Shaklee Studies

This section was compiled by Frank M. Painter, D.C.
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Acidophilus Antioxidants Beta Carotene Bioflavonoids

Black Cohosh Calcium Chromium Coenzyme - Q10

Echinacea Fiber GLA Garlic

Ginger Gingko biloba Ginseng Glucosamine

Guaraná Leucine Magnesium Milk Thistle

Nutrient Depletion Omega-3s Resveratrol Saw Palmetto

Selenium Soy Protein St. John's Wort Sterols/Stanols

   The Vitamins   

B   Complex C   Complex D   Vitamin E   Complex

The Alternative Medicine Approach to Disease

    Supplement Use and the Incidence of Diabetes    

Prevalence of Elevated HbA1c Among Multiple Dietary Supplement Users
American Diabetes Association’s 2017 Conference Presentation ~ FULL TEXT

After adjusting for age, sex, income, education and BMI, we observed that the prevalence of diabetes among non-supplement users was almost 2-fold higher compared to the long-term multi-supplement users (LTMS) users.


    Filling Those Nutritional Gaps    

Filling Nutritional Gaps
With Dietary Supplements

The Health Resource

This group of long-term multiple dietary supplement users consumed a broad array of vitamin/mineral, herbal, and condition-specific dietary supplements on a daily basis.   They were more likely to have optimal concentrations of chronic disease-related biomarkers, and less likely to have suboptimal blood nutrient concentrations, elevated blood pressure, and diabetes compared to non-users and multivitamin/mineral users.   These findings should be confirmed by studying the dietary supplement usage patterns, health, and nutritional status of other groups of heavy users of dietary supplements.


    The Landmark Study    

Usage Patterns, Health, and Nutritional Status of Long-term
Multiple Dietary Supplement Users

Nutrition Journal 2007 (Oct 24);   6:   30 ~ FULL TEXT

National nutrition surveys confirm that children are not consuming the recommended number of food group servings based on the Food Guide Pyramid, with 63% of 2-9 year-olds not consuming enough fruit, 78% not consuming enough vegetables, and only 12.7% consuming two or more servings of whole grains per day. [1, 2]


    The Vivix Studies    

The Macular Degeneration Study 2
Effect of AREDS2 Plus a Resveratrol-Rich Formulation on Atrophic
Age-Related Macular Degeneration: a Case Report

Poster Presentation @ Resveratrol (2016) ~ FULL TEXT

Supplementation with AREDS2 plus a rveratrol/polyphenol-rich supplement (RPS) restored the subject’s vision in her right eye from 20/70 to 20/30 after 4 months. After 11 months, the distorted retinal pigment epithelium was restored (Figure 2) resulting in an improved vision of 5 Snellen lines to 20/25.

The Improved New Vivix Study
Synergistic Effects of Phenolic Mixtures in Human Cell Models of Aging
ExperimentalBiology.Org ~ 2015 ~ FULL TEXT

It is commonly thought that the polyphenol resveratrol is responsible for the health benefits of drinking wine.   Grapes, though, contain numerous other active components along with other polyphenols beyond resveratrol that may be responsible for the effects.   This study was designed to investigate the difference between resveratrol alone versus a complex mixture of polyphenols in different laboratory models of aging.

The Telomere Study
Cross-Sectional Analysis of Telomere Length in People 33-80 Years of Age:
Effects of Dietary Supplementation

American College of Nutrition's 55th Annual Conference (2014) ~ FULL TEXT

The results of this cross-sectional study suggest that heavy Shaklee dietary supplementation significantly attenuated telomere shortening in subjects compared to a healthy control group.   Longitudinal studies are warranted to further explore the link between nutritional supplementation and healthy aging in the context of reduced rate of telomere shortening.

The Macular Degeneration Study
Effect of the Combination of AREDS2 Formulation and a Polyphenol
Preparation on Dry Age-related Macular Degeneration:
Analysis of Case Studies

American Society for Nutrition Conference (2014) ~ FULL TEXT

Overall, supplementation with AREDS2 plus a resveratrol/polyphenol-enriched supplement (RPS) for at least four months resulted in structural and/or visual improvements in approximately 70% of patients.   The limitations of these case presentations are that the observations do not distinguish between the possibilities that the effects of the polyphenol preparation on retinal structure/function depend on synergistic interactions with AREDS2, or if the polyphenols alone are responsible.

The Burger King Breakfast Study
A Resveratrol and Polyphenol Preparation Suppresses Oxidative
and Inflammatory Stress Response to a High-Fat,
High-Carbohydrate Meal

J Clin Endocrinol Metab. 2011 (May);   96 (5):   1409–1414 ~ FULL TEXT

In this randomized, placebo-controlled clinical study, performed by scientists at State University of New York at Buffalo, participants were fed a 910-calorie, fast food breakfast, including sausage, cheese and fried potatoes (Burger King/McDonalds-style breakfast).   Half the group received a resveratrol and polyphenol supplement.   Everyone’s blood was tested for the activity levels of a key genetic molecule, called Nrf2 (pronounced Nerf 2), which is the coordinator of antioxidant protection within every cell in your body.


    The CINCH and Shaklee 180 Soy Protein Studies    

The South Shore YMCA Study II
Exercise and Nutrition Effects on Body Composition and Blood Measures
in Overweight Adults

Journal of Exercise Physiologyonline 2017 (Feb);   20 (1): 200–220 ~ FULL TEXT

Participants of the exercise program who did not receive the added nutritional support (the control group) typically lost 3.5 pounds of lean body muscle mass during the trial period.   The active participants in this study (exercise plus a structured meal plan) gained 3.7 pounds of lean body mass, and experienced significant improvements in blood pressure and hemoglobin A1c during the same trial period.

The Employees Study II
Effects of a Physician-supervised, Structured Meal Replacement Program
on Body Composition and Weight Loss

American College of Nutrition Proceedings (2015) ~ FULL TEXT

After 12 weeks, participants lost an average of 12.7 lb (or 6.9%) of their initial body weight (p<0.0001). Fat mass was significantly reduced by 16.6 lb (p<0.001) with a concomitant increase of 3.9 lb in fat-free mass (p<0.03). Body Mass Index (BMI) was significantly reduced from 31.4 to 29.2 kg/m2 (p<0.0001). Categorical shift in weight classification was observed in 5 out of 14 subjects who were obese at baseline.

The The Employees Study
Outcomes of a 3-Month Employee Wellness Weight Loss Challenge:
A Physician-Supervised, Structured Meal Replacement Program

American College of Nutrition's 55th Annual Conference (2014) ~ FULL TEXT

The 3 month results indicate that this structured meal replacement program combined with physician supervision exhibited a good completion rate and significant & clinically meaningful weight loss. Longterm studies are warranted to evaluate the effects of this program on weight loss and weight loss maintenance over an extended period of usage.

The Mobile App Followup Study
Effect of an Online, Mobile App-mediated Structured Meal Replacement
Program on Weight Management: Outcomes in a Real World Setting

ObesityWeek 2014 ~ FULL TEXT

Shaklee 180 structured meal replacement program promoted a healthy and clinically meaningful weight loss in a relatively short time frame.   People on this diet program lost an average of 4.0 lb per month over 3 months.

The South Shore YMCA Study
Protein and Body Composition
Fitness Management 2008 (May) ~ FULL TEXT

Subjects who ingested the post-exercise protein drink increased their lean weight by 5.5 pounds, and decreased their fat weight by 9 pounds — a 14.5-pound improvement in body composition.   Those who did not receive supplemental protein increased their lean weight by 3.9 pounds, and decreased their fat weight by 4.9 pounds — an 8.8-pound improvement in body composition.   Based on the results of this study, we found that a standard strength/endurance exercise program consistent with ACSM training guidelines is effective at increasing lean weight, decreasing fat weight and reducing resting blood pressure.   Furthermore, we believe that consuming supplemental protein shortly after each training session is beneficial in helping promote desirable body composition changes (increased lean weight and decreased fat weight) associated with a standard strength/endurance exercise program.


    OmegaGuard Studies    

The Role of Fish Oil in Inflammatory Eye Diseases
Biomedicine Hub. 2017 (Feb 21);   2 (1):   1–12 ~ FULL TEXT

Consumption of fish oil is associated with reduced morbidity and mortality of cardiovascular diseases and also reduces the severity of many other inflammatory diseases and autoimmune disorders. The beneficial effects are attributed to the anti-inflammatory effects of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), found in fish oils. The mechanism of the anti-inflammatory effects was long thought to be by modulating the production of proinflammatory mediators, including prostaglandins, thromboxanes, and leukotrienes. Recent advances in research into the novel lipid mediators (resolvins, protectins, and maresins) derived from EPA and DHA and their role in the resolution of inflammation have shed new light on the pleiotropic nature of these fatty acids. In this review, we focus on the effects of EPA and DHA from fish oil in the treatment of two common inflammatory eye diseases – dry eye disease and age-related macular degeneration. Evidence from recent studies lends support to a role of fish oil in the treatment of these two eye diseases.

Reduced Asthma Symptoms with n-3 Fatty Acid Ingestion
Are Related to 5-series Leukotriene Production

Am J Clin Nutr. 1997 (Apr);   65 (4):   1011–1017 ~ FULL TEXT

In summary, the incorporation of a source of n-3 PUFA in the diet, ie, fish or fish oil, could alleviate minor respiratory problems in asthmatics or decrease the degree of respiratory problems among a subset of severe asthmatics who respond to diet. Increased consumption of n-3 PUFAs can produce beneficial alterations in 4- and 5-series leukotriene synthesis. These findings raise the possibility that dietary supplementation with marine oils or highly enriched sources of n-3 PUFAs may be another viable treatment modality for asthma.


    Immune Studies (NutriFeron, Defend & Resist, Vita-Lea)    

An Open-label Study of Administration of EH0202, A Health-food Additive,
to Patients With Chronic Hepatitis C

J Gastroenterol. 2004 (Sep);   39 (9):   873–878 ~ FULL TEXT

There was a statistically significant decrease in HCV-RNA levels in patients with high viral titers after 3 months of EH0202 administration.   No serious adverse events were observed with the EH0202 treatment.   These findings suggest that EH0202 may be safe and useful in the treatment of patients with chronic hepatitis C.   Further studies are, however, needed to obtain a definitive conclusion.

A Pilot Study of a Kampo Formula, EH0202, With Intriguing Results
for Menopausal Symptoms

J Altern Complement Med. 2004 (Apr);   10 (2):   397–399 ~ FULL TEXT

H0202 (MACH) decreased the plasma FSH level and stimulated myelopoiesis through the cytokine system, thereby clinically reduced menopausal symptoms in postmenopausal women. Therefore, in postmenopausal women, this product probably acts as an immunomodulator and endocrine modulator.

Clinical Efficacy of EH0202, a Kampo formula,
on the Health of Middle-aged Women

Am J Chin Med. 2004;   32 (5):   755–770 ~ FULL TEXT

After taking EH0202 for six months, women reported a decrease in menopausal symptoms as well as a decrease in blood pressure and improved blood lipids (total and LDL cholesterol).

Treatment of the Common Cold with Unrefined Echinacea.
A Randomized, Double-blind, Placebo-controlled Trial

Annals of Internal Medicine 2002 (Dec 17);   137 (12):   939–946 ~ FULL TEXT

148 students with common colds of recent onset were randomized to receive echinacea or a placebo, and were tracked for 10 days. This study appears to show that once the cold virus is well-established that echinacea does not appear to moderate the severity or duration of symptoms.

Effect of Long-Term Vitamin-Mineral Supplements on Immune Response
in Older Healthy Adults

J Am Coll Nutr. 1998;   17:   511

Infection-related illness (IML) was significantly lower for Group I than Group 2 for the entire year. While IRL were lower for the first semester, the difference between groups was not statistically significant. Serum folate (+9.04 ng/dL p<0.01) and serum vitamin A (+16.35 µg/dl, p<0.01) were higher for Group I after 1 year. Folate (-0.47 ng/mL) and zinc (-0.37 µg/L) correlated negatively with days of illness (p<0.05): the higher the level of folate and zinc, the fewer days of illness.


    7-Day Cleanse Program    

Safety, Tolerability And Efficacy Of A 7-Day Cleanse Program: A Pilot Study
ObesityWeek 2014 ~ FULL TEXT

This study showed that the cleanse programs were safe and well-tolerated. Significant weight loss was observed after 7 days. The addition of laxative was more effective in promoting elimination/bowel movements and reducing bloating/gassiness. This program may be used as an adjunct prior to a weight loss program.


    Shaklee Support for Basic Science    

Human Parainfluenza Virus Infection of the Airway Epithelium:
Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein
Activation and Modulates Infectivity

J Virol. 2009 (Jul);   83 (13):   6900–6908 ~ FULL TEXT

This study was designed to help understand the progression of parainfluenza infection for the development of potential anti-viral strategies. The study suggested that the most direct strategy for preventing infection may be by interfering with the initial receptor binding of the virus to the host cell.

Since 12–01–2015

Updated 11-03–2018

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