Eur J Clin Pharmacol. 2013 (Feb); 69 (2): 269–277
Kristine Heitmann , Hedvig Nordeng, Lone Holst
Department of Public Health and Primary Health Care
and Centre of Pharmacy,
University of Bergen,
P.O. Box 7804, 5020,
PURPOSE: The objective of the study was to examine the safety of ginger use during pregnancy on congenital malformations and selected pregnancy outcomes.
METHODS: The Norwegian Mother and Child Cohort study, a large population-based cohort, provided the data used in this study. Our study population consisted of 68,522 women. Data on ginger use and socio-demographic factors were retrieved from three self-administered questionnaires completed by the women during weeks 17 and 30 of the pregnancy and when their child was 6 months old. Data on pregnancy outcomes were provided by the Medical Birth Registry of Norway.
RESULTS: Among the 68,522 women in the study, 1,020 (1.5 %) women reported using ginger during pregnancy. The use of ginger during pregnancy was not associated with any increased risk of congenital malformations. No increased risk for stillbirth/perinatal death, preterm birth, low birth weight, or low Apgar score was detected for the women exposed to ginger during pregnancy compared to women who had not been exposed.
CONCLUSION: Use of ginger during pregnancy does not seem to increase the risk of congenital malformations, stillbirth/perinatal death, preterm birth, low birth weight, or low Apgar score. This finding is clinically important for health care professionals giving advice to pregnant women with NPV.