Chardonnay Grape Seed
(Vitis vinifera)

This section was compiled by Frank M. Painter, D.C.
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Chardonnay Research Abstracts

Cytotoxicity and Apoptotic Cell Death Induced by Vitis vinifera
and Seed Extracts in A431 Skin Cancer Cells

Cytotechnology. 2018 (Apr);   70 (2):   537–554

Vitis vinifera peel and seed extracts were able to impart cytotoxic effects, induced apoptosis and apoptotic morphological changes in A431 cells significantly (p < 0.01) and this effect is associated with the interference with mitochondrial membrane potential. This reduction in mitochondrial membrane potential probably initiated the apoptotic cascade in the extracts treated cells. Vitis vinifera peel and seed phytochemicals can selectively target cancer cells and the phytochemicals that are occluded can serve as potential anticancer agents providing better efficacy in killing cancer cells.

Neuroprotective Role of Hydroalcoholic Extract of
Vitis vinifera Against Aluminium-induced
Oxidative Stress in Rat Brain

Neurotoxicology. 2014 (Mar);   41:   73–79

V. vinifera extract supplementation to Al treated animals caused a significant improvement in the activity of enzyme acetylcholinesterase which was altered by Al. Serum glucose, TG, TC, ALP and ALT were brought back to normal levels. Further, V. vinifera extract when given along with Al was also able to regulate the levels of Anti-oxidant parameters in brain and the values were found close to the normal controls. Histopathological studies revealed neurodegeneration and vacuolated cytoplasm after Al treatment. Therefore, the study strengthens the hypothesis that V. vinifera extract can be used as a neuroprotectant during Al induced neurotoxicity.

Neuroprotective Effects of Vitis vinifera Extract on
Prediabetic Mice Induced by a High-fat Diet

Korean J Intern Med. 2013 (Sep);   28 (5):   579–586 ~ FULL TEXT

This study provides scientific support for the therapeutic potential of VVE in peripheral neuropathy in an HD mouse model. Our results suggest that VVE could play a role in the management of peripheral neuropathy, similar to other antioxidants known to be beneficial for diabetic peripheral neuropathy.

Induction of Apoptosis By Grape Seed Extract (Vitis vinifera)
in Oral Squamous Cell Carcinoma

Bosn J Basic Med Sci. 2013 (Aug);   13 (3):   186–191

The results showed apoptotic potential of GSE, confirmed by significant inhibition of cell growth and viability in a dose- and time- dependent manner without inducing damage to non-cancerous cell line HUVEC. The results of this study suggest that this plant contains potential bioactive compound(s) for the treatment of oral squamous cell carcinoma.

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