence	no evidence	no evidence	insufficient evidence	no evidence	no evidence
Biofeedback: Versus Escitalopram	insufficient evidence	no evidence	no evidence	insufficient evidence	no evidence	no evidence
CBT: Versus Pregabalin; Duloxetine	no evidence	small^b +	no evidence	no evidence	none^b +	no evidence

: Short-Term: 1 to <6 months; Intermediate-Term: ≥6 to <12 months; Long-Term: ≥12 months
: Effect Size: none, small, moderate, or large improvement
: Strength of Evidence: + = low, ++ = moderate, +++ = high
: CBT = cognitive-behavioral therapy; none = no effect/no statistically significant effect; SOE = strength of evidence.
a: SOE and effect size based on totality of evidence from prior report and new trials
b: New trial did not change effect size or SOE

Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update [Internet].

Comparative Effectiveness Review, No. 227.

Skelly AC, Chou R, Dettori JR, et al.

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