Shaklee Studies

Shaklee Support for Basic Science

Human Parainfluenza Virus Infection of the Airway Epithelium: Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein Activation and Modulates Infectivity Journal of Virology 2009 (Jul);   83 (13):   6900–6908 ~ FULL TEXT The study suggested that the most direct strategy for preventing infection may be by interfering with the initial receptor binding of the virus to the host cell.

Determination of Coenzyme Q10 Content in Raw Materials and Dietary Supplements by High-performance Liquid Chromatography-UV: Collaborative Study Journal of AOAC International 2008 (Jul);   91 (4):   702–708 ~ FULL TEXT The findings of the study suggest that high-performance liquid chromatographic (HPLC)-UV is the method recommended by Official First Action for determination of CoQ10 in raw materials and dietary supplement finished products containing CoQ10.

Supplement Use and Improved Health

	The Telomere Study 2 Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls Journal of Food and Nutrition Sciences 2018 (Nov 26);   6 (5):   129–134 This study showed that long-term multi-supplement users had longer telomere length in their 50s, 60s and 70s compared to controls. The results suggest that heavy dietary supplementation may attenuate telomere shortening and is consistent with a previous study’s findings that long-term multiple dietary supplement usage was associated with significantly improved health and nutritional status. Based on the published literature and putative mechanisms, supplements containing vitamins C, D and E, carotenoids, omega-3 fatty acids and polyphenols may all contribute to the effects on telomere length. Further research, including prospective longitudinal studies, is needed to have a better understanding of the active nutrients and their mechanisms of action. You may also want to review our: All About Telomeres Page
	Prevalence of Elevated HbA1c Among Multiple Dietary Supplement Users American Diabetes Association’s 2017 Conference Presentation ~ FULL TEXT After adjusting for age, sex, income, education and BMI, we observed that the prevalence of diabetes among non-supplement users was almost 2-fold higher compared to the long-term multi-supplement users (LTMS) users.
	The Telomere Study 1 Cross-Sectional Analysis of Telomere Length in People 33-80 Years of Age: Effects of Dietary Supplementation American College of Nutrition's 55th Annual Conference (2014) ~ FULL TEXT The results of this cross-sectional study suggest that heavy Shaklee dietary supplementation significantly attenuated telomere shortening in subjects compared to a healthy control group.   Longitudinal studies are warranted to further explore the link between nutritional supplementation and healthy aging in the context of reduced rate of telomere shortening You may also want to review our: All About Telomeres Page
	Effect of Long-Term Vitamin-Mineral Supplements on Immune Response in Older Healthy Adults Journal of the American College of Nutrition 1998;   17:   511 Infection-related illness (IML) was significantly lower for Group I than Group 2 for the entire year. While IRL were lower for the first semester, the difference between groups was not statistically significant. Serum folate (+9.04 ng/dL p<0.01) and serum vitamin A (+16.35 µg/dl, p<0.01) were higher for Group I after 1 year. Folate (-0.47 ng/mL) and zinc (-0.37 µg/L) correlated negatively with days of illness (p<0.05): the higher the level of folate and zinc, the fewer days of illness.

Filling Those Nutritional Gaps

Filling Nutritional Gaps With Dietary Supplements The Health Resource This group of long-term multiple dietary supplement users consumed a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis.   They were more likely to have optimal concentrations of chronic disease-related biomarkers, and less likely to have suboptimal blood nutrient concentrations, elevated blood pressure, and diabetes compared to non-users and multivitamin/mineral users.   These findings should be confirmed by studying the dietary supplement usage patterns, health, and nutritional status of other groups of heavy users of dietary supplements.

The Landmark Studies

	A Different Kind of a Landmark Study Selecting a Dietary Supplement with Appropriate Dosing for 6 Key Nutrients in Pregnancy Am J Clin Nutr 2023 (Apr); 117 (4): 823–829 ~ FULL TEXT This study was not funded or sponsored by Shaklee Corporation. But, like Shaklee's Landmark Studies, this paper is another Landmark of a sort, in which scientists from 10 different medical institutions pooled their resources to review 20,547 dietary supplements, to find out how many of them contained the proper dosage all 6 of the key nutrients that support a healthy pregnancy . Guess what? Shaklee's Life Strip with Iron was the ONLY supplement to pass their test! Once again, Shaklee science prevails, and this study irrefutably puts Shaklee at the top of the nutrition industry.
	The Landmark Study II A Beneficial Cardiometabolic Health Profile Associated with Dietary Supplement Use: A Cross-sectional Study Int J Vitam Nutr Res 2021 (Mar 1); 1–11 ~ FULL TEXT Ten years later, after 30 or more years of multiple supplement usage, these long-term multiple supplement users had better cardiometabolic profiles as compared to a non-supplementing NHANES cohort-including higher HDL cholesterol, lower LDL cholesterol and lower fasting blood glucose levels. For almost all categories, the LTMDS cohort had significantly lower medication usage. You may also enjoy this earlier poster, presented at the 2019 American Society for Nutrition Annual Conference, Baltimore, MD, USA.
	The Landmark Study I Usage Patterns, Health, and Nutritional Status of Long-term Multiple Dietary Supplement Users Nutrition Journal 2007 (Oct 24); 6: 30 ~ FULL TEXT Long-term supplement users (multivitamin/mineral, extra vitamin C and B vitamins, Omega-3) were more likely to have optimal levels of blood nutrients, lower blood pressure, less diabetes, lower homocysteine, C-reactive protein, higher HDL, and lower triglyceride levels than non-supplemental users. You may also enjoy this Landmark Poster

The Vivix Studies

	The Telomere Study 2 Telomere Length of Multiple Dietary Supplement Users - A Cross-sectional Study in Comparison with Age-matched Controls Journal of Food and Nutrition Sciences 2018 (Nov 26);   6 (5):   129–134 This study showed that long-term multi-supplement users had longer telomere length in their 50s, 60s and 70s compared to controls. The results suggest that heavy dietary supplementation may attenuate telomere shortening and is consistent with a previous study’s findings that long-term multiple dietary supplement usage was associated with significantly improved health and nutritional status. Based on the published literature and putative mechanisms, supplements containing vitamins C, D and E, carotenoids, omega-3 fatty acids and polyphenols may all contribute to the effects on telomere length. Further research, including prospective longitudinal studies, is needed to have a better understanding of the active nutrients and their mechanisms of action.
	The Macular Degeneration Study 2 Effect of AREDS2 Plus a Resveratrol-Rich Formulation on Atrophic Age-Related Macular Degeneration: a Case Report Poster Presentation @ Resveratrol (2016) ~ FULL TEXT Supplementation with AREDS2 plus a rveratrol/polyphenol-rich supplement (RPS) restored the subject’s vision in her right eye from 20/70 to 20/30 after 4 months. After 11 months, the distorted retinal pigment epithelium was restored (Figure 2) resulting in an improved vision of 5 Snellen lines to 20/25.
	The Improved New Vivix Study Synergistic Effects of Phenolic Mixtures in Human Cell Models of Aging ExperimentalBiology.Org ~ 2015 ~ FULL TEXT It is commonly thought that the polyphenol resveratrol is responsible for the health benefits of drinking wine.   Grapes, though, contain numerous other active components along with other polyphenols beyond resveratrol that may be responsible for the effects.   This study was designed to investigate the difference between resveratrol alone versus a complex mixture of polyphenols in different laboratory models of aging.
	The Telomere Study 1 Cross-Sectional Analysis of Telomere Length in People 33-80 Years of Age: Effects of Dietary Supplementation American College of Nutrition's 55th Annual Conference (2014) ~ FULL TEXT The results of this cross-sectional study suggest that heavy Shaklee dietary supplementation significantly attenuated telomere shortening in subjects compared to a healthy control group.   Longitudinal studies are warranted to further explore the link between nutritional supplementation and healthy aging in the context of reduced rate of telomere shortening. You may also want to review our: All About Telomeres Page
	The Macular Degeneration Study Effect of the Combination of AREDS2 Formulation and a Polyphenol Preparation on Dry Age-related Macular Degeneration: Analysis of Case Studies American Society for Nutrition Conference (2014) ~ FULL TEXT Overall, supplementation with AREDS2 plus a resveratrol/polyphenol-enriched supplement (RPS) for at least four months resulted in structural and/or visual improvements in approximately 70% of patients.   The limitations of these case presentations are that the observations do not distinguish between the possibilities that the effects of the polyphenol preparation on retinal structure/function depend on synergistic interactions with AREDS2, or if the polyphenols alone are responsible.
	The Burger King Breakfast Study A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal J Clin Endocrinol Metab. 2011 (May);   96 (5):   1409–1414 ~ FULL TEXT In this randomized, placebo-controlled clinical study, performed by scientists at State University of New York at Buffalo, participants were fed a 910-calorie, fast food breakfast, including sausage, cheese and fried potatoes (Burger King/McDonalds-style breakfast).   Half the group received a resveratrol and polyphenol supplement.   Everyone’s blood was tested for the activity levels of a key genetic molecule, called Nrf2 (pronounced Nerf 2), which is the coordinator of antioxidant protection within every cell in your body.

The CINCH and Shaklee 180 Soy Protein Studies

	The South Shore YMCA Study III Effects of Resistance Exercise and Protein on Body Composition Following Weight Loss Journal of Clinical Exercise and Physiology 2018;   7 (2):   25–32 ~ FULL TEXT Excessive body fat is associated with a variety of risk factors including elevated plasma cholesterol, plasma glucose, and resting blood pressure, which are associated with development of type 2 diabetes and cardiovascular disease. [21] Although almost 70% of Americans are presently following reduced calorie diet plans [2], approximately 70% of our adult population remain overweight or obese. [1] Diet programs are effective for temporary weight reduction [8, 11], but almost all successful dieters return to their prediet weight within a relatively short time period. [8–11] Unlike most weight maintenance programs, our protocol involved 2 weekly exercise sessions (40 min of combined resistance and aerobic exercise) and a daily meal replacement protein shake. This program maintained the subjects' postdiet body weight over a 9–month period, with a significant decrease in fat mass and a significant increase in lean mass. This weight maintenance approach appears to present a sustainable lifestyle change that may be particularly beneficial for participants in clinical exercise programs whose progress may be enhanced by body weight maintenance and body composition improvement.
	The South Shore YMCA Study II Exercise and Nutrition Effects on Body Composition and Blood Measures in Overweight Adults Journal of Exercise Physiologyonline 2017 (Feb);   20 (1): 200–220 ~ FULL TEXT Participants of the exercise program who did not receive the added nutritional support (the control group) typically lost 3.5 pounds of lean body muscle mass during the trial period.   The active participants in this study (exercise plus a structured meal plan) gained 3.7 pounds of lean body mass, and experienced significant improvements in blood pressure and hemoglobin A1c during the same trial period.
	The Employees Study II Effects of a Physician-supervised, Structured Meal Replacement Program on Body Composition and Weight Loss American College of Nutrition Proceedings (2015) ~ FULL TEXT After 12 weeks, participants lost an average of 12.7 lb (or 6.9%) of their initial body weight (p<0.0001). Fat mass was significantly reduced by 16.6 lb (p<0.001) with a concomitant increase of 3.9 lb in fat-free mass (p<0.03). Body Mass Index (BMI) was significantly reduced from 31.4 to 29.2 kg/m2 (p<0.0001). Categorical shift in weight classification was observed in 5 out of 14 subjects who were obese at baseline.
	The The Employees Study Outcomes of a 3-Month Employee Wellness Weight Loss Challenge: A Physician-Supervised, Structured Meal Replacement Program American College of Nutrition's 55th Annual Conference (2014) ~ FULL TEXT The 3 month results indicate that this structured meal replacement program combined with physician supervision exhibited a good completion rate and significant & clinically meaningful weight loss. Longterm studies are warranted to evaluate the effects of this program on weight loss and weight loss maintenance over an extended period of usage.
	The Mobile App Followup Study Effect of an Online, Mobile App-mediated Structured Meal Replacement Program on Weight Management: Outcomes in a Real World Setting ObesityWeek 2014 ~ FULL TEXT Shaklee 180 structured meal replacement program promoted a healthy and clinically meaningful weight loss in a relatively short time frame.   People on this diet program lost an average of 4.0 lb per month over 3 months.
	The South Shore YMCA Study I Protein and Body Composition Fitness Management 2008 (May) ~ FULL TEXT Subjects who ingested the post-exercise protein drink increased their lean weight by 5.5 pounds, and decreased their fat weight by 9 pounds — a 14.5-pound improvement in body composition.   Those who did not receive supplemental protein increased their lean weight by 3.9 pounds, and decreased their fat weight by 4.9 pounds — an 8.8-pound improvement in body composition.   Based on the results of this study, we found that a standard strength/endurance exercise program consistent with ACSM training guidelines is effective at increasing lean weight, decreasing fat weight and reducing resting blood pressure.   Furthermore, we believe that consuming supplemental protein shortly after each training session is beneficial in helping promote desirable body composition changes (increased lean weight and decreased fat weight) associated with a standard strength/endurance exercise program.

Sport Drink Studies

Do Sports Drinks Cause Kidney Stones? Urological Research 2009 (Feb); 37 (1): 41–46 ~ FULL TEXT The effect of commercial oral rehydration solutions ("sports drinks") relative to water on risk of nephrolithiasis has not been studied previously. We studied the effect of two sports drinks, Performance (Shaklee Corp., Pleasanton, CA, USA) and Gatorade (Gatorade, Chicago, IL, USA) on urinary chemistry and measures of lithogenicity in non-stone formers. Ingestion of Performance, but not Gatorade, led to an increase in mean urinary citrate excretion and pH as compared to water. The increase in citrate is likely to be a clinically significant effect. pH is an important determinant of alkali load in beverages containing organic anions. Performance, with more citrate and a higher pH than Gatorade, could represent a superior alternative to water for reducing urinary lithogenicity. Most sports drinks with significant carbohydrate content however may contain too many calories, and fructose, to be preferred beverages for stone prevention.

OmegaGuard Studies

The Role of Fish Oil in Inflammatory Eye Diseases Biomedicine Hub. 2017 (Feb 21);   2 (1):   1–12 ~ FULL TEXT Consumption of fish oil is associated with reduced morbidity and mortality of cardiovascular diseases and also reduces the severity of many other inflammatory diseases and autoimmune disorders. The beneficial effects are attributed to the anti-inflammatory effects of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oils. The mechanism of the anti-inflammatory effects was long thought to be by modulating the production of proinflammatory mediators, including prostaglandins, thromboxanes, and leukotrienes. Recent advances in research into the novel lipid mediators (resolvins, protectins, and maresins) derived from EPA and DHA and their role in the resolution of inflammation have shed new light on the pleiotropic nature of these fatty acids. In this review, we focus on the effects of EPA and DHA from fish oil in the treatment of two common inflammatory eye diseases – dry eye disease and age-related macular degeneration. Evidence from recent studies lends support to a role of fish oil in the treatment of these two eye diseases. You may also want to review our: Omega-3 Fatty Acids Page

Reduced Asthma Symptoms with n-3 Fatty Acid Ingestion Are Related to 5-series Leukotriene Production Am J Clin Nutr. 1997 (Apr);   65 (4):   1011–1017 ~ FULL TEXT In summary, the incorporation of a source of n-3 PUFA in the diet, ie, fish or fish oil, could alleviate minor respiratory problems in asthmatics or decrease the degree of respiratory problems among a subset of severe asthmatics who respond to diet. Increased consumption of n-3 PUFAs can produce beneficial alterations in 4- and 5-series leukotriene synthesis. These findings raise the possibility that dietary supplementation with marine oils or highly enriched sources of n-3 PUFAs may be another viable treatment modality for asthma.

Immune Studies (NutriFeron, Defend & Resist)

	An Open-label Study of Administration of EH0202, A Health-food Additive, to Patients With Chronic Hepatitis C J Gastroenterol. 2004 (Sep);   39 (9):   873–878 ~ FULL TEXT There was a statistically significant decrease in HCV-RNA levels in patients with high viral titers after 3 months of EH0202 administration.   No serious adverse events were observed with the EH0202 treatment.   These findings suggest that EH0202 may be safe and useful in the treatment of patients with chronic hepatitis C.   Further studies are, however, needed to obtain a definitive conclusion.
	A Pilot Study of a Kampo Formula, EH0202, with Intriguing Results for Menopausal Symptoms J Altern Complement Med. 2004 (Apr);   10 (2):   397–399 ~ FULL TEXT H0202 (MACH) decreased the plasma FSH level and stimulated myelopoiesis through the cytokine system, thereby clinically reduced menopausal symptoms in postmenopausal women. Therefore, in postmenopausal women, this product probably acts as an immunomodulator and endocrine modulator.
	Clinical Efficacy of EH0202, a Kampo formula, on the Health of Middle-aged Women Am J Chin Med. 2004;   32 (5):   755–770 ~ FULL TEXT After taking EH0202 for six months, women reported a decrease in menopausal symptoms as well as a decrease in blood pressure and improved blood lipids (total and LDL cholesterol).
	Treatment of the Common Cold with Unrefined Echinacea. A Randomized, Double-blind, Placebo-controlled Trial Annals of Internal Medicine 2002 (Dec 17);   137 (12):   939–946 ~ FULL TEXT 148 students with common colds of recent onset were randomized to receive echinacea or a placebo, and were tracked for 10 days. This study appears to show that once the cold virus is well-established that echinacea does not appear to moderate the severity or duration of symptoms.
	Effect of Long-Term Vitamin-Mineral Supplements on Immune Response in Older Healthy Adults Journal of the American College of Nutrition 1998; 17: 511 Taking a multivitamin/mineral supplement is commonly thought to help fill in nutritional gaps and prevent deficiency diseases, but what additional health benefits are associated with supplement use are less defined. The results (from this study) confirm that adding a multiple vitamin and mineral supplement to the typical diets of healthy older individuals may lesson infection related illness and enhance immune function. These findings are in agreement with previous research (Chandra et al. Lancet 1992 Nov 7), and suggest that the addition of a multiple vitamin and mineral supplement to the typical diets of healthy older individuals may help maintain normal immune function.

7-Day Cleanse Program

Safety, Tolerability And Efficacy Of A 7-Day Cleanse Program: A Pilot Study ObesityWeek 2014 ~ FULL TEXT This study showed that the cleanse programs were safe and well-tolerated. Significant weight loss was observed after 7 days. The addition of laxative was more effective in promoting elimination/bowel movements and reducing bloating/gassiness. This program may be used as an adjunct prior to a weight loss program.

Since 12–01–2015

Updated 9-03-2024