Gabapentin and Pregabalin Not Effective for Low Back Pain
with or without Radiculopathy
American Family Physician 2019 (Mar 15); 99 (6): Online~ FULL TEXT
Particularly in this era of heightened awareness of the potential harms of opioids, anticonvulsants are often prescribed for the treatment of painful conditions. Although there is evidence of their effectiveness, primarily for peripheral and diabetic neuropathy, anticonvulsants are increasingly prescribed for other conditions, including low back pain. This systematic review included a comprehensive search of the literature, and the authors identified nine randomized trials (three of which were crossover studies) that compared topiramate (Topamax), pregabalin (Lyrica), or gabapentin with placebo in patients with low back pain with or without radiculopathy.