Chiropractic & Osteopathy 2010 (Jun 2); 18: 13 ~ FULL TEXT
Fay Karpouzis, Rod Bonello, and Henry Pollard
Department of Chiropractic,
Faculty of Science, Macquarie University,
Sydney, NSW 2109, Australia.
Background Psychostimulants are first line of therapy for pediatric and adolescent AD/HD. The evidence suggests that up to 30% of those prescribed stimulant medications do not show clinically significant outcomes. In addition, many children and adolescents experience side-effects from these medications. As a result, parents are seeking alternate interventions for their children. Complementary and alternative medicine therapies for behavioural disorders such as AD/HD are increasing with as many as 68% of parents having sought help from alternative practitioners, including chiropractors.
Objective The review seeks to answer the question of whether chiropractic care can reduce symptoms of inattention, impulsivity and hyperactivity for pediatric and adolescent AD/HD.
Methods Electronic databases (Cochrane CENTRAL register of Controlled Trials, Cochrane Database of Systematic reviews, MEDLINE, PsycINFO, CINAHL, Scopus, ISI Web of Science, Index to Chiropractic Literature) were searched from inception until July 2009 for English language studies for chiropractic care and AD/HD. Inclusion and exclusion criteria were applied to select studies. All randomised controlled trials were evaluated using the Jadad score and a checklist developed from the CONSORT (Consolidated Standards of Reporting Trials) guidelines.
Results The search yielded 58 citations of which 22 were intervention studies. Of these, only three studies were identified for pediatric and adolescent AD/HD cohorts. The methodological quality was poor and none of the studies qualified using inclusion criteria.
Conclusions To date there is insufficient evidence to evaluate the efficacy of chiropractic care for pediatric and adolescent AD/HD. The claim that chiropractic care improves pediatric and adolescent AD/HD, is only supported by low levels of scientific evidence. In the interest of pediatric and adolescent health, if chiropractic care for AD/HD is to continue, more rigorous scientific research needs to be undertaken to examine the efficacy and effectiveness of chiropractic treatment. Adequately-sized RCTs using clinically relevant outcomes and standardised measures to examine the effectiveness of chiropractic care verses no-treatment/placebo control or standard care (pharmacological and psychosocial care) are needed to determine whether chiropractic care is an effective alternative intervention for pediatric and adolescent AD/HD.
From the FULL TEXT Article:
Attention-Deficit/Hyperactivity Disorder (AD/HD) is considered to be one of the most frequently diagnosed disruptive behaviour disorders in childhood , with world wide prevalence rates of 812%.  The American prevalence rates range between 37% , and 412%.  The Australian prevalence rates show 11% of 617 year olds are diagnosed with this disorder , where as the English and Welsh AD/HD prevalence rates find 5% of 616 year olds have the disorder.  The Diagnostic and Statistical Manual of Mental Disorders 4th Edition Text Revision (DSM-IV-TR) , is the most widely used classification system for mental disorders. [10, 11] The DSM-IV-TR characterises AD/HD as inappropriate, chronic levels of inattention, hyperactivity and impulsivity.  These children continually experience difficulties in academic achievement, and behavioural control, and as a consequence, they have difficulty in establishing positive relationships with family, authority figures and their peers.  As a result, much attention has been devoted to the development and evaluation of assessment and treatment for this disorder over the last fifty years. [2, 1517] The majority of the AD/HD literature is dedicated to the treatment of this disorder. [2, 1518] Most of this research can be found in the area of pharmacological therapies [12, 16, 17], with less emphasis in psychotherapy and other psychosocial interventions.  There is even less research in the area of AD/HD and complementary and alternative medicine (CAM) therapies. [20, 21]
Even though psychostimulants are the first line of therapy for pediatric AD/HD [2, 12, 22, 23], the evidence reveals that up to 30% of these children do not show clinically significant outcomes, and others experience side-effects [12, 2428], and need to discontinue their medications. [5, 28] For these children alternative strategies need to be considered and instigated. [5, 27, 29]
In general, parents seek CAM therapies for their children for various reasons, such as they "feel mainstream medicine has let them down" , p. 573], because a particular treatment was considered ineffective, fear of drug adverse effects and a need for more personal attention . [31, 32] Furthermore, parents often prefer to try something 'natural' for their children. [20, 29, 30, 33]
It is obvious that parents with children diagnosed with AD/HD seek CAM therapies. [20, 3438] In fact, CAM therapies are sought more often by parents who have children with developmental and behavioural disorders such as AD/HD, than with any other condition. [20, 33, 34, 39] Controversy over the safety and appropriateness of stimulant treatment has led to increased parental anxiety and the increased use of CAM therapies. [20, 31, 40] Major concern regarding the side effect profile of stimulant medications [29, 31, 34, 4143], has been the main reason parents have turned to alternative therapies. [20, 3436, 38, 42, 43] Many parents and even teachers are receptive to, and have a preference for non-pharmacological or behavioural therapies for children with AD/HD. [44, 45] In fact, parents and teachers show preferences for multidisciplinary approaches, which lead to reductions in medications. [44, 46, 47]
In different surveys conducted around the world, CAM use for AD/HD ranged from 12% in Florida USA , 28% in Shaare Zedek, Israel , 54% in Boston USA , 64% in Perth Australia , and 68% in Melbourne Australia.  The American Academy of pediatrics recognised the increasing use of CAM therapies in children and, as a result, assembled a Task Force on Complementary and Alternative Medicine in 2008 to address issues related to the use of CAM for this population.  This task force found that chiropractic care is one of the most common CAM practices provided at the professional level.  Other studies have also confirmed this finding. [32, 48, 49] Up to 10% of the US population seek care from chiropractors for non-musculoskeletal conditions. [48, 50, 51] Studies have confirmed that up to 14% of all chiropractic visits were for pediatric patients [39, 52], and that chiropractors were the most common CAM providers visited by children and adolescents. [31, 52] One study indicated that pediatric populations seek chiropractic care predominantly for non-musculoskeletal conditions or when asymptomatic. 
A survey conducted in the USA on the presenting complaints of pediatric patients (under 18 years of age) for chiropractic care found that parents consulted chiropractors for their children's musculoskeletal (MSK) and non-musculoskeletal (non-MSK) conditions in addition to wellness care.  Of these pediatric chiropractic visits, 44% were for MSK conditions and 56% were for non-MSK conditions.  In this USA survey, included in the list of the most common non-MSK conditions parents sought chiropractic care for their children was hyperactivity. 
A survey conducted in Australia of pediatric chiropractic care for children under 18 years of age found that parents (like their American counterparts) also sought care from chiropractors for their children's MSK and non-MSK complaints.  Within the Australian survey, parents consulted chiropractors for their children's non-MSK conditions, and included in that list were irritability, behavioural problems, AD/HD, and learning difficulties.  These two surveys have found that parents seek chiropractic care for their children's AD/HD, irritability, attentional and behavioural issues, as well as their learning disabilities from chiropractors, both in Australia,  and the USA. 
Although figures appear low, parents are presenting to chiropractors with their children [50, 53, 55], looking for alternative therapies for AD/HD. [42, 43] Anecdotally it has been suggested that AD/HD may be managed by chiropractic care, however to date no systematic review on the safety and efficacy of chiropractic care for pediatric and adolescent AD/HD has been conducted. A systematic review conducted to determine whether evidence exists for the therapeutic application of manipulation for pediatric health for musculoskeletal and non-musculoskeletal conditions revealed only low levels of scientific evidence.  In view of the large numbers of children and adolescents being diagnosed with AD/HD and the increased use of CAM therapies, of which chiropractic care is one of the most common, this review is relevant and important.
To evaluate the evidence of the effect of chiropractic care for the treatment and/or management of children and adolescents with AD/HD.
The following electronic databases were searched by the primary author, with English language and human subjects as restrictions, from inception to July 2009: Index to Chiropractic Literature; Cochrane Central Register of Controlled Trials; Cochrane Library of Systematic Reviews; PubMed; MEDLINE-Ovid; PsycINFO; CINAHL (Cumulative Index to Nursing and Allied Health Literature); Mantis; Scopus and ISI Web of Science.
The following key words were used in the search strategy: "Attention Deficit Hyperactivity Disorder", "AD/HD", "Hyperactivity", "ADD", "Attention" and "chiropractic", "manipulative therapies", "spinal manipulation", "physical therapies", "complementary therapies", "alternate therapies".
Searching other resources
The primary author conducted a hand search for articles held in the library at Macquarie University that did not have an e-copy available on-line. The chiropractic journals that were hand searched were DC Tracts (Vol. 4, 1992 - Vol. 14, 2002) and Journal of Manipulative and Physiological Therapeutics (Vol. 12, 1989). In addition, the reference lists of the retrieved papers were hand searched and screened to identify any additional studies that were not captured by electronic and manual searches. At the conclusion of these search procedures, all references were screened to avoid duplication.
The primary author conducted the search and retrieved all relevant articles for the review and selected the articles that were Level I, II, III and IV evidence for chiropractic and AD/HD. All three reviewers agreed on the inclusion and the exclusion criteria outlined in Table 1. All three reviewers agreed on the Level of Evidence scale as outlined in Table 2. All full text articles retrieved were independently reviewed by at least two authors and the selection criteria were applied. Papers that did not meet the inclusion criteria were excluded from the systematic review.
Level of evidence
The scale of evidence adopted for this review was taken from the Cochrane Effective Practice and Organisation of Care (EPOC) Collaborative Review Group.  EPOC not only includes Level I and II evidence, but Level III evidence in its approach to systematic reviews.
The hierarchy of evidence is tabled below and adapted from the National Health and Medical Research Council (NHMRC) Levels of Evidence (Table 2). 
Types of outcome measures
The primary outcomes considered in this review were the severity of symptoms of inattention, impulsivity, and hyperactivity. Outcome measures considered for inclusion were of ratings on standard, psychometrically sound, reliable and validated assessment questionnaires measuring changes in attentional, impulsive, and hyperactive symptoms over time. The outcome measures considered for inclusion are those used by the American Academy of Child and Adolescent Psychiatry.  These were chosen as they are considered common behaviour rating scales used in the assessment of AD/HD and for the monitoring of treatment. (Refer to Table 3)
Types of interventions
More than 100 different techniques are used by the chiropractic profession.  Although chiropractic techniques have been evolving for 114 years a complete discussion of what constitutes a chiropractic technique is beyond the scope of this paper. Furthermore, chiropractic is not a unimodal approach for treatment and/or management of musculoskeletal and non-musculoskeletal conditions, and it is not synonymous with the term spinal manipulation.  Chiropractors are qualified providers of spinal manipulation, spinal adjustments and other manual treatments, exercise instruction and patient education , often encompassing the biopsychosocial principles of health.  For those that are interested in the variety of techniques used by chiropractors, a list from a survey conducted in Australasia and North America can be found in Additional file 1
, and many others can be located on the web.  As a result, no chiropractic interventions were excluded from this review.
The methodological quality of the studies that qualified for inclusion was assessed using the five-point Jadad score  (Additional file 2), and a 15 item checklist which is not validated but was developed by Hawk and colleagues  from the CONSORT statement  (Refer to Additional file 3).
Selection of Studies
The search strategy yielded 58 citations. Of these citations, 22 citations were of intervention studies, 12 from peer-reviewed journals , and 10 from non-peer-reviewed journals.  Two studies were excluded as full-text of these articles was not available [85, 88] (Refer to Additional files 4 and 5).
Studies were then independently screened by the authors to decide whether the studies met the criteria for inclusion. The authors found that this screening process yielded no studies that were Level I or II evidence. Four Level III evidence studies were found, but they did not meet the inclusion criteria for this review (Refer to Table 4). Therefore, scoring studies for methodological quality was not necessary. The authors of this review were not blinded to the authors, institutions, or the journals of publication of the articles. Please see Additional files 4 and 5 for a table of all citations.
What were the predominant types of research designs used?
An important result of this review is that the authors found that no studies met the inclusion criteria for this topic. The natural conclusion one draws from such a discovery, is that no evidence of studies for or against this treatment (chiropractic care) for this condition (pediatric and adolescent AD/HD) using RCTs (Level II evidence) were found. The reviewers then questioned whether or not their eligibility criteria were too strict or inappropriately defined.  In fact, evidence at lower levels of the hierarchy of evidence, such as non-randomised, quasi-experimental group designs or single-subject experimental designs could exist and could contribute valuable information.  The reviewers discovered that no RCTs existed on the subject matter and after discussion and reviewing the EPOC guidelines the eligibility criteria were extended to include Level III evidence (Table 2). Despite this extension of evidence to include Level III evidence the four intervention studies that were found did not meet the inclusion criteria (Refer to Table 4).
Researchers have used the term 'empty' review when a search to address a research question yields no eligible studies. [89, 90] At first this may appear as though the review has no intrinsic value. However, knowing that there are no studies of a particular type on a specific topic has the potential to generate meaningful and useful information.  For researchers, empty reviews serve the purpose of highlighting research gaps and directing future original research projects, as was the case for these authors. There was a gap in the knowledge that needed an answer to an important clinical question: "does chiropractic care have a role to play in the treatment and/or management of pediatric and adolescent AD/HD?"
The inclusion of a log of rejected trials is an important aspect of any systematic review.  As part of the Cochrane review process a log of rejected trials is expected, outlining the studies that were excluded as well as listing the reasons for their exclusion.  Table 4 outlines the rejected studies and the reasons they were rejected.
This 'empty review' allows for the opportunity to learn from the excluded studies. For instance:
What types of populations have been studied?
Which types of chiropractic interventions have been tested?
What types of outcome measures if any, were used?
According to this systematic review, 15 case studies have been published [6769, 7174, 79, 8288]; three case series [70, 80, 81]; one single subject design study (n = 7) ; two uncontrolled, non-random experimental trials (n = 41 and n = 13) [75, 77]; and one controlled, non-random, experimental clinical trial (n = 24)  for AD/HD and chiropractic care. Of these, two studies targeted adult AD/HD populations [70, 75], three studies targeted pediatric and adolescent populations.  It is obvious from this review that there is a paucity of studies on pediatric and adolescent AD/HD and that the most predominant type of research design is the case study.
As for the types of chiropractic interventions investigated it was not a homogeneous finding. The chiropractic profession has over one hundred different techniques , and there was no shortage of variety in the studies found for this review. The following were some of the techniques investigated in the chiropractic and AD/HD literature:
Sacro-Occipital Technique (SOT),
Toggle Recoil Technique,
Torque Release Technique,
Network Spinal Analysis,
Chiropractic Biophysics, and
As part of the interventions described in the published articles, advice on exercise and/or dietary modifications was also given in conjunction with some form of chiropractic treatment in seven of the studies reviewed [67, 6971, 79, 81, 86] (Refer to Additional files 4 and 5).
In regard to the outcome measures used in these studies very few chiropractors actually used validated psychometric measures, in fact only one pediatric study used a known psychometric measure i.e. Werry-Weiss-Peters Parent Rating Scales.  However, according to Miller and colleagues this psychometric measure is best used when AD/HD is present with mental retardation.  This study also used electrodermal activity of skin conductance, and cervical x-rays.  The only other studies that used a psychometric outcome measures were the two adult AD/HD studies. One study used the Test of Variables of Attention (TOVA)  and the other used the Conners' Continuous Performance Test (CCPT).  When reviewing the literature it is important to evaluate whether the patients (i.e. children and adolescents) presented to a chiropractor for treatment of traditional musculoskeletal conditions or whether they presented with a primary diagnosis of AD/HD. In every single case study the parents presented their child or adolescent to the chiropractor with a primary complaint of AD/HD, and chose to seek chiropractic care for their child's or adolescent's AD/HD symptoms. An interesting finding was that chiropractors used outcome measures that they would traditionally use for musculoskeletal conditions (i.e. x-rays, thermal scans, and surface electromyography) for AD/HD. These types of outcome measures are not used for AD/HD symptomatology in AD/HD studies published in the medical literature. One study used thermal scans with surface electromyography (sEMG) pre and post intervention as a measure of outcomes.  Two studies used sEMG as outcome measures [69, 70], and another two studies used paraspinal thermal scans. [67, 79] Two studies used rating scales designed by the chiropractor rather than using established reliable and validated psychometric rating scales. [69, 78] Furthermore, all of the studies used subjective statements of a child's improvement taken from parents and/or teachers, and even a bus driver.  In all fairness many case studies presented were retrospective (although many were ambiguous) in nature and as a result it is highly probable that these chiropractors did not have any intentions of publishing and as a result did not seek out and use appropriate outcome measures for AD/HD symptomatology. However, it must be noted that even those few studies that were prospective in nature the chiropractors involved did not seek and use appropriate outcome measures.
When conducting research in the area of AD/HD a good guide to use is the "Practice Parameters for the Assessment and Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder".  Choosing psychometric measures that are recommended by the American Academy of Child and Adolescent Psychiatry  (Refer to Table 3), ensures that the outcome measures have normative values and are likely to yield a measure of AD/HD behaviours that are reliable.
For clinicians, an empty review provides valuable information showing that there is no evidence in support of a treatment on the basis of the inclusion criteria used in the review process. [89, 90] Furthermore, empty reviews inform decision makers in health care when there is lack of robust evidence in favour of (or against) a particular health care intervention.  As was found in this review, there is no robust evidence in favour of chiropractic care for pediatric and adolescent AD/HD. It is important that chiropractors seek out the best evidence available. However, the absence of RCTs in this area does not need to immobilize clinical decision making, nor does it necessarily justify the abandonment of an intervention.  According to Sackett and colleagues [94, 95], clinical expertise can be defined as "the proficiency and judgment that individual clinicians acquire through clinical experience and clinical practice" , p.71]. Responsible practitioners need to integrate this evidence with their clinical expertise and should apply a common sense approach to each individual patient. Furthermore, all health care providers have a responsibility to inform their patients when a particular intervention does not have scientific validation, and that all they have is clinical experience and anecdotal evidence to support their treatment strategy, which is in keeping within the scope of evidence based practices. 
If the chiropractic profession chooses to conduct research in the area of pediatric and adolescent AD/HD then appropriate study designs need to be followed. The gold standard for claiming a particular intervention caused the desired effect is the randomised controlled clinical trial (RCT). The CONSORT group recommendations are suggested to develop a stringent a set of guidelines designed to improve the reporting of RCTs.  The CONSORT Group also developed an extension of the CONSORT Statement for non-pharmacologic treatments , which can be easily applied to chiropractic intervention studies. If these guidelines are used in the design of a RCT then a robust study can be designed to minimise the risk of bias (internal validity) and to account for the applicability of a trial's outcomes to the target population (i.e. generalisability or external validity). 
With the increase use of CAM therapies the CONSORT group have assessed the quality of randomised trials for pediatric CAM therapies. They found that only 40% of the CONSORT checklist items were included in the published articles.  In order for these types of studies to be a valid source of information about pediatric CAM therapies, they need to be conducted and reported with the highest possible standards.  Unfortunately, the searches for this systematic review did not uncover any RCTs for the use of chiropractic care in pediatric or adolescent AD/HD cohorts. Chiropractic researchers can learn from the CONSORT group in order to design, conduct and report trials that will be valid and applicable in the future.
Lastly, it is important for chiropractors and chiropractic researchers to report any risks, side-effects or adverse events in relation to chiropractic interventions. "Every healthcare intervention comes with risk, great or small, of harmful or adverse effects".  In all the studies reviewed for this systematic review there was not one mention of side effects or adverse reactions except for one study in which one adolescent girl reported feeling 'high' after her first adjustment.  However, it can not be assumed that the determination of side-effects was a specific goals of any of the studies reviewed, as it was not explicitly stated. It is strongly recommended that future studies for these age groups should include side effect and adverse reaction data. According to the Cochrane review it is important to minimize bias when conducting reviews by including an evaluation of adverse effects.  However, to date only one narrative report , and one systematic review for pediatric spinal manipulation , have been conducted reporting adverse events. Despite these, there are not enough data to evaluate causation or incidence rates of these rare adverse events. The importance of a prospective population-based active surveillance study has been recommended , in order to assess the severity and frequency of adverse events as a result of chiropractic care within the pediatric population. It is recommended that clinicians who administer spinal manipulation to pediatric populations should inform the parents that spinal manipulations may cause rare but serious adverse events. 
A limitation of this review is that the search strategy included a literature search of articles only in the English language. It is possible that other articles have been published on AD/HD and chiropractic care in non-English journals. Another limitation that needs to be considered is publication bias as unpublished literature and abstracts from conference proceedings were not sought. Furthermore, hand searches were only conducted for a limited number of chiropractic journals held in the Macquarie University library.
The current finding for this systematic review has been classified as an 'empty review'. As a result, to date there is no high quality evidence to evaluate the efficacy of chiropractic care for pediatric and adolescent AD/HD. The claims made by chiropractors that chiropractic care improves AD/HD symptomatology for young people is only supported by low levels of scientific evidence. In the interest of pediatric and adolescent health, if chiropractic care is to continue for this clinical population, more rigorous scientific research needs to be undertaken to examine the efficacy and effectiveness of chiropractic treatment for AD/HD. Adequately-sized RCTs using clinically relevant outcomes and standardised measures to examine the effectiveness of chiropractic care verses no-treatment/placebo control or standard care (pharmacological and psychosocial care) are needed to determine whether chiropractic care is an effective alternative intervention for pediatric and adolescent AD/HD.
AD/HD: Attention-Deficit/Hyperactivity Disorder;
ADD: Attention Deficit Disorder;
DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders 4th Edition Text Revision;
DSM-IV: Diagnostic and Statistical Manual of Mental Disorders 4th Edition;
DSM-III: Diagnostic and Statistical Manual of Mental Disorders 3rd Edition;
ICD-10: International Classification of Diseases 10th Revision;
CAM: Complementary and Alternative Medicine;
CINAHL: Cumulative Index to Nursing and Allied Health Literature;
AACAP: American Academy of Child and Adolescent Psychiatry;
EPOC: Cochrane Effective Practice and Organisation of Care Collaborative Review Group;
NHMRC: National Health and Medical Research Council;
CONSORT: Consolidated Standards of Reporting Trials;
RCT: Randomised Controlled Trial;
CCPT: Conners' Continuous Performance Test;
sEMG: Surface Electromyography.
The authors declare that they have no competing interests.
FK, RB and HP conceived the research project. All authors contributed to the writing of the manuscript. All authors read and approved the final manuscript
Additional file 1:
Survey list of top 15 techniques used by chiropractors in Australasia and North America. This table summarises the top 15 techniques used by chiropractors in Australasia and North America according to a survey conducted by Walker et al. 
Click here for file (32K, DOC)
Additional file 2:
Jadad Five-Point Scale used to score studies. Sourced from an article published by Jadad et al on assessing the quality of randomised clinical trials. 
Click here for file (31K, DOC)
Additional file 3:
Modified CONSORT checklist. Modified CONSORT checklist sourced from an article published by Hawk et al  used for assessing the quality of randomised controlled trials.
Click here for file (35K, DOC)
Additional file 4:
Summary of intervention studies for chiropractic care for AD/HD from peer-reviewed journals. The summary presented in this table is of intervention studies of chiropractic care for AD/HD from full text publications from peer-reviewed journals used for the systematic review.
Click here for file (45K, DOC)
Additional file 5:
Summary of intervention studies for chiropractic care for AD/HD from non-peer-reviewed journals. The summary presented in this table is of intervention studies of chiropractic care for AD/HD from non-peer-reviewed journals used for the systematic review.
Click here for file (41K, DOC)
American Psychiatric Association.
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision.
Washington DC: American Psychiatric Association; 2000
Pliszka SR. the AACAP Work Group on Quality Issues.
Practice Parameters for the Assessment and Treatment of Children and Adolescents with Attention-Deficit/Hyperactivity Disorder.
J Am Acad Child Adolesc Psychiatry. 2007;46:894921
Bjornstad G, Montgomery P.
Family therapy for attention-deficit disorder or attention-deficit/hyperactivity disorder in children and adolescents.
Cochrane Database of Syst Rev. 2005. p. CD005042
Rapport MD, Chung KM, Shore G, Denney CB, Isaacs P.
Upgrading the science and technology of assessment and diagnosis: laboratory and clinic based assessment of children with ADHD.
J Clin Child Psychol. 2000;29:555569
Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. 2.
New York: The Guilford Press; 1998
Biederman J, Faraone SV.
Attention-deficit hyperactivity disorder.
American Academy of Pediatrics.
Clinical Practice Guideline: Diagnosis and Evaluation of the Child With Attention-Deficit/Hyperactivity Disorder.
Sawyer MG, Arney FM, Baghurst PA, Clark JJ, Graetz BW, Kosky RJ, Nurcombe B, Patton GC, Prior MR, Raphael B, Rey JM, Whaites LC, Zubrick SR.
The mental health of young people in Australia: key findings from the child and adolescent component of the national survey of mental health and well being.
Aust NZ J Psychiatry. 2001;35:806814
National Institute for Health & Clinical Excellence. Methylphenidate, atomoxetine and dexamfetamine for attention deficit hyperactivity disorder (ADHD) in children and adolescents: Guidance TA98.
National Institute for Health & Clinical Excellence (NICE), London, UK; 2006
Sψrensen MJ, Mors O, Thomsen P.
DSM-IV or ICD-10-DCR diagnoses in child and adolescent psychiatry: does it matter?
Eur Child Adolesc Psychiatry. 2005;14:335340
Eiraldi RB, Power TJ, Karustis JL, Goldstein SG.
Assessing ADHD and comorbid disorders in children: the Child Behavior Checklist and the Devereux Scales of Mental Disorders.
J Clin Child Psychol. 2000;29:316
Brams M, Muniz R, Childress A, Giblin J, Mao A, Turnbow J, Borrello M, McCague K, Lopez F, Silva R.
A Randomized, Double-Blind, Crossover Study of Once-Daily Dexmethylphenidate in Children with Attention-Deficit Hyperactivity Disorder Rapid Onset of Effect.
CNS Drugs. 2008;22:693704
Global issues related to the impact of untreated attention-deficit/hyperactivity disorder from childhood to young adulthood.
Postgrad Med. 2008;120:4859
Perwien AR, Faries DE, Kratochvil CJ, Sumner CR, Kelsey DK, Allen AJ.
Improvement in health-related quality of life in children with ADHD: an analysis of placebo controlled studies of atomoxetine.
J Dev Behav Pediatr. 2004;25:264271
Naglieri J, Goldstein S, Delauder B, Schwebach A.
Relationships between the WISC-III and the Cognitive Assessment System with Conners' Rating Scales and continuous performance tests.
Arch Clin Neuropsych. 2005;20:385401
Johnston C, Leung D.
Effects of medication, behavioral, and combined treatments on parents' and children's attributions for the behavior of children with attention-deficit hyperactivity disorder.
J Consult Clin Psychol. 2001;69:6776
Dulcan M, Dunne JE, Ayers W, Arnold V, Benson S, Bernet W, Buckstein O, Kinlan J, Leonard H, Licamele W, McClellan J.
Practice parameters for the assessment and treatment of children, adolescents and adults with Attention Deficit/Hyperactivity Disorder.
J Am Acad Child Adolesc Psychiatry. 1997;36:85S121S
Waslick B, Greenhill LL.
In: Textbook of Child and Adolescent Psychiatry. 3. Wiener J, Dulcan M, editor.
American Psychiatric Publishing; 2004. Attention-Deficit/Hyperactivity Disorder; pp. 485508
Schachter H, Pham B, King J, Langford S, Moher D.
How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis.
Can Med Assoc J. 2001;165:14751488
The Role of Complementary and Alternative Medicine in Attention-Deficit Hyperactivity Disorder.
J Dev Behav Pediatr. 2002;23:S37S45
Treatment alternatives for attention-deficit/hyperactivity disorder (ADHD)
J Atten Disord. 1999;3:3048
Wilens TE, Adler LA, Adams J, Sgambati S, Rotrosen J, Sawtelle R, Utzinger L, Fusillo S.
Misuse and Diversion of Stimulants Prescribed for ADHD: A Systematic Review of the Literature.
J Am Acad Child Adolesc Psychiatry. 2008;47:2131
Longer term effects of stimulant treatments for Attention-Deficit/Hyperactivity Disorder.
J Atten Disord. 2002. pp. S4556
Lerner M, Wigal T.
Long-Term Safety of Stimulant Medications Used to Treat Children with ADHD.
Pediatr Ann. 2008;37:3745
Greenhill LL, Biederman J, Boellner SW, Rugino TA, Sangal RB, Earl CQ, Jiang JG, Swanson JM.
A randomized, double-blind, placebo-controlled study of modafinil film-coated tablets in children and adolescents with Attention-Deficit/Hyperactivity Disorder.
J Am Acad Child Adolesc Psychiatry. 2006;45:503511
Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Leibson CL, Jacobsen SJ.
Long-Term Stimulant Medication Treatment of Attention-Deficit/Hyperactivity Disorder: Results from a Population-Based Study.
J Dev Behav Pediatr. 2006;27:110
ADHD and Drug Therapy: is it Still a Valid Treatment?
J Child Health Care. 2004;8:6981
Biederman J, Spencer T.
Non-Stimulant treatments for ADHD.
Eur Child Adolesc Psychiatry. 2000;9(Supplement 1):I51I59
Brue AW, Oakland TD.
Alternative treatments for attention-deficit/hyperactivity disorder: does evidence support their use?
Altern Ther Health Med. 2002;8:6870
South M, Lim A.
Use of complementary and alternative medicine in children:Too important to ignore.
J Paediatr Child Health. 2003;39:573574
Kemper KJ, Vohra S, Walls R.
Task Force on Complementary Alternative Medicine, Provisional Section on Complementary Holistic Integrative Medicine.
The use of complementary and alternative medicine in pediatrics.
Spigelblatt L, Laine-Ammara G, Pless IB, Guyver A.
The use of alternative medicine by children.
Rojas N, Chan E.
Old and new controversies in the alternative treatment of attention-deficit hyperactivity disorder.
Ment Retard Dev Dis Res Rev. 2005;11:116130
Sinha D, Efron D.
Complementary and alternative medicine use in children with attention deficit hyperactivity disorder.
J Paediatr Child Health. 2005;41(1-2):2326
Bush G, Valera EM, Seidman LJ.
Functional neuroimaging of attention-deficit/hyperactivity disorder: A review and suggested future directions.
Biol Psychiatry. 2005;57:12731284
Gross-Tsur V, Lahad A, Shalev R.
Use of Complementary Medicine in Children With Attention Deficit Hyperactivity Disorder and Epilepsy.
Pediatr Neurol. 2003;29:5355
Bussing R, Zima BT, Gary FA, Garvan CW.
Use of Complementary and Alternative Medicine for Symptoms of Attention-Deficit Hyperactivity Disorder.
Psychiatr Serv. 2002;53:10961102
Stubberfield T, Wray J, Parry T.
Utilization of alternative therapies in attention-deficit hyperactivity disorder.
J Pediatr Child Health. 1999;35:450453
Sawni-Sikand A, Schubiner H, Thomas RL.
Use of complementary/alternative therapies among children in primary care pediatrics.
Ambul Pediatr. 2002;2:99103
Chan E, Rappaport LA, Kemper KJ.
Complementary and alternative therapies in childhood attention and hyperactivity problems.
J Dev Behav Pediatr. 2003;24:48
dosReis S, Myers MA.
Parental attitudes and involvement in psychopharmacological treatment for ADHD: a conceptual model.
Int Rev Psychiatry. 2008;20:135141
Attention-deficit/hyperactivity disorder and complementary/alternative medicine.
Adolesc Med. 2008;19:313326.
Alternative and controversial treatments for attention-deficit/hyperactivity disorder.
Pediatr Clin North Am. 1999;46:977992
Krain A, Kendall P, Power T.
The role of treatment acceptability in the initiation of treatment for ADHD.
J Atten Disord. 2005;9:425434
Satisfaction with Treatment Satisfaction with Treatment for Attention-Deficit/Hyperactivity Disorder.
Am J Manag Care. 2004;10:S107116
Brown RT, Amler RW, Freeman WS, Perrin JM, Stein MT, Feldman HM, Pierce K, Wolraich ML.
American Academy of Pediatrics Committee on Quality Improvement, Subcommittee on Attention-Deficit/Hyperactivity Disorder.
Treatment of Attention-Deficit/Hyperactivity Disorder: Overview of the Evidence.
Farmer E, Compton S, Burns B, Robertson E. Review of the evidence base for treating of childhood psychopathology: externalizing disorders. J Consult
Clin Psychol. 2002;70:12671302
Barnes, PM and Bloom, BS.
Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007
National Health Statistics Reports. 2008; 12: 124
Prevalence of complementary/alternative medicine for children: a systematic review.
Eur J Pediatr. 1999;158:711
Hawk C, Khorsan R, Lisi AJ, Ferrance RJ, Evans MW.
Chiropractic care for nonmusculoskeletal conditions: a systematic review with implications for whole systems research.
J Altern Complement Med. 2007;13:491512
Hawk C, Long C, Boulangerc K.
Prevalence of Nonmusculoskeletal Complaints in Chiropractic Practice:Report from a Practice- Based Research Program.
J Manipulative Physiol Ther. 2001;24:157169
Pitetti R, Singh S, Hornyak D, Garcia SE, Herr S.
Complementary and alternative medicine use in children.
Pediatr Emerg Care. 2001;17:165169
The presenting complaints of pediatric patients for chiropractic care: Results from a practice-based research network.
Clin Chiropr. 2008;11:193198
Jamison J, Davies N.
pediatric Patients Seeking Chiropractic Care: An Australian Case Study.
Chiropr J Aust. 2005;35:143146
Bablis P, Pollard H, Bonello R.
A retrospective analysis of self-reported symptoms from 761 consecutive new patients presenting to a Neuro Emotional Technique chiropractic clinic.
Complement Ther Clin Pract. 2009;15:166171
Gotlib A, Rupert R.
Chiropractic Manipulation In Pediatric Health Conditions --
An Updated Systematic Review
Chiropractic & Osteopathy 2008 (Sep 12); 16: 11
Cochrane Effective Practice and Organisation of Care Review Group (EPOC):
Data collection checklist.
National Health and Medical Research Council.
NHMRC additional levels of evidence and grades for recommendations for developers of guidelines.
Stage 2 consultation 2008. Australian Government ed. Canberra, ACT; 2008
In: Foundations of Chiropractic: Subluxation Second Edition. 2.
Gatterman MI, editor. Philadelphia, PA:
Mosby Inc; 2005. Chiropractic Technique.
Chiropractors: clarifying the issues.
Br Med J. 2009;339:b2782
World Health Organization (WHO) guidelines on basic training and safety in chiropractic.
World Federation of Chiropractic.
Walker S, Bablis P, Pollard H, McHardy A.
Practitioner Perceptions of Emotions Associated with Pain: A Survey.
J Chiropr Med. 2005;4:1118
Jadad A, Moore R, Carroll D, Jenkinson C, Reynolds J, Gavaghan D, McQuy H.
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Control Clin Trials. 1996;17:112
Moher D, Jones A, Lepage L. for the CONSORT Group.
Use of the CONSORT Statement and Quality of Reports of Randomised Trials: A Comparative Before-and After-Evaluation.
Wittman R, Vallone S, Williams K. Chiropractic management of six-year-old child with attention deficit hyperactivity disorder (ADHD) J Clin Chiropr Pediatr. 2009;10:612620
Improvement in a child with Attention Deficit Hyperactivity Disorder, Kyphotic Cervical Curve and Vertebral Subluxation Undergoing Chiropractic Care.
J Vert Sublux Res. 2009. pp. 15
Successful care of a young female with ADD/ADHD and vertebral subluxation: a case study.
J Vert Sublux Res. 2008. pp. 17
Improvement in attention in patients undergoing network spinal analysis: A case series using objective measures of attention.
J Vert Sublux Res. 2007. pp. 19
Chiropractic management of a child with ADD/ADHD.
J Vert Sublux Res. 2007. pp. 14
Lovett L, Blum C.
Behavioral and Learning Changes Secondary to Chiropractic Care to Reduce Subluxations in a Child with Attention Deficit Hyperactivity Disorder: A Case Study.
J Vert Sublux Res. 2006. pp. 16
Bastecki A, Harrison D, Haas JW.
Cervical Kyphosis Is a Possible Link to Attention-Deficit/Hyperactivity Disorder.
J Manipulative Physiol Ther. 2004;27:525e521e525
Upper cervical chiropractic care for a nine-year-old male with Tourette syndrome, attention deficit hyperactivity disorder, depression, asthma, insomnia, and headaches: a case report.
J Vert Sublux Res. 2003;12:111
Goff P, Sheader WE, Sheader DF, Thornton M.
Using a computerized continuous performance test to assess the effects of chiropractic adjustment on attention span: A pilot study.
Chiropr J Aust. 2000;30:4854
Giesen JM, Center DB, Leach RA.
An evaluation of chiropractic manipulation as a treatment of hyperactivity in children.
J Manipulative Physiol Ther. 1989;12:353363
Brzozowske W, Walton E.
The effect of chiropractic treatment on students with learning and behavioral impairments resulting form neurological dysfunction.
J Aust Chiro Assoc. 1980;11:1318
Brzozowske W, Walton E.
The effect of chiropractic treatment on students with learning and behavioral impairments resulting form neurological dysfunction.
J Aust Chiro Assoc. 1977;11:S127S140
Stone-McCoy PA, Przybysz L.
Chiropractic Management of a Child with Attention Deficit Hyperactivity Disorder & Vertebral Subluxation: A Case Study.
J Pediatr Maternal & Family Health - Chiropr. 2009. pp. 18
ADHD research project collects case study reports.
Chiropr J. 2007;21(1):36
Mileski M, McClay R.
The Role of Chiropractic in the Treatment of ADHD.
Dynamic Chiropr. 2003;21:16
A Case Study of ADHD.
ICA Review. 1998;54:5461
Adjusting the hyperactive/ADD pediatric patient.
Chiropr Pediatr. 1997;2:1216
Child with chronic illness: Respiratory infections, ADHD, and fatigue response to Chiropractic Care.
Chiropr Pediatr. 1997;3:1213
A multi-faceted chiropractic approach to attention deficit hyperactivity disorder: a case report.
Int Chiropr Assoc. 1995. pp. 4143
Not a Cookie Cutter Problem: Attention Deficit Hyperactivity Disorder.
Dynamic Chiropr. 1994;12:17
Epileptic seizures, Nocturnal enuresis and Attention Deficit Disorder.
Chiropr Pediatr. 1994;1:1
Andersen C, Partridge J.
Seizures plus Attention Deficit Hyperactivity Disorder: A case report.
Int Chiropr Assoc. 1993;49:3537
Lang A, Edwards N, Fleiszer A.
Empty systematic reviews: hidden perils and lessons learned.
J Clin Epidemiol. 2007;60:595597
Schlosser RW, Sigafoos J.
'Empty' reviews and evidence-based practice.
Evidence-Based Commun Asses Interven. 2009;3:13
Higgins JPT, Green S.
The Cochrane Library. 4. Chichester, UK: John Wiley & Sons, Ltd; 2006.
Cochrane Handbook for Systematic Review of Interventions 4.2.6 [updated September 2006]
Miller M, Fee V, Jones C.
Psychometric properties of ADHD rating scales among children with mental retardation II:Validity.
Res Dev Disabil. 2004;25:477492
Green S, Higgins JPT, Schόnemann HJ, Becker L.
Response to paper by Lang A, Edwards N, and Fleiszer
A. J Clin Epidemiol. 2007;60:598599
Sackett DL, Rosenberg WMC, Gray Muir JA, Haynes BR, Richardson SW.
Evidence based medicine: what it is and what it isn't.
Br Med J. 1996;312:7172
Straus SE, Sackett DL.
Applying evidence to the individual patient.
Ann Oncol. 1999;10:2932
Begg C, Cho M, S E, Horton R, Moher D, Olkin I, Pitkin R, Rennie D, Schulz K, Simel D, Stroup D.
Improving the quality of reporting of randomised controlled trials: the CONSORT statement.
Boutron I, Moher D, Altman D, Schulz K, Ravaud P. for the CONSORT Group.
Extending the CONSORT Statement to Randomized Trials of Nonpharmacologic Treatments: Explanation and Elaboration.
Ann Intern Med. 2008;148:295309
Zwarenstein M, Treweek S, Gagnier J, Altman D, Tunis S, Haynes B, Oxman A, Moher D.
CONSORT Group. Improving the reporting of pragmatic trials: an extension of the CONSORT statement.
Br Med J. 2008;337:a2390
Moher D, Soeken K, Sampson M, Ben-Porat L, Berman B.
Assessing the quality of reports of randomized trials in pediatric complementary and alternative medicine.
BMC Pediatrics. 2002;2:2
Risk Assessment of Neurological and/or Vertebrobasilar Complications in the Pediatric Chiropractic Patient.
J Vert Sublux Res. 1998;2:19
Vohra, S, Johnston, BC, Cramer, K, and Humphreys, K.
Adverse Events Associated with Pediatric Spinal Manipulation: A Systematic Review
Pediatrics. 2007 (Jan); 119 (1): e275e283
Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment.
New York: The Guilford Press; 1990
DuPaul GJ, Power TJ, Anastopoulos AD, Reid R.
ADHD Rating Scales-IV: Checklists, Norms and Clinical Interpretation.
New York: Guilford; 1998
The Brown Attention Deficit Disorder Scales.
San Antonio, TX: Psychological Corporation; 2001
Conners CK. Conners'
Toronto: Multi-Health System; 1997
Loney J, Milich M. In:
Advances in Behavioral and Developmental Pediatrics. Wolraich M, Routh DK, editor.
Greenwich, CT:JAI; 1982. Hyperactivity, inattention, and aggression in clinical practice; pp. 113147
School-Based Assessments and Intervention for ADD Students. Irvine:
KC Publishing; 1992
Wigal SB, Gupta S, Guinta D, Swanson JM.
Reliability and validity of the SKAMP rating scale in a laboratory school setting.
Psychopharmacol Bull. 1998;34:4753
Wolraich ML, Lambert EW, Baumgaertel A, Garcia-Tornel S, Feurer ID, Bickman L, Doffing MA.
Teachers' screening for attention deficit/hyperactivity disorder: comparing multinational samples on teacher ratings of ADHD.
J Abnorm Child Psychol. 2003;31:445455
Wolraich ML, Lambert W, Doffing MA, Bickman L, Simmons T, Worley K.
Psychometric properties of the Vanderbilt ADHD diagnostic parent rating scale in a referred population.
J Pediatr Psychol. 2003;28:559567
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