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Table 1

Return to:   Multimodal Chiropractic Care for Pain and Disability in a Patient Diagnosed
With Ehlers-Danlos Syndrome-Hypermobility Type

The Villefranche Criteria for Major Ehlers-Danlos Syndrome Subtypes

SubtypeMajor CriteriaMinor Criteria
ClassicSkin extensibility
Widened atrophic scars
Joint hypermobility
Smooth, velvety skin
Molluscoid pseudotumors
Subcutaneous spheroids
Complication of joint hypermobility
Muscle hypotonia, motor delay
Easy bruising
Manifestation of tissue extensibility
Surgical complication
Positive family history

HypermobilityHyperextensible and/or smooth, velvety skin
Generalized joint hypermobility
Recurring joint dislocations
Chronic joint/limb pain
Positive family history

VascularThin, translucent skin
Arterial/intestinal/uterine fragility or rupture
Extensive bruising
Characteristic facial appearance
Hypermobility of small joints
Tendon and muscle rupture
Talipes equinovarus
Early-onset varicose veins
Arteriovenous, carotid-cavernous, carotid-cavernous sinus fistula
Gingival recessions
Positive family history, sudden death in a close relative

KyphoscolioticGeneralized joint hypermobility
Congenital hypotonia
Congenital and progressive scoliosis
Scleral fragility and rupture of the ocular globe
Tissue fragility, including atrophic scars
Easy bruising
Arterial rupture
Marfanoid habitus
Positive family history

ArthrochalasisGeneralized joint hypermobility and recurrent subluxations
Congenital bilateral hip dislocation
Skin hyperextensibility
Tissue fragility, including atrophic scars
Easy bruising

DermatosparaxisSevere skin fragility
Sagging, redundant skin
Soft, doughy skin texture
Easy bruising
Premature rupture of fetal membranes
Large hernias (umbilical, inguinal)