Chiropractic & Manual Therapies 2011 (Jan 11); 19: 2 ~ FULL TEXT
Michael H. Carstensen, Mashael Al-Harbi, Jean-Luc Urbain,
Department of Medical Imaging,
St Joseph´s Hospital,
268 Grosvenor Street, N6A 4V2,
London, Ontario, Canada
Mechanical low back pain is a common indication for Nuclear Medicine imaging. Whole-body bone scan is a very sensitive but poorly specific study for the detection of metabolic bone abnormalities. The accurate localisation of metabolically active bone disease is often difficult in 2D imaging but single photon emission computed tomography/computed tomography (SPECT/CT) allows accurate diagnosis and anatomic localisation of osteoblastic and osteolytic lesions in 3D imaging. We present a clinical case of a patient referred for evaluation of chronic lower back pain with no history of trauma, spinal surgery, or cancer. Planar whole-body scan showed heterogeneous tracer uptake in the lumbar spine with intense localization to the right lateral aspect of L3. Integrated SPECT/CT of the lumbar spine detected active bone metabolism in the right L3/L4 facet joint in the presence of minimal signs of degenerative osteoarthrosis on CT images, while a segment demonstrating more gross degenerative changes was quiescent with only mild tracer uptake. The usefulness of integrated SPECT/CT for anatomical and functional assessment of back pain opens promising opportunities both for multi-disciplinary clinical assessment and treatment for manual therapists and for research into the effectiveness of manual therapies.
The concept of lumbar facet joints causing or contributing to mechanical low back pain
syndromes has been debated in the health care literature for decades . Practitioners
of the various manual therapies commonly treat patients presenting with low back pain
but are faced with the diagnostic challenge of trying to identify a tissue source of low
back pain. While this complaint may be the result of any of a number of pathologies,
the vast majority of low back pain falls under the diagnostic umbrella of ‘‘ mechanical
low back pain ’’ . We present here the case of a patient with radiological signs of
marked lumbosacral junction facet joint osteoarthrosis and clinical symptoms supportive
of pathology in this region but with SPECT/CT findings suggestive of an active bony
lesion at a more remote spinal segment.
The patient in question was a 45–year-old Hispanic female who had lived in Canada for
the previous 11 years. She reported a long history of manual labour and subsisted on
similar occupations since arriving in Canada. At the time of her presentation, her
occupation required prolonged periods of standing. The patient’s chief complaint was
chronic low back pain. There was no antecedent trauma, bone surgery, or history of
cancer. The onset of low back pain was described as insidious, with constant achy pain
of at least two years duration which was progressively worsening. The pain remained
localised to the central lower back in the area of the lumbosacral junction. The pain was
rated at 3/10 (verbal scoring) at its best and 8/10 (verbal scoring) at its worst. An
increase in pain was associated with an increased level of physical activity during the
day, with the pain typically worse in the evening. During periods of increased pain,
there were intermittent incidences of pain radiating to the right-sided posterior thigh and
leg with “pins and needles” in the lateral toes of the right foot. Treatment to date had
consisted of non-steroidal anti-inflammatory medication, which she felt had been of
limited benefit. There had been no use of acupuncture, massage therapy, therapeutic
exercise, or any manual therapies for this condition. The patient was referred to the
department of Medical Imaging for evaluation of chronic lower back pain.
The patient reported that no spinal imaging had been performed in investigation of
these complaints. This was confirmed by a review of the patient’s records.
Imaging specialists typically do not examine patients who are referred into an imaging
department for investigation. As such, no physical examination was performed in this
case. Permission was granted after the images were interpreted only to interview the
patient for this case report.
A three-phase bone scan was performed with 99mTc(Technetium)-MDP (methylene
diphosphonate) including blood flow and blood pool imaging followed by a
delayed whole-body scan. SPECT/CT imaging centered over the lumbar spine was
subsequently performed on a Symbia T6 (Siemens), a dual-head gamma-camera
incorporating a low-dose 6–slice non-contrast enhanced CT (12 mAs, 130 kVp, Effective
Dose < 4 mSv). The CT scan duration was less than 1 min. Overall, the SPECT/CT
scan duration was about 20 min. The SPECT/CT fused images were displayed on the
e-soft 2007 workstation (Siemens) in axial, sagittal, and coronal slices.
The blood flow and pool images were unremarkable, suggesting no active inflammatory
process. The delayed whole-body images showed degenerative changes in multiple
sites in the axial and appendicular skeleton. Heterogeneous tracer uptake was noted at
multiple spinal levels with marked increased focal tracer uptake in the right lateral
aspect of L3 (Figure 1).
Delayed Whole Body images
anterior (L) and posterior showing focal tracer uptake
in right L3/L4 facet joint region (continuous black arrow)
SPECT/CT images confirmed intense tracer uptake in the right L3/L4 facet joint (Figure
2). In the absence of other osteoblastic or osteolytic pathology, this is most consistent
with active degenerative osteoarthrosis. Mild tracer uptake is also noted in the right
facet joint of L5/S1 in the presence of marked degenerative arthrosis, which is
consistent with limited active bony pathology. The low-dose CT images from the
SPECT/CT are not of diagnostic quality but they are adequate for anatomical
localization and gross tissue evaluation. In reviewing the axial CT images, there are
many abnormalities to note. At the level of the L3/L4 right facet joint, there are only mild
indicators of degenerative joint disease: focal joint space narrowing and early sclerosis
(Figure 3). In addition to marked degeneration of the right L5/S1 facet (Figure 4), there
is a left-sided discontinuity of the pars interarticularis and an incidental spina bifida
occulta at L5 (Figure 5).
SPECT/CT images confirmed intense
tracer uptake in the right L3/L4 facet joint.
In reviewing the axial CT images,
there are many abnormalities to note.
At the level of the L3/L4 right facet joint, there are only
mild indicators of degenerative joint disease: focal joint
space narrowing and early sclerosis.
CT image from SPECT/CT
demonstrating marked degenerative arthrosis at
right L5/S1 facet (white arrow).
CT image from SPECT/CT
demonstrating discontinuity of the left pars
interarticularis (continuous arrow) and an
incidental spina bifida occulta (dashed arrow).
As a category, mechanical low back pain accounts for up to 97% of low back pain
diagnoses [1, 2]. A diagnosis of mechanical low back pain implies that there are no
vascular, infectious, inflammatory or neoplastic etiologies underlying the patient’s
complaints but does little to clinically isolate a specific source of pain or identify a
definitive avenue of treatment. This diagnosis encompasses a broad subset of possible
tissue pathologies, many of which cannot be accurately diagnosed by physical
examination. This may limit a manual therapist’s ability to specifically prescribe a
treatment regimen or accurately predict a response to treatment.
Lumbar facet joint capsules are richly innervated with nociceptive and autonomic nerve
fibers and, as such, are a potential source of low back pain . Despite a broad range
of reported prevalence, this position is generally accepted and is supported by
investigations that have injected facet joints with corticosteroids and anesthetic agents
and demonstrated success in relieving some low back pain .
Undifferentiated lower back pain is a well established clinical indication for
planar/SPECT bone scintigraphy [5, 6]. Integrated SPECT/CT imaging is useful for
anatomic and functional evaluation of benign and malignant spine bone diseases,
particularly for evaluation of chronic low back pain [7–13]. The use of a low radiation
dose multislice CT for 3D anatomic localisation of disk and facet degenerative disease
improves the diagnostic accuracy and the specificity of planar/SPECT bone scintigraphy
[11, 12, 13]. The CT images will also provide additional 3D detail about anatomic
structures included in the region of interest that do not actively uptake radiotracer. The
CT component of SPECT/CT provides a lower radiation dose than diagnostic multidetector
CT imaging, with an effective radiation dose of less than 4 mSv generating a
radiation burden in the order of the yearly natural background exposure (approximately
3 mSv). The fast CT scanner (less than 1 min) may be used routinely for anatomic
mapping in bone scintigraphy procedures .
This case highlights several interesting findings for the clinical setting and raises a
number of potential research opportunities. Perhaps the most impressive finding is the
demonstration of metabolically active bone in a facet joint with minimal overt
degenerative changes that likely would not have been identified as pathological on plain
radiographs. While it is well documented that clinical symptoms do not correlate well
with radiographic and multidetector CT findings [2, 14, 15], the increased radiotracer
uptake found on the SPECT part from SPECT/CT may be due to painful facet
arthropathy, ongoing degenerative changes or the chronic sequelae of adverse
mechanical loading. This case has also demonstrated that facet hypertrophy found on
CT does not correlate with SPECT positivity, suggesting that facet hypertrophy has
either a latent period or represents an end-point as part of the degenerative process. It
is possible that by the time facet hypertrophy is notable on anatomic imaging, the
metabolic activity of the bone is normalising, as demonstrated by the limited tracer
uptake at the right L5/S1 facet joint. Rehabilitative treatment directed at SPECT
positivity may also allow potentially corrective conservative intervention before
advanced degenerative changes occur, theoretically reducing the likelihood of disability
due to profound alteration of joint mechanics.
In this particular patient’s clinical presentation, the CT findings of L5/S1 facet joint
hypertrophy coupled with paresthesias to the right posterior thigh and leg and the lateral
toes of the right foot is suggestive of a localised lesion to the L5/S1 segment, possibly
affecting the right S1 nerve root. Because the SPECT findings do not reveal any
significant active bony uptake in this region, any pain arising from this level may be due
to non-osseous tissues being irritated, such as pain sensitive soft tissues (disc,
ligament, muscle) or the exiting nerve root being affected by discal pathology and the
hypertrophied facet demonstrated at this level. CT provides limited resolution of soft
tissues in spine imaging and a more thorough evaluation of soft tissues would require
the superior tissue resolution of MRI. However, given the findings of intense tracer
uptake at the L3/L4 facet, the clinical presentation of low back pain may be due to local
facet joint pathology at L3/L4 or a combination of pathologies in different tissues at
For manual therapists, one possible algorithm of investigation and treatment in such
cases is to coordinate physical assessment with diagnostic or therapeutic facet joint
injections for metabolically active facet joints found by SPECT/CT . This approach
can be beneficial by localizing the source of low back pain if the injection relieves the
chief complaint. This approach may also be used in conjunction with manual therapies
and targeted rehabilitation to improve the biomechanical function of the spine through
muscle strengthening and muscle recruitment, and to improve joint mobility via
mobilization and/or manipulation while the patient is experiencing pain relief from a
therapeutic injection .
With the ability of SPECT/CT to identify sites of active bony metabolism, a role in
manual therapy research becomes evident. The ability to objectively document sites of
active biomechanical stress or degeneration opens up the possibility of using
SPECT/CT to assess the effectiveness of manipulative and stabilization therapies. If
such therapies are able to affect the biomechanics and stability of the spine, then
SPECT/CT offers an avenue for objective assessment of their effectiveness. While
such research may be technically and ethically difficult, SPECT/CT documentation of
facet arthropathy has the potential to support the hypothesis that improving
biomechanical function may both relieve pain and affect the degenerative process.
Facet arthropathy is a commonly accepted causative or contributing agent to low back
pain syndromes. The ability of integrated SPECT/CT to precisely localise metabolically
active facet joints may provide direction of treatment to manual therapies focused on
improving spinal function. It is postulated here that improvements in biomechanical
function, accompanied by patient subjective improvement, may demonstrate
improvement or resolution of SPECT/CT findings of facet arthropathy. Research would
have to be carefully designed to test this hypothesis.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent has been provided to the Editor-in-Chief of this journal.
The authors declare that they have no competing interests.
MC performed the literature review, interviewed the patient and prepared the manuscript. JLU, MA and TB contributed to the drafting of the manuscript as well as critical review and image interpretation. All authors approved of the final manuscript
The authors would like to thank Drs. I. Gulka, A. Leung, G. Garvin, and J. Rogers from the department of Diagnostic Radiology (St Joseph's Hospital Health Care and London Health Sciences Centre, London, Ontario) for their assistance in reviewing the CT imaging.
Kalichman L, Hunter DJ:
Lumbar Facet Joint Osteoarthritis: A Review.
Arthritis Rheum 2007, 37(2):69-80.
Deyo, RA, Weinstein, JN:
Primary Care: Low back pain.
N Engl J Med 2001,
The lumbosacral connection: The ligamentous structure of the low back
and its relationship to back pain.
In The Integrated Function of the Lumbar Spine and Sacroiliac Joint,
Proceedings of the Second International Congress on Low Back Pain.
Edited by Vleeming A, Mooney V, Dorman T, Snijders C; 1995.
Low back pain: current physiologic concepts.
Clinics 1999, 17(1):1-15.
Bombardieri E, Aktolun C, Baum RF, Bishof-Delaloye A,
Buscombe J, Chatal JF, Maffioli L, Moncayo R, Mortelmans L, Reske SN:
Bone Scintigraphy Procedures guidelines for Tumour imaging.
Kanmaz B, Collier BD, Liu Y, Uzum F, Uygur G, Akansel G, Gunes I,
Krasnow AZ, Hellman RS, Isitman AT, and Carrera G:
SPET and three-phase bone scintigraphy in adult patients with chronic low back pain.
Nucl Med Commun 1998, 19:13-21.
Hybrid SPECT/CT: a new era for SPECT imaging?
Eur J Nucl Med
Mol Imaging 2005, 32(5):521-4.
Even-Sapir E, Flusser G, Lerman H, Lievshitz G, Metser U:
low-dose CT: a clinically relevant constituent in the imaging algorithm
of nononcologic patients referred for bone scintigraphy.
J Nucl Med 2007,
Belhocine T, Rachinsky I, Akincioglu C, Gambhir S, Wilcox B,
Vezina W, Stitt L,
Driedger A, Urbain JL:
How Useful is an Integrated SPECT/CT in Clinical Setting and Research?:
Evaluation of a Low Radiation Dose 4 Slice System.
The Open Medical Imaging Journal 2008, 2:80-109.
Buck AK, Nekolla S, Ziegler S, Beer A, Krause BJ, Herrmann K,
Scheidhauer K, Wester HJ, rummeny EJ, Schwaiger M, Drzezga A:
J Nucl Med 2008, 49(8):1305-19.
Gnanasegaran G, Barwick T, Adamson K, Mohan H, Sharp D, Fogelman I:
Multislice SPECT/CT in Benign and Malignant Bone Disease:
When the Ordinary Turns Into the Extraordinary.
Semin Nucl Med 2009, 39(6):431-42.
Papathanassiou D, Bruna-Muraille C, Jouannaud C Gagneux-Lemoussu L,
Eschard JP, Leihn JC:
Single-photon emission computed tomography combined with computed
tomography (SPECT/CT) in bone diseases.
Joint Bone Spine 2009, 76:474–80.
McDonald M, Cooper R, Wang MY:
Use of computed tomography-singlephoton emission computed tomography
fusion for diagnosing painful facet arthropathy. Technical note.
Neurosurg Focus 2007, 22(1):E2.
Ryan PJ, Evans PA, Gibson T, Fogelman I:
Chronic lower back pain :
Comparison of bone SPECT with Radiography and CT.
Kalichman L, Li L, Kim DH, Guermazi A, Berkin V, O ;Donnell CJ, Hoffman U,
Cole R, Hunter DJ:
Facet Joint Osteoarthritis and Low Back Pain in the
Spine 2010, 33(23):2560–565.
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