Mediterranean Diet and Telomere Length in Nurses’ Health Study: Population Based Cohort Study
SOURCE: British Medical Journal 2014 (Dec 2) ~ FULL TEXT
Marta Crous-Bou, Teresa T Fung, Jennifer Prescott,
Bettina Julin, Mengmeng Du, Qi Sun, Kathryn M Rexrode,
Frank B Hu, Immaculata De Vivo
Channing Division of Network Medicine,
Department of Medicine,
Brigham and Women’s Hospital
and Harvard Medical School,
Boston, MA 02115, USA
OBJECTIVE: To examine whether adherence to the Mediterranean diet was associated with longer telomere length, a biomarker of aging.
DESIGN: Population based cohort study.
SETTING: Nurses’ Health Study, an ongoing prospective cohort study of 121,700 nurses enrolled in 1976; in 1989-90 a subset of 32,825 women provided blood samples.
PARTICIPANTS: 4676 disease-free women from nested case-control studies within the Nurses’ Health Study with telomere length measured who also completed food frequency questionnaires.
MAIN OUTCOME MEASURE: Association between relative telomere lengths in peripheral blood leukocytes measured by quantitative real time polymerase chain reaction and Alternate Mediterranean Diet score calculated from self reported dietary data.
RESULTS: Greater adherence to the Mediterranean diet was associated with longer telomeres after adjustment for potential confounders. Least squares mean telomere length z scores were -0.038 (SE 0.035) for the lowest Mediterranean diet score groups and 0.072 (0.030) for the highest group (P for trend = 0.004).
There are more articles like this @ our: