Stroke and
Essential Fatty Acids

This section was compiled by Frank M. Painter, D.C.
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Stroke & EFA Articles

A New Paradigm for Stroke Prevention
LE Magazine April 2005

Stroke is the third leading cause of death in the US. Fortunately, diagnostic imaging for stroke risk and stroke-prevention strategies have advanced greatly in recent years. It is now possible to reduce the artery-clogging plaque that leads to stroke, offering hope that this debilitating condition can be prevented.

Stroke & EFA Abstracts

Cognitive Function After Supplementation With B Vitamins and
Long-chain Omega-3 Fatty Acids: Ancillary Findings From
the SU.FOL.OM3 Randomized Trial

Am J Clin Nutr. 2011 (Jul); 94 (1): 278286 ~ FULL TEXT

This study investigated the effects of supplementation on cognition in a high-risk population. In subjects with prior stroke, B vitamins plus omega-3 fatty acids were associated with a higher score on the temporal orientation cognition task vs those assigned to placebo. Effects may be group specific and may be useful in interventions aimed at preventing cognitive decline in high-risk individuals

Very Long Chain N-3 Fatty Acids Intake and Carotid Atherosclerosis:
An Epidemiological Study Evaluated by Ultrasonography

Atherosclerosis 2004 (Sep); 176 (1): 145149

Epidemiological studies have shown an inverse relationship between intake of N-3 fatty acids and incidence of stroke. And, there is a high incidence of stroke in patients with carotid atherosclerosis. We investigated the relationship between intake of N-3 fatty acids and carotid atherosclerosis in the cross-sectional study.

Association of N-3 Polyunsaturated Fatty Acids with Stability of
Atherosclerotic Plaques: A Randomised Controlled Trial

Lancet 2003 (Feb 8); 361 (9356): 477485

Atherosclerotic plaques readily incorporate n-3 PUFAs from fish-oil supplementation, inducing changes that can enhance stability of atherosclerotic plaques. By contrast, increased consumption of n-6 PUFAs does not affect carotid plaque fatty-acid composition or stability over the time course studied here. Stability of plaques could explain reductions in non-fatal and fatal cardiovascular events associated with increased n-3 PUFA intake.

Fish Consumption, Fish Oil, Omega-3 Fatty Acids,
and Cardiovascular Disease

Arterioscler Thromb Vasc Biol 2003 (Feb 1); 23 (2): e20-30 ~ FULL TEXT

Since the first AHA Science Advisory "Fish Consumption, Fish Oil, Lipids, and Coronary Heart Disease," 1 important new findings, including evidence from randomized controlled trials (RCTs), have been reported about the beneficial effects of omega-3 (or n-3) fatty acids on cardiovascular disease (CVD) in patients with preexisting CVD as well as in healthy individuals. 2 New information about how omega-3 fatty acids affect cardiac function (including antiarrhythmic effects), hemodynamics (cardiac mechanics), and arterial endothelial function have helped clarify potential mechanisms of action. The present Statement will address distinctions between plant-derived (-linolenic acid, C18:3n-3) and marine-derived (eicosapentaenoic acid, C20:5n-3 [EPA] and docosahexaenoic acid, C22:6n-3 [DHA]) omega-3 fatty acids.intake.

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