TW Gynäkologie 1997; 10: 172-175
Liske E, Gerhard I, Wüstenberg P
In a multicentric postmarketing surveillance the therapeutic efficacy and safety of the pharmaceutical combination of Black Cohosh (Cimicifuga racemosa) and St John's Wort (Hypericum perforatum) was investigated in psychovegetative disorders during menopause. The global efficacy assessment (CGI, item 3.1) showed a good to very good response in 81% of the cases, 12% considered the efficacy as sufficient and 7% as inadequate. The global tolerability assessment (CGI, item 3.2) was very good in 99% of the cases. All seven typical symptoms were significantly improved. The therapeutic efficacy in the pre- or postmenopause was equally good, there also were no age-specific differences.