FROM:
Prostaglandins Leukot Essent Fatty Acids 1996 (Mar); 54 (3): 183–6
Bordia T, Mohammed N, Thomson M, Ali M
Department of Biochemistry,
Faculty of Science,
Kuwait University,
13060 Safat, Kuwait
Aqueous extracts of garlic (Allium sativum) and onion (Allium
cepa) were given orally or intraperitoneally to rats for a period
of 4 weeks. Thromboxane B2 levels were significantly inhibited at
50 mg/kg of aqueous garlic extract, which is a low dose. At 500
mg/kg of garlic and onion, there was a further reduction in
thromboxane B2 levels in the serum of rats. Boiled garlic and
onion at high concentrations of 500 mg/kg had very little effect
on thromboxane B2 synthesis. Garlic was found to be more potent
than onion in lowering thromboxane B2 levels. A high dose of
garlic and onion produced toxicity in rats.
The data show that garlic and onion can be taken frequently in
low doses without any side effects, and can still produce an
antithrombotic effect. The garlic and onion need to be consumed
raw.