FROM:
Eur J Gastroenterol Hepatol 1999 (Mar); 11 (3): 305–308
Rumi G Jr; Szabo I; Vincze A; Matus Z; Toth G; Rumi G; Mozsik G
OBJECTIVE: Several retrospective and prospective
epidemiological investigations have demonstrated that a diet rich in carotenoids
could prevent the development of pre-cancerous and neoplastic lesions of the digestive tract. The aim of this examination was to analyse the correlation between colorectal polyps with different
histological classifications and serum carotenoid levels.
DESIGN AND METHODS: A 10 ml blood sample was taken from all of the
patients after the colonoscopic diagnosis. The serum levels of vitamin A, lutein, zeaxanthin, alpha- and ß-cryptoxanthin, alpha- and ß-carotene were measured in patients with
adenomatous colorectal polyp (n = 59, 35 males, 24 females) by high-pressure
liquid chromatography (HPLC) and compared with those in healthy
subjects (n = 20, 10 males, 10 females). The patients were
separated into four groups depending on their histological
findings.
RESULTS: The serum levels of vitamin A and zeaxanthin
were significantly lower in all patients with polyps (vitamin A:
0.913 +/- 0.112 micromol/l, zeaxanthin: 0.071 +/- 0.012
micromol/l) than in the control healthy group (vitamin A: 2.036 +/- 0.354
micromol/l, zeaxanthin: 0.138 +/- 0.048 micromol/l). The lowest levels were found in patients with focal adenocarcinoma in the polyp. There were no significant differences in the serum levels
of other carotenoids. The serum levels of cholesterol, haemoglobin, total protein and albumin were normal in these patients.
CONCLUSIONS: There are close and inverse correlations between the serum level of carotenoids and colorectal polyps with different histological grades. The low mean carotenoid levels in patients with adenocarcinoma in the polyp indicate that deficiency of carotenoids may be an important factor in the development of colorectal cancer.