J Manipulative Physiol Ther. 2014 (Jun); 37 (5): 300–311 ~ FULL TEXT
Darcy A. Vavrek, ND, MS, Rajiv Sharma, PhD, Mitchell Haas, DC, MA
University of Western States,
OBJECTIVE: The purpose of this analysis is to report the incremental costs and benefits of different doses of spinal manipulative therapy (SMT) in patients with chronic low back pain (LBP).
METHODS: We randomized 400 patients with chronic LBP to receive a dose of 0, 6, 12, or 18 sessions of SMT. Participants were scheduled for 18 visits for 6 weeks and received SMT or light massage control from a doctor of chiropractic. Societal costs in the year after study enrollment were estimated using patient reports of health care use and lost productivity. The main health outcomes were the number of pain-free days and disability-free days. Multiple regression was performed on outcomes and log-transformed cost data.
RESULTS: Lost productivity accounts for most societal costs of chronic LBP. Cost of treatment and lost productivity ranged from $3398 for 12 SMT sessions to $3815 for 0 SMT sessions with no statistically significant differences between groups. Baseline patient characteristics related to increase in costs were greater age (P = .03), greater disability (P = .01), lower quality-adjusted life year scores (P = .01), and higher costs in the period preceding enrollment (P < .01). Pain-free and disability-free days were greater for all SMT doses compared with control, but only SMT 12 yielded a statistically significant benefit of 22.9 pain-free days (P = .03) and 19.8 disability-free days (P = .04). No statistically significant group differences in quality-adjusted life years were noted.
CONCLUSIONS: A dose of 12 SMT sessions yielded a modest benefit in pain-free and disability-free days. Care of chronic LBP with SMT did not increase the costs of treatment plus lost productivity.
From the FULL TEXT Article:
The estimated incidence of moderate back pain is 10–15% of the adult population, with a point prevalence of 15–30%. [1–3] Low back pain is the 5th most common reason for physician office visits in the US. [4, 5] Amongst people with LBP, who see a complementary and alternative medicine (CAM) practitioner for any reason, approximately 49% see a doctor of chiropractic for LBP. [6, 7] The use of CAM, including chiropractic care, has increased significantly over the past 50 years, [2, 8] and may be associated with lower treatment costs. [9–11]
Back pain is the 4th costliest health and productivity burden for US employers among physical and mental health conditions. [7, 12] Biennial expenditures were estimated as high as $35.7 billion for ambulatory services for chronic back pain in 2006 to 2007.  Including indirect costs, annual US costs of LBP could range from $84.1 to $624.8 billion. [5, 7] A recent study in the UK found that patients with chronic LBP had annual treatment costs that were twice those of matched controls.  Furthermore, episodes of LBP have been associated with increased spending on other health conditions. 
The utilization of any kind of patient-initiated treatment is intermittent and ongoing LBP often persists beyond reception of care.  The costs paid by the insurer for a course of care provided by a doctor of chiropractic may be as much as 40% less than care provided by an MD.  While patients do not seem to seek coordinated care across provider types within LPB episodes, perhaps this integration will improve over time.  Few studies have been done evaluating the dose effect of spinal manipulative therapy (SMT). [19–21] The scientific evidence on SMT for the relief of chronic LBP has been well discussed in systematic reviews. [22, 23]
Previously reported data for our trial showed a sustainable within dose-group treatment effect across multiple dose groups to 52 weeks and, while 12 SMT visits were favored, this was not well distinguished from 6 and 18 visits.  The purpose of this analysis is to report the incremental cost of treatment and lost productivity as well as the benefit in terms of pain-free and disability-free days.
This secondary analysis utilized data from a prospective open-label, randomized controlled trial registered on ClinicalTrials.gov (NCT00376350). This trial is discussed in detail by Haas et al.  The study was conducted in Portland, Oregon between March 2007 and July 2011. A total of 400 participants were randomized to receive a dose of 0, 6, 12, or 18 SMT sessions out of 18 treatment visits with a doctor of chiropractic. All participants were assigned 3 treatments per week for 6 weeks. Treating physicians provided care at each visit: SMT or a minimal light massage control to isolate the effect of SMT from the effect of touching the patient therapeutically.
Volunteers with a current episode of chronic LBP [25, 26] of mechanical origin lasting 3 months or longer were eligible if they were at least 18 years old, ambulatory, and English literate.  Participants were required to have some LBP on at least 30 days of the prior 6 weeks and a minimum score of 25 on the 100–point pain intensity scale described below. They were excluded for contraindications to SMT such as active cancer, spine pathology, inflammatory arthropathies, autoimmune disorders, and anti-coagulant conditions. Also excluded were potentially confounding conditions including neurodegenerative diseases, pain radiating below the knee, organic referred pain, and disability compensation.  This study was approved by the University of Western States Institutional Review Board.
The SMT treatments consisted of high-velocity, low-amplitude spinal manipulation of the lumbar spine and transition thoracic regions.  The light massage used as the control intervention was gentler and of shorter duration than recommended for therapeutic massage practice. [29, 30]
The main outcome measures for this analysis were pain-free days (PFDs) and disability-free days (DFDs), defined as the estimated number of days in the year following randomization that the participant was free of LBP and disability. PFDs and DFDs were computed using methods similar to those employed by Lave et al  to calculate depression-free days and by Dickinson et al  to calculate pain-related disability-free days. Patients with Modified Von Korff scores of over 80 were assumed to be impacted on all intervening days by pain/disability, and those with scores no greater than 20 were assumed free of pain/disability on those days. For those with intermediate pain or disability scores, the number of days of discomfort was assumed to increase linearly with the score. The mean of 2 consecutive scores was used to estimate the number of days with pain/disability in the intervening time interval.
Modified Von Korff LBP pain intensity and pain-related functional disability range from 0 to 100, with higher scores denoting greater severity.  The pain score is an average of 3 scales, 0 to 10 each, multiplied by 10: back pain today, worst back pain in the last 4 weeks, and average back pain in the last 4 weeks. Similarly, the disability score is the rescaled average of 3 questions, also 0 to 10 each, covering interference with daily activities, social and recreational activities, and the ability to work outside or around the house. Pain and disability are recognized as key indicators of severity in pain conditions, and indices measuring pain and disability from a composite of several patient responses have desirable psychometric properties for assessments of health. [34, 35]
Quality-adjusted life years (QALY) were computed from EuroQol–5D measures collected at baseline, 12, 24, 39, and 52 weeks.36, 37 Other patient measures, including reports of health care utilization, were collected at baseline, 6, 12, 18, 24, 39, and 52 weeks summarizing experiences over the prior four-weeks.
Our objective was to estimate costs from a societal perspective consisting of costs of study-provided care, patient reports of outside care, and lost productivity. While treatment and lost productivity likely account for a majority of costs related to LBP, some costs were not included in our data. These include the cost transportation and travel time to obtain care, as well as the cost of any equipment purchases, or modifications to accommodate LBP. Consequently, we may underestimate the full societal cost of LBP.
To estimate costs of treatment not included as part of the study protocol, we used patient reports of outside care utilization in the previous 4 weeks. Patient reports of care are widely employed to estimate utilization and are regarded as reliable over short time periods.  Medicare’s 2009 national non-facility (i.e., non-hospital) payments were used to estimate costs of patient-reported visits to health care providers.  The resource-based relative value scale underlying these payments is designed to reflect the resources used to provide services.  Assigned costs of treatment are listed in Table 1. Physician fees for emergency department visits were estimated using Medicare’s 2009 national facility payment to account for hospital facility fees under the hospital outpatient prospective payment system.  We assumed that the light massage control was minimally therapeutic, being similar to a massage that might be delivered for a few minutes by a friend, and assigned it no cost. 
Patients reported no hospitalizations, and a single patient from the SMT 6 group reported 2 surgeries. It is unknown whether or not these were performed inside or outside the hospital. The costs for these 2 surgeries were excluded from the analysis. The minimum cost of back surgery is estimated at $15,000, and including these costs would create an extreme outlier. Costs of patient-reported use of over-the-counter and prescription medicines were estimated using per use rates of $0.20 and $1.00 respectively.
Lost Productivity Costs
Lost productivity was computed from patient reports of days with inability to perform usual activities including employment, household work, and self-care. Work status (and the related concept of productivity) is determined by a complex array of psychological, social, and economic factors.  Measurements of lost productivity due to impaired health including pain have mostly relied on direct patient reports of missed work or impaired ability. [43, 44] There is wide variation in the literature regarding methods employed in the computation of lost productivity due to impaired health. [7, 44, 45] Taking this into account, the cost of productivity lost due to LBP was computed from the number of days the patients were kept from their usual activities by LBP. Taking a societal (as opposed to purely employment-based) perspective on productivity, we assumed that on each day that a patient was kept from usual activities, s/he lost 6 hours of productive time (half of an approximate workday involving 8 hours of paid labor and 2 hours of self-care/household work). Each lost hour was assigned a cost of $15.95, the US median wage in 2009.  Annual costs reflect imputed costs incurred in the entire one-year study period from baseline to 52 weeks.
Regression models of the natural logarithm of costs were used to compute the adjusted effect of treatment dose on treatment costs alone, as well as including the cost of lost productivity. Semi-log models such as these are commonly used to address skewness in cost data.  They yield an adjusted ratio of treatment group to control group costs.
Duan’s smearing estimator (assuming homoscedasticity) was appropriate for use in all retransformations as we found no evidence of heteroscedasticity in the cost regressions.  Costs of study-provided treatment were excluded because they are additive and non-stochastic. Including these in the multiplicative log models would have created a functional misspecification resulting in biased results. 
Baseline explanatory variables (covariates) included in all regression models were age, sex, white non-Hispanic, married, college-educated, low-income (<$20,000), smoker, prior treatment experience with SMT and massage treatment, differential confidence in treatment success between SMT and massage, as well as baseline pain, disability, and QALY scores. Log of treatment costs in the 4 weeks before baseline was included in treatment cost regressions while log of treatment plus lost productivity in the 4 weeks before baseline was included in treatment plus lost productivity cost regressions.
To further demonstrate the variation in costs of treatment and lost productivity, we created 3 illustrative patient profiles by selecting 3 sets of patient characteristics and fitting our regression models post hoc. The patient in Profile M has baseline characteristics close to the mean for those enrolled in this study. Profiles L and H depict patients with baseline characteristics that are predictive of lower and higher costs respectively. The values of the baseline continuous variables in Profiles L and H were approximately 1 standard deviation from the values for Profile M. The costs of study-provided treatment are included, and the incremental effects of dose as well as some other key predictors of costs in the regression models were computed. [32, 50]
Linear regression models were used to compute the adjusted effect of treatment dose on the number of PFDs and DFDs experienced by patients. The same covariates used in the cost analysis were included with the exception of baseline cost variables.
Statistical testing for all variables was set at a 2–sided alpha of .05. A full intention-to-treat analysis was conducted with each participant included in the original allocation groups; missing data were imputed when possible. Two subjects declined to give annual income information and so were removed from modeling. Multiple-testing adjustments were not made because this was a secondary analysis. Analyses were conducted with Stata 11.0 (StataCorp, College Station, TX) and SAS 9.2 (SAS Institute, Inc. Cary, NC).
Figure 1 shows compliance with follow-up. Details are published elsewhere.  Compliance was excellent ranging from 81% to 99% per group per time point. There were 9 subjects who were entirely lost to follow-up after enrollment and were not included in the analysis. For the cost comparisons, the surgery patient was removed. Two participants refused to report income and were removed from adjusted analyses.
Baseline Patient Characteristics and Costs
Mean age for all groups was 41 years, 15% were minorities, and the groups were divided nearly evenly between men and women (Table 2). Over half of all patients reported having college degrees, 36% were married, and 11% were smokers. Participants had moderate low back pain with a mean pain of 51.5 on a 100–point Modified Von Korff scale and mean disability of 45.3 with an average QALY of 0.71. Mean treatment costs in the 4 weeks preceding the baseline were a modest $10.1, on average, and mean costs including the cost of lost productivity in the 4 weeks preceding baseline were substantially larger, $558, on average. No meaningful differences between groups at baseline were noted.
Treatment and Lost Productivity Costs During the Study Period
Table 3 shows that unadjusted one-year costs for treatment outside the study protocol for the groups ranged from $287 to $623. Mean costs for the one-year study period were much larger when the costs of lost productivity were added to the costs of outside care yielding $2,838 to $3,815. No statistically significant differences were observed.
The adjusted group effects in semi-log cost regressions are multiplicative, which are interpreted as ratios of costs compared to control. Annual treatment costs comparisons revealed ratios of 1.15, 1.18, and 0.78 respectively. Costs with lost productivity added resulted in ratios of 0.91, 1.02, and 0.90 respectively. These results were not statistically significant, and no trends across study groups can be inferred given the variability in the costs.
In Table 4, the full regression model for the natural log of annual costs shows that greater age (P=0.02) and disability (P=0.01) were predictors of higher annual treatment costs, while higher baseline QALY scores (P<0.01) predicted lower treatment costs. In the model that also includes costs of lost productivity, college education (P=0.02) and previous experience with massage (P=0.04) were predictive of higher costs, while higher baseline QALY scores (P<0.01) were predictive of lower costs. Costs in the 4 weeks preceding the baseline were strong predictors of higher costs in both these models (P<0.01).
Pain-Free and LBP-Related Disability-Free Days
Table 4 also shows the regression models for LBP-related PFDs and DFDs that patients experienced during the one-year study period. Compared to the SMT 0 reference group, patients benefitted from 16.8 to 22.9 more PFDs and 12.3 to 19.4 more DFDs. The greatest benefits in PFDs and DFDs were for the SMT 12 group and were the only statistically significant results (P=0.03 and 0.04, respectively). In addition, baseline health as measured by pain, disability, and the QALY score was strongly predictive of the number of PFDs and DFDs that patients experienced. A one-point increase in baseline pain on a 100–point scale predicted a 2.7–point decrease in PFDs (P<0.01), and a one-point increase in baseline disability predicted a 1.4–point decrease in DFDs (P < 0.01). QALY scores are measured on a much narrower, approximately 1 point scale. Each 0.01 point increase in the baseline QALY score predicted 1.07 and 1.05 additional PFDs and DFDs during the study period (P=0.01 and P<0.01, respectively).
EuroQol–5D based QALY scores increased 4% to 6% during the one-year study period to 0.81 for SMT 0, 0.80 for SMT 6, 0.83 for SMT 12 and 0.81 for SMT 18. A regression analysis similar to the ones for PFDs/DFDs above found that relative to SMT 0, each dose of SMT yielded an additional 0.00 to 0.01 QALYs. None of the differences either between study groups or across time within study groups were statistically significant.
Incremental Effects of SMT Dose and Patient Characteristics on Adjusted Costs
The costs related to the 3 patient profiles are reported in Table 5. They include the cost of study-provided care, the cost of outside care and, where indicated, the cost of lost productivity. The effects of treatment groups and changes in selected baseline characteristics are presented for each profile.
For Profile M, doses of SMT 6, 12, and 18 predicted increases of $317, $123, and $345 in annual treatment costs, respectively, when compared to no SMT. When lost productivity was included, the doses predicted increases of $734, $94, and $476. Compared to the SMT 0 group, the treatment cost of an additional PFD was $19, $5, and $19 and the treatment cost of an additional DFD was $25, $6, and $28 for SMT 6, 12, and 18 respectively. When treatment and lost productivity were considered, the cost of an additional PFD was $44, $4, and $26 and the cost of an additional DFD was $57, $5, $39 for the 3 dose groups, respectively.
Treatment and lost productivity costs were less responsive to SMT dose for the lower cost patient in Profile L. Baseline patient characteristics such as smoking, age, and disability also had smaller effects on costs for such patients when compared to effects on Profile M.
For Profile H, doses of SMT 6, 12, and 18 predicted increases of $1,217, –$271, and $39 in annual treatment costs, respectively when compared to SMT 0. When the cost of lost productivity was included, the increases were predicted to be $2,777, –$277, and $710. Compared to the SMT 0 group, the treatment cost of an additional PFD was $72, –$12, and $2 and the treatment cost of an additional DFD was $95, –$14, and $3 for SMT 6, 12, and 18 respectively. When treatment and lost productivity were considered, the cost of an additional PFD was $165, –$12, and $39 and the cost of an additional DFD was $217, –$14, and $58 for the 3 dose groups, respectively.
Sensitivity analyses that excluded weeks not covered by patient reports yielded results that were very similar to those obtained from analysis of annualized cost data for treatment costs but somewhat more favorable to the highest dose of SMT for costs of treatment plus lost productivity (Table 3).
Post-hoc power analysis of costs of lost productivity and treatments outside the study protocol showed that our trial had 80% power to detect cost increases of 145% for SMT 6, 101% for SMT 12, and 107% for SMT 18 relative to the reference SMT 0 group. Our trial had 80% power to detect relative cost decreases compared to SMT 0 of 44%, 53%, and 50% for the 3 groups, respectively.
This study shows that manipulation can have a modicum of benefit in LBP-related pain and disability without significantly increasing treatment or societal costs. In the main results paper reporting pain and disability on 100–point scales, Haas et al  found an 8.6–point advantage in pain (p=.002) and 7.5–point advantage in disability (p=.011) for SMT 12 compared to the control at 12 weeks. In this study, we found that this benefit may occur without significant increases in costs of treatment or lost productivity. We also found a modest incremental benefit of 23 PFDs and 19 DFDs from 12 spinal manipulation treatments relative to a no manipulation control. The incremental benefits from the other doses examined showed an increase in PFDs and DFDs, but not with statistical significance. SMT dose did not have a statistically significant effect on either QALYs, treatment costs, or on the combined cost of treatment and lost productivity.
Finding no statistically significant QALY differences either between study groups or across time within study groups is consistent with several prior studies suggesting that QALY scores are insensitive to small or moderate changes in health. [32, 51, 52] It is not uncommon for studies of chronic conditions, especially chronic pain to employ other measures of patient benefit in addition to QALYs. For example, Niemisto et al  used measures including VAS pain, self-rated disability, health-related quality of life, and patient satisfaction.
A number of studies have previously examined the benefits and cost of SMT in patients with low back pain.
[50, 53–58] The estimated benefits and costs have varied between studies, and part of the difference in results may arise because the studies examined different or unspecified doses of SMT. Our results indicate that incremental benefits vary with SMT dose with SMT 12 yielding the greatest benefit. Our analysis of the effect of the SMT dose on costs should be interpreted with caution because of the large variability in costs (low power). Substantially larger sample sizes appear to be required in trials of SMT in patients with chronic LBP in order to detect differences in costs of treatment and, especially, lost productivity between patients receiving different doses of SMT.
The modest size of the incremental benefit from SMT 12 is not unusual for studies of interventions in patients with chronic pain. In their analysis of the cost of manipulation, stabilizing exercises, and physician consultation in comparison to physician consultation alone, Niemisto et al  found mean intervention group improvements relative to control of 6.3 points in pain and an improvement of 2.3 points in disability after 12 months when both pain and disability were measured on scales of 0 to 100. In a study of a collaborative intervention to treat chronic pain among veterans, the intervention yielded 16 additional pain disability free days relative to control. 
Our results confirm previous findings that the cost of lost productivity due to LBP is often much higher than the cost of treatment. A systematic review of LBP cost of illness studies lists 8 studies that examined both direct (mostly treatment) and indirect (mostly lost productivity) costs.  In 6 of these studies, direct costs comprised less that 20% of combined direct and indirect costs. In our study, cost of productivity lost due to LBP is between approximately 2.5 to 10 fold higher than the cost of treatment.
Kominski et al58 found LBP patients’ baseline characteristics including age, education, and baseline health to be important predictors of treatment costs. Our cost analyses reemphasize the importance of similar baseline patient characteristics, especially baseline pain and disability, as important predictors of treatment costs and lost productivity. In a result consistent with a previous analysis of treatment costs among patients with chronic pain, our results show that costs in the period preceding enrollment in the trial can also be predictive of the costs of treatment and lost productivity. 
A recent study on patients with back and neck problems found that CAM users had lower costs than non-CAM users.9 Our results suggest a potentially more complex relationship for LBP treated by doctors of chiropractic. For patients with characteristics predictive of high costs (Profile H, Table 5), costs of treatment obtained outside the study were much larger than the costs of study-provided treatment, and costs of lost productivity were even larger. Furthermore, costs may increase with SMT for patients whose baseline characteristics predict low costs (Profile L) in contrast to the decrease with some SMT doses for patients whose baseline characteristics predict high costs (Profile H). This highlights the disproportionate share of the economic burden of LBP that patients similar to our Profile H bear in terms of treatment and lost productivity. Larger trials are necessary to clarify the actual causal relationships.
While there are no published standardized measures of the individual financial consequences of pain,59 there are measures of meaningful clinical improvement to pain and disability. Retrospective reports of interference with daily activities show internal consistency and convergent validity [59, 60] and 11–point numerical rating scales provide sufficient levels of discrimination with similar sensitivity to 101–point scales. [59, 61] Using first-return-to-work as an indicator of recovery is challenging because it is frequently followed by recurrences of work absence.  It is difficult to measure work disability outside the usual measures of absence from/presence at work and the number of days of work absence. New measures, such as the clinical return-to-work-rule and testing at-work disability, may be of interest in future research. [59, 63, 64]
The selected participants for this study were not on disability nor were they seeking disability claims. In addition, potential participants with confounding conditions were excluded. Our sample size was too small to sufficiently capture subjects who would eventually elect to get surgery, and the one patient who did so, was removed as an outlier. Therefore, this study population best generalizes to a subset of the population missing work. In addition, as over 70% of the participants had previous experience with SMT and over 40% had experience with massage, the expectations of the patients were balanced at baseline. An analysis of the doctor patient encounter showed that expectations were balanced across groups and had no notable effect on follow-up LBP.  Still, caution in interpretation of the results is advised.
In this study, patients’ mean baseline QALY score was 0.75 which is higher than that observed in most other LBP trials, and may limit direct comparisons of results and may present ceiling effects. In their review of studies of interventions for LBP, Dagenais et al  compiled a list of baseline QALY scores in the reviewed studies (their Table 5) that ranged from 0.35 to 0.71; improvements in QALY scores reported by the studies tended to be smaller in groups with higher baseline scores.
Similarly, the existence of a variety of payment systems and costing methodologies complicates direct comparisons of cost results from different studies. Our use of Medicare payments to estimate treatment costs may have contributed to our finding of low treatment costs relative to studies that have used charges, prices paid by private insurers, or other methods. Mean annual treatment costs of study-provided and outside care across the different SMT doses ranged from $315 to $897. While these costs are broadly comparable to those reported by Herman et al  for the cost of naturopathic care for LBP, other studies have reported substantially higher costs, especially if treatment involved surgery. Martin et al  found through analysis of a nationally representative sample that patients with back and neck problems had mean costs of $6,096 in 2005. The minimum cost of lumbar surgery has been estimated at $15,000. 
Using patient reports of health at specific time points or during specific periods to estimate health in intervening periods is common in cost analyses, and we employ this approach to compute DFDs for the complete 1 year duration of the study. [31, 66, 70] However, it remains possible that this extrapolation may introduce an unknown bias into our estimates. We similarly use patient reports of health care utilization and activity restriction in 4–week periods preceding the 6, 12, 18, 24, 39, and 52–week time points to estimate annual treatment and lost productivity costs. The possibility of conservative bias due to extrapolation cannot be ruled out. Our estimates of the cost of productivity lost due to LBP are also conservative. Using mean as opposed to median wages to estimate the cost of each hour of productivity lost would have increased these costs by approximately 30%. Attributing a full workday (8 hours) of lost productivity to each day when a patient was kept from usual activities due to LBP would have compounded the increase by another third. The cost analyses which yield results slightly more favorable to doses SMT 12 and SMT 18 are not statistically significant.
SMT showed a modicum of benefit in LBP and LBP-related disability without increasing costs from a societal prospective (treatment costs and productivity together). Inference regarding cost is preliminary because of low statistical power. The SMT 12 group had the most PFDs and DFDs compared to SMT 0. SMT 12 was also favored when looking at predicted mean costs but the incremental cost of SMT interventions depended upon the characteristics of patients being treated. Specifically, for patients who were likely to have high costs, the SMT 12 intervention was cost decreasing (but not statistically significant). This report adds to the evidence that a dose of 12 SMT treatments appears to be reasonable for use in a comparative effectiveness trial.
FUNDING SOURCES AND CONFLICTS OF INTEREST
No funding sources or conflicts of interest were reported for this study.
Darcy A Vavrek, Assistant Professor, University of Western States.
Rajiv Sharma, Portland State University.
Mitchell Haas, Associate Vice President of Research, University of Western States.
Epidemiological features of chronic low-back pain.
Deyo RA, Mirza SK, Martin BI.
Back pain prevalence and visit rates: Estimates from U.S. national surveys, 2002.
Woolf AD, Pfleger B.
Burden of Major Musculoskeletal Conditions
Bull World Health Organ 2003 (Nov 14); 81: 646–656
Hart LG, Deyo RA, Cherkin DC.
Physician office visits for low back pain.
Gore M, Sadosky A, Stacey BR, Tai KS, Leslie D.
The Burden of Chronic Low Back Pain: Clinical Comorbidities, Treatment Patterns,
and Health Care Costs in Usual Care Settings
Spine (Phila Pa 1976). 2012 (May 15); 37 (11): E668–677
Lind BK, Lafferty WE, Tyree PT, Sherman KJ, Deyo RA, Cherkin DC.
The role of alternative medical providers for the outpatient treatment
of insured patients with back pain.
Dagenais S, Caro J, Haldeman S.
A Systematic Review of Low Back Pain Cost of Illness Studies
in the United States and Internationally
Spine J 2008 (Jan); 8 (1): 8–20
Kessler RC, Davis RB, Foster DF, et al.
Long-Term Trends in the Use of Complementary and Alternative Medical Therapies
in the United States
Annals of Internal Medicine 2001 (Aug 21); 135 (4): 262–268
Martin, BI, Gerkovich, MM, Deyo, RA et al.
The Association of Complementary and Alternative Medicine Use and Health Care Expenditures
for Back and Neck Problems
Medical Care 2012 (Dec); 50 (12): 1029–1036
Haas M, Sharma R, Stano M.
Cost-effectiveness of Medical and Chiropractic Care for Acute and Chronic Low Back Pain
J Manipulative Physiol Ther 2005 (Oct); 28 (8): 555–563
Sharma R, Haas M, Stano M, Spegman A, Gehring R.
Determinants of costs and pain improvement for medical and chiropractic care of low back pain.
J Manipulative Physiol Ther. 2009;32:252–61
Goetzel RZ, Hawkins K, Ozminkowski RJ, Wang S.
The health and productivity cost burden of the “top 10” physical and mental health conditions
affecting six large U.S. employers in 1999.
J Occup Environ Med. 2003;45:5–14
Smith, M, Davis, MA, Stano, M, and Whedon, JM.
Aging Baby Boomers and the Rising Cost of Chronic Back Pain:
Secular Trend Analysis of Longitudinal Medical Expenditures
Panel Survey Data for Years 2000 to 2007
J Manipulative Physiol Ther. 2013 (Jan); 36 (1): 2–11
Hong J, Reed C, Novick D, Happich M.
Costs associated with treatment of chronic low back pain:
An analysis of the UK general practice research database.
Nimgade A, McNeely E, Milton D, Celona J.
Increased expenditures for other health conditions after an incident of low back pain.
Identifying Episodes of Back Pain Using Medical Expenditures Panel Survey Data:
Patient Experience, Use of Services, and Chronicity
Journal of Manipulative and Physiological Therapeutics. 2010;33(8):562–575
Liliedahl RL, Finch MD, Axene DV, Goertz CM.
Cost of Care for Common Back Pain Conditions Initiated With Chiropractic
Doctor vs Medical Doctor/Doctor of Osteopathy as First Physician:
Experience of One Tennessee-Based General Health Insurer
J Manipulative Physiol Ther 2010 (Nov); 33 (9): 640–643
Weigel PA, Hockenberry JM, Bentler SE, Kaskie B, Wolinsky FD.
Chiropractic Episodes and the Co-occurrence of
Chiropractic and Health Services
Use Among Older Medicare Beneficiaries
J Manipulative Physiol Ther 2012 (Mar); 35 (3): 168-175
Haas M, Spegman A et al. (2010)
Dose Response and Efficacy of Spinal Manipulation for Chronic Cervicogenic Headache:
A Pilot Randomized Controlled Trial
Spine J. 2010 (Feb); 10 (2): 117–128
Haas M, Groupp E, Aickin M, Fairweather A, Ganger B, Attwood M, et al.
Dose Response for Chiropractic Care of Chronic Cervicogenic Headache
and Associated Neck Pain: A Randomized Pilot Study
J Manipulative Physiol Ther 2004 (Nov); 27 (9): 547—553
Haas M, Groupp E, Kraemer DF.
Dose-response for Chiropractic Care of Chronic Low Back Pain
Spine J 2004 (Sep); 4 (5): 574–583
Bronfort G, Haas M, Evans R, Leininger B, Triano J.
Effectiveness of Manual Therapies: The UK Evidence Report
Chiropractic & Osteopathy 2010 (Feb 25); 18 (1): 3
Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, van Tulder MW.
Spinal manipulative therapy for chronic low-back pain: An update of a cochrane review.
Haas M, Vavrek D, Peterson D, Polissar N, Neradilek MB.
Dose-response and Efficacy of Spinal Manipulation for Care of Chronic Low Back Pain:
A Randomized Controlled Trial
Spine J. 2014 (Jul 1); 14 (7): 1106–1116
Problems of classification of low-back pain.
Rheumatol Rehabil. 1977;16:34–6
DiFabio RP, Mackey G, Holte JB.
Physical therapy outcomes for patients receiving workers’ compensation following
treatment for herniated lumbar disc and mechanical low back pain syndrome.
J Orthop Spotrs Phys Ther. 1996;23(3):180–7
Shekelle P, Adams A, Chassin M, Hurwitz E, Brook R.
Spinal manipulation for low-back pain.
Ann Intern Med. 1992;117:590–8
Peterson DH, Bergmann TF.
Chiropractic technique: principles and practice.
St. Louis: Mosby; 2002.
Furlan AD, Brosseau L, Imamura M, Irvin E.
Massage for low back pain: A systematic review within the framework of the
cochrane collaboration back review group.
Cherkin DC, Deyo RA, Sherman KJ, Hart G, Street JH, Hrbek A, et al.
Characteristics of Visits to Licensed Acupuncturists, Chiropractors,
Massage Therapists, and Naturopathic Physicians
J Am Board Fam Pract 2002; 15 (6):463-480
Lave JR, Frank RG, Schulberg HC, Kamlet MS.
Cost-effectiveness of treatments for major depression in primary care practice.
Arch Gen Psychiatry. 1998;55:645–51
Dickinson KC, Sharma R, Duckart JP, Corson K, Gerrity MS, Dobscha SK.
VA healthcare costs of a collaborative intervention for chronic pain in primary care.
Med Care. 2010;48:38–44
Underwood MR, Barnett AG, Vickers MR.
Evaluation of two time-specific back pain outcome measures.
Von Korff M, Ormel J, Keefe FJ, Dworkin SF.
Grading the severity of chronic pain.
Airaksinen O, Brox JI, Cedraschi C, et al.
COST B13 Working Group on Guidelines for Chronic Low Back Pain Chapter 4.
European Guidelines for the Management of Chronic Nonspecific Low Back Pain
European Spine Journal 2006 (Mar); 15 Suppl 2: S192–300
The EuroQol Group.
EuroQol-a new facility for the measurement of health-related quality of life.
Health Policy. 1990;16:199–208
EuroQol: The current state of play.
Health Policy. 1996;37:53–72
Ritter PL, Stewart AL, Kaymaz H, Sobel DS, Block DA, Lorig KR.
Self-reports of health care utilization compared to provider records.
J Clin Epidemiol. 2001;54:136–41
[Last accessed on:8/10/2012];
Medicare’s 2009 national non-facility (i.e., non-hospital) payments. Available from:
Folland S, Goodman AC, Stano M.
The economics of health and health care. 6.
Boston: Prentice Hall; 2010. p. 601.
[Last accessed on:01/11/2013];
Hospital Outpatient Prospective Payment System Limited Data Set. Available from:
Dionne CE, Von Korff M, Koepsell TD, Deyo RA, Barlow WE, Checkoway H.
A comparison of pain, functional limitations, and work status indices as
outcome measures in back pain research.
Stewart WF, Ricci JA, Chee E, Morganstein D, Lipton R.
Lost Productive Time and Cost Due to Common Pain Conditions in the US Workforce
JAMA 2003 (Nov 12); 290 (18): 2443–2454
Mattke S, Balakrishnan A, Bergamo G, Newberry SJ.
A review of methods to measure health-related productivity loss.
Am J Manag Care. 2007;13:211–7
Mitchell RJ, Bates P.
Measuring health-related productivity loss.
Popul Health Manag. 2011;14:93–8
Bureau of Labor Statistics,
U.S. Department of Labor.
OES Highlights, An Overview of U.S. Occupational Employment and Wages in 2009.
[Last accessed on:02/05/2013].
Diehr P, Yanez D, Ash A, Hornbrook M, Lin DY.
Methods for analyzing health care utilization and costs.
Annu Rev Public Health. 1999;20:125–44
Smearing estimate: A nonparametric retransformation method.
J Am Stat Assoc. 1983;78:606–10.
Judge GG, Hill RC, Griffiths WE, Lutkepohl H, Lee T.
Chapter 20 In: Introduction to the Theory and Practice of Econometrics. 2.
USA: John Wiley & Sons; 1988.
Sharma R, Haas M, Stano M.
Patient Attitudes, Insurance, and Other Determinants of
Self-referral to Medical and Chiropractic Physicians
American Journal of Public Health 2003 (Dec); 93 (12): 2111–2117
Jenkinson C, Gray A, Doll H, Lawrence K, Keoghane S, Layte R.
Evaluation of index and profile measures of health status in a randomized controlled triall.
Med Care. 1997;35:1109–18
Harper R, Brazier JE, Waterhouse JC, Walters SJ, Jones NM, Howard P.
Comparison of outcome measures for patients with chronic obstructive pulmonary disease
(COPD) in an outpatient setting.
Niemisto L, Rissanen P, Sarna S, Lahtinen-Suopanki T, Lindgren KA, Hurri H.
Cost-effectiveness of combined manipulation, stabilizing exercises, and physician consultation
compared to physician consultation alone for chronic low back pain:
A prospective randomized trial with 2-year follow-up.
McMorland G, Suter E.
Chiropractic management of mechanical neck and low-back pain:
A retrospective, outcome-based analysis.
J Manipulative Physiol Ther. 2000;23:307–11
Niemisto L, Lahtinen-Suopanki T,
Rissanen P, Lindgren K-A, Sarna S, Hurri H.
A Randomized Trial of Combined Manipulation, Stabilizing Exercises,
and Physician Consultation Compared to Physician Consultation
for Chronic Low Back Pain
Spine (Phila Pa 1976) 2003 (Oct 1); 28 (19): 2185–2191
Underwood M, UK BEAM Trial Team.
United Kingdom Back Pain Exercise and Manipulation (UK BEAM) Randomized Tial:
Effectiveness of Physical Treatments for Back Pain in Primary Care
British Medical Journal 2004 (Dec 11); 329 (7479): 1377–1384
United Kingdom Back Pain Exercise and Manipulation (UK BEAM) Randomised Trial
Cost Effectiveness of Physical Treatments for Back Pain in Primary Care
British Medical Journal 2004 (Dec 11); 329 (7479): 1381–1385
Kominski GF, Heslin KC, Morgenstern H, Hurwitz EL, Harber PI.
Economic evaluation of four treatments for low-back pain:
Results from a randomized controlled trial.
Med Care. 2005;43:428–35
Croft P, Blyth F, van der Windt D.
Chronic pain epidemiology: from aetiology to public health.
Oxford: Oxford University Press; 2010. p. 365.
Turk DC, Melzack R.
Handbook of pain assessment. 2.
New York: Guilford Press; 2001. p. 760.
Jensen MP, Turner JA, Romano JM.
What is the maximum number of levels needed in pain intensity measurement?
Baldwin ML, Johnson WG, Butler RJ.
The error of using returns-to-work to measure the outcomes of health care.
Am J Ind Med. 1996;29:632–41
Beaton DE, Kennedy CA.
Beyond return to work: Testing a measure of at-work disability in workers
with musculoskeletal pain.
Qual Life Res. 2005;14:1869–79
Dionne CE, Bourbonnais R, Fremont P, Rossignol M, Stock SR, Larocque I.
A clinical return-to-work rule for patients with back pain.
Haas M, Vavrek D, Neradilek MB, Polissar N.
A Path Analysis of the Effects of the Doctor-patient Encounter and Expectancy in an Open-label
Randomized Trial of Spinal Manipulation for the Care of Low Back Pain
BMC Complement Altern Med. 2014 (Jan 13); 14: 16
Dagenais S, Roffey DM, Wai EK, Haldeman S, Caro J.
Can cost utility evaluations inform decision making about interventions for low back pain?
Spine J. 2009;9:944–57
Herman PM, Szczurko O, Cooley K, Mills E.
Cost-effectiveness of naturopathic care for chronic low back pain.
Altern Ther Health Med. 2008;14:32–8
Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al.
Expenditures and Health Status Among Adults With Back and Neck Problems
JAMA 2008 (Feb 13); 299 (6): 656–664
Clinical effectiveness and cost-effectiveness of treatments for patients with chronic pain.
Clin J Pain. 2002;18:355–65
Dakin H, Gray A, Fitzpatrick R, Maclennan G, Murray D.
KAT Trial Group. Rationing of total knee replacement:
A cost-effectiveness analysis on a large trial data set.
BMJ Open. 2012;2:e000332. 2011-000332. Print 2012
Return to LOW BACK PAIN
Return to COST-EFFECTIVENESS