Can Garlic Reduce Levels of Serum Lipids? A Controlled Clinical Study

Can Garlic Reduce
Levels of Serum Lipids?
A Controlled Clinical Study

This section is compiled by Frank M. Painter, D.C.
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FROM:   Am J Med 1993 (Jun);  94 (6):  632635

Jain AK, Vargas R, Gotzkowsky S, McMahon FG

Clinical Research Center,
New Orleans, Louisiana 70112

PURPOSE:   To assess the effects of standardized garlic powder tablets on serum lipids and lipoproteins, glucose, and blood pressure.

SUBJECTS AND METHODS:  Forty-two healthy adults (19 men, 23 women), mean age of 52 +/- 12 years, with a serum total cholesterol (TC) level of greater than or equal to 220 mg/dL received, in a randomized, double-blind fashion, either 300 mg three times a day of standardized garlic powder in tablet form or placebo. Diets and physical activity were unchanged. This study was conducted in an outpatient, clinical research unit.

RESULTS:  The baseline serum TC level of 262 +/- 34 mg/dL was reduced to 247 +/- 40 mg/dL (p < 0.01) after 12 weeks of standard garlic treatment. Corresponding values for placebo were 276 +/- 34 mg/dL before and 274 +/- 29 mg/dL after placebo treatment. Low-density lipoprotein cholesterol (LDL-C) was reduced by 11% by garlic treatment and 3% by placebo (p < 0.05). There were no significant changes in high-density lipoprotein cholesterol, triglycerides, serum glucose, blood pressure, and other monitored parameters.

CONCLUSIONS:  Treatment with standardized garlic 900 mg/d produced a significantly greater reduction in serum TC and LDL-C than placebo. The garlic formulation was well tolerated without any odor problems.

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