What is Isorhamnetin?
Isorhamnetin is a flavonoid, which occurs naturally in plants, but is also a metabolite of quercetin (isorhamnetin is methylated quercetin).
Distribution
Red turnip, goldenrod, mustard leaf, ginkgo biloba.
Health Benefits of Isorhamnetin
Isorhamnetin is not that much studied than quercetin. However, the few that exist indicate that isorhamnetin has similar health benefits: it may reduce the risk of cancer, improve heart health and ease diabetes complications.
Anti-cancer
The anti-cancer effect of isorhamnetin has been demonstrated in in-vivo and in-vitro tests. In-vitro tests with lung cancer cells, liver cancer cells and esophageal cancer cells showed that isorhamnetin induces apoptosis of these cells. An in-vivo experiment with mice that were injected with isorhamnetin showed a reduced tumor weight.
Heart health
Both quercetin and isorhamnetin help to improve heart health. They improve the endothelial function through their antioxidant action and reduce the oxidation of HDL, resulting in a decreased risk of arteriosclerosis. Isorhamnetin is a potential candidate to explain the reduction of blood pressure and vascular protective effects observed in animal models of hypertension.
Diabetes complications
Some studies have focused on the ability of isorhamnetin to attenuate diabetes complications, such as diabetic cataract, lipid peroxidation and high blood glucose levels.
Synonyms
3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on;
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
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